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Sheena Josselyn

TitleSenior Scientist
InstitutionThe Hospital for Sick Children
DepartmentNeurosciences & Mental Health
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Biography 
    Collapse education and training
    Queens University, Kingston, ONBSc (Hons)1987Life Sciences
    Queens University, Kingston, ONBA (Hons)1989Psychology
    Queens University, Kingston, ONMA1991Clinical Psychology
    University of Toronto, Toronto, ONPhD1996Psychology, Neuroscience
    Clarke Institute of PsychiatryPost-doctoral Fellow1997
    Yale University School of MedicinePost-doctoral Fellow1998
    University of California, Los Angeles (UCLA), CaliforniaResearch Associate2003
    Collapse awards and honors
    2017Senior Fellow, Massey College (University of Toronto)
    2016Senior Fellow, Canadian Institute for Advanced Research (CIFAR)
    2016 - 2023Canada Research Chair (CRC) in Brain and Cognition Tier I
    2009 - 2014Canada Research Chair (CRC) in Molecular and Cellular Cognition Tier II (renewal)
    2008 - 2011EJLB Scholar
    2007 - 2009Alzheimer’s Society of Canada Young Investigators Award
    2004 - 2009Canada Research Chair in Molecular and Cellular Cognition Tier II
    2001 - 2003National Alliance for Research on Schizophrenia and Depression (NARSAD) Young Investigator Fellowshi
    1999 - 2001National Alliance for Research on Schizophrenia and Depression (NARSAD) Young Investigator Fellowshi
    1997 - 1999Natural Science and Engineering Research Council of Canada (NSERC) Post-Doctoral Fellowship
    1994 - 1994University of Toronto Open Fellowship
    1993 - 1994Ontario Graduate Scholarship
    1990 - 1993Natural Science and Engineering Research Council of Canada (NSERC) Pre-Doctoral Fellowship
    1989 - 1990Queen’s University Dean’s Award

    Collapse Overview 
    Collapse overview
    Sheena Josselyn is a Senior Scientist in the Neurosciences & Mental Health program at The Hospital for Sick Children (SickKids) and a Professor in the departments of Psychology and Physiology and the Institute of Medical Sciences at the University of Toronto in Canada. She holds a Canada Research Chair in Molecular and Cellular Cognition and is an EJLB Scholar. Her undergraduate degrees and a Masters degree in Clinical Psychology were granted by Queen’s University in Kingston (Canada). Her mentor was Dr. Richard Beninger. Sheena received a PhD in Neuroscience/Psychology from the University of Toronto with Dr. Franco Vaccarino as her supervisor. She conducted post-doctoral work with Dr. Mike Davis (Yale University) and Dr. Alcino Silva (UCLA). Her program of research is dedicated to understanding the neural basis of cognitive function and dysfunction. To unravel the molecular, cellular and circuit processes that underlie memory, her lab uses a multidisciplinary approach that focuses on mice and attempts to translate these basic findings into humans.

    Dr. Josselyn received the Innovations in Psychopharmacology Award from the Canadian College of Neuropsychopharmacology (CCNP) and the Effron Award from the American College of Neuropsychopharmacology (ACNP).


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Rao-Ruiz P, Yu J, Kushner SA, Josselyn SA. Neuronal competition: microcircuit mechanisms define the sparsity of the engram. Curr Opin Neurobiol. 2018 Nov 10; 54:163-170. PMID: 30423499.
      View in: PubMed
    2. Josselyn SA. The past, present and future of light-gated ion channels and optogenetics. Elife. 2018 10 22; 7. PMID: 30343681.
      View in: PubMed
    3. Josselyn SA, Frankland PW. Fear Extinction Requires Reward. Cell. 2018 Oct 18; 175(3):639-640. PMID: 30340037.
      View in: PubMed
    4. Josselyn S. Editorial: MCCS 2018: Time and Memory. Neurobiol Learn Mem. 2018 Sep; 153(Pt A):1. PMID: 30055663.
      View in: PubMed
    5. Sekeres MJ, Riggs L, Decker A, de Medeiros CB, Bacopulos A, Skocic J, Szulc-Lerch K, Bouffet E, Levine B, Grady CL, Mabbott DJ, Josselyn SA, Frankland PW. Impaired Recent, but Preserved Remote, Autobiographical Memory in Pediatric Brain Tumor Patients. J Neurosci. 2018 Sep 19; 38(38):8251-8261. PMID: 30126966.
