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Walter Kahr

TitleStaff Physician
InstitutionThe Hospital for Sick Children
DepartmentHaematology/Oncology
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
ORCID ORCID Icon0000-0002-2832-7158 Additional info
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    Collapse Biography 
    Collapse education and training
    University of Toronto, TorontoPhD1994Department of Biochemistry, Faculty of Medicine
    University of Toronto, TorontoMD1994Department of Medicine, Faculty of Medicine
    McMaster University, HamiltonPost-Doctoral Research Fellowship2002Department of Pathology and Molecular Medicine
    McMaster University, Hamilton1999Hematology, Department of Medicine, Faculty of Health Sciences
    University of Toronto, Toronto1997Internal Medicine, Department of Medicine, Faculty of Medicine
    Collapse awards and honors
    2017Platelet Journal-Cover Competition Award
    2001The International Society on Thrombosis and Haemostasis Award
    2000The American Society of Hematology Travel Award
    1998Berlex Research Award
    1998The American Society of Hematology Travel Award
    2006 - 2009Phase II Clinician Scientist Award, Heart and Stroke Foundation of Ontario
    2001Post Doctoral Fellowship Award, Heart and Stroke Foundation of Canada
    1999Post Doctoral Fellowship Award, Medical Research Council/HSFC
    1999RCPSC Amgen Research Award, Canadian Hematology Society
    1990Summer Scholarship, Medical Research Council of Canada
    2005Dean's Fund New Staff Grant Competition, University of Toronto
    1996Department of Medicine Research Competition, University of Toronto
    1991Summer Scholarship, Medical Alumni Association

    Collapse Overview 
    Collapse overview
    Dr. Kahr received his MD and PhD (Biochemistry) from the University of Toronto in 1994. Following post-graduate training in Internal Medicine at the University of Toronto (1994-1997), Dr. Kahr completed a haematology fellowship in the Department of Medicine (1997-1999) and a post-doctoral fellowship in the Department of Pathology and Molecular Medicine (1999-2002) at McMaster University in Hamilton. During his post-doctoral fellowship, Dr. Kahr discovered that the underlying inherited bleeding defect in the Québec platelet disorder was the abnormal expression of urokinase in patient platelets.

    Dr. Kahr joined the Division of Haematology/Oncology at The Hospital for Sick Children (SickKids) in 2003 as a Clinician-Scientist. He has set up a research laboratory in the Cell Biology Program and is the recipient of a Phase II Clinician Scientist Award from the Heart and Stroke Foundation of Ontario. Dr. Kahr's clinical interests are in the field of haemostasis and thrombosis and his research focus is on the development and function of platelets in health and disease.


    Collapse Research 
    Collapse research activities and funding
         (Walter Kahr)Apr 1, 2010 - Mar 31, 2013
    CHS
    VWD Plasma and Platelets: Functional Characterization of Quantitative and Qualitative VWF Mutations
    Role: Co-Investigator

         (Walter Kahr)Apr 1, 2010 - Mar 31, 2015
    CIHR
    Studies of alpha granule formation in human megakaryocytes and platelets
    Role: Principal Applicant

         (Walter Kahr)Apr 1, 2012 - Mar 31, 2017
    CIHR
    Molecular insights into gray platelet syndrome
    Role: Principal Applicant

         (Walter Kahr)Apr 1, 2013 - Mar 31, 2015
    CHS
    Incorporation of rFVIII into platelets as a potential therapy in patients with inhibitory antibodies to factor VIII
    Role: Principal Applicant

         (Walter Kahr)Apr 1, 2017 - Mar 31, 2019
    CHS
    VWF in megakaryocytes and the role of platelet-VWF in VWD
    Role: Principal Applicant

         (Walter Kahr)Apr 1, 2017 - Mar 31, 2022
    CIHR
    Role of NBEAL2 in blood platelet maturation
    Role: Principal Applicant

         (Walter Kahr)Apr 1, 2018 - Mar 31, 2023
    CIHR
    Role of VPS33B-VPS16B in platelet granule formation
    Role: Principal applicant

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Pluthero FG, Kahr WHA. Recent advances in inherited platelet disorders. Curr Opin Hematol. 2019 Sep; 26(5):313-319. PMID: 31348050.
