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Paul Frankland

TitleSenior Scientist
InstitutionThe Hospital for Sick Children
DepartmentNeurosciences & Mental Health
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Epp JR, Botly LCP, Josselyn SA, Frankland PW. Voluntary Exercise Increases Neurogenesis and Mediates Forgetting of Complex Paired Associates Memories. Neuroscience. 2021 Aug 30. PMID: 34464663.
      View in: PubMed
    2. Ko SY, Frankland PW. Neurogenesis-dependent transformation of hippocampal engrams. Neurosci Lett. 2021 09 25; 762:136176. PMID: 34400284.
      View in: PubMed
    3. Ben-Ami Bartal I, Breton JM, Sheng H, Long KL, Chen S, Halliday A, Kenney JW, Wheeler AL, Frankland P, Shilyansky C, Deisseroth K, Keltner D, Kaufer D. Neural correlates of ingroup bias for prosociality in rats. Elife. 2021 07 13; 10. PMID: 34253289.
      View in: PubMed
    4. Miller AMP, Frankland PW. To learn something new, do something new. Cell Res. 2021 Jun; 31(6):611-612. PMID: 33911206.
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    5. Vetere G, Xia F, Ramsaran AI, Tran LM, Josselyn SA, Frankland PW. An inhibitory hippocampal-thalamic pathway modulates remote memory retrieval. Nat Neurosci. 2021 05; 24(5):685-693. PMID: 33782621.
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    6. Frankland PW, Josselyn SA. Starring role for astrocytes in memory. Nat Neurosci. 2020 10; 23(10):1181-1182. PMID: 32747788.
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    7. Lau JMH, Rashid AJ, Jacob AD, Frankland PW, Schacter DL, Josselyn SA. The role of neuronal excitability, allocation to an engram and memory linking in the behavioral generation of a false memory in mice. Neurobiol Learn Mem. 2020 10; 174:107284. PMID: 32745601.
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    8. Tran LM, Mocle AJ, Ramsaran AI, Jacob AD, Frankland PW, Josselyn SA. Automated Curation of CNMF-E-Extracted ROI Spatial Footprints and Calcium Traces Using Open-Source AutoML Tools. Front Neural Circuits. 2020; 14:42. PMID: 32792911.
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    9. Noori R, Park D, Griffiths JD, Bells S, Frankland PW, Mabbott D, Lefebvre J. Activity-dependent myelination: A glial mechanism of oscillatory self-organization in large-scale brain networks. Proc Natl Acad Sci U S A. 2020 06 16; 117(24):13227-13237. PMID: 32482855.
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    10. Hasegawa S, Fukushima H, Hosoda H, Serita T, Ishikawa R, Rokukawa T, Kawahara-Miki R, Zhang Y, Ohta M, Okada S, Tanimizu T, Josselyn SA, Frankland PW, Kida S. Hippocampal clock regulates memory retrieval via Dopamine and PKA-induced GluA1 phosphorylation. Nat Commun. 2019 12 18; 10(1):5766. PMID: 31852900.
      View in: PubMed
    11. Park A, Jacob AD, Walters BJ, Park S, Rashid AJ, Jung JH, Lau J, Woolley GA, Frankland PW, Josselyn SA. A time-dependent role for the transcription factor CREB in neuronal allocation to an engram underlying a fear memory revealed using a novel in vivo optogenetic tool to modulate CREB function. Neuropsychopharmacology. 2020 05; 45(6):916-924. PMID: 31837649.
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    12. Steadman PE, Xia F, Ahmed M, Mocle AJ, Penning ARA, Geraghty AC, Steenland HW, Monje M, Josselyn SA, Frankland PW. Disruption of Oligodendrogenesis Impairs Memory Consolidation in Adult Mice. Neuron. 2020 01 08; 105(1):150-164.e6. PMID: 31753579.
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    13. Frankland PW, Josselyn SA, Köhler S. The neurobiological foundation of memory retrieval. Nat Neurosci. 2019 10; 22(10):1576-1585. PMID: 31551594.
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    14. Tran LM, Josselyn SA, Richards BA, Frankland PW. Forgetting at biologically realistic levels of neurogenesis in a large-scale hippocampal model. Behav Brain Res. 2019 12 30; 376:112180. PMID: 31472193.
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    15. Clayton DF, Anreiter I, Aristizabal M, Frankland PW, Binder EB, Citri A. The role of the genome in experience-dependent plasticity: Extending the analogy of the genomic action potential. Proc Natl Acad Sci U S A. 2020 09 22; 117(38):23252-23260. PMID: 31127037.
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    16. Vetere G, Tran LM, Moberg S, Steadman PE, Restivo L, Morrison FG, Ressler KJ, Josselyn SA, Frankland PW. Memory formation in the absence of experience. Nat Neurosci. 2019 06; 22(6):933-940. PMID: 31036944.
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    17. Cuartero MI, de la Parra J, Pérez-Ruiz A, Bravo-Ferrer I, Durán-Laforet V, García-Culebras A, García-Segura JM, Dhaliwal J, Frankland PW, Lizasoain I, Moro MÁ. Abolition of aberrant neurogenesis ameliorates cognitive impairment after stroke in mice. J Clin Invest. 2019 04 01; 129(4):1536-1550. PMID: 30676325.
