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Nades Palaniyar

TitleSenior Scientist
InstitutionThe Hospital for Sick Children
DepartmentTranslational Medicine
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
ORCID ORCID Icon0000-0002-2170-8548 Additional info
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    Collapse Biography 
    Collapse education and training
    University of Peradeniya, Sri LankaBSc10/1986Basic and Applied Biology
    University of Peradeniya, Sri LankaMSc08/1989Human and Animal Physiology
    University of Guelph, CanadaPhD04/1997Molecular Biology and Genetics
    University of Guelph, CanadaPost-doctorate10/1998Innate immunity/Microscopy
    University of Cincinnati, United States of AmericaPost-doctorate05/2000Pulmonary Innate Immunity
    University of Oxford, United KingdomPost-doctorate02/2004Lung Molecular Innate Immunity
    Harvard Medical School, Shriners/Massachusetts General Hospital, United States of AmericaVisiting Research Fellow (sabbatical)12/2017Pulmonary Immunity during Burn injury and neuroimmunology

    Collapse Overview 
    Collapse overview
    Infection and inflammation are major contributors to many devastating lung diseases. Dr. Palaniyar studies innate immunity, infection, inflammation and immune cell clearance in the lungs. His research over the last 13 years has brought forward many new advances in the field.

    Dr. Palaniyar joined the Hospital for Sick Children as a scientist in 2004, and has continued to work on the immune functions of SP-D; the same year, neutrophil extracellular trap (NET) formation (NETosis) had been discovered as an unique form of cell death that can help to trap and kill bacteria. Dr. Palaniyar focused on developing several animal models to study pulmonary NETosis in vivo. Dr. Palaniyar’s PhD studies focused on the microbial immune evasion and genomic DNA replication. He has learned DNA biogenesis (replication, repair and recombination) and discovered novel functions of genes (DNA polymerase, helicase, ssDNA binding proteins). As a Postdoctoral Fellow he studied the structure and function of lipid associated proteins (Myelin basic protein and proteolipid protein) and innate immune proteins (pulmonary surfactant proteins SP-A and SP-D).

    In Cincinnati, Dr. Palaniyar generated transgenic mice to study the functions of various domains of SP-A and SP-D. At the University of Oxford, he focused more on SP-D and discovered that SP-D and other collectins (collagenous lectins) binds effectively DNA (JBC 2004). Recently, Dr. Palaniyar was on a 6-month sabbatical at Shriners hospitals for Children - Boston to develop a pulmonary NETosis model to study the effect of burn injury on immune suppression in the lungs. The current proposal focusses on this mouse model to further understand the effect of burn injury in pulmonary immunosuppression leading to sepsis.

    Dr. Palaniyar has been very interested in translating basic science findings to clinical conditions. Therefore, he have been conducting several clinically relevant studies (Roles of neutrophils and NETs in bronchiolitis obliterans and pulmonary infections in stem cell transplant children; NETs in Ex Vivo Lung Perfusion (EVLP) system, NETs in thrombomicroangiopathy/complement system, NETs in cystic fibrosis lung disease). NETs are considered to be double edge swords, and Dr. Palaniyar has been conducting pioneering research work over the last decade on this topic.

    Dr. Palaniyar’s lab consists of a strong group of trainees – MSc, PhD, PDFs and team investigators to work on NETosis and SP-D. They have conceived and proved several novel ideas (functions of neutrophil mitochondria, neutrophil transcription, NETosis pathway details, relevance of NET - trapping but not effective killing of bacteria; a novel form of neutrophil death termed ApoNETosis). They have identified several candidate drugs to regulate (suppress/promote) NETosis by drug screening. Dr. Palaniyar’s lab is currently validating these drug targets. If some of these drugs become clinically useful, those compounds could be tested in the burn model (other than the DNAse enzyme). Dr. Palaniyar also has clinical and basic collaborative studies – both local and international.