      View in: PubMed
    2. Egan G, Pluthero FG, Bouskill V, Hilliard P, Drury LJ, Carcao MD, Kahr WHA. Abnormal fibrinolysis recognized by thromboelastography in a case of severe bleeding with normal coagulation and platelet function, leads to detection of a novel SERPINF2 variant causing severe alpha-2-antiplasmin deficiency. Br J Haematol. 2019 Jul 08. PMID: 31282989.
      View in: PubMed
    3. Lo RW, Li L, Leung R, Pluthero FG, Kahr WHA. NBEAL2 (Neurobeachin-Like 2) Is Required for Retention of Cargo Proteins by a-Granules During Their Production by Megakaryocytes. Arterioscler Thromb Vasc Biol. 2018 10; 38(10):2435-2447. PMID: 30354215.
      View in: PubMed
    4. Pluthero FG, Di Paola J, Carcao MD, Kahr WHA. NBEAL2 mutations and bleeding in patients with gray platelet syndrome. Platelets. 2018 Sep; 29(6):632-635. PMID: 29869935.
      View in: PubMed
    5. Pluthero FG, Kahr WHA. The Birth and Death of Platelets in Health and Disease. Physiology (Bethesda). 2018 05 01; 33(3):225-234. PMID: 29638183.
      View in: PubMed
    6. Azzouz L, Cherry A, Riedl M, Khan M, Pluthero FG, Kahr WHA, Palaniyar N, Licht C. Relative antibacterial functions of complement and NETs: NETs trap and complement effectively kills bacteria. Mol Immunol. 2018 05; 97:71-81. PMID: 29571059.
      View in: PubMed
    7. Pluthero FG, Kahr WHA. Imaging Platelets and Megakaryocytes by High-Resolution Laser Fluorescence Microscopy. Methods Mol Biol. 2018; 1812:13-31. PMID: 30171570.
      View in: PubMed
    8. Pluthero FG, Kahr WHA. Balancing the yin and yang of SINE. Blood. 2017 08 31; 130(9):1077-1078. PMID: 28860324.
      View in: PubMed
    9. Bowman ML, Pluthero FG, Tuttle A, Casey L, Li L, Christensen H, Robinson KS, Lillicrap D, Kahr WHA, James P. Discrepant platelet and plasma von Willebrand factor in von Willebrand disease patients with p.Pro2808Leufs*24. J Thromb Haemost. 2017 07; 15(7):1403-1411. PMID: 28453889.
      View in: PubMed
    10. Al-Battat S, Rand ML, Bouskill V, Lau W, Blanchette VS, Kahr WHA, Rivard GE, Carcao MD. Glanzmann thrombasthenia platelets compete with transfused platelets, reducing the haemostatic impact of platelet transfusions. Br J Haematol. 2018 05; 181(3):410-413. PMID: 28466602.
      View in: PubMed
    11. Kahr WH, Pluthero FG, Elkadri A, Warner N, Drobac M, Chen CH, Lo RW, Li L, Li R, Li Q, Thoeni C, Pan J, Leung G, Lara-Corrales I, Murchie R, Cutz E, Laxer RM, Upton J, Roifman CM, Yeung RS, Brumell JH, Muise AM. Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease. Nat Commun. 2017 04 03; 8:14816. PMID: 28368018.
      View in: PubMed
    12. Chen CH, Lo RW, Urban D, Pluthero FG, Kahr WH. a-granule biogenesis: from disease to discovery. Platelets. 2017 Mar; 28(2):147-154. PMID: 28277061.
      View in: PubMed
    13. Sholzberg M, Floros G, Schneiderman JE, Kahr WH, Rand M, Pluthero F, Hossain T, Mahamad S, Nisenbaum R, Zhang C, O'Neill NE, Teitel J, Carcao M. Effect of moderate intensity exercise on haemostatic capacity in adults with haemophilia A and B: pilot study. Haemophilia. 2017 03; 23(2):e162-e165. PMID: 28111839.
      View in: PubMed
    14. Laskine-Holland ML, Kahr WH, Crawford-Lean L, Humpl T, Honjo O, Foreman C, Jain M, O'Leary JD. The Association Between Cyanosis and Thromboelastometry (ROTEM) in Children With Congenital Heart Defects: A Retrospective Cohort Study. Anesth Analg. 2017 01; 124(1):23-29. PMID: 27861436.
