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David Kaplan

TitleSenior Scientist
InstitutionThe Hospital for Sick Children
DepartmentNeurosciences & Mental Health
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Yuan AL, Ricks CB, Bohm AK, Lun X, Maxwell L, Safdar S, Bukhari S, Gerber A, Sayeed W, Bering EA, Pedersen H, Chan JA, Shen Y, Marra M, Kaplan DR, Mason W, Goodman LD, Ezhilarasan R, Kaufmann AB, Cabral M, Robbins SM, Senger DL, Cahill DP, Sulman EP, Cairncross JG, Blough MD. ABT-888 restores sensitivity in temozolomide resistant glioma cells and xenografts. PLoS One. 2018; 13(8):e0202860. PMID: 30153289.
      View in: PubMed
    2. Qazi MA, Vora P, Venugopal C, Adams J, Singh M, Hu A, Gorelik M, Subapanditha MK, Savage N, Yang J, Chokshi C, London M, Gont A, Bobrowski D, Grinshtein N, Brown KR, Murty NK, Nilvebrant J, Kaplan D, Moffat J, Sidhu S, Singh SK. Cotargeting Ephrin Receptor Tyrosine Kinases A2 and A3 in Cancer Stem Cells Reduces Growth of Recurrent Glioblastoma. Cancer Res. 2018 Sep 01; 78(17):5023-5037. PMID: 29945963.
      View in: PubMed
    3. Storer MA, Gallagher D, Fatt MP, Simonetta JV, Kaplan DR, Miller FD. Interleukin-6 Regulates Adult Neural Stem Cell Numbers during Normal and Abnormal Post-natal Development. Stem Cell Reports. 2018 May 08; 10(5):1464-1480. PMID: 29628394.
      View in: PubMed
    4. Zahr SK, Yang G, Kazan H, Borrett MJ, Yuzwa SA, Voronova A, Kaplan DR, Miller FD. A Translational Repression Complex in Developing Mammalian Neural Stem Cells that Regulates Neuronal Specification. Neuron. 2018 Feb 07; 97(3):520-537.e6. PMID: 29395907.
      View in: PubMed
    5. Yuzwa SA, Borrett MJ, Innes BT, Voronova A, Ketela T, Kaplan DR, Bader GD, Miller FD. Developmental Emergence of Adult Neural Stem Cells as Revealed by Single-Cell Transcriptional Profiling. Cell Rep. 2017 Dec 26; 21(13):3970-3986. PMID: 29281841.
      View in: PubMed
    6. Feinberg K, Kolaj A, Wu C, Grinshtein N, Krieger JR, Moran MF, Rubin LL, Miller FD, Kaplan DR. A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria. J Cell Biol. 2017 11 06; 216(11):3655-3675. PMID: 28877995.
      View in: PubMed
    7. Singh M, Venugopal C, Tokar T, Brown KR, McFarlane N, Bakhshinyan D, Vijayakumar T, Manoranjan B, Mahendram S, Vora P, Qazi M, Dhillon M, Tong A, Durrer K, Murty N, Hallet R, Hassell JA, Kaplan DR, Cutz JC, Jurisica I, Moffat J, Singh SK. RNAi screen identifies essential regulators of human brain metastasis-initiating cells. Acta Neuropathol. 2017 12; 134(6):923-940. PMID: 28766011.
      View in: PubMed
    8. Voronova A, Yuzwa SA, Wang BS, Zahr S, Syal C, Wang J, Kaplan DR, Miller FD. Migrating Interneurons Secrete Fractalkine to Promote Oligodendrocyte Formation in the Developing Mammalian Brain. Neuron. 2017 May 03; 94(3):500-516.e9. PMID: 28472653.
      View in: PubMed
    9. Bazenet C, Desmond H, Frank E, Doherty P, Eilers A, Gatchalian C, Glicksman M, Graczyk P, Gusovsky F, Ham J, Kaplan D, Klymkoswsky M, Kotkow K, Krolewski R, Lang P, O'Neil AL, McCarthy MJ, Meiri K, Miller F, Neumage MM, Ozek C, Philpott K, Piccinotti S, Price F, Raff M, Ratcliffe M, Relton J, Rhodes K, Schwob J, Smales C, Smith T, Spadoni C, Taylor J, Vekrellis K, Whitfield J. Lee Rubin: Our mentor and role model. Science. 2017 Feb 24; 355(6327):806. PMID: 28232547.
      View in: PubMed
    10. Seong BK, Fathers KE, Hallett R, Yung CK, Stein LD, Mouaaz S, Kee L, Hawkins CE, Irwin MS, Kaplan DR. A Metastatic Mouse Model Identifies Genes That Regulate Neuroblastoma Metastasis. Cancer Res. 2017 02 01; 77(3):696-706. PMID: 27899382.
      View in: PubMed
    11. Yang G, Cancino GI, Zahr SK, Guskjolen A, Voronova A, Gallagher D, Frankland PW, Kaplan DR, Miller FD. A Glo1-Methylglyoxal Pathway that Is Perturbed in Maternal Diabetes Regulates Embryonic and Adult Neural Stem Cell Pools in Murine Offspring. Cell Rep. 2016 10 18; 17(4):1022-1036. PMID: 27760310.