    Collapse Research 
    Collapse research activities and funding
         (Nades Palaniyar)Apr 1, 2013 - Apr 1, 2019
    Natural Sciences and Engineering Research Council of Canada (NSERC)
    Generating Innate Immune Diversity to Recognize Newly Emerging Pathogens
    Role: Principal Investigator

         (Neil Sweezey)Apr 1, 2015 - Mar 31, 2019
    Cystic Fibrosis Canada
    Narrowing the gender gap: Modulating estrogen / IL-17 signaling to control Th17 cells Co-applicant and neutrophil extracellular traps in the cystic fibrosis lung
    Role: Co-investigator

         (Nades Palaniyar)Apr 1, 2016 - Mar 31, 2018
    Canadian Institutes of Health Research (CIHR)
    Sex differences in NETosis; effects on infection and inflammation in children
    Role: Principal Investigator

         (Nades Palaniyar)Apr 1, 2016 - Mar 31, 2019
    Cystic Fibrosis Canada
    pH-mediated correction of immune functions of neutrophils to improve CF lung disease
    Role: Principal Investigator

         (Christoph Licht)Jul 1, 2017 - Jun 30, 2021
    Canadian Institutes of Health Research (CIHR)
    NETs in complement-mediated TMA
    Role: Co-investigator

         (Meraj Khan)Sep 1, 2017 - Aug 31, 2018
    SickKids-CF Canada Program for Individualized CF Therapy, CF Therapy Synergy Grant Competition
    Establishing iPS-derived neutrophils for personalized medicine studies
    Role: Co-investigator

         (Nades Palaniyar)Apr 1, 2018 - Apr 1, 2023
    Natural Sciences and Engineering Research Council of Canada (NSERC)
    Innate immune proteins regulating microparticle-mediated lung inflammation
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Khan MA, Pace-Asciak C, Al-Hassan JM, Afzal M, Liu YF, Oommen S, Paul BM, Nair D, Palaniyar N. Furanoid F-Acid F6 Uniquely Induces NETosis Compared to C16 and C18 Fatty Acids in Human Neutrophils. Biomolecules. 2018 Nov 13; 8(4). PMID: 30428625.
      View in: PubMed
    2. Azzouz D, Palaniyar N. ApoNETosis: discovery of a novel form of neutrophil death with concomitant apoptosis and NETosis. Cell Death Dis. 2018 Aug 06; 9(8):839. PMID: 30082793.
      View in: PubMed
    3. Azzouz D, Khan MA, Sweezey N, Palaniyar N. Two-in-one: UV radiation simultaneously induces apoptosis and NETosis. Cell Death Discov. 2018; 4:51. PMID: 29736268.
      View in: PubMed
    4. Azzouz L, Cherry A, Riedl M, Khan M, Pluthero FG, Kahr WHA, Palaniyar N, Licht C. Relative antibacterial functions of complement and NETs: NETs trap and complement effectively kills bacteria. Mol Immunol. 2018 May; 97:71-81. PMID: 29571059.
      View in: PubMed
    5. Khan MA, Philip LM, Cheung G, Vadakepeedika S, Grasemann H, Sweezey N, Palaniyar N. Regulating NETosis: Increasing pH Promotes NADPH Oxidase-Dependent NETosis. Front Med (Lausanne). 2018; 5:19. PMID: 29487850.
      View in: PubMed
    6. Naffah de Souza C, Breda LCD, Khan MA, de Almeida SR, Câmara NOS, Sweezey N, Palaniyar N. Alkaline pH Promotes NADPH Oxidase-Independent Neutrophil Extracellular Trap Formation: A Matter of Mitochondrial Reactive Oxygen Species Generation and Citrullination and Cleavage of Histone. Front Immunol. 2017; 8:1849. PMID: 29375550.
      View in: PubMed
    7. Djiadeu P, Farmakovski N, Azzouz D, Kotra LP, Sweezey N, Palaniyar N. Surfactant protein D regulates caspase-8-mediated cascade of the intrinsic pathway of apoptosis while promoting bleb formation. Mol Immunol. 2017 12; 92:190-198. PMID: 29107869.