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    18. Carr MJ, Toma JS, Johnston APW, Steadman PE, Yuzwa SA, Mahmud N, Frankland PW, Kaplan DR, Miller FD. Mesenchymal Precursor Cells in Adult Nerves Contribute to Mammalian Tissue Repair and Regeneration. Cell Stem Cell. 2019 02 07; 24(2):240-256.e9. PMID: 30503141.
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    19. Josselyn SA, Frankland PW. Fear Extinction Requires Reward. Cell. 2018 10 18; 175(3):639-640. PMID: 30340037.
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    20. Ramsaran AI, Schlichting ML, Frankland PW. The ontogeny of memory persistence and specificity. Dev Cogn Neurosci. 2019 04; 36:100591. PMID: 30316637.
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    21. Xia F, Frankland PW. Cognitive Neuroscience: Exciting Developments in Schematic Learning. Curr Biol. 2018 09 24; 28(18):R1096-R1098. PMID: 30253148.
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    22. Syal C, Seegobin M, Sarma SN, Gouveia A, Hsu K, Niibori Y, He L, Wondisford FE, Frankland PW, Wang J. Ectopic expression of aPKC-mediated phosphorylation in p300 modulates hippocampal neurogenesis, CREB binding and fear memory differently with age. Sci Rep. 2018 09 10; 8(1):13489. PMID: 30201979.
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    23. Sekeres MJ, Riggs L, Decker A, de Medeiros CB, Bacopulos A, Skocic J, Szulc-Lerch K, Bouffet E, Levine B, Grady CL, Mabbott DJ, Josselyn SA, Frankland PW. Impaired Recent, but Preserved Remote, Autobiographical Memory in Pediatric Brain Tumor Patients. J Neurosci. 2018 09 19; 38(38):8251-8261. PMID: 30126966.
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    24. Guskjolen A, Kenney JW, de la Parra J, Yeung BA, Josselyn SA, Frankland PW. Recovery of "Lost" Infant Memories in Mice. Curr Biol. 2018 07 23; 28(14):2283-2290.e3. PMID: 29983316.
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    25. Jacob AD, Ramsaran AI, Mocle AJ, Tran LM, Yan C, Frankland PW, Josselyn SA. A Compact Head-Mounted Endoscope for In Vivo Calcium Imaging in Freely Behaving Mice. Curr Protoc Neurosci. 2018 07; 84(1):e51. PMID: 29944206.
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    26. Kramer EE, Steadman PE, Epp JR, Frankland PW, Josselyn SA. Assessing Individual Neuronal Activity Across the Intact Brain: Using Hybridization Chain Reaction (HCR) to Detect Arc mRNA Localized to the Nucleus in Volumes of Cleared Brain Tissue. Curr Protoc Neurosci. 2018 07; 84(1):e49. PMID: 29944213.
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    27. Frankland PW, Josselyn SA. Facing your fears. Science. 2018 06 15; 360(6394):1186-1187. PMID: 29903963.
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    28. Miller AMP, Frankland PW, Josselyn SA. Memory: Ironing Out a Wrinkle in Time. Curr Biol. 2018 05 21; 28(10):R599-R601. PMID: 29787721.
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    29. Josselyn SA, Frankland PW. Memory Allocation: Mechanisms and Function. Annu Rev Neurosci. 2018 07 08; 41:389-413. PMID: 29709212.
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    30. Kempermann G, Gage FH, Aigner L, Song H, Curtis MA, Thuret S, Kuhn HG, Jessberger S, Frankland PW, Cameron HA, Gould E, Hen R, Abrous DN, Toni N, Schinder AF, Zhao X, Lucassen PJ, Frisén J. Human Adult Neurogenesis: Evidence and Remaining Questions. Cell Stem Cell. 2018 Jul 05; 23(1):25-30. PMID: 29681514.
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    31. Gao A, Xia F, Guskjolen AJ, Ramsaran AI, Santoro A, Josselyn SA, Frankland PW. Elevation of Hippocampal Neurogenesis Induces a Temporally Graded Pattern of Forgetting of Contextual Fear Memories. J Neurosci. 2018 03 28; 38(13):3190-3198. PMID: 29453206.
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    32. Xia F, Richards BA, Tran MM, Josselyn SA, Takehara-Nishiuchi K, Frankland PW. Parvalbumin-positive interneurons mediate neocortical-hippocampal interactions that are necessary for memory consolidation. Elife. 2017 09 29; 6. PMID: 28960176.
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    33. Kenney JW, Scott IC, Josselyn SA, Frankland PW. Contextual fear conditioning in zebrafish. Learn Mem. 2017 10; 24(10):516-523. PMID: 28916626.
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    34. Richards BA, Frankland PW. The Persistence and Transience of Memory. Neuron. 2017 Jun 21; 94(6):1071-1084. PMID: 28641107.
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    35. Xia F, Yiu A, Stone SSD, Oh S, Lozano AM, Josselyn SA, Frankland PW. Entorhinal Cortical Deep Brain Stimulation Rescues Memory Deficits in Both Young and Old Mice Genetically Engineered to Model Alzheimer's Disease. Neuropsychopharmacology. 2017 Dec; 42(13):2493-2503. PMID: 28540926.
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    36. Snyder JS, Cahill SP, Frankland PW. Running promotes spatial bias independently of adult neurogenesis. Hippocampus. 2017 08; 27(8):871-882. PMID: 28474795.
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    37. Josselyn SA, Köhler S, Frankland PW. Heroes of the Engram. J Neurosci. 2017 05 03; 37(18):4647-4657. PMID: 28469009.
