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Institution

Theo Moraes

TitleStaff Physician
InstitutionThe Hospital for Sick Children
DepartmentRespiratory Medicine
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Navaranjan G, Takaro TK, Wheeler AJ, Diamond ML, Shu H, Azad MB, Becker AB, Dai R, Harris SA, Lefebvre DL, Lu Z, Mandhane PJ, McLean K, Moraes TJ, Scott JA, Turvey SE, Sears MR, Subbarao P, Brook JR. Early life exposure to phthalates in the Canadian Healthy Infant Longitudinal Development (CHILD) study: a multi-city birth cohort. J Expo Sci Environ Epidemiol. 2019 Oct 22. PMID: 31641275.
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    2. Miliku K, Duan QL, Moraes TJ, Becker AB, Mandhane PJ, Turvey SE, Lefebvre DL, Sears MR, Subbarao P, Field CJ, Azad MB. Human milk fatty acid composition is associated with dietary, genetic, sociodemographic, and environmental factors in the CHILD Cohort Study. Am J Clin Nutr. 2019 Oct 07. PMID: 31589250.
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    3. Campisi ES, Schneiderman JE, Owen B, Moraes TJ, Campisi P. Exercise-induced laryngeal obstruction: Quality initiative to improve assessment and management. Int J Pediatr Otorhinolaryngol. 2019 Sep 11; 127:109677. PMID: 31526937.
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    4. Sbihi H, Jones MJ, MacIsaac JL, Brauer M, Allen RW, Sears MR, Subbarao P, Mandhane PJ, Moraes TJ, Azad MB, Becker AB, Brook JR, Kobor MS, Turvey SE. Prenatal exposure to traffic-related air pollution, the gestational epigenetic clock, and risk of early-life allergic sensitization. J Allergy Clin Immunol. 2019 Aug 27. PMID: 31470034.
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    5. Wu YS, Jiang J, Ahmadi S, Lew A, Laselva O, Xia S, Bartlett C, Ip W, Wellhauser L, Ouyang H, Gonska T, Moraes TJ, Bear CE. ORKAMBI-Mediated Rescue of Mucociliary Clearance in Cystic Fibrosis Primary Respiratory Cultures Is Enhanced by Arginine Uptake, Arginase Inhibition, and Promotion of Nitric Oxide Signaling to the Cystic Fibrosis Transmembrane Conductance Regulator Channel. Mol Pharmacol. 2019 Oct; 96(4):515-525. PMID: 31427400.
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    6. Chen W, Subbarao P, McGihon RE, Feldman LY, Zhu J, Lou W, Gershon AS, Abdullah K, Moraes TJ, Dubeau A, Sears MR, Lefebvre DL, Turvey SE, Mandhane PJ, Azad MB, To T. Patterns of health care use related to respiratory conditions in early life: A birth cohort study with linked administrative data. Pediatr Pulmonol. 2019 Aug; 54(8):1267-1276. PMID: 31172683.
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    7. Hoang JA, Mashouri P, Dai R, Brydges MG, Dubeau A, Lépine C, Yin X, Kowalik K, DeLorenzo S, Upton JEM, Moraes TJ, Amin R, Narang I, Boutis K, Schuh S, Maksym GN, Brudno M, Ramani A, Subbarao P, Eiwegger T. Extract and component-specific sensitization patterns in Canadian moderate-to-severe preschool asthmatics. Allergy. 2019 May 24. PMID: 31125434.
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    8. Moossavi S, Atakora F, Miliku K, Sepehri S, Robertson B, Duan QL, Becker AB, Mandhane PJ, Turvey SE, Moraes TJ, Lefebvre DL, Sears MR, Subbarao P, Field CJ, Bode L, Khafipour E, Azad MB. Integrated Analysis of Human Milk Microbiota With Oligosaccharides and Fatty Acids in the CHILD Cohort. Front Nutr. 2019; 6:58. PMID: 31157227.