      View in: PubMed
    8. Khan MA, Farahvash A, Douda DN, Licht JC, Grasemann H, Sweezey N, Palaniyar N. JNK Activation Turns on LPS- and Gram-Negative Bacteria-Induced NADPH Oxidase-Dependent Suicidal NETosis. Sci Rep. 2017 06 13; 7(1):3409. PMID: 28611461.
      View in: PubMed
    9. Djiadeu P, Kotra LP, Sweezey N, Palaniyar N. Surfactant protein D delays Fas- and TRAIL-mediated extrinsic pathway of apoptosis in T cells. Apoptosis. 2017 05; 22(5):730-740. PMID: 28168327.
      View in: PubMed
    10. Djiadeu P, Azzouz D, Khan MA, Kotra LP, Sweezey N, Palaniyar N. Ultraviolet irradiation increases green fluorescence of dihydrorhodamine (DHR) 123: false-positive results for reactive oxygen species generation. Pharmacol Res Perspect. 2017 04; 5(2):e00303. PMID: 28357129.
      View in: PubMed
    11. Khan MA, Palaniyar N. Transcriptional firing helps to drive NETosis. Sci Rep. 2017 02 08; 7:41749. PMID: 28176807.
      View in: PubMed
    12. Riedl M, Noone DG, Khan MA, Pluthero FG, Kahr WHA, Palaniyar N, Licht C. Complement Activation Induces Neutrophil Adhesion and Neutrophil-Platelet Aggregate Formation on Vascular Endothelial Cells. Kidney Int Rep. 2017 Jan; 2(1):66-75. PMID: 29142942.
      View in: PubMed
    13. Noone DG, Riedl M, Pluthero FG, Bowman ML, Liszewski MK, Lu L, Quan Y, Balgobin S, Schneppenheim R, Schneppenheim S, Budde U, James P, Atkinson JP, Palaniyar N, Kahr WH, Licht C. Von Willebrand factor regulates complement on endothelial cells. Kidney Int. 2016 07; 90(1):123-34. PMID: 27236750.
      View in: PubMed
    14. Yuen J, Pluthero FG, Douda DN, Riedl M, Cherry A, Ulanova M, Kahr WH, Palaniyar N, Licht C. NETosing Neutrophils Activate Complement Both on Their Own NETs and Bacteria via Alternative and Non-alternative Pathways. Front Immunol. 2016; 7:137. PMID: 27148258; PMCID: PMC4831636.
    15. Gassas A, Krueger J, Zaidman I, Schechter T, Craig-Barnes H, Ali M, Palaniyar N. Infections and neutrophils in the pathogenesis of bronchiolitis obliterans syndrome in children after allogeneic stem cell transplantation. Pediatr Transplant. 2016 Mar; 20(2):303-6. PMID: 26918734.
      View in: PubMed
    16. Palaniyar N, Mall MA, Taube C, Worgall S, Grasemann H. New Developments in Cystic Fibrosis Airway Inflammation. Mediators Inflamm. 2015; 2015:769425. PMID: 26221065; PMCID: PMC4499624.
    17. Ghorbani P, Santhakumar P, Hu Q, Djiadeu P, Wolever TM, Palaniyar N, Grasemann H. Short-chain fatty acids affect cystic fibrosis airway inflammation and bacterial growth. Eur Respir J. 2015 Oct; 46(4):1033-45. PMID: 26022954.
      View in: PubMed
    18. Gassas A, Schechter T, Krueger J, Craig-Barnes H, Sung L, Ali M, Dell S, Egeler RM, Zaidman I, Palaniyar N. Serum Krebs Von Den Lungen-6 as a Biomarker for Early Detection of Bronchiolitis Obliterans Syndrome in Children Undergoing Allogeneic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2015 Aug; 21(8):1524-8. PMID: 25963919.