      View in: PubMed
    12. Grinshtein N, Rioseco CC, Marcellus R, Uehling D, Aman A, Lun X, Muto O, Podmore L, Lever J, Shen Y, Blough MD, Cairncross GJ, Robbins SM, Jones SJ, Marra MA, Al-Awar R, Senger DL, Kaplan DR. Small molecule epigenetic screen identifies novel EZH2 and HDAC inhibitors that target glioblastoma brain tumor-initiating cells. Oncotarget. 2016 09 13; 7(37):59360-59376. PMID: 27449082.
      View in: PubMed
    13. Yuzwa SA, Yang G, Borrett MJ, Clarke G, Cancino GI, Zahr SK, Zandstra PW, Kaplan DR, Miller FD. Proneurogenic Ligands Defined by Modeling Developing Cortex Growth Factor Communication Networks. Neuron. 2016 Sep 07; 91(5):988-1004. PMID: 27545711.
      View in: PubMed
    14. Hallett RM, Seong AB, Kaplan DR, Irwin MS. Transcript signatures that predict outcome and identify targetable pathways in MYCN-amplified neuroblastoma. Mol Oncol. 2016 11; 10(9):1461-1472. PMID: 27599694.
      View in: PubMed
    15. Johnston AP, Yuzwa SA, Carr MJ, Mahmud N, Storer MA, Krause MP, Jones K, Paul S, Kaplan DR, Miller FD. Dedifferentiated Schwann Cell Precursors Secreting Paracrine Factors Are Required for Regeneration of the Mammalian Digit Tip. Cell Stem Cell. 2016 10 06; 19(4):433-448. PMID: 27376984.
      View in: PubMed
    16. Yu CH, Halapy H, Kaplan D, Brydges R, Hall S, Wong R. Effects of a Longitudinal Interprofessional Educational Outreach Program on Collaboration. J Contin Educ Health Prof. 2016; 36(1):24-31. PMID: 26954242.
      View in: PubMed
    17. Naska S, Yuzwa SA, Johnston AP, Paul S, Smith KM, Paris M, Sefton MV, Datti A, Miller FD, Kaplan DR. Identification of Drugs that Regulate Dermal Stem Cells and Enhance Skin Repair. Stem Cell Reports. 2016 Jan 12; 6(1):74-84. PMID: 26724904; PMCID: PMC4719140.
    18. Amadei G, Zander MA, Yang G, Dumelie JG, Vessey JP, Lipshitz HD, Smibert CA, Kaplan DR, Miller FD. A Smaug2-Based Translational Repression Complex Determines the Balance between Precursor Maintenance versus Differentiation during Mammalian Neurogenesis. J Neurosci. 2015 Nov 25; 35(47):15666-81. PMID: 26609159.
      View in: PubMed
    19. Fatt M, Hsu K, He L, Wondisford F, Miller FD, Kaplan DR, Wang J. Metformin Acts on Two Different Molecular Pathways to Enhance Adult Neural Precursor Proliferation/Self-Renewal and Differentiation. Stem Cell Reports. 2015 Dec 08; 5(6):988-995. PMID: 26677765; PMCID: PMC4682208.
    20. Zander MA, Burns SE, Yang G, Kaplan DR, Miller FD. REMOVED: Snail coordinately regulates downstream pathways to control multiple aspects of mammalian neural precursor development. Int J Dev Neurosci. 2015 Dec; 47(Pt A):103. PMID: 29887047.
      View in: PubMed
    21. Thurber AE, Omenetto FG, Kaplan DL. In vivo bioresponses to silk proteins. Biomaterials. 2015 Dec; 71:145-157. PMID: 26322725; PMCID: PMC4573254 [Available on 12/01/16].
    22. Voronova A, Gallagher D, Zander M, Cancino G, Bramall A, Krause MP, Abad C, Tekin M, Neilsen PM, Callen DF, Scherer SW, Keller GM, Kaplan DR, Walz K, Miller FD. Ankrd11 is a chromatin regulator involved in autism that is essential for neural development. Springerplus. 2015; 4(Suppl 1):L28. PMID: 27386191; PMCID: PMC4796256.
    23. Pesaresi M, Soon-Shiong R, French L, Kaplan DR, Miller FD, Paus T. Axon diameter and axonal transport: In vivo and in vitro effects of androgens. Neuroimage. 2015 Jul 15; 115:191-201. PMID: 25956809; PMCID: PMC4461529.
    24. Cancino GI, Fatt MP, Miller FD, Kaplan DR. Conditional ablation of p63 indicates that it is essential for embryonic development of the central nervous system. Cell Cycle. 2015; 14(20):3270-81. PMID: 26359534; PMCID: PMC4825551.
    25. Gallagher D, Voronova A, Zander MA, Cancino GI, Bramall A, Krause MP, Abad C, Tekin M, Neilsen PM, Callen DF, Scherer SW, Keller GM, Kaplan DR, Walz K, Miller FD. Ankrd11 is a chromatin regulator involved in autism that is essential for neural development. Dev Cell. 2015 Jan 12; 32(1):31-42. PMID: 25556659.