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    9. Tamana SK, Ezeugwu V, Chikuma J, Lefebvre DL, Azad MB, Moraes TJ, Subbarao P, Becker AB, Turvey SE, Sears MR, Dick BD, Carson V, Rasmussen C, Pei J, Mandhane PJ. Screen-time is associated with inattention problems in preschoolers: Results from the CHILD birth cohort study. PLoS One. 2019; 14(4):e0213995. PMID: 30995220.
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    10. Moossavi S, Sepehri S, Robertson B, Bode L, Goruk S, Field CJ, Lix LM, de Souza RJ, Becker AB, Mandhane PJ, Turvey SE, Subbarao P, Moraes TJ, Lefebvre DL, Sears MR, Khafipour E, Azad MB. Composition and Variation of the Human Milk Microbiota Are Influenced by Maternal and Early-Life Factors. Cell Host Microbe. 2019 02 13; 25(2):324-335.e4. PMID: 30763539.
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    11. Wong MKW, Haliburton B, Graham A, Lapidus-Krol E, Moraes TJ, Marcon MA, Chiu PPL. Requirement and Duration of Tube Feed Supplementation among Congenital Diaphragmatic Hernia Patients. J Pediatr Surg. 2019 May; 54(5):895-898. PMID: 30773392.
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    12. Matenchuk BA, Tamana SK, Lou WYW, Lefebvre DL, Sears MR, Becker AB, Azad MB, Moraes TJ, Turvey SE, Subbarao P, Kozyrskyj AL, Mandhane PJ. Prenatal depression and birth mode sequentially mediate maternal education's influence on infant sleep duration. Sleep Med. 2019 Jul; 59:24-32. PMID: 31153013.
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    13. Wigen RB, Duan W, Moraes TJ, Chiu PPL. Predictors of Long-Term Pulmonary Morbidity in Children with Congenital Diaphragmatic Hernia. Eur J Pediatr Surg. 2019 Feb; 29(1):120-124. PMID: 30583297.
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    14. Cusack L, Sbihi H, Larkin A, Chow A, Brook JR, Moraes T, Mandhane PJ, Becker AB, Azad MB, Subbarao P, Kozyrskyj A, Takaro TK, Sears MR, Turvey SE, Hystad P. Residential green space and pathways to term birth weight in the Canadian Healthy Infant Longitudinal Development (CHILD) Study. Int J Health Geogr. 2018 12 04; 17(1):43. PMID: 30514315.
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    15. Norris MJ, Malhi M, Duan W, Ouyang H, Granados A, Cen Y, Tseng YC, Gubbay J, Maynes J, Moraes TJ. Targeting Intracellular Ion Homeostasis for the Control of Respiratory Syncytial Virus. Am J Respir Cell Mol Biol. 2018 12; 59(6):733-744. PMID: 30095982.
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    16. Dharma C, Lefebvre DL, Tran MM, Lu Z, Lou WYW, Subbarao P, Becker AB, Mandhane PJ, Turvey SE, Moraes TJ, Azad MB, Sears MR. Diagnosing atopic dermatitis in infancy: Questionnaire reports vs criteria-based assessment. Paediatr Perinat Epidemiol. 2018 11; 32(6):556-567. PMID: 30461044.
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    17. Azad MB, Robertson B, Atakora F, Becker AB, Subbarao P, Moraes TJ, Mandhane PJ, Turvey SE, Lefebvre DL, Sears MR, Bode L. Human Milk Oligosaccharide Concentrations Are Associated with Multiple Fixed and Modifiable Maternal Characteristics, Environmental Factors, and Feeding Practices. J Nutr. 2018 11 01; 148(11):1733-1742. PMID: 30247646.
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    18. Eckford PDW, McCormack J, Munsie L, He G, Stanojevic S, Pereira SL, Ho K, Avolio J, Bartlett C, Yang JY, Wong AP, Wellhauser L, Huan LJ, Jiang JX, Ouyang H, Du K, Klingel M, Kyriakopoulou L, Gonska T, Moraes TJ, Strug LJ, Rossant J, Ratjen F, Bear CE. The CF Canada-Sick Kids Program in individual CF therapy: A resource for the advancement of personalized medicine in CF. J Cyst Fibros. 2019 Jan; 18(1):35-43. PMID: 29685812.