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    38. Vetere G, Kenney JW, Tran LM, Xia F, Steadman PE, Parkinson J, Josselyn SA, Frankland PW. Chemogenetic Interrogation of a Brain-wide Fear Memory Network in Mice. Neuron. 2017 Apr 19; 94(2):363-374.e4. PMID: 28426969.
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    39. Tanimizu T, Kenney JW, Okano E, Kadoma K, Frankland PW, Kida S. Functional Connectivity of Multiple Brain Regions Required for the Consolidation of Social Recognition Memory. J Neurosci. 2017 04 12; 37(15):4103-4116. PMID: 28292834.
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    40. Walters BJ, Mercaldo V, Gillon CJ, Yip M, Neve RL, Boyce FM, Frankland PW, Josselyn SA. The Role of The RNA Demethylase FTO (Fat Mass and Obesity-Associated) and mRNA Methylation in Hippocampal Memory Formation. Neuropsychopharmacology. 2017 Jun; 42(7):1502-1510. PMID: 28205605.
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    41. Guskjolen A, Josselyn SA, Frankland PW. Age-dependent changes in spatial memory retention and flexibility in mice. Neurobiol Learn Mem. 2017 Sep; 143:59-66. PMID: 27988313.
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    42. Santoro A, Frankland PW, Richards BA. Memory Transformation Enhances Reinforcement Learning in Dynamic Environments. J Neurosci. 2016 11 30; 36(48):12228-12242. PMID: 27903731.
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    43. Yang G, Cancino GI, Zahr SK, Guskjolen A, Voronova A, Gallagher D, Frankland PW, Kaplan DR, Miller FD. A Glo1-Methylglyoxal Pathway that Is Perturbed in Maternal Diabetes Regulates Embryonic and Adult Neural Stem Cell Pools in Murine Offspring. Cell Rep. 2016 10 18; 17(4):1022-1036. PMID: 27760310.
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    44. Ishikawa R, Fukushima H, Frankland PW, Kida S. Hippocampal neurogenesis enhancers promote forgetting of remote fear memory after hippocampal reactivation by retrieval. Elife. 2016 Sep 26; 5. PMID: 27669409.
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    45. Epp JR, Frankland PW. Re-engineering the Hippocampus. Neuron. 2016 Sep 21; 91(6):1190-1191. PMID: 27657446.
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    46. Gouveia A, Hsu K, Niibori Y, Seegobin M, Cancino GI, He L, Wondisford FE, Bennett S, Lagace D, Frankland PW, Wang J. The aPKC-CBP Pathway Regulates Adult Hippocampal Neurogenesis in an Age-Dependent Manner. Stem Cell Reports. 2016 10 11; 7(4):719-734. PMID: 27618724.
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    47. Rashid AJ, Yan C, Mercaldo V, Hsiang HL, Park S, Cole CJ, De Cristofaro A, Yu J, Ramakrishnan C, Lee SY, Deisseroth K, Frankland PW, Josselyn SA. Competition between engrams influences fear memory formation and recall. Science. 2016 07 22; 353(6297):383-7. PMID: 27463673.
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    48. Morrison DJ, Rashid AJ, Yiu AP, Yan C, Frankland PW, Josselyn SA. Parvalbumin interneurons constrain the size of the lateral amygdala engram. Neurobiol Learn Mem. 2016 Nov; 135:91-99. PMID: 27422019.
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    49. Frankland PW, Josselyn SA. Neuroscience: In search of the memory molecule. Nature. 2016 07 07; 535(7610):41-2. PMID: 27362229.
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    50. Park S, Kramer EE, Mercaldo V, Rashid AJ, Insel N, Frankland PW, Josselyn SA. Neuronal Allocation to a Hippocampal Engram. Neuropsychopharmacology. 2016 12; 41(13):2987-2993. PMID: 27187069.
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    51. Ramsaran AI, Frankland PW. The Young and the Promiscuous. Neuron. 2016 Apr 06; 90(1):6-8. PMID: 27054613.
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    52. Epp JR, Silva Mera R, Köhler S, Josselyn SA, Frankland PW. Neurogenesis-mediated forgetting minimizes proactive interference. Nat Commun. 2016 Feb 26; 7:10838. PMID: 26917323.
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    53. Frankland PW, Josselyn SA. Hippocampal Neurogenesis and Memory Clearance. Neuropsychopharmacology. 2016 Jan; 41(1):382-3. PMID: 26657960.
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    54. Berndt A, Lee SY, Wietek J, Ramakrishnan C, Steinberg EE, Rashid AJ, Kim H, Park S, Santoro A, Frankland PW, Iyer SM, Pak S, Ährlund-Richter S, Delp SL, Malenka RC, Josselyn SA, Carlén M, Hegemann P, Deisseroth K. Structural foundations of optogenetics: Determinants of channelrhodopsin ion selectivity. Proc Natl Acad Sci U S A. 2016 Jan 26; 113(4):822-9. PMID: 26699459.
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    55. Chakravarty MM, Hamani C, Martinez-Canabal A, Ellegood J, Laliberté C, Nobrega JN, Sankar T, Lozano AM, Frankland PW, Lerch JP. Deep brain stimulation of the ventromedial prefrontal cortex causes reorganization of neuronal processes and vasculature. Neuroimage. 2016 Jan 15; 125:422-427. PMID: 26525655.