      View in: PubMed
    26. Yang G, Smibert CA, Kaplan DR, Miller FD. An eIF4E1/4E-T complex determines the genesis of neurons from precursors by translationally repressing a proneurogenic transcription program. Neuron. 2014 Nov 19; 84(4):723-39. PMID: 25456498.
      View in: PubMed
    27. Chavali PL, Saini RK, Zhai Q, Vizlin-Hodzic D, Venkatabalasubramanian S, Hayashi A, Johansson E, Zeng ZJ, Mohlin S, Påhlman S, Hansford L, Kaplan DR, Funa K. TLX activates MMP-2, promotes self-renewal of tumor spheres in neuroblastoma and correlates with poor patient survival. Cell Death Dis. 2014 Oct 30; 5:e1502. PMID: 25356871; PMCID: PMC4237266.
    28. Zander MA, Cancino GI, Gridley T, Kaplan DR, Miller FD. The Snail transcription factor regulates the numbers of neural precursor cells and newborn neurons throughout mammalian life. PLoS One. 2014; 9(8):e104767. PMID: 25136812; PMCID: PMC4138084.
    29. Krause MP, Dworski S, Feinberg K, Jones K, Johnston AP, Paul S, Paris M, Peles E, Bagli D, Forrest CR, Kaplan DR, Miller FD. Direct genesis of functional rodent and human schwann cells from skin mesenchymal precursors. Stem Cell Reports. 2014 Jul 08; 3(1):85-100. PMID: 25068124; PMCID: PMC4110792.
    30. Fatt MP, Cancino GI, Miller FD, Kaplan DR. p63 and p73 coordinate p53 function to determine the balance between survival, cell death, and senescence in adult neural precursor cells. Cell Death Differ. 2014 Oct; 21(10):1546-59. PMID: 24809925; PMCID: PMC4158681.
    31. Lescarbeau RM, Kaplan DL. Quantitative analysis of castration resistant prostate cancer progression through phosphoproteome signaling. BMC Cancer. 2014 May 08; 14:325. PMID: 24885093; PMCID: PMC4031492.
    32. Zander MA, Burns SE, Yang G, Kaplan DR, Miller FD. Snail coordinately regulates downstream pathways to control multiple aspects of mammalian neural precursor development. J Neurosci. 2014 Apr 09; 34(15):5164-75. PMID: 24719096; PMCID: PMC3983799.
    33. Lau ST, Hansford LM, Chan WK, Chan GC, Wan TS, Wong KK, Kaplan DR, Tam PK, Ngan ES. Prokineticin signaling is required for the maintenance of a de novo population of c-KIT? cells to sustain neuroblastoma progression. Oncogene. 2015 Feb 19; 34(8):1019-34. PMID: 24632619.
      View in: PubMed
    34. Dixit R, Wilkinson G, Cancino GI, Shaker T, Adnani L, Li S, Dennis D, Kurrasch D, Chan JA, Olson EC, Kaplan DR, Zimmer C, Schuurmans C. Neurog1 and Neurog2 control two waves of neuronal differentiation in the piriform cortex. J Neurosci. 2014 Jan 08; 34(2):539-53. PMID: 24403153.
      View in: PubMed
    35. Vojvodic M, Hansford LM, Morozova O, Blakely KM, Taylor P, Fathers KE, Moffat J, Marra M, Smith KM, Moran MF, Kaplan DR. A phosphoproteomics approach to identify candidate kinase inhibitor pathway targets in lymphoma-like primary cell lines. Curr Drug Discov Technol. 2013 Dec; 10(4):283-304. PMID: 23701117.
      View in: PubMed
    36. Tsui D, Voronova A, Gallagher D, Kaplan DR, Miller FD, Wang J. CBP regulates the differentiation of interneurons from ventral forebrain neural precursors during murine development. Dev Biol. 2014 Jan 15; 385(2):230-41. PMID: 24247009.
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    37. Gallagher D, Norman AA, Woodard CL, Yang G, Gauthier-Fisher A, Fujitani M, Vessey JP, Cancino GI, Sachewsky N, Woltjen K, Fatt MP, Morshead CM, Kaplan DR, Miller FD. Transient maternal IL-6 mediates long-lasting changes in neural stem cell pools by deregulating an endogenous self-renewal pathway. Cell Stem Cell. 2013 Nov 07; 13(5):564-76. PMID: 24209760.
      View in: PubMed
    38. Cancino GI, Yiu AP, Fatt MP, Dugani CB, Flores ER, Frankland PW, Josselyn SA, Miller FD, Kaplan DR. p63 Regulates adult neural precursor and newly born neuron survival to control hippocampal-dependent Behavior. J Neurosci. 2013 Jul 31; 33(31):12569-85. PMID: 23904595; PMCID: PMC3728680.
    39. Johnston AP, Naska S, Jones K, Jinno H, Kaplan DR, Miller FD. Sox2-mediated regulation of adult neural crest precursors and skin repair. Stem Cell Reports. 2013; 1(1):38-45. PMID: 24052940; PMCID: PMC3757738.