      View in: PubMed
    15. Urban D, Pluthero FG, Christensen H, Baidya S, Rand ML, Das A, Shah PS, Chitayat D, Blanchette VS, Kahr WH. Decreased numbers of dense granules in fetal and neonatal platelets. Haematologica. 2017 02; 102(2):e36-e38. PMID: 27810994.
      View in: PubMed
    16. Nance D, Campbell RA, Rowley JW, Downie JM, Jorde LB, Kahr WH, Mereby SA, Tolley ND, Zimmerman GA, Weyrich AS, Rondina MT. Combined variants in factor VIII and prostaglandin synthase-1 amplify hemorrhage severity across three generations of descendants. J Thromb Haemost. 2016 11; 14(11):2230-2240. PMID: 27629384.
      View in: PubMed
    17. Riedl M, Noone DG, Khan MA, Pluthero FG, Kahr WHA, Palaniyar N, Licht C. Complement Activation Induces Neutrophil Adhesion and Neutrophil-Platelet Aggregate Formation on Vascular Endothelial Cells. Kidney Int Rep. 2017 Jan; 2(1):66-75. PMID: 29142942.
      View in: PubMed
    18. Noone DG, Riedl M, Pluthero FG, Bowman ML, Liszewski MK, Lu L, Quan Y, Balgobin S, Schneppenheim R, Schneppenheim S, Budde U, James P, Atkinson JP, Palaniyar N, Kahr WH, Licht C. Von Willebrand factor regulates complement on endothelial cells. Kidney Int. 2016 07; 90(1):123-34. PMID: 27236750.
      View in: PubMed
    19. Wang TF, Dawson JE, Forman-Kay JD, Kahr WHA, Williams S, Chan AK, Kumar R. Molecular structural analysis of a novel and de-novo mutation in the SERPINC1 gene associated with type 1 antithrombin deficiency. Br J Haematol. 2017 05; 177(4):654-656. PMID: 27098850.
      View in: PubMed
    20. Simeoni I, Stephens JC, Hu F, Deevi SV, Megy K, Bariana TK, Lentaigne C, Schulman S, Sivapalaratnam S, Vries MJ, Westbury SK, Greene D, Papadia S, Alessi MC, Attwood AP, Ballmaier M, Baynam G, Bermejo E, Bertoli M, Bray PF, Bury L, Cattaneo M, Collins P, Daugherty LC, Favier R, French DL, Furie B, Gattens M, Germeshausen M, Ghevaert C, Goodeve AC, Guerrero JA, Hampshire DJ, Hart DP, Heemskerk JW, Henskens YM, Hill M, Hogg N, Jolley JD, Kahr WH, Kelly AM, Kerr R, Kostadima M, Kunishima S, Lambert MP, Liesner R, López JA, Mapeta RP, Mathias M, Millar CM, Nathwani A, Neerman-Arbez M, Nurden AT, Nurden P, Othman M, Peerlinck K, Perry DJ, Poudel P, Reitsma P, Rondina MT, Smethurst PA, Stevenson W, Szkotak A, Tuna S, van Geet C, Whitehorn D, Wilcox DA, Zhang B, Revel-Vilk S, Gresele P, Bellissimo DB, Penkett CJ, Laffan MA, Mumford AD, Rendon A, Gomez K, Freson K, Ouwehand WH, Turro E. A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders. Blood. 2016 06 09; 127(23):2791-803. PMID: 27084890.
      View in: PubMed
    21. Yuen J, Pluthero FG, Douda DN, Riedl M, Cherry A, Ulanova M, Kahr WH, Palaniyar N, Licht C. NETosing Neutrophils Activate Complement Both on Their Own NETs and Bacteria via Alternative and Non-alternative Pathways. Front Immunol. 2016; 7:137. PMID: 27148258.
      View in: PubMed
    22. Crescente M, Pluthero FG, Li L, Lo RW, Walsh TG, Schenk MP, Holbrook LM, Louriero S, Ali MS, Vaiyapuri S, Falet H, Jones IM, Poole AW, Kahr WH, Gibbins JM. Intracellular Trafficking, Localization, and Mobilization of Platelet-Borne Thiol Isomerases. Arterioscler Thromb Vasc Biol. 2016 06; 36(6):1164-73. PMID: 27079884.