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    56. Josselyn SA, Köhler S, Frankland PW. Finding the engram. Nat Rev Neurosci. 2015 Sep; 16(9):521-34. PMID: 26289572.
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    57. Restivo L, Niibori Y, Mercaldo V, Josselyn SA, Frankland PW. Development of Adult-Generated Cell Connectivity with Excitatory and Inhibitory Cell Populations in the Hippocampus. J Neurosci. 2015 Jul 22; 35(29):10600-12. PMID: 26203153.
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    58. Epp JR, Niibori Y, Liz Hsiang HL, Mercaldo V, Deisseroth K, Josselyn SA, Frankland PW. Optimization of CLARITY for Clearing Whole-Brain and Other Intact Organs eNeuro. 2015 May-Jun; 2(3). PMID: 26464982.
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    59. Frankland PW, Josselyn SA. Memory allocation. Neuropsychopharmacology. 2015 Jan; 40(1):243. PMID: 25482172.
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    60. Kenney JW, Frankland PW. Making connections. Elife. 2014 Nov 19; 3. PMID: 25407769.
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    61. Arruda-Carvalho M, Akers KG, Guskjolen A, Sakaguchi M, Josselyn SA, Frankland PW. Posttraining ablation of adult-generated olfactory granule cells degrades odor-reward memories. J Neurosci. 2014 Nov 19; 34(47):15793-803. PMID: 25411506.
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    62. Josselyn S, Frankland PW. Another twist in the histone memory code. Cell Res. 2015 Feb; 25(2):151-2. PMID: 25342557.
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    63. Santoro A, Frankland PW. Chasing the trace. Neuron. 2014 Oct 22; 84(2):243-6. PMID: 25374349.
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    64. Hsiang HL, Epp JR, van den Oever MC, Yan C, Rashid AJ, Insel N, Ye L, Niibori Y, Deisseroth K, Frankland PW, Josselyn SA. Manipulating a "cocaine engram" in mice. J Neurosci. 2014 Oct 15; 34(42):14115-27. PMID: 25319707.
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    65. Insel N, Frankland PW. Mechanism, function, and computation in neural systems. Behav Processes. 2015 Aug; 117:4-11. PMID: 25256163.
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    66. Arruda-Carvalho M, Restivo L, Guskjolen A, Epp JR, Elgersma Y, Josselyn SA, Frankland PW. Conditional deletion of a-CaMKII impairs integration of adult-generated granule cells into dentate gyrus circuits and hippocampus-dependent learning. J Neurosci. 2014 Sep 03; 34(36):11919-28. PMID: 25186740.
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    67. Yiu AP, Mercaldo V, Yan C, Richards B, Rashid AJ, Hsiang HL, Pressey J, Mahadevan V, Tran MM, Kushner SA, Woodin MA, Frankland PW, Josselyn SA. Neurons are recruited to a memory trace based on relative neuronal excitability immediately before training. Neuron. 2014 Aug 06; 83(3):722-35. PMID: 25102562.
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    68. Richards BA, Xia F, Santoro A, Husse J, Woodin MA, Josselyn SA, Frankland PW. Patterns across multiple memories are identified over time. Nat Neurosci. 2014 Jul; 17(7):981-6. PMID: 24880213.
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    69. Akers KG, Martinez-Canabal A, Restivo L, Yiu AP, De Cristofaro A, Hsiang HL, Wheeler AL, Guskjolen A, Niibori Y, Shoji H, Ohira K, Richards BA, Miyakawa T, Josselyn SA, Frankland PW. Hippocampal neurogenesis regulates forgetting during adulthood and infancy. Science. 2014 May 09; 344(6184):598-602. PMID: 24812394.
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    70. Vousden DA, Epp J, Okuno H, Nieman BJ, van Eede M, Dazai J, Ragan T, Bito H, Frankland PW, Lerch JP, Henkelman RM. Whole-brain mapping of behaviourally induced neural activation in mice. Brain Struct Funct. 2015 Jul; 220(4):2043-57. PMID: 24760545.
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    71. Turnbull J, Epp JR, Goldsmith D, Zhao X, Pencea N, Wang P, Frankland PW, Ackerley CA, Minassian BA. PTG protein depletion rescues malin-deficient Lafora disease in mouse. Ann Neurol. 2014 Mar; 75(3):442-6. PMID: 24419970.
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    72. Sargin D, Mercaldo V, Yiu AP, Higgs G, Han JH, Frankland PW, Josselyn SA. CREB regulates spine density of lateral amygdala neurons: implications for memory allocation. Front Behav Neurosci. 2013; 7:209. PMID: 24391565.
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    73. Turnbull J, Tiberia E, Pereira S, Zhao X, Pencea N, Wheeler AL, Yu WQ, Ivovic A, Naranian T, Israelian N, Draginov A, Piliguian M, Frankland PW, Wang P, Ackerley CA, Giacca A, Minassian BA. Deficiency of a glycogen synthase-associated protein, Epm2aip1, causes decreased glycogen synthesis and hepatic insulin resistance. J Biol Chem. 2013 Nov 29; 288(48):34627-37. PMID: 24142699.
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    74. Martinez-Canabal A, Wheeler AL, Sarkis D, Lerch JP, Lu WY, Buckwalter MS, Wyss-Coray T, Josselyn SA, Frankland PW. Chronic over-expression of TGFß1 alters hippocampal structure and causes learning deficits. Hippocampus. 2013 Dec; 23(12):1198-211. PMID: 23804429.