      View in: PubMed
    6. Guskjolen A, Kenney JW, de la Parra J, Yeung BA, Josselyn SA, Frankland PW. Recovery of "Lost" Infant Memories in Mice. Curr Biol. 2018 Jul 23; 28(14):2283-2290.e3. PMID: 29983316.
      View in: PubMed
    7. Jacob AD, Ramsaran AI, Mocle AJ, Tran LM, Yan C, Frankland PW, Josselyn SA. A Compact Head-Mounted Endoscope for In Vivo Calcium Imaging in Freely Behaving Mice. Curr Protoc Neurosci. 2018 Jul; 84(1):e51. PMID: 29944206.
      View in: PubMed
    8. Kramer EE, Steadman PE, Epp JR, Frankland PW, Josselyn SA. Assessing Individual Neuronal Activity Across the Intact Brain: Using Hybridization Chain Reaction (HCR) to Detect Arc mRNA Localized to the Nucleus in Volumes of Cleared Brain Tissue. Curr Protoc Neurosci. 2018 Jul; 84(1):e49. PMID: 29944213.
      View in: PubMed
    9. Frankland PW, Josselyn SA. Facing your fears. Science. 2018 06 15; 360(6394):1186-1187. PMID: 29903963.
      View in: PubMed
    10. Miller AMP, Frankland PW, Josselyn SA. Memory: Ironing Out a Wrinkle in Time. Curr Biol. 2018 May 21; 28(10):R599-R601. PMID: 29787721.
      View in: PubMed
    11. Josselyn SA, Frankland PW. Memory Allocation: Mechanisms and Function. Annu Rev Neurosci. 2018 Jul 08; 41:389-413. PMID: 29709212.
      View in: PubMed
    12. Gao A, Xia F, Guskjolen AJ, Ramsaran AI, Santoro A, Josselyn SA, Frankland PW. Elevation of Hippocampal Neurogenesis Induces a Temporally Graded Pattern of Forgetting of Contextual Fear Memories. J Neurosci. 2018 Mar 28; 38(13):3190-3198. PMID: 29453206.
      View in: PubMed
    13. Xia F, Richards BA, Tran MM, Josselyn SA, Takehara-Nishiuchi K, Frankland PW. Parvalbumin-positive interneurons mediate neocortical-hippocampal interactions that are necessary for memory consolidation. Elife. 2017 09 29; 6. PMID: 28960176.
      View in: PubMed
    14. Kenney JW, Scott IC, Josselyn SA, Frankland PW. Contextual fear conditioning in zebrafish. Learn Mem. 2017 10; 24(10):516-523. PMID: 28916626.
      View in: PubMed
    15. Xia F, Yiu A, Stone SSD, Oh S, Lozano AM, Josselyn SA, Frankland PW. Entorhinal Cortical Deep Brain Stimulation Rescues Memory Deficits in Both Young and Old Mice Genetically Engineered to Model Alzheimer's Disease. Neuropsychopharmacology. 2017 Dec; 42(13):2493-2503. PMID: 28540926.
      View in: PubMed
    16. Josselyn SA, Köhler S, Frankland PW. Heroes of the Engram. J Neurosci. 2017 05 03; 37(18):4647-4657. PMID: 28469009.
      View in: PubMed
    17. Vetere G, Kenney JW, Tran LM, Xia F, Steadman PE, Parkinson J, Josselyn SA, Frankland PW. Chemogenetic Interrogation of a Brain-wide Fear Memory Network in Mice. Neuron. 2017 Apr 19; 94(2):363-374.e4. PMID: 28426969.
      View in: PubMed
    18. Walters BJ, Mercaldo V, Gillon CJ, Yip M, Neve RL, Boyce FM, Frankland PW, Josselyn SA. The Role of The RNA Demethylase FTO (Fat Mass and Obesity-Associated) and mRNA Methylation in Hippocampal Memory Formation. Neuropsychopharmacology. 2017 Jun; 42(7):1502-1510. PMID: 28205605.
      View in: PubMed
    19. Guskjolen A, Josselyn SA, Frankland PW. Age-dependent changes in spatial memory retention and flexibility in mice. Neurobiol Learn Mem. 2017 Sep; 143:59-66. PMID: 27988313.
      View in: PubMed
    20. Rashid AJ, Yan C, Mercaldo V, Hsiang HL, Park S, Cole CJ, De Cristofaro A, Yu J, Ramakrishnan C, Lee SY, Deisseroth K, Frankland PW, Josselyn SA. Competition between engrams influences fear memory formation and recall. Science. 2016 07 22; 353(6297):383-7. PMID: 27463673.