      View in: PubMed
    23. Rondina MT, Freitag M, Pluthero FG, Kahr WH, Rowley JW, Kraiss LW, Franks Z, Zimmerman GA, Weyrich AS, Schwertz H. Non-genomic activities of retinoic acid receptor alpha control actin cytoskeletal events in human platelets. J Thromb Haemost. 2016 05; 14(5):1082-94. PMID: 26848712.
      View in: PubMed
    24. Kumar R, Bouskill V, Schneiderman JE, Pluthero FG, Kahr WH, Craik A, Clark D, Whitney K, Zhang C, Rand ML, Carcao M. Impact of aerobic exercise on haemostatic indices in paediatric patients with haemophilia. Thromb Haemost. 2016 06 02; 115(6):1120-8. PMID: 26917411.
      View in: PubMed
    25. Pluthero FG, Kahr WH. Platelet production: new players in the field. Blood. 2016 Feb 18; 127(7):797-9. PMID: 26893396.
      View in: PubMed
    26. Begonja AJ, Pluthero FG, Suphamungmee W, Giannini S, Christensen H, Leung R, Lo RW, Nakamura F, Lehman W, Plomann M, Hoffmeister KM, Kahr WH, Hartwig JH, Falet H. FlnA binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and platelets. Blood. 2015 Jul 02; 126(1):80-8. PMID: 25838348.
      View in: PubMed
    27. Noetzli L, Lo RW, Lee-Sherick AB, Callaghan M, Noris P, Savoia A, Rajpurkar M, Jones K, Gowan K, Balduini C, Pecci A, Gnan C, De Rocco D, Doubek M, Li L, Lu L, Leung R, Landolt-Marticorena C, Hunger S, Heller P, Gutierrez-Hartmann A, Xiayuan L, Pluthero FG, Rowley JW, Weyrich AS, Kahr WHA, Porter CC, Di Paola J. Germline mutations in ETV6 are associated with thrombocytopenia, red cell macrocytosis and predisposition to lymphoblastic leukemia. Nat Genet. 2015 May; 47(5):535-538. PMID: 25807284.
      View in: PubMed
    28. Kumar R, Dawson JE, Chan AK, Forman-Kay JD, Kahr WH, Williams S. c.1058C>T variant in the SERPINC1 gene is pathogenic for antithrombin deficiency. Br J Haematol. 2015 Jul; 170(1):123-5. PMID: 25522812.
      View in: PubMed
    29. Bender M, Giannini S, Grozovsky R, Jönsson T, Christensen H, Pluthero FG, Ko A, Mullally A, Kahr WH, Hoffmeister KM, Falet H. Dynamin 2-dependent endocytosis is required for normal megakaryocyte development in mice. Blood. 2015 Feb 05; 125(6):1014-24. PMID: 25468568.
      View in: PubMed
    30. Landolt-Marticorena C, Kahr WH. Inherited macrothrombocytopenias on the rise. Blood. 2014 Oct 16; 124(16):2473-5. PMID: 25323684.
      View in: PubMed
    31. Shi DS, Smith MC, Campbell RA, Zimmerman PW, Franks ZB, Kraemer BF, Machlus KR, Ling J, Kamba P, Schwertz H, Rowley JW, Miles RR, Liu ZJ, Sola-Visner M, Italiano JE, Christensen H, Kahr WH, Li DY, Weyrich AS. Proteasome function is required for platelet production. J Clin Invest. 2014 Sep; 124(9):3757-66. PMID: 25061876.
      View in: PubMed
    32. Avila ML, Duan L, Cipolla A, Kim A, Kahr WH, Williams S, Brandão LR. Postthrombotic syndrome following upper extremity deep vein thrombosis in children. Blood. 2014 Aug 14; 124(7):1166-73. PMID: 24957144.
      View in: PubMed
    33. Kumar R, Chan AK, Dawson JE, Forman-Kay JD, Kahr WH, Williams S. Clinical presentation and molecular basis of congenital antithrombin deficiency in children: a cohort study. Br J Haematol. 2014 Jul; 166(1):130-9. PMID: 24684277.