    40. Arun V, Worrell L, Wiley JC, Kaplan DR, Guha A. Neurofibromin interacts with the cytoplasmic Dynein Heavy Chain 1 in melanosomes of human melanocytes. FEBS Lett. 2013 May 21; 587(10):1466-73. PMID: 23583712.
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    41. Arun V, Wiley JC, Kaur H, Kaplan DR, Guha A. A novel neurofibromin (NF1) interaction with the leucine-rich pentatricopeptide repeat motif-containing protein links neurofibromatosis type 1 and the French Canadian variant of Leigh's syndrome in a common molecular complex. J Neurosci Res. 2013 Apr; 91(4):494-505. PMID: 23361976.
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    42. Tsui D, Vessey JP, Tomita H, Kaplan DR, Miller FD. FoxP2 regulates neurogenesis during embryonic cortical development. J Neurosci. 2013 Jan 02; 33(1):244-58. PMID: 23283338.
      View in: PubMed
    43. Wang PY, Currier MA, Hansford L, Kaplan D, Chiocca EA, Uchida H, Goins WF, Cohen JB, Glorioso JC, van Kuppevelt TH, Mo X, Cripe TP. Expression of HSV-1 receptors in EBV-associated lymphoproliferative disease determines susceptibility to oncolytic HSV. Gene Ther. 2013 Jul; 20(7):761-9. PMID: 23254370; PMCID: PMC3609913.
    44. Vessey JP, Amadei G, Burns SE, Kiebler MA, Kaplan DR, Miller FD. An asymmetrically localized Staufen2-dependent RNA complex regulates maintenance of mammalian neural stem cells. Cell Stem Cell. 2012 Oct 05; 11(4):517-28. PMID: 22902294.
      View in: PubMed
    45. Lescarbeau RM, Seib FP, Prewitz M, Werner C, Kaplan DL. In vitro model of metastasis to bone marrow mediates prostate cancer castration resistant growth through paracrine and extracellular matrix factors. PLoS One. 2012; 7(8):e40372. PMID: 22870197; PMCID: PMC3411611.
    46. Wang J, Gallagher D, DeVito LM, Cancino GI, Tsui D, He L, Keller GM, Frankland PW, Kaplan DR, Miller FD. Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation. Cell Stem Cell. 2012 Jul 06; 11(1):23-35. PMID: 22770240.
      View in: PubMed
    47. Miller FD, Kaplan DR. Mobilizing endogenous stem cells for repair and regeneration: are we there yet? Cell Stem Cell. 2012 Jun 14; 10(6):650-2. PMID: 22704501.
      View in: PubMed
    48. Cancino GI, Miller FD, Kaplan DR. p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer's disease. Neurobiol Aging. 2013 Feb; 34(2):387-99. PMID: 22592019.
      View in: PubMed
    49. Grinshtein N, Datti A, Fujitani M, Uehling D, Prakesch M, Isaac M, Irwin MS, Wrana JL, Al-Awar R, Kaplan DR. Small molecule kinase inhibitor screen identifies polo-like kinase 1 as a target for neuroblastoma tumor-initiating cells. Cancer Res. 2011 Feb 15; 71(4):1385-95. PMID: 21303981.
      View in: PubMed
    50. Antony JM, Paquin A, Nutt SL, Kaplan DR, Miller FD. Endogenous microglia regulate development of embryonic cortical precursor cells. J Neurosci Res. 2011 Mar; 89(3):286-98. PMID: 21259316.
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    51. Castelo-Branco P, Zhang C, Lipman T, Fujitani M, Hansford L, Clarke I, Harley CB, Tressler R, Malkin D, Walker E, Kaplan DR, Dirks P, Tabori U. Neural tumor-initiating cells have distinct telomere maintenance and can be safely targeted for telomerase inhibition. Clin Cancer Res. 2011 Jan 01; 17(1):111-21. PMID: 21208905.
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    52. Fujitani M, Cancino GI, Dugani CB, Weaver IC, Gauthier-Fisher A, Paquin A, Mak TW, Wojtowicz MJ, Miller FD, Kaplan DR. TAp73 acts via the bHLH Hey2 to promote long-term maintenance of neural precursors. Curr Biol. 2010 Nov 23; 20(22):2058-65. PMID: 21074438.
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    53. Chung J, Lau J, Cheng LS, Grant RI, Robinson F, Ketela T, Reis PP, Roche O, Kamel-Reid S, Moffat J, Ohh M, Perez-Ordonez B, Kaplan DR, Irwin MS. SATB2 augments ?Np63a in head and neck squamous cell carcinoma. EMBO Rep. 2010 Oct; 11(10):777-83. PMID: 20829881; PMCID: PMC2948183.
    54. Dugani CB, Paquin A, Kaplan DR, Miller FD. Coffin-Lowry syndrome: a role for RSK2 in mammalian neurogenesis. Dev Biol. 2010 Nov 15; 347(2):348-59. PMID: 20832397.
