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Michael Moran

TitleSenior Scientist
InstitutionThe Hospital for Sick Children
DepartmentCell Biology
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Harada H, Farhani N, Wang XF, Sugita S, Charish J, Attisano L, Moran M, Cloutier JF, Reber M, Bremner R, Monnier PP. Extracellular phosphorylation drives the formation of neuronal circuitry. Nat Chem Biol. 2019 Aug 26. PMID: 31451763.
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    2. Wang D, Pham NA, Freeman TM, Raghavan V, Navab R, Chang J, Zhu CQ, Ly D, Tong J, Wouters BG, Pintilie M, Moran MF, Liu G, Shepherd FA, Tsao MS. Somatic Alteration Burden Involving Non-Cancer Genes Predicts Prognosis in Early-Stage Non-Small Cell Lung Cancer. Cancers (Basel). 2019 Jul 19; 11(7). PMID: 31330989.
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    3. Sachdeva R, Wu M, Smiljanic S, Kaskun O, Ghannad-Zadeh K, Celebre A, Isaev K, Morrissy AS, Guan J, Tong J, Chan J, Wilson TM, Al-Omaishi S, Munoz DG, Dirks PB, Moran MF, Taylor MD, Reimand J, Das S. ID1 Is Critical for Tumorigenesis and Regulates Chemoresistance in Glioblastoma. Cancer Res. 2019 Aug 15; 79(16):4057-4071. PMID: 31292163.
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    4. Guan S, Moran M, Ma B. Prediction of LC-MS/MS properties of peptides from sequence by deep learning. Mol Cell Proteomics. 2019 Jun 27. PMID: 31249099.
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    5. Goff SL, Mazor KM, Priya A, Moran M, Pekow PS, Lindenauer PK. Organizational characteristics associated with high performance on quality measures in pediatric primary care: A positive deviance study. Health Care Manage Rev. 2019 May 20. PMID: 31116122.
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    6. Krieger JR, Wybenga-Groot LE, Tong J, Bache N, Tsao MS, Moran MF. Evosep One Enables Robust Deep Proteome Coverage Using Tandem Mass Tags while Significantly Reducing Instrument Time. J Proteome Res. 2019 May 03; 18(5):2346-2353. PMID: 30938160.
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    7. Teyra J, Singer AU, Schmitges FW, Jaynes P, Kit Leng Lui S, Polyak MJ, Fodil N, Krieger JR, Tong J, Schwerdtfeger C, Brasher BB, Ceccarelli DFJ, Moffat J, Sicheri F, Moran MF, Gros P, Eichhorn PJA, Lenter M, Boehmelt G, Sidhu SS. Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15. Structure. 2019 Apr 02; 27(4):590-605.e5. PMID: 30713027.
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    8. Veggiani G, Huang H, Yates BP, Tong J, Kaneko T, Joshi R, Li SSC, Moran MF, Gish G, Sidhu SS. Engineered SH2 domains with tailored specificities and enhanced affinities for phosphoproteome analysis. Protein Sci. 2019 Feb; 28(2):403-413. PMID: 30431205.
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    9. Chan JTH, Liu Y, Khan S, St-Germain JR, Zou C, Leung LYT, Yang J, Shi M, Grunebaum E, Campisi P, Propst EJ, Holler T, Bar-Or A, Wither JE, Cairo CW, Moran MF, Palazzo AF, Cooper MD, Ehrhardt GRA. A tyrosine sulfation-dependent HLA-I modification identifies memory B cells and plasma cells. Sci Adv. 2018 11; 4(11):eaar7653. PMID: 30417091.
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    10. Xu Y, Taylor P, Andrade J, Ueberheide B, Shuch B, Glazer PM, Bindra RS, Moran MF, Linehan WM, Neel BG. Pathologic Oxidation of PTPN12 Underlies ABL1 Phosphorylation in Hereditary Leiomyomatosis and Renal Cell Carcinoma. Cancer Res. 2018 12 01; 78(23):6539-6548. PMID: 30297534.
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    11. Zeng Y, Wang S, Gao S, Soares F, Ahmed M, Guo H, Wang M, Hua JT, Guan J, Moran MF, Tsao MS, He HH. Refined RIP-seq protocol for epitranscriptome analysis with low input materials. PLoS Biol. 2018 09; 16(9):e2006092. PMID: 30212448.