      View in: PubMed
    19. Yildiz C, Palaniyar N, Otulakowski G, Khan MA, Post M, Kuebler WM, Tanswell K, Belcastro R, Masood A, Engelberts D, Kavanagh BP. Mechanical ventilation induces neutrophil extracellular trap formation. Anesthesiology. 2015 Apr; 122(4):864-75. PMID: 25665049.
      View in: PubMed
    20. Douda DN, Khan MA, Grasemann H, Palaniyar N. SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx. Proc Natl Acad Sci U S A. 2015 Mar 03; 112(9):2817-22. PMID: 25730848; PMCID: PMC4352781.
    21. Douda DN, Grasemann H, Pace-Asciak C, Palaniyar N. A lipid mediator hepoxilin A3 is a natural inducer of neutrophil extracellular traps in human neutrophils. Mediators Inflamm. 2015; 2015:520871. PMID: 25784781; PMCID: PMC4345265.
    22. Jin L, Batra S, Douda DN, Palaniyar N, Jeyaseelan S. CXCL1 contributes to host defense in polymicrobial sepsis via modulating T cell and neutrophil functions. J Immunol. 2014 Oct 01; 193(7):3549-58. PMID: 25172493; PMCID: PMC4170008.
    23. Tolosa MF, Palaniyar N. Severe respiratory insufficiency during pandemic H1N1 infection: prognostic value and therapeutic potential of pulmonary surfactant protein A. Crit Care. 2014 Aug 07; 18(4):479. PMID: 25184962; PMCID: PMC4423634.
    24. Bade G, Khan MA, Srivastava AK, Khare P, Solaiappan KK, Guleria R, Palaniyar N, Talwar A. Serum cytokine profiling and enrichment analysis reveal the involvement of immunological and inflammatory pathways in stable patients with chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2014; 9:759-73. PMID: 25125975; PMCID: PMC4130715.
    25. Peter MR, Jerkic M, Sotov V, Douda DN, Ardelean DS, Ghamami N, Lakschevitz F, Khan MA, Robertson SJ, Glogauer M, Philpott DJ, Palaniyar N, Letarte M. Impaired resolution of inflammation in the Endoglin heterozygous mouse model of chronic colitis. Mediators Inflamm. 2014; 2014:767185. PMID: 25114380; PMCID: PMC4121192.
    26. Côté O, Clark ME, Viel L, Labbé G, Seah SY, Khan MA, Douda DN, Palaniyar N, Bienzle D. Secretoglobin 1A1 and 1A1A differentially regulate neutrophil reactive oxygen species production, phagocytosis and extracellular trap formation. PLoS One. 2014; 9(4):e96217. PMID: 24777050; PMCID: PMC4002474.
    27. Mehl A, Ghorbani P, Douda D, Huang H, Palaniyar N, Ratjen F, Grasemann H. Effect of arginase inhibition on pulmonary L-arginine metabolism in murine Pseudomonas pneumonia. PLoS One. 2014; 9(3):e90232. PMID: 24595185; PMCID: PMC3940779.
    28. Douda DN, Yip L, Khan MA, Grasemann H, Palaniyar N. Akt is essential to induce NADPH-dependent NETosis and to switch the neutrophil death to apoptosis. Blood. 2014 Jan 23; 123(4):597-600. PMID: 24458280.
      View in: PubMed
    29. Dhanju R, Min W, Ackerley C, Cimpean L, Palaniyar N, Roifman CM, Grunebaum E. Pulmonary alveolar proteinosis in adenosine deaminase-deficient mice. J Allergy Clin Immunol. 2014 May; 133(5):1467-71, 1471.e1-4. PMID: 24439080.
      View in: PubMed
    30. Madsen J, Gaiha GD, Palaniyar N, Dong T, Mitchell DA, Clark HW. Surfactant Protein D modulates HIV infection of both T-cells and dendritic cells. PLoS One. 2013; 8(3):e59047. PMID: 23527085; PMCID: PMC3601116.