      View in: PubMed
    21. Morrison DJ, Rashid AJ, Yiu AP, Yan C, Frankland PW, Josselyn SA. Parvalbumin interneurons constrain the size of the lateral amygdala engram. Neurobiol Learn Mem. 2016 Nov; 135:91-99. PMID: 27422019.
      View in: PubMed
    22. Frankland PW, Josselyn SA. Neuroscience: In search of the memory molecule. Nature. 2016 07 07; 535(7610):41-2. PMID: 27362229.
      View in: PubMed
    23. Park S, Kramer EE, Mercaldo V, Rashid AJ, Insel N, Frankland PW, Josselyn SA. Neuronal Allocation to a Hippocampal Engram. Neuropsychopharmacology. 2016 12; 41(13):2987-2993. PMID: 27187069.
      View in: PubMed
    24. Epp JR, Silva Mera R, Köhler S, Josselyn SA, Frankland PW. Neurogenesis-mediated forgetting minimizes proactive interference. Nat Commun. 2016 Feb 26; 7:10838. PMID: 26917323; PMCID: PMC4773435.
    25. Walters BJ, Azam AB, Gillon CJ, Josselyn SA, Zovkic IB. Advanced In vivo Use of CRISPR/Cas9 and Anti-sense DNA Inhibition for Gene Manipulation in the Brain. Front Genet. 2015; 6:362. PMID: 26793235; PMCID: PMC4709581.
    26. Frankland PW, Josselyn SA. Hippocampal Neurogenesis and Memory Clearance. Neuropsychopharmacology. 2016 Jan; 41(1):382-3. PMID: 26657960; PMCID: PMC4677136 [Available on 01/01/17].
    27. Berndt A, Lee SY, Wietek J, Ramakrishnan C, Steinberg EE, Rashid AJ, Kim H, Park S, Santoro A, Frankland PW, Iyer SM, Pak S, Ährlund-Richter S, Delp SL, Malenka RC, Josselyn SA, Carlén M, Hegemann P, Deisseroth K. Structural foundations of optogenetics: Determinants of channelrhodopsin ion selectivity. Proc Natl Acad Sci U S A. 2016 Jan 26; 113(4):822-9. PMID: 26699459; PMCID: PMC4743797.
    28. Ali AM, Reis JM, Xia Y, Rashid AJ, Mercaldo V, Walters BJ, Brechun KE, Borisenko V, Josselyn SA, Karanicolas J, Woolley GA. Optogenetic Inhibitor of the Transcription Factor CREB. Chem Biol. 2015 Nov 19; 22(11):1531-1539. PMID: 26590638; PMCID: PMC4656143 [Available on 11/19/16].
    29. Ehrlich DE, Josselyn SA. Plasticity-related genes in brain development and amygdala-dependent learning. Genes Brain Behav. 2016 Jan; 15(1):125-43. PMID: 26419764.
      View in: PubMed
    30. Josselyn SA, Köhler S, Frankland PW. Finding the engram. Nat Rev Neurosci. 2015 Sep; 16(9):521-34. PMID: 26289572.
      View in: PubMed
    31. Adamantidis A, Arber S, Bains JS, Bamberg E, Bonci A, Buzsáki G, Cardin JA, Costa RM, Dan Y, Goda Y, Graybiel AM, Häusser M, Hegemann P, Huguenard JR, Insel TR, Janak PH, Johnston D, Josselyn SA, Koch C, Kreitzer AC, Lüscher C, Malenka RC, Miesenböck G, Nagel G, Roska B, Schnitzer MJ, Shenoy KV, Soltesz I, Sternson SM, Tsien RW, Tsien RY, Turrigiano GG, Tye KM, Wilson RI. Optogenetics: 10 years after ChR2 in neurons--views from the community. Nat Neurosci. 2015 Sep; 18(9):1202-12. PMID: 26308981.
      View in: PubMed
    32. Restivo L, Niibori Y, Mercaldo V, Josselyn SA, Frankland PW. Development of Adult-Generated Cell Connectivity with Excitatory and Inhibitory Cell Populations in the Hippocampus. J Neurosci. 2015 Jul 22; 35(29):10600-12. PMID: 26203153.
      View in: PubMed
    33. Epp JR, Niibori Y, Liz Hsiang HL, Mercaldo V, Deisseroth K, Josselyn SA, Frankland PW. Optimization of CLARITY for Clearing Whole-Brain and Other Intact Organs eNeuro. 2015 May-Jun; 2(3). PMID: 26464982; PMCID: PMC4586927.