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    55. Smith KM, Datti A, Fujitani M, Grinshtein N, Zhang L, Morozova O, Blakely KM, Rotenberg SA, Hansford LM, Miller FD, Yeger H, Irwin MS, Moffat J, Marra MA, Baruchel S, Wrana JL, Kaplan DR. Selective targeting of neuroblastoma tumour-initiating cells by compounds identified in stem cell-based small molecule screens. EMBO Mol Med. 2010 Sep; 2(9):371-84. PMID: 20721990; PMCID: PMC3377336.
    56. Naska S, Lin DC, Miller FD, Kaplan DR. p75NTR is an obligate signaling receptor required for cues that cause sympathetic neuron growth cone collapse. Mol Cell Neurosci. 2010 Oct; 45(2):108-20. PMID: 20584617.
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    57. Mieszawska AJ, Kaplan DL. Smart biomaterials - regulating cell behavior through signaling molecules. BMC Biol. 2010 May 19; 8:59. PMID: 20529238; PMCID: PMC2873335.
    58. Park KJ, Grosso CA, Aubert I, Kaplan DR, Miller FD. p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain. Nat Neurosci. 2010 May; 13(5):559-66. PMID: 20348920.
      View in: PubMed
    59. Wilhelm MT, Rufini A, Wetzel MK, Tsuchihara K, Inoue S, Tomasini R, Itie-Youten A, Wakeham A, Arsenian-Henriksson M, Melino G, Kaplan DR, Miller FD, Mak TW. Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway. Genes Dev. 2010 Mar 15; 24(6):549-60. PMID: 20194434; PMCID: PMC2841333.
    60. Wang J, Weaver IC, Gauthier-Fisher A, Wang H, He L, Yeomans J, Wondisford F, Kaplan DR, Miller FD. CBP histone acetyltransferase activity regulates embryonic neural differentiation in the normal and Rubinstein-Taybi syndrome brain. Dev Cell. 2010 Jan 19; 18(1):114-25. PMID: 20152182.
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    61. Pietras A, Hansford LM, Johnsson AS, Bridges E, Sjölund J, Gisselsson D, Rehn M, Beckman S, Noguera R, Navarro S, Cammenga J, Fredlund E, Kaplan DR, Påhlman S. HIF-2alpha maintains an undifferentiated state in neural crest-like human neuroblastoma tumor-initiating cells. Proc Natl Acad Sci U S A. 2009 Sep 29; 106(39):16805-10. PMID: 19805377; PMCID: PMC2745331.
    62. Harel L, Costa B, Tcherpakov M, Zapatka M, Oberthuer A, Hansford LM, Vojvodic M, Levy Z, Chen ZY, Lee FS, Avigad S, Yaniv I, Shi L, Eils R, Fischer M, Brors B, Kaplan DR, Fainzilber M. CCM2 mediates death signaling by the TrkA receptor tyrosine kinase. Neuron. 2009 Sep 10; 63(5):585-91. PMID: 19755102.
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    63. Lavoie JF, Biernaskie JA, Chen Y, Bagli D, Alman B, Kaplan DR, Miller FD. Skin-derived precursors differentiate into skeletogenic cell types and contribute to bone repair. Stem Cells Dev. 2009 Jul-Aug; 18(6):893-906. PMID: 18834279.
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    64. Dugani CB, Paquin A, Fujitani M, Kaplan DR, Miller FD. p63 antagonizes p53 to promote the survival of embryonic neural precursor cells. J Neurosci. 2009 May 20; 29(20):6710-21. PMID: 19458240.
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    65. Gauthier-Fisher A, Lin DC, Greeve M, Kaplan DR, Rottapel R, Miller FD. Lfc and Tctex-1 regulate the genesis of neurons from cortical precursor cells. Nat Neurosci. 2009 Jun; 12(6):735-44. PMID: 19448628.
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    66. Zhang L, Smith KM, Chong AL, Stempak D, Yeger H, Marrano P, Thorner PS, Irwin MS, Kaplan DR, Baruchel S. In vivo antitumor and antimetastatic activity of sunitinib in preclinical neuroblastoma mouse model. Neoplasia. 2009 May; 11(5):426-35. PMID: 19412427; PMCID: PMC2671855.
    67. Paquin A, Hordo C, Kaplan DR, Miller FD. Costello syndrome H-Ras alleles regulate cortical development. Dev Biol. 2009 Jun 15; 330(2):440-51. PMID: 19371735.
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    68. Tomasini R, Tsuchihara K, Wilhelm M, Fujitani M, Rufini A, Cheung CC, Khan F, Itie-Youten A, Wakeham A, Tsao MS, Iovanna JL, Squire J, Jurisica I, Kaplan D, Melino G, Jurisicova A, Mak TW. TAp73 knockout shows genomic instability with infertility and tumor suppressor functions. Genes Dev. 2008 Oct 01; 22(19):2677-91. PMID: 18805989; PMCID: PMC2559903.
    69. Wetzel MK, Naska S, Laliberté CL, Rymar VV, Fujitani M, Biernaskie JA, Cole CJ, Lerch JP, Spring S, Wang SH, Frankland PW, Henkelman RM, Josselyn SA, Sadikot AF, Miller FD, Kaplan DR. p73 regulates neurodegeneration and phospho-tau accumulation during aging and Alzheimer's disease. Neuron. 2008 Sep 11; 59(5):708-21. PMID: 18786355.