      View in: PubMed
    34. Pecci A, Klersy C, Gresele P, Lee KJ, De Rocco D, Bozzi V, Russo G, Heller PG, Loffredo G, Ballmaier M, Fabris F, Beggiato E, Kahr WH, Pujol-Moix N, Platokouki H, Van Geet C, Noris P, Yerram P, Hermans C, Gerber B, Economou M, De Groot M, Zieger B, De Candia E, Fraticelli V, Kersseboom R, Piccoli GB, Zimmermann S, Fierro T, Glembotsky AC, Vianello F, Zaninetti C, Nicchia E, Güthner C, Baronci C, Seri M, Knight PJ, Balduini CL, Savoia A. MYH9-related disease: a novel prognostic model to predict the clinical evolution of the disease based on genotype-phenotype correlations. Hum Mutat. 2014 Feb; 35(2):236-47. PMID: 24186861.
      View in: PubMed
    35. Chen Y, Aardema J, Kale S, Whichard ZL, Awomolo A, Blanchard E, Chang B, Myers DR, Ju L, Tran R, Reece D, Christensen H, Boukour S, Debili N, Strom TS, Rawlings D, Vázquez FX, Voth GA, Zhu C, Kahr WH, Lam WA, Corey SJ. Loss of the F-BAR protein CIP4 reduces platelet production by impairing membrane-cytoskeleton remodeling. Blood. 2013 Sep 05; 122(10):1695-706. PMID: 23881916.
      View in: PubMed
    36. Kahr WH, Lo RW, Li L, Pluthero FG, Christensen H, Ni R, Vaezzadeh N, Hawkins CE, Weyrich AS, Di Paola J, Landolt-Marticorena C, Gross PL. Abnormal megakaryocyte development and platelet function in Nbeal2(-/-) mice. Blood. 2013 Nov 07; 122(19):3349-58. PMID: 23861251.
      View in: PubMed
    37. Kumar R, Kahr WH. Congenital thrombocytopenia: clinical manifestations, laboratory abnormalities, and molecular defects of a heterogeneous group of conditions. Hematol Oncol Clin North Am. 2013 Jun; 27(3):465-94. PMID: 23714308.
      View in: PubMed
    38. Labarque V, Stain AM, Blanchette V, Kahr WH, Carcao MD. Intracranial haemorrhage in von Willebrand disease: a report on six cases. Haemophilia. 2013 Jul; 19(4):602-6. PMID: 23556472.
      View in: PubMed
    39. Tran TH, Al-Harfi I, Harle CC, Kahr WH, Morrison GC, Kornecki A. Coagulation assessment in children with diabetic ketoacidosis. Pediatr Crit Care Med. 2013 Mar; 14(3):256-60. PMID: 23392364.
      View in: PubMed
    40. Kraemer BF, Campbell RA, Schwertz H, Franks ZG, Vieira de Abreu A, Grundler K, Kile BT, Dhakal BK, Rondina MT, Kahr WH, Mulvey MA, Blaylock RC, Zimmerman GA, Weyrich AS. Bacteria differentially induce degradation of Bcl-xL, a survival protein, by human platelets. Blood. 2012 Dec 13; 120(25):5014-20. PMID: 23086749.
      View in: PubMed
    41. Kahr WH, Dror Y. Gray platelet syndrome: macrothrombocytopenia with deficient a-granules. Blood. 2012 Sep 27; 120(13):2543. PMID: 23193541.
      View in: PubMed
    42. Urban D, Li L, Christensen H, Pluthero FG, Chen SZ, Puhacz M, Garg PM, Lanka KK, Cummings JJ, Kramer H, Wasmuth JD, Parkinson J, Kahr WH. The VPS33B-binding protein VPS16B is required in megakaryocyte and platelet a-granule biogenesis. Blood. 2012 Dec 13; 120(25):5032-40. PMID: 23002115.
      View in: PubMed
    43. Guerin A, Stavropoulos DJ, Diab Y, Chénier S, Christensen H, Kahr WH, Babul-Hirji R, Chitayat D. Interstitial deletion of 11q-implicating the KIRREL3 gene in the neurocognitive delay associated with Jacobsen syndrome. Am J Med Genet A. 2012 Oct; 158A(10):2551-6. PMID: 22965935.