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    75. Pederson BA, Turnbull J, Epp JR, Weaver SA, Zhao X, Pencea N, Roach PJ, Frankland PW, Ackerley CA, Minassian BA. Inhibiting glycogen synthesis prevents Lafora disease in a mouse model. Ann Neurol. 2013 Aug; 74(2):297-300. PMID: 23913475.
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    76. Cancino GI, Yiu AP, Fatt MP, Dugani CB, Flores ER, Frankland PW, Josselyn SA, Miller FD, Kaplan DR. p63 Regulates adult neural precursor and newly born neuron survival to control hippocampal-dependent Behavior. J Neurosci. 2013 Jul 31; 33(31):12569-85. PMID: 23904595.
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    77. Sargin D, Botly LC, Higgs G, Marsolais A, Frankland PW, Egan SE, Josselyn SA. Reprint of: disrupting Jagged1-Notch signaling impairs spatial memory formation in adult mice. Neurobiol Learn Mem. 2013 Oct; 105:20-30. PMID: 23850596.
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    78. Frankland PW, Köhler S, Josselyn SA. Hippocampal neurogenesis and forgetting. Trends Neurosci. 2013 Sep; 36(9):497-503. PMID: 23768770.
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    79. Sargin D, Botly LC, Higgs G, Marsolais A, Frankland PW, Egan SE, Josselyn SA. Disrupting Jagged1-Notch signaling impairs spatial memory formation in adult mice. Neurobiol Learn Mem. 2013 Jul; 103:39-49. PMID: 23567106.
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    80. Josselyn SA, Frankland PW. mTORC2: actin on your memory. Nat Neurosci. 2013 Apr; 16(4):379-80. PMID: 23528935.
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    81. Richards BA, Frankland PW. The conjunctive trace. Hippocampus. 2013 Mar; 23(3):207-12. PMID: 23389924.
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    82. Frankland PW. Neurogenic evangelism: comment on Urbach et al. (2013). Behav Neurosci. 2013 Feb; 127(1):126-9. PMID: 23398444.
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    83. Wheeler AL, Lerch JP, Chakravarty MM, Friedel M, Sled JG, Fletcher PJ, Josselyn SA, Frankland PW. Adolescent cocaine exposure causes enduring macroscale changes in mouse brain structure. J Neurosci. 2013 Jan 30; 33(5):1797-803a. PMID: 23365219.
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    84. Wheeler AL, Teixeira CM, Wang AH, Xiong X, Kovacevic N, Lerch JP, McIntosh AR, Parkinson J, Frankland PW. Identification of a functional connectome for long-term fear memory in mice. PLoS Comput Biol. 2013; 9(1):e1002853. PMID: 23300432.
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    85. Frankland PW, Josselyn SA. Neuroscience: Memory and the single molecule. Nature. 2013 Jan 17; 493(7432):312-3. PMID: 23283170.
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    86. Sekeres MJ, Mercaldo V, Richards B, Sargin D, Mahadevan V, Woodin MA, Frankland PW, Josselyn SA. Increasing CRTC1 function in the dentate gyrus during memory formation or reactivation increases memory strength without compromising memory quality. J Neurosci. 2012 Dec 05; 32(49):17857-68. PMID: 23223304.
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    87. Akers KG, Arruda-Carvalho M, Josselyn SA, Frankland PW. Ontogeny of contextual fear memory formation, specificity, and persistence in mice. Learn Mem. 2012 Nov 16; 19(12):598-604. PMID: 23161449.
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    88. Gu Y, Arruda-Carvalho M, Wang J, Janoschka SR, Josselyn SA, Frankland PW, Ge S. Optical controlling reveals time-dependent roles for adult-born dentate granule cells. Nat Neurosci. 2012 Dec; 15(12):1700-6. PMID: 23143513.
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    89. Josselyn SA, Frankland PW. Infantile amnesia: a neurogenic hypothesis. Learn Mem. 2012 Aug 16; 19(9):423-33. PMID: 22904373.
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    90. Cole CJ, Mercaldo V, Restivo L, Yiu AP, Sekeres MJ, Han JH, Vetere G, Pekar T, Ross PJ, Neve RL, Frankland PW, Josselyn SA. MEF2 negatively regulates learning-induced structural plasticity and memory formation. Nat Neurosci. 2012 Sep; 15(9):1255-64. PMID: 22885849.
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    91. Martinez-Canabal A, Akers KG, Josselyn SA, Frankland PW. Age-dependent effects of hippocampal neurogenesis suppression on spatial learning. Hippocampus. 2013 Jan; 23(1):66-74. PMID: 22826108.
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    92. Wang J, Gallagher D, DeVito LM, Cancino GI, Tsui D, He L, Keller GM, Frankland PW, Kaplan DR, Miller FD. Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation. Cell Stem Cell. 2012 Jul 06; 11(1):23-35. PMID: 22770240.
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    93. Girard JM, Stone SS, Lohi H, Blaszykowski C, Teixeira C, Turnbull J, Wang A, Draginov A, Wang P, Zhao XC, Ackerley CA, Frankland PW, Minassian BA. Phosphorylation prevents polyglucosan transport in Lafora disease. Neurology. 2012 Jul 03; 79(1):100-2. PMID: 22622857.
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    94. Niibori Y, Yu TS, Epp JR, Akers KG, Josselyn SA, Frankland PW. Suppression of adult neurogenesis impairs population coding of similar contexts in hippocampal CA3 region. Nat Commun. 2012; 3:1253. PMID: 23212382.