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    19. Azad MB, Vehling L, Chan D, Klopp A, Nickel NC, McGavock JM, Becker AB, Mandhane PJ, Turvey SE, Moraes TJ, Taylor MS, Lefebvre DL, Sears MR, Subbarao P. Infant Feeding and Weight Gain: Separating Breast Milk From Breastfeeding and Formula From Food. Pediatrics. 2018 10; 142(4). PMID: 30249624.
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    20. Dharma C, Lefebvre DL, Lu Z, Lou WYW, Becker AB, Mandhane PJ, Turvey SE, Moraes TJ, Azad MB, Chen E, Elliott SJ, Kozyrskyj AL, Sears MR, Subbarao P. Risk for Maternal Depressive Symptoms and Perceived Stress by Ethnicities in Canada: From Pregnancy Through the Preschool Years. Can J Psychiatry. 2019 Mar; 64(3):190-198. PMID: 30068224.
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    21. Forbes JD, Azad MB, Vehling L, Tun HM, Konya TB, Guttman DS, Field CJ, Lefebvre D, Sears MR, Becker AB, Mandhane PJ, Turvey SE, Moraes TJ, Subbarao P, Scott JA, Kozyrskyj AL. Association of Exposure to Formula in the Hospital and Subsequent Infant Feeding Practices With Gut Microbiota and Risk of Overweight in the First Year of Life. JAMA Pediatr. 2018 07 02; 172(7):e181161. PMID: 29868719.
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    22. Lu Z, Foong RE, Kowalik K, Moraes TJ, Boyce A, Dubeau A, Balkovec S, Gustafsson PM, Becker AB, Mandhane PJ, Turvey SE, Lou W, Ratjen F, Sears M, Subbarao P. Ventilation inhomogeneity in infants with recurrent wheezing. Thorax. 2018 10; 73(10):936-941. PMID: 29907664.
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    23. Lu Z, Foong RE, Kowalik K, Moraes TJ, Dubeau A, Lefebvre D, Davis SD, Balkovec S, Becker A, Mandhane P, Turvey SE, Lou W, Sears MR, Ratjen F, Subbarao P. Reference equations for the interpretation of forced expiratory and plethysmographic measurements in infants. Pediatr Pulmonol. 2018 07; 53(7):907-916. PMID: 29790670.
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    24. Cao H, Ouyang H, Grasemann H, Bartlett C, Du K, Duan R, Shi F, Estrada M, Seigel KE, Coates AL, Yeger H, Bear CE, Gonska T, Moraes TJ, Hu J. Transducing Airway Basal Cells with a Helper-Dependent Adenoviral Vector for Lung Gene Therapy. Hum Gene Ther. 2018 06; 29(6):643-652. PMID: 29320887.
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    25. Vehling L, Chan D, McGavock J, Becker AB, Subbarao P, Moraes TJ, Mandhane PJ, Turvey SE, Lefebvre DL, Sears MR, Azad MB. Exclusive breastfeeding in hospital predicts longer breastfeeding duration in Canada: Implications for health equity. Birth. 2018 12; 45(4):440-449. PMID: 29498088.
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    26. Moraes TJ, Sears MR, Subbarao P. Epidemiology of Asthma and Influence of Ethnicity. Semin Respir Crit Care Med. 2018 Feb; 39(1):3-11. PMID: 29427980.
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    27. Moraes TJ, Sears MR. Lower respiratory infections in early life are linked to later asthma. Thorax. 2018 02; 73(2):105-106. PMID: 29170249.
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    28. Mastrangelo P, Norris MJ, Duan W, Barrett EG, Moraes TJ, Hegele RG. Targeting Host Cell Surface Nucleolin for RSV Therapy: Challenges and Opportunities. Vaccines (Basel). 2017 Sep 19; 5(3). PMID: 28925950.
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    29. Molinski SV, Ahmadi S, Ip W, Ouyang H, Villella A, Miller JP, Lee PS, Kulleperuma K, Du K, Di Paola M, Eckford PD, Laselva O, Huan LJ, Wellhauser L, Li E, Ray PN, Pomès R, Moraes TJ, Gonska T, Ratjen F, Bear CE. Orkambi® and amplifier co-therapy improves function from a rare CFTR mutation in gene-edited cells and patient tissue. EMBO Mol Med. 2017 09; 9(9):1224-1243. PMID: 28667089.