      View in: PubMed
    70. Singh KK, Park KJ, Hong EJ, Kramer BM, Greenberg ME, Kaplan DR, Miller FD. Developmental axon pruning mediated by BDNF-p75NTR-dependent axon degeneration. Nat Neurosci. 2008 Jun; 11(6):649-58. PMID: 18382462.
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    71. Hansford LM, McKee AE, Zhang L, George RE, Gerstle JT, Thorner PS, Smith KM, Look AT, Yeger H, Miller FD, Irwin MS, Thiele CJ, Kaplan DR. Neuroblastoma cells isolated from bone marrow metastases contain a naturally enriched tumor-initiating cell. Cancer Res. 2007 Dec 01; 67(23):11234-43. PMID: 18056449.
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    72. Taniguchi J, Fujitani M, Endo M, Kubo T, Fujitani M, Miller FD, Kaplan DR, Yamashita T. Rap1 is involved in the signal transduction of myelin-associated glycoprotein. Cell Death Differ. 2008 Feb; 15(2):408-19. PMID: 18049479.
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    73. Bartkowska K, Paquin A, Gauthier AS, Kaplan DR, Miller FD. Trk signaling regulates neural precursor cell proliferation and differentiation during cortical development. Development. 2007 Dec; 134(24):4369-80. PMID: 18003743.
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    74. Kaplan DR, Miller FD. Developing with BDNF: a moving experience. Neuron. 2007 Jul 05; 55(1):1-2. PMID: 17610810.
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    75. Gauthier AS, Furstoss O, Araki T, Chan R, Neel BG, Kaplan DR, Miller FD. Control of CNS cell-fate decisions by SHP-2 and its dysregulation in Noonan syndrome. Neuron. 2007 Apr 19; 54(2):245-62. PMID: 17442246; PMCID: PMC1900070.
    76. Quevedo C, Kaplan DR, Derry WB. AKT-1 regulates DNA-damage-induced germline apoptosis in C. elegans. Curr Biol. 2007 Feb 06; 17(3):286-92. PMID: 17276923.
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    77. Miller FD, Kaplan DR. To die or not to die: neurons and p63. Cell Cycle. 2007 Feb 01; 6(3):312-7. PMID: 17264677.
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    78. Naska S, Park KJ, Hannigan GE, Dedhar S, Miller FD, Kaplan DR. An essential role for the integrin-linked kinase-glycogen synthase kinase-3 beta pathway during dendrite initiation and growth. J Neurosci. 2006 Dec 20; 26(51):13344-56. PMID: 17182785.
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    79. Lin DC, Quevedo C, Brewer NE, Bell A, Testa JR, Grimes ML, Miller FD, Kaplan DR. APPL1 associates with TrkA and GIPC1 and is required for nerve growth factor-mediated signal transduction. Mol Cell Biol. 2006 Dec; 26(23):8928-41. PMID: 17000777; PMCID: PMC1636815.
    80. Lau L, Hansford LM, Cheng LS, Hang M, Baruchel S, Kaplan DR, Irwin MS. Cyclooxygenase inhibitors modulate the p53/HDM2 pathway and enhance chemotherapy-induced apoptosis in neuroblastoma. Oncogene. 2007 Mar 22; 26(13):1920-31. PMID: 16983334.
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    81. Wei Q, Clarke L, Scheidenhelm DK, Qian B, Tong A, Sabha N, Karim Z, Bock NA, Reti R, Swoboda R, Purev E, Lavoie JF, Bajenaru ML, Shannon P, Herlyn D, Kaplan D, Henkelman RM, Gutmann DH, Guha A. High-grade glioma formation results from postnatal pten loss or mutant epidermal growth factor receptor expression in a transgenic mouse glioma model. Cancer Res. 2006 Aug 01; 66(15):7429-37. PMID: 16885338.
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    82. Volosin M, Song W, Almeida RD, Kaplan DR, Hempstead BL, Friedman WJ. Interaction of survival and death signaling in basal forebrain neurons: roles of neurotrophins and proneurotrophins. J Neurosci. 2006 Jul 19; 26(29):7756-66. PMID: 16855103.
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    83. Hibbert AP, Kramer BM, Miller FD, Kaplan DR. The localization, trafficking and retrograde transport of BDNF bound to p75NTR in sympathetic neurons. Mol Cell Neurosci. 2006 Aug; 32(4):387-402. PMID: 16843677.
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    84. Jacobs WB, Kaplan DR, Miller FD. The p53 family in nervous system development and disease. J Neurochem. 2006 Jun; 97(6):1571-84. PMID: 16805769.
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    85. Fernandes KJ, Kobayashi NR, Gallagher CJ, Barnabé-Heider F, Aumont A, Kaplan DR, Miller FD. Analysis of the neurogenic potential of multipotent skin-derived precursors. Exp Neurol. 2006 Sep; 201(1):32-48. PMID: 16678161.
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    86. Kaplan DR, Miller FD. When a motor goes bad: a kinesin regulates neuronal survival. Cell. 2006 Apr 21; 125(2):224-6. PMID: 16630809.