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    12. Gill MK, Christova T, Zhang YY, Gregorieff A, Zhang L, Narimatsu M, Song S, Xiong S, Couzens AL, Tong J, Krieger JR, Moran MF, Zlotta AR, van der Kwast TH, Gingras AC, Sicheri F, Wrana JL, Attisano L. A feed forward loop enforces YAP/TAZ signaling during tumorigenesis. Nat Commun. 2018 08 29; 9(1):3510. PMID: 30158528.
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    13. Wang S, Juan J, Zhang Z, Du Y, Xu Y, Tong J, Cao B, Moran MF, Zeng Y, Mao X. Inhibition of the deubiquitinase USP5 leads to c-Maf protein degradation and myeloma cell apoptosis. Cell Death Dis. 2017 09 21; 8(9):e3058. PMID: 28933784.
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    14. Xie JL, Qin L, Miao Z, Grys BT, Diaz JC, Ting K, Krieger JR, Tong J, Tan K, Leach MD, Ketela T, Moran MF, Krysan DJ, Boone C, Andrews BJ, Selmecki A, Ho Wong K, Robbins N, Cowen LE. The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation. Nat Commun. 2017 09 11; 8(1):499. PMID: 28894103.
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    15. Feinberg K, Kolaj A, Wu C, Grinshtein N, Krieger JR, Moran MF, Rubin LL, Miller FD, Kaplan DR. A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria. J Cell Biol. 2017 11 06; 216(11):3655-3675. PMID: 28877995.
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    16. Xu Y, Zhang Z, Li J, Tong J, Cao B, Taylor P, Tang X, Wu D, Moran MF, Zeng Y, Mao X. The ubiquitin-conjugating enzyme UBE2O modulates c-Maf stability and induces myeloma cell apoptosis. J Hematol Oncol. 2017 07 03; 10(1):132. PMID: 28673317.
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    17. Pal S, Lant B, Yu B, Tian R, Tong J, Krieger JR, Moran MF, Gingras AC, Derry WB. CCM-3 Promotes C. elegans Germline Development by Regulating Vesicle Trafficking Cytokinesis and Polarity. Curr Biol. 2017 Mar 20; 27(6):868-876. PMID: 28285997.
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    18. Tong J, Helmy M, Cavalli FM, Jin L, St-Germain J, Karisch R, Taylor P, Minden MD, Taylor MD, Neel BG, Bader GD, Moran MF. Integrated analysis of proteome, phosphotyrosine-proteome, tyrosine-kinome, and tyrosine-phosphatome in acute myeloid leukemia. Proteomics. 2017 03; 17(6). PMID: 28176486.
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    19. Tong J, Cao B, Martyn GD, Krieger JR, Taylor P, Yates B, Sidhu SS, Li SS, Mao X, Moran MF. Protein-phosphotyrosine proteome profiling by superbinder-SH2 domain affinity purification mass spectrometry, sSH2-AP-MS. Proteomics. 2017 03; 17(6). PMID: 27880036.
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    20. Wang D, Pham NA, Tong J, Sakashita S, Allo G, Kim L, Yanagawa N, Raghavan V, Wei Y, To C, Trinh QM, Starmans MH, Chan-Seng-Yue MA, Chadwick D, Li L, Zhu CQ, Liu N, Li M, Lee S, Ignatchenko V, Strumpf D, Taylor P, Moghal N, Liu G, Boutros PC, Kislinger T, Pintilie M, Jurisica I, Shepherd FA, McPherson JD, Muthuswamy L, Moran MF, Tsao MS. Molecular heterogeneity of non-small cell lung carcinoma patient-derived xenografts closely reflect their primary tumors. Int J Cancer. 2017 Feb 01; 140(3):662-673. PMID: 27750381.
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    21. Matsumoto Y, La Rose J, Kent OA, Wagner MJ, Narimatsu M, Levy AD, Omar MH, Tong J, Krieger JR, Riggs E, Storozhuk Y, Pasquale J, Ventura M, Yeganeh B, Post M, Moran MF, Grynpas MD, Wrana JL, Superti-Furga G, Koleske AJ, Pendergast AM, Rottapel R. Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2. J Clin Invest. 2016 12 01; 126(12):4482-4496. PMID: 27797343.
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    22. Izrailit J, Jaiswal A, Zheng W, Moran MF, Reedijk M. Cellular stress induces TRB3/USP9x-dependent Notch activation in cancer. Oncogene. 2017 02 23; 36(8):1048-1057. PMID: 27593927.