    34. Wong AH, Josselyn SA. Caution When Diagnosing Your Mouse With Schizophrenia: The Use and Misuse of Model Animals for Understanding Psychiatric Disorders. Biol Psychiatry. 2016 Jan 01; 79(1):32-8. PMID: 26058706.
      View in: PubMed
    35. Frankland PW, Josselyn SA. Memory allocation. Neuropsychopharmacology. 2015 Jan; 40(1):243. PMID: 25482172; PMCID: PMC4262914.
    36. Arruda-Carvalho M, Akers KG, Guskjolen A, Sakaguchi M, Josselyn SA, Frankland PW. Posttraining ablation of adult-generated olfactory granule cells degrades odor-reward memories. J Neurosci. 2014 Nov 19; 34(47):15793-803. PMID: 25411506.
      View in: PubMed
    37. Josselyn S, Frankland PW. Another twist in the histone memory code. Cell Res. 2015 Feb; 25(2):151-2. PMID: 25342557; PMCID: PMC4650565.
    38. Alberini CM, Josselyn S, Tsai LH. Editorial. Molecular and Cellular Cognition Society (MCCS) meetings. Neurobiol Learn Mem. 2014 Nov; 115:1-2. PMID: 25438252.
      View in: PubMed
    39. Hsiang HL, Epp JR, van den Oever MC, Yan C, Rashid AJ, Insel N, Ye L, Niibori Y, Deisseroth K, Frankland PW, Josselyn SA. Manipulating a "cocaine engram" in mice. J Neurosci. 2014 Oct 15; 34(42):14115-27. PMID: 25319707.
      View in: PubMed
    40. Allemang-Grand R, Scholz J, Ellegood J, Cahill LS, Laliberté C, Fraser PE, Josselyn SA, Sled JG, Lerch JP. Altered brain development in an early-onset murine model of Alzheimer's disease. Neurobiol Aging. 2015 Feb; 36(2):638-47. PMID: 25311279.
      View in: PubMed
    41. Arruda-Carvalho M, Restivo L, Guskjolen A, Epp JR, Elgersma Y, Josselyn SA, Frankland PW. Conditional deletion of a-CaMKII impairs integration of adult-generated granule cells into dentate gyrus circuits and hippocampus-dependent learning. J Neurosci. 2014 Sep 03; 34(36):11919-28. PMID: 25186740.
      View in: PubMed
    42. Yiu AP, Mercaldo V, Yan C, Richards B, Rashid AJ, Hsiang HL, Pressey J, Mahadevan V, Tran MM, Kushner SA, Woodin MA, Frankland PW, Josselyn SA. Neurons are recruited to a memory trace based on relative neuronal excitability immediately before training. Neuron. 2014 Aug 06; 83(3):722-35. PMID: 25102562.
      View in: PubMed
    43. Vieira PA, Lovelace JW, Corches A, Rashid AJ, Josselyn SA, Korzus E. Prefrontal consolidation supports the attainment of fear memory accuracy. Learn Mem. 2014 Aug; 21(8):394-405. PMID: 25031365; PMCID: PMC4105719.
    44. Richards BA, Xia F, Santoro A, Husse J, Woodin MA, Josselyn SA, Frankland PW. Patterns across multiple memories are identified over time. Nat Neurosci. 2014 Jul; 17(7):981-6. PMID: 24880213.
      View in: PubMed
    45. Akers KG, Martinez-Canabal A, Restivo L, Yiu AP, De Cristofaro A, Hsiang HL, Wheeler AL, Guskjolen A, Niibori Y, Shoji H, Ohira K, Richards BA, Miyakawa T, Josselyn SA, Frankland PW. Hippocampal neurogenesis regulates forgetting during adulthood and infancy. Science. 2014 May 09; 344(6184):598-602. PMID: 24812394.
      View in: PubMed
    46. Sargin D, Mercaldo V, Yiu AP, Higgs G, Han JH, Frankland PW, Josselyn SA. CREB regulates spine density of lateral amygdala neurons: implications for memory allocation. Front Behav Neurosci. 2013; 7:209. PMID: 24391565; PMCID: PMC3868910.
    47. Kim J, Kwon JT, Kim HS, Josselyn SA, Han JH. Memory recall and modifications by activating neurons with elevated CREB. Nat Neurosci. 2014 Jan; 17(1):65-72. PMID: 24212670.