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    30. Katz SL, Luu TM, Nuyt AM, Lacaze T, Adamo KB, Adatia I, Humpl T, Jankov RP, Moraes TJ, Staub K, Stickland MK, Thebaud B. Long-term follow-up of cardiorespiratory outcomes in children born extremely preterm: Recommendations from a Canadian consensus workshop. Paediatr Child Health. 2017 May; 22(2):75-79. PMID: 29479185.
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    31. Ahmadi S, Bozoky Z, Di Paola M, Xia S, Li C, Wong AP, Wellhauser L, Molinski SV, Ip W, Ouyang H, Avolio J, Forman-Kay JD, Ratjen F, Hirota JA, Rommens J, Rossant J, Gonska T, Moraes TJ, Bear CE. Phenotypic profiling of CFTR modulators in patient-derived respiratory epithelia. NPJ Genom Med. 2017 Apr 14; 2:12. PMID: 28649446.
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    32. Khayat A, Medin D, Syed F, Moraes TJ, Bin-Hasan S, Narang I, Al-Saleh S, Amin R. Intelligent volume-assured pressured support (iVAPS) for the treatment of congenital central hypoventilation syndrome. Sleep Breath. 2017 May; 21(2):513-519. PMID: 28190166.
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    33. Haliburton B, Mouzaki M, Chiang M, Scaini V, Marcon M, Duan W, Wilson D, Chiu PP, Moraes TJ. Pulmonary function and nutritional morbidity in children and adolescents with congenital diaphragmatic hernia. J Pediatr Surg. 2017 Feb; 52(2):252-256. PMID: 27912974.
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    34. Banerji A, Ng K, Moraes TJ, Panzov V, Robinson J, Lee BE. Cost-effectiveness of palivizumab compared to no prophylaxis in term infants residing in the Canadian Arctic. CMAJ Open. 2016 Oct-Dec; 4(4):E623-E633. PMID: 28443266.
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    35. Banerji A, Panzov V, Young M, Robinson J, Lee B, Moraes T, Mamdani M, Giles BL, Jiang D, Bisson D, Dennis M, Morel J, Hall J, Hui C, Paes B, Mahony JB. Hospital admissions for lower respiratory tract infections among infants in the Canadian Arctic: a cohort study. CMAJ Open. 2016 Oct-Dec; 4(4):E615-E622. PMID: 28018874.
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    36. Haliburton B, Chiang M, Marcon M, Moraes TJ, Chiu PP, Mouzaki M. Nutritional Intake, Energy Expenditure, and Growth of Infants Following Congenital Diaphragmatic Hernia Repair. J Pediatr Gastroenterol Nutr. 2016 Mar; 62(3):474-8. PMID: 26465794.
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    37. Redouane B, Cohen E, Stephens D, Keilty K, Mouzaki M, Narayanan U, Moraes T, Amin R. Parental Perceptions of Quality of Life in Children on Long-Term Ventilation at Home as Compared to Enterostomy Tubes. PLoS One. 2016; 11(2):e0149999. PMID: 26914939.
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    38. King SK, Alfaraj M, Gaiteiro R, O'Brien K, Moraes T, Humpl T, Marcon M, Chiang M, Reyes J, Haliburton B, Ryan G, Cox P, Chiu PP. Congenital diaphragmatic hernia: Observed/expected lung-to-head ratio as a predictor of long-term morbidity. J Pediatr Surg. 2016 May; 51(5):699-702. PMID: 26932249.
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    39. Norris MJ, Duan W, Cen Y, Moraes TJ. Agonistic 4-1BB antibody fails to reduce disease burden during acute respiratory syncytial virus (RSV) infection. Antiviral Res. 2016 Jan; 125:46-50. PMID: 26597692.
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    40. Cao H, Ouyang H, Ip W, Du K, Duan W, Avolio J, Wu J, Duan C, Yeger H, Bear CE, Gonska T, Hu J, Moraes TJ. Testing gene therapy vectors in human primary nasal epithelial cultures. Mol Ther Methods Clin Dev. 2015; 2:15034. PMID: 26730394.