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    95. Arruda-Carvalho M, Sakaguchi M, Akers KG, Josselyn SA, Frankland PW. Posttraining ablation of adult-generated neurons degrades previously acquired memories. J Neurosci. 2011 Oct 19; 31(42):15113-27. PMID: 22016545.
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    96. Stone SS, Teixeira CM, Devito LM, Zaslavsky K, Josselyn SA, Lozano AM, Frankland PW. Stimulation of entorhinal cortex promotes adult neurogenesis and facilitates spatial memory. J Neurosci. 2011 Sep 21; 31(38):13469-84. PMID: 21940440.
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    97. Sakaguchi M, Arruda-Carvalho M, Kang NH, Imaizumi Y, Poirier F, Okano H, Frankland PW. Impaired spatial and contextual memory formation in galectin-1 deficient mice. Mol Brain. 2011 Sep 01; 4:33. PMID: 21884595.
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    98. Leslie AT, Akers KG, Krakowski AD, Stone SS, Sakaguchi M, Arruda-Carvalho M, Frankland PW. Impact of early adverse experience on complexity of adult-generated neurons. Transl Psychiatry. 2011 Aug 30; 1:e35. PMID: 22832609.
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    99. Akers KG, Kushner SA, Leslie AT, Clarke L, van der Kooy D, Lerch JP, Frankland PW. Fetal alcohol exposure leads to abnormal olfactory bulb development and impaired odor discrimination in adult mice. Mol Brain. 2011 Jul 07; 4:29. PMID: 21736737.
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    100. Vetere G, Restivo L, Cole CJ, Ross PJ, Ammassari-Teule M, Josselyn SA, Frankland PW. Spine growth in the anterior cingulate cortex is necessary for the consolidation of contextual fear memory. Proc Natl Acad Sci U S A. 2011 May 17; 108(20):8456-60. PMID: 21531906.
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    101. Lerch JP, Yiu AP, Martinez-Canabal A, Pekar T, Bohbot VD, Frankland PW, Henkelman RM, Josselyn SA, Sled JG. Maze training in mice induces MRI-detectable brain shape changes specific to the type of learning. Neuroimage. 2011 Feb 01; 54(3):2086-95. PMID: 20932918.
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    102. Bae JJ, Xiang YY, Martinez-Canabal A, Frankland PW, Yang BB, Lu WY. Increased transforming growth factor-ß1 modulates glutamate receptor expression in the hippocampus. Int J Physiol Pathophysiol Pharmacol. 2011; 3(1):9-20. PMID: 21479098.
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    103. Stone SS, Teixeira CM, Zaslavsky K, Wheeler AL, Martinez-Canabal A, Wang AH, Sakaguchi M, Lozano AM, Frankland PW. Functional convergence of developmentally and adult-generated granule cells in dentate gyrus circuits supporting hippocampus-dependent memory. Hippocampus. 2011 Dec; 21(12):1348-62. PMID: 20824726.
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    104. Sekeres MJ, Neve RL, Frankland PW, Josselyn SA. Dorsal hippocampal CREB is both necessary and sufficient for spatial memory. Learn Mem. 2010 Jun; 17(6):280-3. PMID: 20495061.
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    105. Restivo L, Frankland PW. Shifting to automatic. Front Integr Neurosci. 2010; 4:1. PMID: 20161992.
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    106. Maei HR, Zaslavsky K, Wang AH, Yiu AP, Teixeira CM, Josselyn SA, Frankland PW. Development and validation of a sensitive entropy-based measure for the water maze. Front Integr Neurosci. 2009; 3:33. PMID: 20057926.
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    107. Winocur G, Frankland PW, Sekeres M, Fogel S, Moscovitch M. Changes in context-specificity during memory reconsolidation: selective effects of hippocampal lesions. Learn Mem. 2009 Nov; 16(11):722-9. PMID: 19875506.
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    108. Nai Q, Li S, Wang SH, Liu J, Lee FJ, Frankland PW, Liu F. Uncoupling the D1-N-methyl-D-aspartate (NMDA) receptor complex promotes NMDA-dependent long-term potentiation and working memory. Biol Psychiatry. 2010 Feb 01; 67(3):246-54. PMID: 19846062.
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    109. Han JH, Kushner SA, Yiu AP, Hsiang HL, Buch T, Waisman A, Bontempi B, Neve RL, Frankland PW, Josselyn SA. Selective erasure of a fear memory. Science. 2009 Mar 13; 323(5920):1492-6. PMID: 19286560.
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    110. Maei HR, Zaslavsky K, Teixeira CM, Frankland PW. What is the Most Sensitive Measure of Water Maze Probe Test Performance? Front Integr Neurosci. 2009; 3:4. PMID: 19404412.
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    111. Wang SH, Teixeira CM, Wheeler AL, Frankland PW. The precision of remote context memories does not require the hippocampus. Nat Neurosci. 2009 Mar; 12(3):253-5. PMID: 19182794.
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    112. Mamiya N, Fukushima H, Suzuki A, Matsuyama Z, Homma S, Frankland PW, Kida S. Brain region-specific gene expression activation required for reconsolidation and extinction of contextual fear memory. J Neurosci. 2009 Jan 14; 29(2):402-13. PMID: 19144840.