      View in: PubMed
    48. Cowansage KK, Bush DE, Josselyn SA, Klann E, Ledoux JE. Basal variability in CREB phosphorylation predicts trait-like differences in amygdala-dependent memory. Proc Natl Acad Sci U S A. 2013 Oct 08; 110(41):16645-50. PMID: 24062441; PMCID: PMC3799321.
    49. Zhang L, Meng K, Jiang X, Liu C, Pao A, Belichenko PV, Kleschevnikov AM, Josselyn S, Liang P, Ye P, Mobley WC, Yu YE. Human chromosome 21 orthologous region on mouse chromosome 17 is a major determinant of Down syndrome-related developmental cognitive deficits. Hum Mol Genet. 2014 Feb 01; 23(3):578-89. PMID: 24041763; PMCID: PMC3888256.
    50. Martinez-Canabal A, Wheeler AL, Sarkis D, Lerch JP, Lu WY, Buckwalter MS, Wyss-Coray T, Josselyn SA, Frankland PW. Chronic over-expression of TGFß1 alters hippocampal structure and causes learning deficits. Hippocampus. 2013 Dec; 23(12):1198-211. PMID: 23804429.
      View in: PubMed
    51. Cancino GI, Yiu AP, Fatt MP, Dugani CB, Flores ER, Frankland PW, Josselyn SA, Miller FD, Kaplan DR. p63 Regulates adult neural precursor and newly born neuron survival to control hippocampal-dependent Behavior. J Neurosci. 2013 Jul 31; 33(31):12569-85. PMID: 23904595; PMCID: PMC3728680.
    52. Rashid AJ, Cole CJ, Josselyn SA. Emerging roles for MEF2 transcription factors in memory. Genes Brain Behav. 2014 Jan; 13(1):118-25. PMID: 23790063.
      View in: PubMed
    53. Sargin D, Botly LC, Higgs G, Marsolais A, Frankland PW, Egan SE, Josselyn SA. Reprint of: disrupting Jagged1-Notch signaling impairs spatial memory formation in adult mice. Neurobiol Learn Mem. 2013 Oct; 105:20-30. PMID: 23850596.
      View in: PubMed
    54. Wasserman DI, Wang HG, Rashid AJ, Josselyn SA, Yeomans JS. Cholinergic control of morphine-induced locomotion in rostromedial tegmental nucleus versus ventral tegmental area sites. Eur J Neurosci. 2013 Sep; 38(5):2774-85. PMID: 23773170.
      View in: PubMed
    55. Frankland PW, Köhler S, Josselyn SA. Hippocampal neurogenesis and forgetting. Trends Neurosci. 2013 Sep; 36(9):497-503. PMID: 23768770.
      View in: PubMed
    56. Sargin D, Botly LC, Higgs G, Marsolais A, Frankland PW, Egan SE, Josselyn SA. Disrupting Jagged1-Notch signaling impairs spatial memory formation in adult mice. Neurobiol Learn Mem. 2013 Jul; 103:39-49. PMID: 23567106.
      View in: PubMed
    57. Josselyn SA, Frankland PW. mTORC2: actin on your memory. Nat Neurosci. 2013 Apr; 16(4):379-80. PMID: 23528935.
      View in: PubMed
    58. Sengar AS, Ellegood J, Yiu AP, Wang H, Wang W, Juneja SC, Lerch JP, Josselyn SA, Henkelman RM, Salter MW, Egan SE. Vertebrate intersectin1 is repurposed to facilitate cortical midline connectivity and higher order cognition. J Neurosci. 2013 Feb 27; 33(9):4055-65. PMID: 23447614.
      View in: PubMed
    59. Wheeler AL, Lerch JP, Chakravarty MM, Friedel M, Sled JG, Fletcher PJ, Josselyn SA, Frankland PW. Adolescent cocaine exposure causes enduring macroscale changes in mouse brain structure. J Neurosci. 2013 Jan 30; 33(5):1797-803a. PMID: 23365219.
      View in: PubMed
    60. Frankland PW, Josselyn SA. Neuroscience: Memory and the single molecule. Nature. 2013 Jan 17; 493(7432):312-3. PMID: 23283170.
      View in: PubMed
    61. Salih DA, Rashid AJ, Colas D, de la Torre-Ubieta L, Zhu RP, Morgan AA, Santo EE, Ucar D, Devarajan K, Cole CJ, Madison DV, Shamloo M, Butte AJ, Bonni A, Josselyn SA, Brunet A. FoxO6 regulates memory consolidation and synaptic function. Genes Dev. 2012 Dec 15; 26(24):2780-801. PMID: 23222102; PMCID: PMC3533081.