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    41. Subbarao P, Anand SS, Becker AB, Befus AD, Brauer M, Brook JR, Denburg JA, HayGlass KT, Kobor MS, Kollmann TR, Kozyrskyj AL, Lou WY, Mandhane PJ, Miller GE, Moraes TJ, Pare PD, Scott JA, Takaro TK, Turvey SE, Duncan JM, Lefebvre DL, Sears MR. The Canadian Healthy Infant Longitudinal Development (CHILD) Study: examining developmental origins of allergy and asthma. Thorax. 2015 Oct; 70(10):998-1000. PMID: 26069286.
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    42. Amin R, Sayal A, Syed F, Daniels C, Hoffman A, Moraes TJ, Cox P. How long does it take to initiate a child on long-term invasive ventilation? Results from a Canadian pediatric home ventilation program. Can Respir J. 2015 Mar-Apr; 22(2):103-8. PMID: 25848720.
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    43. Haliburton B, Mouzaki M, Chiang M, Scaini V, Marcon M, Moraes TJ, Chiu PP. Long-term nutritional morbidity for congenital diaphragmatic hernia survivors: Failure to thrive extends well into childhood and adolescence. J Pediatr Surg. 2015 May; 50(5):734-8. PMID: 25783378.
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    44. Moraes TJ, Lefebvre DL, Chooniedass R, Becker AB, Brook JR, Denburg J, HayGlass KT, Hegele RG, Kollmann TR, Macri J, Mandhane PJ, Scott JA, Subbarao P, Takaro TK, Turvey SE, Duncan JD, Sears MR, Befus AD. The Canadian healthy infant longitudinal development birth cohort study: biological samples and biobanking. Paediatr Perinat Epidemiol. 2015 Jan; 29(1):84-92. PMID: 25405552.
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    45. Shakeri A, Mastrangelo P, Griffin JK, Moraes TJ, Hegele RG. Respiratory syncytial virus receptor expression in the mouse and viral tropism. Histol Histopathol. 2015 Apr; 30(4):401-11. PMID: 25374027.
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    46. Moraes T. Are we too passive in our attempts to prevent respiratory syncytial virus infection in Northern Canada? Can Respir J. 2014 May-Jun; 21(3):163-4. PMID: 24914608.
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    47. Marchant DJ, Bellac CL, Moraes TJ, Wadsworth SJ, Dufour A, Butler GS, Bilawchuk LM, Hendry RG, Robertson AG, Cheung CT, Ng J, Ang L, Luo Z, Heilbron K, Norris MJ, Duan W, Bucyk T, Karpov A, Devel L, Georgiadis D, Hegele RG, Luo H, Granville DJ, Dive V, McManus BM, Overall CM. A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity. Nat Med. 2014 May; 20(5):493-502. PMID: 24784232.
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    48. Amin R, Sayal P, Syed F, Chaves A, Moraes TJ, MacLusky I. Pediatric long-term home mechanical ventilation: twenty years of follow-up from one Canadian center. Pediatr Pulmonol. 2014 Aug; 49(8):816-24. PMID: 24000198.
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    49. Amin R, Moraes TJ, Skitch A, Irwin MS, Meyn S, Witmans M. Diagnostic practices and disease surveillance in Canadian children with congenital central hypoventilation syndrome. Can Respir J. 2013 May-Jun; 20(3):165-70. PMID: 23762885.
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    50. Armstrong SM, Wang C, Tigdi J, Si X, Dumpit C, Charles S, Gamage A, Moraes TJ, Lee WL. Influenza infects lung microvascular endothelium leading to microvascular leak: role of apoptosis and claudin-5. PLoS One. 2012; 7(10):e47323. PMID: 23115643.
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    51. Snell LM, Lin GH, McPherson AJ, Moraes TJ, Watts TH. T-cell intrinsic effects of GITR and 4-1BB during viral infection and cancer immunotherapy. Immunol Rev. 2011 Nov; 244(1):197-217. PMID: 22017440.