    31. Gassas A, Craig-Barnes H, Dell SD, Cox P, Schechter T, Doyle J, Sung L, Egeler M, Palaniyar N. Severe lung injury and lung biopsy in children post-hematopoietic stem cell transplantation: The differences between allogeneic and autologous transplantation. Pediatr Transplant. 2013 May; 17(3):278-84. PMID: 23461864.
      View in: PubMed
    32. Cheng OZ, Palaniyar N. NET balancing: a problem in inflammatory lung diseases. Front Immunol. 2013; 4:1. PMID: 23355837; PMCID: PMC3553399.
    33. Gassas A, Craig-Barnes H, Dell S, Doyle J, Schechter T, Sung L, Egeler M, Palaniyar N. Chest health surveillance utility in the early detection of bronchiolitis obliterans syndrome in children after allo-SCT. Bone Marrow Transplant. 2013 Jun; 48(6):814-8. PMID: 23165500.
      View in: PubMed
    34. Lee BH, Hwang DM, Palaniyar N, Grinstein S, Philpott DJ, Hu J. Activation of P2X(7) receptor by ATP plays an important role in regulating inflammatory responses during acute viral infection. PLoS One. 2012; 7(4):e35812. PMID: 22558229; PMCID: PMC3338466.
    35. Douda DN, Jackson R, Grasemann H, Palaniyar N. Innate immune collectin surfactant protein D simultaneously binds both neutrophil extracellular traps and carbohydrate ligands and promotes bacterial trapping. J Immunol. 2011 Aug 15; 187(4):1856-65. PMID: 21724991.
      View in: PubMed
    36. Litvack ML, Post M, Palaniyar N. IgM promotes the clearance of small particles and apoptotic microparticles by macrophages. PLoS One. 2011 Mar 23; 6(3):e17223. PMID: 21448268; PMCID: PMC3063157.
    37. Litvack ML, Djiadeu P, Renganathan SD, Sy S, Post M, Palaniyar N. Natural IgM and innate immune collectin SP-D bind to late apoptotic cells and enhance their clearance by alveolar macrophages in vivo. Mol Immunol. 2010 Nov-Dec; 48(1-3):37-47. PMID: 21035192.
      View in: PubMed
    38. Hansen S, Selman L, Palaniyar N, Ziegler K, Brandt J, Kliem A, Jonasson M, Skjoedt MO, Nielsen O, Hartshorn K, Jørgensen TJ, Skjødt K, Holmskov U. Collectin 11 (CL-11, CL-K1) is a MASP-1/3-associated plasma collectin with microbial-binding activity. J Immunol. 2010 Nov 15; 185(10):6096-104. PMID: 20956340.
      View in: PubMed
    39. Lee BH, Kushwah R, Wu J, Ng P, Palaniyar N, Grinstein S, Philpott DJ, Hu J. Adenoviral vectors stimulate innate immune responses in macrophages through cross-talk with epithelial cells. Immunol Lett. 2010 Nov 30; 134(1):93-102. PMID: 20850478.
      View in: PubMed
    40. Krogh-Meibom T, Ingvartsen KL, Tornoe I, Palaniyar N, Willis AC, Holmskov U. A simple two-step purification procedure for the iC3b binding collectin conglutinin. J Immunol Methods. 2010 Oct 31; 362(1-2):204-8. PMID: 20833176.
      View in: PubMed
    41. Palaniyar N. Antibody equivalent molecules of the innate immune system: parallels between innate and adaptive immune proteins. Innate Immun. 2010 Jun; 16(3):131-7. PMID: 20529970.
      View in: PubMed
    42. Litvack ML, Palaniyar N. Review: Soluble innate immune pattern-recognition proteins for clearing dying cells and cellular components: implications on exacerbating or resolving inflammation. Innate Immun. 2010 Jun; 16(3):191-200. PMID: 20529971.