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    87. Jacobs WB, Govoni G, Ho D, Atwal JK, Barnabe-Heider F, Keyes WM, Mills AA, Miller FD, Kaplan DR. p63 is an essential proapoptotic protein during neural development. Neuron. 2005 Dec 08; 48(5):743-56. PMID: 16337913.
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    88. Barnabé-Heider F, Wasylnka JA, Fernandes KJ, Porsche C, Sendtner M, Kaplan DR, Miller FD. Evidence that embryonic neurons regulate the onset of cortical gliogenesis via cardiotrophin-1. Neuron. 2005 Oct 20; 48(2):253-65. PMID: 16242406.
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    89. Lavoie JF, Lesauteur L, Kohn J, Wong J, Furtoss O, Thiele CJ, Miller FD, Kaplan DR. TrkA induces apoptosis of neuroblastoma cells and does so via a p53-dependent mechanism. J Biol Chem. 2005 Aug 12; 280(32):29199-207. PMID: 15961390.
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    90. Subramaniam S, Shahani N, Strelau J, Laliberté C, Brandt R, Kaplan D, Unsicker K. Insulin-like growth factor 1 inhibits extracellular signal-regulated kinase to promote neuronal survival via the phosphatidylinositol 3-kinase/protein kinase A/c-Raf pathway. J Neurosci. 2005 Mar 16; 25(11):2838-52. PMID: 15772344.
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    91. Torkin R, Lavoie JF, Kaplan DR, Yeger H. Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma. Mol Cancer Ther. 2005 Jan; 4(1):1-11. PMID: 15657348.
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    92. Fernandes KJ, McKenzie IA, Mill P, Smith KM, Akhavan M, Barnabé-Heider F, Biernaskie J, Junek A, Kobayashi NR, Toma JG, Kaplan DR, Labosky PA, Rafuse V, Hui CC, Miller FD. A dermal niche for multipotent adult skin-derived precursor cells. Nat Cell Biol. 2004 Nov; 6(11):1082-93. PMID: 15517002.
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    93. Angers-Loustau A, Hering R, Werbowetski TE, Kaplan DR, Del Maestro RF. SRC regulates actin dynamics and invasion of malignant glial cells in three dimensions. Mol Cancer Res. 2004 Nov; 2(11):595-605. PMID: 15561776.
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    94. Walsh GS, Orike N, Kaplan DR, Miller FD. The invulnerability of adult neurons: a critical role for p73. J Neurosci. 2004 Oct 27; 24(43):9638-47. PMID: 15509751.
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    95. Lee AF, Ho DK, Zanassi P, Walsh GS, Kaplan DR, Miller FD. Evidence that DeltaNp73 promotes neuronal survival by p53-dependent and p53-independent mechanisms. J Neurosci. 2004 Oct 13; 24(41):9174-84. PMID: 15483136.
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    96. Shalin SC, Zirrgiebel U, Honsa KJ, Julien JP, Miller FD, Kaplan DR, Sweatt JD. Neuronal MEK is important for normal fear conditioning in mice. J Neurosci Res. 2004 Mar 15; 75(6):760-70. PMID: 14994337.
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    97. Kaplan DR, Miller FD. Neurobiology: a move to sort life from death. Nature. 2004 Feb 26; 427(6977):798-9. PMID: 14985746.
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    98. Marsh HN, Dubreuil CI, Quevedo C, Lee A, Majdan M, Walsh GS, Hausdorff S, Said FA, Zoueva O, Kozlowski M, Siminovitch K, Neel BG, Miller FD, Kaplan DR. SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase. J Cell Biol. 2003 Dec 08; 163(5):999-1010. PMID: 14662744; PMCID: PMC2173621.
    99. Pollock GS, Robichon R, Boyd KA, Kerkel KA, Kramer M, Lyles J, Ambalavanar R, Khan A, Kaplan DR, Williams RW, Frost DO. TrkB receptor signaling regulates developmental death dynamics, but not final number, of retinal ganglion cells. J Neurosci. 2003 Nov 05; 23(31):10137-45. PMID: 14602830.
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    100. Atwal JK, Singh KK, Tessier-Lavigne M, Miller FD, Kaplan DR. Semaphorin 3F antagonizes neurotrophin-induced phosphatidylinositol 3-kinase and mitogen-activated protein kinase kinase signaling: a mechanism for growth cone collapse. J Neurosci. 2003 Aug 20; 23(20):7602-9. PMID: 12930799.
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    101. Miller FD, Kaplan DR. Signaling mechanisms underlying dendrite formation. Curr Opin Neurobiol. 2003 Jun; 13(3):391-8. PMID: 12850225.
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    102. Kaplan DR, Miller FD. Axon growth inhibition: signals from the p75 neurotrophin receptor. Nat Neurosci. 2003 May; 6(5):435-6. PMID: 12715005.
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    103. Miller FD, Kaplan DR. Neurobiology. TRK makes the retrograde. Science. 2002 Feb 22; 295(5559):1471-3. PMID: 11859179.