      View in: PubMed
    44. Patel S, Huang YW, Reheman A, Pluthero FG, Chaturvedi S, Mukovozov IM, Tole S, Liu GY, Li L, Durocher Y, Ni H, Kahr WH, Robinson LA. The cell motility modulator Slit2 is a potent inhibitor of platelet function. Circulation. 2012 Sep 11; 126(11):1385-95. PMID: 22865890.
      View in: PubMed
    45. Noone D, Al-Matrafi J, Tinckam K, Zipfel PF, Herzenberg AM, Thorner PS, Pluthero FG, Kahr WH, Filler G, Hebert D, Harvey E, Licht C. Antibody mediated rejection associated with complement factor h-related protein 3/1 deficiency successfully treated with eculizumab. Am J Transplant. 2012 Sep; 12(9):2546-53. PMID: 22681773.
      View in: PubMed
    46. Rand ML, Wang H, Pluthero FG, Stafford AR, Ni R, Vaezzadeh N, Allison AC, Kahr WH, Weitz JI, Gross PL. Diannexin, an annexin A5 homodimer, binds phosphatidylserine with high affinity and is a potent inhibitor of platelet-mediated events during thrombus formation. J Thromb Haemost. 2012 Jun; 10(6):1109-19. PMID: 22463102.
      View in: PubMed
    47. Mendoza-Londono R, Chitayat D, Kahr WH, Hinek A, Blaser S, Dupuis L, Goh E, Badilla-Porras R, Howard A, Mittaz L, Superti-Furga A, Unger S, Nishimura G, Bonafe L. Extracellular matrix and platelet function in patients with musculocontractural Ehlers-Danlos syndrome caused by mutations in the CHST14 gene. Am J Med Genet A. 2012 Jun; 158A(6):1344-54. PMID: 22581468.
      View in: PubMed
    48. Yu A, Stephens D, Feldman BM, Parkin PC, Kahr WH, Brandão LR, Shouldice M, Levin AV. The role of prothrombotic factors in the ocular manifestations of abusive and non-abusive head trauma: a feasibility study. Child Abuse Negl. 2012 Apr; 36(4):333-41. PMID: 22575907.
      View in: PubMed
    49. Schechter T, Finkelstein Y, Ali M, Kahr WH, Williams S, Chan AK, Deveber G, Brandão LR. Unfractionated heparin dosing in young infants: clinical outcomes in a cohort monitored with anti-factor Xa levels. J Thromb Haemost. 2012 Mar; 10(3):368-74. PMID: 22244010.
      View in: PubMed
    50. Kraemer BF, Campbell RA, Schwertz H, Cody MJ, Franks Z, Tolley ND, Kahr WH, Lindemann S, Seizer P, Yost CC, Zimmerman GA, Weyrich AS. Novel anti-bacterial activities of ß-defensin 1 in human platelets: suppression of pathogen growth and signaling of neutrophil extracellular trap formation. PLoS Pathog. 2011 Nov; 7(11):e1002355. PMID: 22102811.
      View in: PubMed
    51. Cox K, Price V, Kahr WH. Inherited platelet disorders: a clinical approach to diagnosis and management. Expert Rev Hematol. 2011 Aug; 4(4):455-72. PMID: 21801136.
      View in: PubMed
    52. Kahr WH, Hinckley J, Li L, Schwertz H, Christensen H, Rowley JW, Pluthero FG, Urban D, Fabbro S, Nixon B, Gadzinski R, Storck M, Wang K, Ryu GY, Jobe SM, Schutte BC, Moseley J, Loughran NB, Parkinson J, Weyrich AS, Di Paola J. Mutations in NBEAL2, encoding a BEACH protein, cause gray platelet syndrome. Nat Genet. 2011 Jul 17; 43(8):738-40. PMID: 21765413.
      View in: PubMed
    53. van Eimeren VF, Billinghurst L, Askalan R, Laughlin S, Brandão LR, Williams S, Kahr WH. Cerebral sinus venous thrombosis in a child with hyperthyroidism. Pediatr Blood Cancer. 2012 Jan; 58(1):107-8. PMID: 21674756.