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    113. Liu XJ, Gingrich JR, Vargas-Caballero M, Dong YN, Sengar A, Beggs S, Wang SH, Ding HK, Frankland PW, Salter MW. Treatment of inflammatory and neuropathic pain by uncoupling Src from the NMDA receptor complex. Nat Med. 2008 Dec; 14(12):1325-32. PMID: 19011637.
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    114. Frankland PW, Miller FD. Regenerating your senses: multiple roles for neurogenesis in the adult brain. Nat Neurosci. 2008 Oct; 11(10):1124-6. PMID: 18818592.
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    115. Wetzel MK, Naska S, Laliberté CL, Rymar VV, Fujitani M, Biernaskie JA, Cole CJ, Lerch JP, Spring S, Wang SH, Frankland PW, Henkelman RM, Josselyn SA, Sadikot AF, Miller FD, Kaplan DR. p73 regulates neurodegeneration and phospho-tau accumulation during aging and Alzheimer's disease. Neuron. 2008 Sep 11; 59(5):708-21. PMID: 18786355.
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    116. Frankland PW, Sakaguchi M, Arruda-Carvalho M. Starting at the endophenotype: A role for alpha-CaMKII in schizophrenia? Mol Brain. 2008 Sep 10; 1:5. PMID: 18803858.
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    117. Suzuki A, Mukawa T, Tsukagoshi A, Frankland PW, Kida S. Activation of LVGCCs and CB1 receptors required for destabilization of reactivated contextual fear memories. Learn Mem. 2008 Jun; 15(6):426-33. PMID: 18511694.
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    118. Ding HK, Teixeira CM, Frankland PW. Inactivation of the anterior cingulate cortex blocks expression of remote, but not recent, conditioned taste aversion memory. Learn Mem. 2008 May; 15(5):290-3. PMID: 18441286.
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    119. Kee N, Teixeira CM, Wang AH, Frankland PW. Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus. Nat Neurosci. 2007 Mar; 10(3):355-62. PMID: 17277773.
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    120. Kee N, Teixeira CM, Wang AH, Frankland PW. Imaging activation of adult-generated granule cells in spatial memory. Nat Protoc. 2007; 2(12):3033-44. PMID: 18079702.
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    121. Teixeira CM, Pomedli SR, Maei HR, Kee N, Frankland PW. Involvement of the anterior cingulate cortex in the expression of remote spatial memory. J Neurosci. 2006 Jul 19; 26(29):7555-64. PMID: 16855083.
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    122. Frankland PW, Ding HK, Takahashi E, Suzuki A, Kida S, Silva AJ. Stability of recent and remote contextual fear memory. Learn Mem. 2006 Jul-Aug; 13(4):451-7. PMID: 16882861.
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    123. Frankland PW, Bontempi B. Fast track to the medial prefrontal cortex. Proc Natl Acad Sci U S A. 2006 Jan 17; 103(3):509-10. PMID: 16407121.
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    124. Li W, Cui Y, Kushner SA, Brown RA, Jentsch JD, Frankland PW, Cannon TD, Silva AJ. The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1. Curr Biol. 2005 Nov 08; 15(21):1961-7. PMID: 16271875.
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    125. Tohmi M, Tsuda N, Mizuno M, Takei N, Frankland PW, Nawa H. Distinct influences of neonatal epidermal growth factor challenge on adult neurobehavioral traits in four mouse strains. Behav Genet. 2005 Sep; 35(5):615-29. PMID: 16184489.
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    126. Frankland PW, Teixeira CM. A pain in the ACC. Mol Pain. 2005 Mar 31; 1:14. PMID: 15813964.
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    127. Frankland PW, Bontempi B. The organization of recent and remote memories. Nat Rev Neurosci. 2005 Feb; 6(2):119-30. PMID: 15685217.
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    128. Suzuki A, Josselyn SA, Frankland PW, Masushige S, Silva AJ, Kida S. Memory reconsolidation and extinction have distinct temporal and biochemical signatures. J Neurosci. 2004 May 19; 24(20):4787-95. PMID: 15152039.
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    129. Frankland PW, Bontempi B, Talton LE, Kaczmarek L, Silva AJ. The involvement of the anterior cingulate cortex in remote contextual fear memory. Science. 2004 May 07; 304(5672):881-3. PMID: 15131309.
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    130. Frankland PW, Wang Y, Rosner B, Shimizu T, Balleine BW, Dykens EM, Ornitz EM, Silva AJ. Sensorimotor gating abnormalities in young males with fragile X syndrome and Fmr1-knockout mice. Mol Psychiatry. 2004 Apr; 9(4):417-25. PMID: 14981523.
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    131. Frankland PW, Josselyn SA, Anagnostaras SG, Kogan JH, Takahashi E, Silva AJ. Consolidation of CS and US representations in associative fear conditioning. Hippocampus. 2004; 14(5):557-69. PMID: 15301434.
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    132. Frankland PW, Ohno M, Takahashi E, Chen AR, Costa RM, Kushner SA, Silva AJ. Pharmacologically regulated induction of silent mutations (PRISM): combined pharmacological and genetic approaches for learning and memory. Neuroscientist. 2003 Apr; 9(2):104-9. PMID: 12708614.
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    133. Ohno M, Frankland PW, Silva AJ. A pharmacogenetic inducible approach to the study of NMDA/alphaCaMKII signaling in synaptic plasticity. Curr Biol. 2002 Apr 16; 12(8):654-6. PMID: 11967152.