    62. Sekeres MJ, Mercaldo V, Richards B, Sargin D, Mahadevan V, Woodin MA, Frankland PW, Josselyn SA. Increasing CRTC1 function in the dentate gyrus during memory formation or reactivation increases memory strength without compromising memory quality. J Neurosci. 2012 Dec 05; 32(49):17857-68. PMID: 23223304.
      View in: PubMed
    63. Akers KG, Arruda-Carvalho M, Josselyn SA, Frankland PW. Ontogeny of contextual fear memory formation, specificity, and persistence in mice. Learn Mem. 2012 Nov 16; 19(12):598-604. PMID: 23161449.
      View in: PubMed
    64. Gu Y, Arruda-Carvalho M, Wang J, Janoschka SR, Josselyn SA, Frankland PW, Ge S. Optical controlling reveals time-dependent roles for adult-born dentate granule cells. Nat Neurosci. 2012 Dec; 15(12):1700-6. PMID: 23143513; PMCID: PMC3509272.
    65. Josselyn SA, Frankland PW. Infantile amnesia: a neurogenic hypothesis. Learn Mem. 2012 Aug 16; 19(9):423-33. PMID: 22904373.
      View in: PubMed
    66. Cole CJ, Mercaldo V, Restivo L, Yiu AP, Sekeres MJ, Han JH, Vetere G, Pekar T, Ross PJ, Neve RL, Frankland PW, Josselyn SA. MEF2 negatively regulates learning-induced structural plasticity and memory formation. Nat Neurosci. 2012 Sep; 15(9):1255-64. PMID: 22885849.
      View in: PubMed
    67. Martinez-Canabal A, Akers KG, Josselyn SA, Frankland PW. Age-dependent effects of hippocampal neurogenesis suppression on spatial learning. Hippocampus. 2013 Jan; 23(1):66-74. PMID: 22826108.
      View in: PubMed
    68. Mansouri A, Min W, Cole CJ, Josselyn SA, Henderson JT, van Eede M, Henkelman RM, Ackerley C, Grunebaum E, Roifman CM. Cerebellar abnormalities in purine nucleoside phosphorylase deficient mice. Neurobiol Dis. 2012 Aug; 47(2):201-9. PMID: 22521465.
      View in: PubMed
    69. Niibori Y, Yu TS, Epp JR, Akers KG, Josselyn SA, Frankland PW. Suppression of adult neurogenesis impairs population coding of similar contexts in hippocampal CA3 region. Nat Commun. 2012; 3:1253. PMID: 23212382; PMCID: PMC4931925.
    70. Arruda-Carvalho M, Sakaguchi M, Akers KG, Josselyn SA, Frankland PW. Posttraining ablation of adult-generated neurons degrades previously acquired memories. J Neurosci. 2011 Oct 19; 31(42):15113-27. PMID: 22016545.
      View in: PubMed
    71. Stone SS, Teixeira CM, Devito LM, Zaslavsky K, Josselyn SA, Lozano AM, Frankland PW. Stimulation of entorhinal cortex promotes adult neurogenesis and facilitates spatial memory. J Neurosci. 2011 Sep 21; 31(38):13469-84. PMID: 21940440.
      View in: PubMed
    72. Josselyn S. Profile of Sheena Josselyn. Interviewed by Kristie Nybo. Biotechniques. 2011 Sep; 51(3):153. PMID: 21906034.
      View in: PubMed
    73. Yiu AP, Rashid AJ, Josselyn SA. Increasing CREB function in the CA1 region of dorsal hippocampus rescues the spatial memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology. 2011 Oct; 36(11):2169-86. PMID: 21734652; PMCID: PMC3176558.
    74. Suzuki A, Fukushima H, Mukawa T, Toyoda H, Wu LJ, Zhao MG, Xu H, Shang Y, Endoh K, Iwamoto T, Mamiya N, Okano E, Hasegawa S, Mercaldo V, Zhang Y, Maeda R, Ohta M, Josselyn SA, Zhuo M, Kida S. Upregulation of CREB-mediated transcription enhances both short- and long-term memory. J Neurosci. 2011 Jun 15; 31(24):8786-802. PMID: 21677163.