      View in: PubMed
    43. Breuiller-Fouché M, Dubois O, Sediki M, Garcia-Verdugo I, Palaniyar N, Tanfin Z, Chissey A, Cabrol D, Charpigny G, Mehats C. Secreted surfactant protein A from fetal membranes induces stress fibers in cultured human myometrial cells. Am J Physiol Endocrinol Metab. 2010 Jun; 298(6):E1188-97. PMID: 20233942.
      View in: PubMed
    44. Craig-Barnes HA, Doumouras BS, Palaniyar N. Surfactant protein D interacts with alpha2-macroglobulin and increases its innate immune potential. J Biol Chem. 2010 Apr 30; 285(18):13461-70. PMID: 20207732; PMCID: PMC2859506.
    45. Douda DN, Farmakovski N, Dell S, Grasemann H, Palaniyar N. SP-D counteracts GM-CSF-mediated increase of granuloma formation by alveolar macrophages in lysinuric protein intolerance. Orphanet J Rare Dis. 2009 Dec 23; 4:29. PMID: 20030831; PMCID: PMC2807424.
    46. Thomsen T, Moeller JB, Schlosser A, Sorensen GL, Moestrup SK, Palaniyar N, Wallis R, Mollenhauer J, Holmskov U. The recognition unit of FIBCD1 organizes into a noncovalently linked tetrameric structure and uses a hydrophobic funnel (S1) for acetyl group recognition. J Biol Chem. 2010 Jan 08; 285(2):1229-38. PMID: 19892701; PMCID: PMC2801251.
    47. Gaiha GD, Dong T, Palaniyar N, Mitchell DA, Reid KB, Clark HW. Surfactant protein A binds to HIV and inhibits direct infection of CD4+ cells, but enhances dendritic cell-mediated viral transfer. J Immunol. 2008 Jul 01; 181(1):601-9. PMID: 18566427.
      View in: PubMed
    48. Schlosser A, Thomsen T, Shipley JM, Hein PW, Brasch F, Tornøe I, Nielsen O, Skjødt K, Palaniyar N, Steinhilber W, McCormack FX, Holmskov U. Microfibril-associated protein 4 binds to surfactant protein A (SP-A) and colocalizes with SP-A in the extracellular matrix of the lung. Scand J Immunol. 2006 Aug; 64(2):104-16. PMID: 16867155.
      View in: PubMed
    49. Juul-Madsen HR, Krogh-Meibom T, Henryon M, Palaniyar N, Heegaard PM, Purup S, Willis AC, Tornøe I, Ingvartsen KL, Hansen S, Holmskov U. Identification and characterization of porcine mannan-binding lectin A (pMBL-A), and determination of serum concentration heritability. Immunogenetics. 2006 Apr; 58(2-3):129-37. PMID: 16518621.
      View in: PubMed
    50. Nadesalingam J, Reid KB, Palaniyar N. Collectin surfactant protein D binds antibodies and interlinks innate and adaptive immune systems. FEBS Lett. 2005 Aug 15; 579(20):4449-53. PMID: 16061223.
      View in: PubMed
    51. Reid KB, Clark H, Palaniyar N. Surfactant and lung inflammation. Thorax. 2005 Aug; 60(8):620-2. PMID: 16061700; PMCID: PMC1747483.
    52. Nadesalingam J, Dodds AW, Reid KB, Palaniyar N. Mannose-binding lectin recognizes peptidoglycan via the N-acetyl glucosamine moiety, and inhibits ligand-induced proinflammatory effect and promotes chemokine production by macrophages. J Immunol. 2005 Aug 01; 175(3):1785-94. PMID: 16034120.
      View in: PubMed
    53. Palaniyar N, Clark H, Nadesalingam J, Shih MJ, Hawgood S, Reid KB. Innate immune collectin surfactant protein D enhances the clearance of DNA by macrophages and minimizes anti-DNA antibody generation. J Immunol. 2005 Jun 01; 174(11):7352-8. PMID: 15905582.