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    134. Yeomans JS, Li L, Scott BW, Frankland PW. Tactile, acoustic and vestibular systems sum to elicit the startle reflex. Neurosci Biobehav Rev. 2002 Jan; 26(1):1-11. PMID: 11835980.
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    135. Ohno M, Frankland PW, Chen AP, Costa RM, Silva AJ. Inducible, pharmacogenetic approaches to the study of learning and memory. Nat Neurosci. 2001 Dec; 4(12):1238-43. PMID: 11713472.
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    136. Frankland PW, O'Brien C, Ohno M, Kirkwood A, Silva AJ. Alpha-CaMKII-dependent plasticity in the cortex is required for permanent memory. Nature. 2001 May 17; 411(6835):309-13. PMID: 11357133.
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    137. Kogan JH, Frankland PW, Silva AJ. Long-term memory underlying hippocampus-dependent social recognition in mice. Hippocampus. 2000; 10(1):47-56. PMID: 10706216.
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    138. Anagnostaras SG, Josselyn SA, Frankland PW, Silva AJ. Computer-assisted behavioral assessment of Pavlovian fear conditioning in mice. Learn Mem. 2000 Jan; 7(1):58-72. PMID: 10706603.
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    139. Scott BW, Frankland PW, Li L, Yeomans JS. Cochlear and trigeminal systems contributing to the startle reflex in rats. Neuroscience. 1999; 91(4):1565-74. PMID: 10391460.
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    140. Frankland PW, Cestari V, Filipkowski RK, McDonald RJ, Silva AJ. The dorsal hippocampus is essential for context discrimination but not for contextual conditioning. Behav Neurosci. 1998 Aug; 112(4):863-74. PMID: 9733192.
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    141. Silva AJ, Giese KP, Fedorov NB, Frankland PW, Kogan JH. Molecular, cellular, and neuroanatomical substrates of place learning. Neurobiol Learn Mem. 1998 Jul-Sep; 70(1-2):44-61. PMID: 9753586.
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    142. Silva AJ, Kogan JH, Frankland PW, Kida S. CREB and memory. Annu Rev Neurosci. 1998; 21:127-48. PMID: 9530494.
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    143. Frankland PW, Josselyn SA, Bradwejn J, Vaccarino FJ, Yeomans JS. Activation of amygdala cholecystokininB receptors potentiates the acoustic startle response in the rat. J Neurosci. 1997 Mar 01; 17(5):1838-47. PMID: 9030642.
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    144. Silva AJ, Frankland PW, Marowitz Z, Friedman E, Laszlo GS, Cioffi D, Jacks T, Bourtchuladze R, Lazlo G. A mouse model for the learning and memory deficits associated with neurofibromatosis type I. Nat Genet. 1997 Mar; 15(3):281-4. PMID: 9054942.
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    145. Kogan JH, Frankland PW, Blendy JA, Coblentz J, Marowitz Z, Schütz G, Silva AJ. Spaced training induces normal long-term memory in CREB mutant mice. Curr Biol. 1997 Jan 01; 7(1):1-11. PMID: 8999994.
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    146. Silva AJ, Rosahl TW, Chapman PF, Marowitz Z, Friedman E, Frankland PW, Cestari V, Cioffi D, Südhof TC, Bourtchuladze R. Impaired learning in mice with abnormal short-lived plasticity. Curr Biol. 1996 Nov 01; 6(11):1509-18. PMID: 8939606.
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    147. Frankland PW, Josselyn SA, Bradwejn J, Vaccarino FJ, Yeomans JS. Intracerebroventricular infusion of the CCKB receptor agonist pentagastrin potentiates acoustic startle. Brain Res. 1996 Sep 09; 733(1):129-32. PMID: 8891258.
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    148. Silva AJ, Fedorov N, Kogan J, Frankland P, Coblentz J, Lundsten R, Friedman E, Smith A, Cho Y, Giese KP. Genetic analysis of function and dysfunction in the central nervous system. Cold Spring Harb Symp Quant Biol. 1996; 61:239-46. PMID: 9246452.
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    149. Yeomans JS, Frankland PW. The acoustic startle reflex: neurons and connections. Brain Res Brain Res Rev. 1995 Nov; 21(3):301-14. PMID: 8806018.
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    150. Frankland PW, Yeomans JS. Fear-potentiated startle and electrically evoked startle mediated by synapses in rostrolateral midbrain. Behav Neurosci. 1995 Aug; 109(4):669-80. PMID: 7576211.
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    151. Frankland PW, Ralph MR. Circadian modulation in the rat acoustic startle circuit. Behav Neurosci. 1995 Feb; 109(1):43-8. PMID: 7734079.
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    152. Frankland PW, Scott BW, Yeomans JS. Axons and synapses mediating electrically evoked startle: collision tests and latency analysis. Brain Res. 1995 Jan 23; 670(1):97-111. PMID: 7719729.
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    153. Josselyn SA, Frankland PW, Petrisano S, Bush DE, Yeomans JS, Vaccarino FJ. The CCKB antagonist, L-365,260, attenuates fear-potentiated startle. Peptides. 1995; 16(7):1313-5. PMID: 8545257.
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    154. Keay K, Westby GW, Frankland P, Dean P, Redgrave P. Organization of the crossed tecto-reticulo-spinal projection in rat--II. Electrophysiological evidence for separate output channels to the periabducens area and caudal medulla. Neuroscience. 1990; 37(3):585-601. PMID: 2247216.
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