      View in: PubMed
    75. Vetere G, Restivo L, Cole CJ, Ross PJ, Ammassari-Teule M, Josselyn SA, Frankland PW. Spine growth in the anterior cingulate cortex is necessary for the consolidation of contextual fear memory. Proc Natl Acad Sci U S A. 2011 May 17; 108(20):8456-60. PMID: 21531906; PMCID: PMC3100962.
    76. Lerch JP, Yiu AP, Martinez-Canabal A, Pekar T, Bohbot VD, Frankland PW, Henkelman RM, Josselyn SA, Sled JG. Maze training in mice induces MRI-detectable brain shape changes specific to the type of learning. Neuroimage. 2011 Feb 01; 54(3):2086-95. PMID: 20932918.
      View in: PubMed
    77. Josselyn SA. Continuing the search for the engram: examining the mechanism of fear memories. J Psychiatry Neurosci. 2010 Jul; 35(4):221-8. PMID: 20569648; PMCID: PMC2895151.
    78. Sekeres MJ, Neve RL, Frankland PW, Josselyn SA. Dorsal hippocampal CREB is both necessary and sufficient for spatial memory. Learn Mem. 2010 Jun; 17(6):280-3. PMID: 20495061.
      View in: PubMed
    79. Maei HR, Zaslavsky K, Wang AH, Yiu AP, Teixeira CM, Josselyn SA, Frankland PW. Development and validation of a sensitive entropy-based measure for the water maze. Front Integr Neurosci. 2009; 3:33. PMID: 20057926; PMCID: PMC2802531.
    80. Han JH, Kushner SA, Yiu AP, Hsiang HL, Buch T, Waisman A, Bontempi B, Neve RL, Frankland PW, Josselyn SA. Selective erasure of a fear memory. Science. 2009 Mar 13; 323(5920):1492-6. PMID: 19286560.
      View in: PubMed
    81. Wetzel MK, Naska S, Laliberté CL, Rymar VV, Fujitani M, Biernaskie JA, Cole CJ, Lerch JP, Spring S, Wang SH, Frankland PW, Henkelman RM, Josselyn SA, Sadikot AF, Miller FD, Kaplan DR. p73 regulates neurodegeneration and phospho-tau accumulation during aging and Alzheimer's disease. Neuron. 2008 Sep 11; 59(5):708-21. PMID: 18786355.
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    82. Han JH, Yiu AP, Cole CJ, Hsiang HL, Neve RL, Josselyn SA. Increasing CREB in the auditory thalamus enhances memory and generalization of auditory conditioned fear. Learn Mem. 2008 Jun; 15(6):443-53. PMID: 18519545; PMCID: PMC2414255.
    83. Han JH, Kushner SA, Yiu AP, Cole CJ, Matynia A, Brown RA, Neve RL, Guzowski JF, Silva AJ, Josselyn SA. Neuronal competition and selection during memory formation. Science. 2007 Apr 20; 316(5823):457-60. PMID: 17446403.
      View in: PubMed
    84. Josselyn SA, Nguyen PV. CREB, synapses and memory disorders: past progress and future challenges. Curr Drug Targets CNS Neurol Disord. 2005 Oct; 4(5):481-97. PMID: 16266283.
      View in: PubMed
    85. Josselyn SA. What's right with my mouse model? New insights into the molecular and cellular basis of cognition from mouse models of Rubinstein-Taybi Syndrome. Learn Mem. 2005 Mar-Apr; 12(2):80-3. PMID: 15805305.
      View in: PubMed
    86. Josselyn SA, Falls WA, Gewirtz JC, Pistell P, Davis M. The nucleus accumbens is not critically involved in mediating the effects of a safety signal on behavior. Neuropsychopharmacology. 2005 Jan; 30(1):17-26. PMID: 15257308.
      View in: PubMed
    87. Josselyn SA, Kida S, Silva AJ. Inducible repression of CREB function disrupts amygdala-dependent memory. Neurobiol Learn Mem. 2004 Sep; 82(2):159-63. PMID: 15341801.
      View in: PubMed
    88. Suzuki A, Josselyn SA, Frankland PW, Masushige S, Silva AJ, Kida S. Memory reconsolidation and extinction have distinct temporal and biochemical signatures. J Neurosci. 2004 May 19; 24(20):4787-95. PMID: 15152039.
      View in: PubMed
    89. Frankland PW, Josselyn SA, Anagnostaras SG, Kogan JH, Takahashi E, Silva AJ. Consolidation of CS and US representations in associative fear conditioning. Hippocampus. 2004; 14(5):557-69. PMID: 15301434.