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    104. Wartiovaara K, Barnabe-Heider F, Miller FD, Kaplan DR. N-myc promotes survival and induces S-phase entry of postmitotic sympathetic neurons. J Neurosci. 2002 Feb 01; 22(3):815-24. PMID: 11826111.
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    105. Miller FD, Kaplan DR. On Trk for retrograde signaling. Neuron. 2001 Dec 06; 32(5):767-70. PMID: 11738023.
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    106. Toma JG, Akhavan M, Fernandes KJ, Barnabé-Heider F, Sadikot A, Kaplan DR, Miller FD. Isolation of multipotent adult stem cells from the dermis of mammalian skin. Nat Cell Biol. 2001 Sep; 3(9):778-84. PMID: 11533656.
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    107. Miller FD, Kaplan DR. Neurotrophin signalling pathways regulating neuronal apoptosis. Cell Mol Life Sci. 2001 Jul; 58(8):1045-53. PMID: 11529497.
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    108. Atwal JK, Massie B, Miller FD, Kaplan DR. The TrkB-Shc site signals neuronal survival and local axon growth via MEK and P13-kinase. Neuron. 2000 Aug; 27(2):265-77. PMID: 10985347.
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    109. Pozniak CD, Radinovic S, Yang A, McKeon F, Kaplan DR, Miller FD. An anti-apoptotic role for the p53 family member, p73, during developmental neuron death. Science. 2000 Jul 14; 289(5477):304-6. PMID: 10894779.
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    110. Kaplan DR, Miller FD. Neurotrophin signal transduction in the nervous system. Curr Opin Neurobiol. 2000 Jun; 10(3):381-91. PMID: 10851172.
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    111. Kaplan D, Zirrgiebel U, Atwal J. Center stage for NGF in peripheral (but not central) sensory neuron outgrowth. Neuron. 2000 Feb; 25(2):253-4. PMID: 10719878.
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    112. Mazzoni IE, Saïd FA, Aloyz R, Miller FD, Kaplan D. Ras regulates sympathetic neuron survival by suppressing the p53-mediated cell death pathway. J Neurosci. 1999 Nov 15; 19(22):9716-27. PMID: 10559381.
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    113. Vaillant AR, Mazzoni I, Tudan C, Boudreau M, Kaplan DR, Miller FD. Depolarization and neurotrophins converge on the phosphatidylinositol 3-kinase-Akt pathway to synergistically regulate neuronal survival. J Cell Biol. 1999 Sep 06; 146(5):955-66. PMID: 10477751; PMCID: PMC2169479.
    114. Aloyz R, Fawcett JP, Kaplan DR, Murphy RA, Miller FD. Activity-dependent activation of TrkB neurotrophin receptors in the adult CNS. Learn Mem. 1999 May-Jun; 6(3):216-31. PMID: 10492004; PMCID: PMC311290.
    115. Aloyz RS, Bamji SX, Pozniak CD, Toma JG, Atwal J, Kaplan DR, Miller FD. p53 is essential for developmental neuron death as regulated by the TrkA and p75 neurotrophin receptors. J Cell Biol. 1998 Dec 14; 143(6):1691-703. PMID: 9852160; PMCID: PMC2132983.
    116. Miller FD, Kaplan DR. Life and death decisions: a biological role for the p75 neurotrophin receptor. Cell Death Differ. 1998 May; 5(5):343-5. PMID: 10200482.
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    117. Kaplan DR, Miller FD. Signal transduction by the neurotrophin receptors. Curr Opin Cell Biol. 1997 Apr; 9(2):213-21. PMID: 9069267.
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    118. Belliveau DJ, Krivko I, Kohn J, Lachance C, Pozniak C, Rusakov D, Kaplan D, Miller FD. NGF and neurotrophin-3 both activate TrkA on sympathetic neurons but differentially regulate survival and neuritogenesis. J Cell Biol. 1997 Jan 27; 136(2):375-88. PMID: 9015308; PMCID: PMC2134821.
    119. van der Geer P, Wiley S, Gish GD, Lai VK, Stephens R, White MF, Kaplan D, Pawson T. Identification of residues that control specific binding of the Shc phosphotyrosine-binding domain to phosphotyrosine sites. Proc Natl Acad Sci U S A. 1996 Feb 06; 93(3):963-8. PMID: 8577769; PMCID: PMC40012.
    120. van der Geer P, Wiley S, Lai VK, Olivier JP, Gish GD, Stephens R, Kaplan D, Shoelson S, Pawson T. A conserved amino-terminal Shc domain binds to phosphotyrosine motifs in activated receptors and phosphopeptides. Curr Biol. 1995 Apr 01; 5(4):404-12. PMID: 7542991.
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    121. Soppet D, Escandon E, Maragos J, Middlemas DS, Reid SW, Blair J, Burton LE, Stanton BR, Kaplan DR, Hunter T, Nikolics K, Parada LF. The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor. Cell. 1991 May 31; 65(5):895-903. PMID: 1645620.
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    122. Pratt DM, Strominger J, Parkman R, Kaplan D, Schwaber J, Rosenberg N, Scher CD. Abelson virus-transformed lymphocytes: null cells that modulate H-2. Cell. 1977 Nov; 12(3):683-90. PMID: 200369.
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