      View in: PubMed
    54. Israels SJ, Kahr WH, Blanchette VS, Luban NL, Rivard GE, Rand ML. Platelet disorders in children: A diagnostic approach. Pediatr Blood Cancer. 2011 Jun; 56(6):975-83. PMID: 21294245.
      View in: PubMed
    55. Akbar MA, Tracy C, Kahr WH, Krämer H. The full-of-bacteria gene is required for phagosome maturation during immune defense in Drosophila. J Cell Biol. 2011 Feb 07; 192(3):383-90. PMID: 21282466.
      View in: PubMed
    56. Fabbro S, Kahr WH, Hinckley J, Wang K, Moseley J, Ryu GY, Nixon B, White JG, Bair T, Schutte B, Di Paola J. Homozygosity mapping with SNP arrays confirms 3p21 as a recessive locus for gray platelet syndrome and narrows the interval significantly. Blood. 2011 Mar 24; 117(12):3430-4. PMID: 21263149.
      View in: PubMed
    57. Kahr WH. Complement halts angiogenesis gone wild. Blood. 2010 Nov 25; 116(22):4393-4. PMID: 21109626.
      View in: PubMed
    58. Pluthero FG, Ryan C, Williams S, Brandão LR, Kahr WH. Decreased in vitro thrombin generation and clot stability in human FXII-null blood and plasma. Br J Haematol. 2011 Jan; 152(1):111-2. PMID: 20880114.
      View in: PubMed
    59. Hartley JL, Zachos NC, Dawood B, Donowitz M, Forman J, Pollitt RJ, Morgan NV, Tee L, Gissen P, Kahr WH, Knisely AS, Watson S, Chitayat D, Booth IW, Protheroe S, Murphy S, de Vries E, Kelly DA, Maher ER. Mutations in TTC37 cause trichohepatoenteric syndrome (phenotypic diarrhea of infancy). Gastroenterology. 2010 Jun; 138(7):2388-98, 2398.e1-2. PMID: 20176027.
      View in: PubMed
    60. Schwertz H, Köster S, Kahr WH, Michetti N, Kraemer BF, Weitz DA, Blaylock RC, Kraiss LW, Greinacher A, Zimmerman GA, Weyrich AS. Anucleate platelets generate progeny. Blood. 2010 May 06; 115(18):3801-9. PMID: 20086251.
      View in: PubMed
    61. Kahr WH, Savoia A, Pluthero FG, Li L, Christensen H, De Rocco D, Traivaree C, Butchart SE, Curtin J, Stollar EJ, Forman-Kay JD, Blanchette VS. Megakaryocyte and platelet abnormalities in a patient with a W33C mutation in the conserved SH3-like domain of myosin heavy chain IIA. Thromb Haemost. 2009 Dec; 102(6):1241-50. PMID: 19967157.
      View in: PubMed
    62. Biss TT, Kahr WH, Brandão LR, Chan AK, Thomas KE, Williams S. The use of elastic compression stockings for post-thrombotic syndrome in a child. Pediatr Blood Cancer. 2009 Sep; 53(3):462-3. PMID: 19459199.
      View in: PubMed
    63. Licht C, Pluthero FG, Li L, Christensen H, Habbig S, Hoppe B, Geary DF, Zipfel PF, Kahr WH. Platelet-associated complement factor H in healthy persons and patients with atypical HUS. Blood. 2009 Nov 12; 114(20):4538-45. PMID: 19704120.
      View in: PubMed
    64. Biss TT, Brandão LR, Kahr WH, Chan AK, Williams S. Clinical probability score and D-dimer estimation lack utility in the diagnosis of childhood pulmonary embolism. J Thromb Haemost. 2009 Oct; 7(10):1633-8. PMID: 19682234.
      View in: PubMed
    65. Kahr WH. Granules and thrombus formation. Blood. 2009 Jul 30; 114(5):932-3. PMID: 19643993.
      View in: PubMed
    66. Bogue CO, Leahy TR, Rea DJ, Bitnun A, Brandao LR, Kahr WH, Jacobson S, Amaral JG, Connolly BL. Idiopathic suppurative pylephlebitis: interventional radiological diagnosis and management. Cardiovasc Intervent Radiol. 2009 Nov; 32(6):1304-7. PMID: 19449066.