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    90. Bozon B, Kelly A, Josselyn SA, Silva AJ, Davis S, Laroche S. MAPK, CREB and zif268 are all required for the consolidation of recognition memory. Philos Trans R Soc Lond B Biol Sci. 2003 Apr 29; 358(1432):805-14. PMID: 12740127; PMCID: PMC1693143.
    91. Silva AJ, Josselyn SA. The molecules of forgetfulness. Nature. 2002 Aug 29; 418(6901):929-30. PMID: 12198533.
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    92. Kida S, Josselyn SA, Peña de Ortiz S, Kogan JH, Chevere I, Masushige S, Silva AJ. CREB required for the stability of new and reactivated fear memories. Nat Neurosci. 2002 Apr; 5(4):348-55. PMID: 11889468.
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    93. Josselyn SA, Shi C, Carlezon WA, Neve RL, Nestler EJ, Davis M. Long-term memory is facilitated by cAMP response element-binding protein overexpression in the amygdala. J Neurosci. 2001 Apr 01; 21(7):2404-12. PMID: 11264314.
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    94. Anagnostaras SG, Josselyn SA, Frankland PW, Silva AJ. Computer-assisted behavioral assessment of Pavlovian fear conditioning in mice. Learn Mem. 2000 Jan; 7(1):58-72. PMID: 10706603; PMCID: PMC311321.
    95. Josselyn SA, Miller R, Beninger RJ. Behavioral effects of clozapine and dopamine receptor subtypes. Neurosci Biobehav Rev. 1997 Sep; 21(5):531-58. PMID: 9353791.
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    96. Josselyn SA, De Cristofaro A, Vaccarino FJ. Evidence for CCK(A) receptor involvement in the acquisition of conditioned activity produced by cocaine in rats. Brain Res. 1997 Jul 18; 763(1):93-102. PMID: 9272833.
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    97. Frankland PW, Josselyn SA, Bradwejn J, Vaccarino FJ, Yeomans JS. Activation of amygdala cholecystokininB receptors potentiates the acoustic startle response in the rat. J Neurosci. 1997 Mar 01; 17(5):1838-47. PMID: 9030642.
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    98. Josselyn SA, Vaccarino FJ. Acquisition of conditioned reward blocked by intra-accumbens infusion of PD-140548, a CCKA receptor antagonist. Pharmacol Biochem Behav. 1996 Nov; 55(3):439-44. PMID: 8951986.
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    99. Josselyn SA, Vaccarino FJ. Opposing effects of CCK(A) and CCK(B) antagonists on the development of conditioned activity in rats. Behav Pharmacol. 1996 Nov; 7(6):505-512. PMID: 11224447.
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    100. Frankland PW, Josselyn SA, Bradwejn J, Vaccarino FJ, Yeomans JS. Intracerebroventricular infusion of the CCKB receptor agonist pentagastrin potentiates acoustic startle. Brain Res. 1996 Sep 09; 733(1):129-32. PMID: 8891258.
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    101. Josselyn SA, Franco VP, Vaccarino FJ. PD-135158, a CCKB receptor antagonist, microinjected into the nucleus accumbens and the expression of conditioned rewarded behavior. Neurosci Lett. 1996 May 10; 209(2):85-8. PMID: 8761988.
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    102. Josselyn SA, Franco VP, Vaccarino FJ. Devazepide, a CCKA receptor antagonist, impairs the acquisition of conditioned reward and conditioned activity. Psychopharmacology (Berl). 1996 Jan; 123(2):131-43. PMID: 8741936.
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    103. Josselyn SA, Frankland PW, Petrisano S, Bush DE, Yeomans JS, Vaccarino FJ. The CCKB antagonist, L-365,260, attenuates fear-potentiated startle. Peptides. 1995; 16(7):1313-5. PMID: 8545257.
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    104. Josselyn SA, Vaccarino FJ. Interaction of CCKB receptors with amphetamine in responding for conditioned rewards. Peptides. 1995; 16(5):959-64. PMID: 7479342.
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    105. Josselyn SA, Beninger RJ. Neuropeptide Y: intraaccumbens injections produce a place preference that is blocked by cis-flupenthixol. Pharmacol Biochem Behav. 1993 Nov; 46(3):543-52. PMID: 8278431.
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    106. Josselyn SA, Beninger RJ. Behavioral effects of intrastriatal caffeine mediated by adenosinergic modulation of dopamine. Pharmacol Biochem Behav. 1991 May; 39(1):97-103. PMID: 1924519.
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