      View in: PubMed
    54. Palaniyar N, Nadesalingam J, Clark H, Shih MJ, Dodds AW, Reid KB. Nucleic acid is a novel ligand for innate, immune pattern recognition collectins surfactant proteins A and D and mannose-binding lectin. J Biol Chem. 2004 Jul 30; 279(31):32728-36. PMID: 15145932.
      View in: PubMed
    55. Clark H, Palaniyar N, Hawgood S, Reid KB. A recombinant fragment of human surfactant protein D reduces alveolar macrophage apoptosis and pro-inflammatory cytokines in mice developing pulmonary emphysema. Ann N Y Acad Sci. 2003 Dec; 1010:113-6. PMID: 15033705.
      View in: PubMed
    56. Palaniyar N, Nadesalingam J, Reid KB. Innate immune collectins bind nucleic acids and enhance DNA clearance in vitro. Ann N Y Acad Sci. 2003 Dec; 1010:467-70. PMID: 15033771.
      View in: PubMed
    57. Palaniyar N, Clark H, Nadesalingam J, Hawgood S, Reid KB. Surfactant protein D binds genomic DNA and apoptotic cells, and enhances their clearance, in vivo. Ann N Y Acad Sci. 2003 Dec; 1010:471-5. PMID: 15033772.
      View in: PubMed
    58. Nadesalingam J, Bernal AL, Dodds AW, Willis AC, Mahoney DJ, Day AJ, Reid KB, Palaniyar N. Identification and characterization of a novel interaction between pulmonary surfactant protein D and decorin. J Biol Chem. 2003 Jul 11; 278(28):25678-87. PMID: 12730206.
      View in: PubMed
    59. Clark H, Palaniyar N, Strong P, Edmondson J, Hawgood S, Reid KB. Surfactant protein D reduces alveolar macrophage apoptosis in vivo. J Immunol. 2002 Sep 15; 169(6):2892-9. PMID: 12218102.
      View in: PubMed
    60. Palaniyar N, Nadesalingam J, Reid KB. Pulmonary innate immune proteins and receptors that interact with gram-positive bacterial ligands. Immunobiology. 2002 Sep; 205(4-5):575-94. PMID: 12396017.
      View in: PubMed
    61. Palaniyar N, Zhang L, Kuzmenko A, Ikegami M, Wan S, Wu H, Korfhagen TR, Whitsett JA, McCormack FX. The role of pulmonary collectin N-terminal domains in surfactant structure, function, and homeostasis in vivo. J Biol Chem. 2002 Jul 26; 277(30):26971-9. PMID: 12015304.
      View in: PubMed
    62. Shibata Y, Zsengeller Z, Otake K, Palaniyar N, Trapnell BC. Alveolar macrophage deficiency in osteopetrotic mice deficient in macrophage colony-stimulating factor is spontaneously corrected with age and associated with matrix metalloproteinase expression and emphysema. Blood. 2001 Nov 01; 98(9):2845-52. PMID: 11675359.
      View in: PubMed
    63. Ikegami M, Elhalwagi BM, Palaniyar N, Dienger K, Korfhagen T, Whitsett JA, McCormack FX. The collagen-like region of surfactant protein A (SP-A) is required for correction of surfactant structural and functional defects in the SP-A null mouse. J Biol Chem. 2001 Oct 19; 276(42):38542-8. PMID: 11504713.
      View in: PubMed
    64. Palaniyar N, Ikegami M, Korfhagen T, Whitsett J, McCormack FX. Domains of surfactant protein A that affect protein oligomerization, lipid structure and surface tension. Comp Biochem Physiol A Mol Integr Physiol. 2001 May; 129(1):109-27. PMID: 11369537.
      View in: PubMed
    65. Ridsdale RA, Palaniyar N, Possmayer F, Harauz G. Formation of folds and vesicles by dipalmitoylphosphatidylcholine monolayers spread in excess. J Membr Biol. 2001 Mar 01; 180(1):21-32. PMID: 11284201.