      View in: PubMed
    67. Yang H, Lang S, Zhai Z, Li L, Kahr WH, Chen P, Brkic J, Spring CM, Flick MJ, Degen JL, Freedman J, Ni H. Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression. Blood. 2009 Jul 09; 114(2):425-36. PMID: 19332769.
      View in: PubMed
    68. Tan M, Armstrong D, Birken C, Bitnun A, Caldarone CA, Cox P, Kahr W, Macgregor D, Askalan R. Bacterial endocarditis in a child presenting with acute arterial ischemic stroke: should thrombolytic therapy be absolutely contraindicated? Dev Med Child Neurol. 2009 Feb; 51(2):151-4. PMID: 19191846.
      View in: PubMed
    69. Maurer-Spurej E, Kahr WH, Carter CJ, Pittendreigh C, Cameron M, Cyr TD. The value of proteomics for the diagnosis of a platelet-related bleeding disorder. Platelets. 2008 Aug; 19(5):342-51. PMID: 18791940.
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    70. Biss TT, Brandão LR, Kahr WH, Chan AK, Williams S. Clinical features and outcome of pulmonary embolism in children. Br J Haematol. 2008 Sep; 142(5):808-18. PMID: 18564359.
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    71. Diamandis M, Adam F, Kahr WH, Wang P, Chorneyko KA, Arsenault AL, Rivard GE, Hayward CP. Insights into abnormal hemostasis in the Quebec platelet disorder from analyses of clot lysis. J Thromb Haemost. 2006 May; 4(5):1086-94. PMID: 16689763.
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    72. Brandão LR, Williams S, Kahr WH, Ryan C, Temple M, Chan AK. Exercise-induced deep vein thrombosis of the upper extremity. 1. Literature review. Acta Haematol. 2006; 115(3-4):214-20. PMID: 16549899.
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    73. Brandão LR, Williams S, Kahr WH, Ryan C, Temple M, Chan AK. Exercise-induced deep vein thrombosis of the upper extremity. 2. A case series in children. Acta Haematol. 2006; 115(3-4):221-9. PMID: 16549900.
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    74. Lo B, Li L, Gissen P, Christensen H, McKiernan PJ, Ye C, Abdelhaleem M, Hayes JA, Williams MD, Chitayat D, Kahr WH. Requirement of VPS33B, a member of the Sec1/Munc18 protein family, in megakaryocyte and platelet alpha-granule biogenesis. Blood. 2005 Dec 15; 106(13):4159-66. PMID: 16123220.
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    75. Hayes JA, Kahr WH, Lo B, Macpherson BA. Liver biopsy complicated by hemorrhage in a patient with ARC syndrome. Paediatr Anaesth. 2004 Nov; 14(11):960-3. PMID: 15500499.
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    76. Sheth PM, Kahr WH, Haq MA, Veljkovic DK, Rivard GE, Hayward CP. Intracellular activation of the fibrinolytic cascade in the Quebec Platelet Disorder. Thromb Haemost. 2003 Aug; 90(2):293-8. PMID: 12888877.
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    77. Kahr WH, Zheng S, Sheth PM, Pai M, Cowie A, Bouchard M, Podor TJ, Rivard GE, Hayward CP. Platelets from patients with the Quebec platelet disorder contain and secrete abnormal amounts of urokinase-type plasminogen activator. Blood. 2001 Jul 15; 98(2):257-65. PMID: 11435291.
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    78. Landolt-Marticorena C, Kahr WH, Zawarinski P, Correa J, Manolson MF. Substrate- and inhibitor-induced conformational changes in the yeast V-ATPase provide evidence for communication between the catalytic and proton-translocating sectors. J Biol Chem. 1999 Sep 10; 274(37):26057-64. PMID: 10473553.
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    79. Kahr WH, Al-Homadhi A, Meharchand J, Bailey DJ, Stewart AK. Testicular plasmacytoma following chemical orchiectomy: potential role of hypogonadism in myeloma proliferation. Leuk Lymphoma. 1998 Jan; 28(3-4):437-42. PMID: 9517517.
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    80. Kahr WH, Lewis PN, Pulleyblank DE. H3 Cys-110 is in close proximity to the C-terminal regions of H2B and H4 in a nucleosome core with an altered internal arrangement of histones. Biochemistry. 1990 Jun 19; 29(24):5821-9. PMID: 2383560.
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