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    52. Tayyari F, Marchant D, Moraes TJ, Duan W, Mastrangelo P, Hegele RG. Identification of nucleolin as a cellular receptor for human respiratory syncytial virus. Nat Med. 2011 Aug 14; 17(9):1132-5. PMID: 21841784.
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    53. Moraes TJ, Lin GH, Wen T, Watts TH. Incorporation of 4-1BB ligand into an adenovirus vaccine vector increases the number of functional antigen-specific CD8 T cells and enhances the duration of protection against influenza-induced respiratory disease. Vaccine. 2011 Aug 26; 29(37):6301-12. PMID: 21704101.
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    54. Moraes TJ, Rafii B, Niessen F, Suzuki T, Martin R, Vachon E, Vogel W, Ruf W, O'Brodovich H, Downey GP. Protease-activated receptor (Par)1 alters bioelectric properties of distal lung epithelia without compromising barrier function. Exp Lung Res. 2009 Mar; 35(2):136-54. PMID: 19263282.
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    55. Lin GH, Sedgmen BJ, Moraes TJ, Snell LM, Topham DJ, Watts TH. Endogenous 4-1BB ligand plays a critical role in protection from influenza-induced disease. J Immunol. 2009 Jan 15; 182(2):934-47. PMID: 19124736.
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    56. Moraes TJ, Martin R, Plumb JD, Vachon E, Cameron CM, Danesh A, Kelvin DJ, Ruf W, Downey GP. Role of PAR2 in murine pulmonary pseudomonal infection. Am J Physiol Lung Cell Mol Physiol. 2008 Feb; 294(2):L368-77. PMID: 18083764.
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    57. Moraes TJ, Downey GP. Death of the septic monocyte: is more better? Crit Care. 2006; 10(3):146. PMID: 16762041.
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    58. Moraes TJ, Zurawska JH, Downey GP. Neutrophil granule contents in the pathogenesis of lung injury. Curr Opin Hematol. 2006 Jan; 13(1):21-7. PMID: 16319683.
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    59. Moraes TJ, Plumb J, Martin R, Vachon E, Cherepanov V, Koh A, Loeve C, Jongstra-Bilen J, Zurawska JH, Kus JV, Burrows LL, Grinstein S, Downey GP. Abnormalities in the pulmonary innate immune system in cystic fibrosis. Am J Respir Cell Mol Biol. 2006 Mar; 34(3):364-74. PMID: 16293782.
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    60. Suzuki T, Moraes TJ, Vachon E, Ginzberg HH, Huang TT, Matthay MA, Hollenberg MD, Marshall J, McCulloch CA, Abreu MT, Chow CW, Downey GP. Proteinase-activated receptor-1 mediates elastase-induced apoptosis of human lung epithelial cells. Am J Respir Cell Mol Biol. 2005 Sep; 33(3):231-47. PMID: 15891109.
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    61. Ginzberg HH, Shannon PT, Suzuki T, Hong O, Vachon E, Moraes T, Abreu MT, Cherepanov V, Wang X, Chow CW, Downey GP. Leukocyte elastase induces epithelial apoptosis: role of mitochondial permeability changes and Akt. Am J Physiol Gastrointest Liver Physiol. 2004 Jul; 287(1):G286-98. PMID: 15194561.
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    62. Moraes TJ, Selvadurai H. Management of exercise-induced bronchospasm in children: the role of leukotriene antagonists. Treat Respir Med. 2004; 3(1):9-15. PMID: 15174889.
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    63. Moraes TJ, Downey GP. Neutrophil cell signaling in infection: role of phosphatidylinositide 3-kinase. Microbes Infect. 2003 Nov; 5(14):1293-8. PMID: 14613772.
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    64. Moraes TJ, Langer JC, Forte V, Shayan K, Sweezey N. Pediatric pulmonary carcinoid: a case report and review of the literature. Pediatr Pulmonol. 2003 Apr; 35(4):318-22. PMID: 12629632.
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    65. Moraes TJ, Chow CW, Downey GP. Proteases and lung injury. Crit Care Med. 2003 Apr; 31(4 Suppl):S189-94. PMID: 12682439.
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