      View in: PubMed
    66. Palaniyar N, McCormack FX, Possmayer F, Harauz G. Three-dimensional structure of rat surfactant protein A trimers in association with phospholipid monolayers. Biochemistry. 2000 May 30; 39(21):6310-6. PMID: 10828943.
      View in: PubMed
    67. Mac Millan SV, Ishiyama N, White GF, Palaniyar N, Hallett FR, Harauz G. Myelin basic protein component C1 in increasing concentrations can elicit fusion, aggregation, and fragmentation of myelin-like membranes. Eur J Cell Biol. 2000 May; 79(5):327-35. PMID: 10887963.
      View in: PubMed
    68. Beniac DR, Wood DD, Palaniyar N, Ottensmeyer FP, Moscarello MA, Harauz G. Cryoelectron microscopy of protein-lipid complexes of human myelin basic protein charge isomers differing in degree of citrullination. J Struct Biol. 2000 Feb; 129(1):80-95. PMID: 10675299.
      View in: PubMed
    69. Tseng M, Palaniyar N, Zhang W, Evans DH. DNA binding and aggregation properties of the vaccinia virus I3L gene product. J Biol Chem. 1999 Jul 30; 274(31):21637-44. PMID: 10419472.
      View in: PubMed
    70. Palaniyar N, Ridsdale RA, Hearn SA, Heng YM, Ottensmeyer FP, Possmayer F, Harauz G. Filaments of surfactant protein A specifically interact with corrugated surfaces of phospholipid membranes. Am J Physiol. 1999 Apr; 276(4 Pt 1):L631-41. PMID: 10198361.
      View in: PubMed
    71. Palaniyar N, Ridsdale RA, Hearn SA, Possmayer F, Harauz G. Formation of membrane lattice structures and their specific interactions with surfactant protein A. Am J Physiol. 1999 Apr; 276(4 Pt 1):L642-9. PMID: 10198362.
      View in: PubMed
    72. Beniac DR, Wood DD, Palaniyar N, Ottensmeyer FP, Moscarello MA, Harauz G. Marburg's variant of multiple sclerosis correlates with a less compact structure of myelin basic protein. Mol Cell Biol Res Commun. 1999 Apr; 1(1):48-51. PMID: 10329477.
      View in: PubMed
    73. Palaniyar N, Gerasimopoulos E, Evans DH. Shope fibroma virus DNA topoisomerase catalyses holliday junction resolution and hairpin formation in vitro. J Mol Biol. 1999 Mar 19; 287(1):9-20. PMID: 10074403.
      View in: PubMed
    74. Ridsdale RA, Palaniyar N, Holterman CE, Inchley K, Possmayer F, Harauz G. Cation-mediated conformational variants of surfactant protein A. Biochim Biophys Acta. 1999 Jan 06; 1453(1):23-34. PMID: 9989242.
      View in: PubMed
    75. Palaniyar N, Semotok JL, Wood DD, Moscarello MA, Harauz G. Human proteolipid protein (PLP) mediates winding and adhesion of phospholipid membranes but prevents their fusion. Biochim Biophys Acta. 1998 Dec 09; 1415(1):85-100. PMID: 9858696.
      View in: PubMed
    76. Palaniyar N, Ridsdale RA, Possmayer F, Harauz G. Surfactant protein A (SP-A) forms a novel supraquaternary structure in the form of fibers. Biochem Biophys Res Commun. 1998 Sep 08; 250(1):131-6. PMID: 9735345.
      View in: PubMed
    77. Palaniyar N, Ridsdale RA, Holterman CE, Inchley K, Possmayer F, Harauz G. Structural changes of surfactant protein A induced by cations reorient the protein on lipid bilayers. J Struct Biol. 1998; 122(3):297-310. PMID: 9774534.
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    78. Palaniyar N, Fisher C, Parks R, Evans DH. SFV topoisomerase: sequence specificity in a genetically mapped interval. Virology. 1996 Jul 15; 221(2):351-4. PMID: 8661446.
      View in: PubMed
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