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    23. Yu C, Liu Y, Chan JTH, Tong J, Li Z, Shi M, Davani D, Parsons M, Khan S, Zhan W, Kyu S, Grunebaum E, Campisi P, Propst EJ, Jaye DL, Trudel S, Moran MF, Ostrowski M, Herrin BR, Lee FE, Sanz I, Cooper MD, Ehrhardt GR. Identification of human plasma cells with a lamprey monoclonal antibody. JCI Insight. 2016; 1(3). PMID: 27152361.
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    24. Zhang Z, Tong J, Tang X, Juan J, Cao B, Hurren R, Chen G, Taylor P, Xu X, Shi CX, Du J, Hou J, Wang G, Wu D, Stewart AK, Schimmer AD, Moran MF, Mao X. The ubiquitin ligase HERC4 mediates c-Maf ubiquitination and delays the growth of multiple myeloma xenografts in nude mice. Blood. 2016 Mar 31; 127(13):1676-86. PMID: 26825710.
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    25. Knight D, Iliadi KG, Iliadi N, Wilk R, Hu J, Krause HM, Taylor P, Moran MF, Boulianne GL. Distinct Regulation of Transmitter Release at the Drosophila NMJ by Different Isoforms of nemy. PLoS One. 2015; 10(8):e0132548. PMID: 26237434.
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    26. Wei Y, Vellanki RN, Coyaud É, Ignatchenko V, Li L, Krieger JR, Taylor P, Tong J, Pham NA, Liu G, Raught B, Wouters BG, Kislinger T, Tsao MS, Moran MF. CHCHD2 Is Coamplified with EGFR in NSCLC and Regulates Mitochondrial Function and Cell Migration. Mol Cancer Res. 2015 Jul; 13(7):1119-29. PMID: 25784717.
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    27. Zhang W, Sakashita S, Taylor P, Tsao MS, Moran MF. Comprehensive proteome analysis of fresh frozen and optimal cutting temperature (OCT) embedded primary non-small cell lung carcinoma by LC-MS/MS. Methods. 2015 Jun 15; 81:50-5. PMID: 25721092.
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    28. Jin LL, Wybenga-Groot LE, Tong J, Taylor P, Minden MD, Trudel S, McGlade CJ, Moran MF. Tyrosine phosphorylation of the Lyn Src homology 2 (SH2) domain modulates its binding affinity and specificity. Mol Cell Proteomics. 2015 Mar; 14(3):695-706. PMID: 25587033.
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    29. Pandey A, Moran MF. Signal transduction. Proteomics. 2015 Jan; 15(2-3):179-82. PMID: 25588725.
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    30. Krieger JR, Taylor P, Moran MF, McGlade CJ. Comprehensive identification of phosphorylation sites on the Numb endocytic adaptor protein. Proteomics. 2015 Jan; 15(2-3):434-46. PMID: 25403733.
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    31. Pasyk S, Molinski S, Ahmadi S, Ramjeesingh M, Huan LJ, Chin S, Du K, Yeger H, Taylor P, Moran MF, Bear CE. The major cystic fibrosis causing mutation exhibits defective propensity for phosphorylation. Proteomics. 2015 Jan; 15(2-3):447-61. PMID: 25330774.
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    32. St-Germain JR, Taylor P, Zhang W, Li Z, Ketela T, Moffat J, Neel BG, Trudel S, Moran MF. Differential regulation of FGFR3 by PTPN1 and PTPN2. Proteomics. 2015 Jan; 15(2-3):419-33. PMID: 25311528.
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    33. Li L, Wei Y, To C, Zhu CQ, Tong J, Pham NA, Taylor P, Ignatchenko V, Ignatchenko A, Zhang W, Wang D, Yanagawa N, Li M, Pintilie M, Liu G, Muthuswamy L, Shepherd FA, Tsao MS, Kislinger T, Moran MF. Integrated omic analysis of lung cancer reveals metabolism proteome signatures with prognostic impact. Nat Commun. 2014 Nov 28; 5:5469. PMID: 25429762.
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    34. Chen G, Xu X, Tong J, Han K, Zhang Z, Tang J, Li S, Yang C, Li J, Cao B, Zhou H, Wu D, Moran MF, Mao X. Ubiquitination of the transcription factor c-MAF is mediated by multiple lysine residues. Int J Biochem Cell Biol. 2014 Dec; 57:157-66. PMID: 25448412.
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    35. Persaud A, Alberts P, Mari S, Tong J, Murchie R, Maspero E, Safi F, Moran MF, Polo S, Rotin D. Tyrosine phosphorylation of NEDD4 activates its ubiquitin ligase activity. Sci Signal. 2014 Oct 07; 7(346):ra95. PMID: 25292214.
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    36. Sharpe DJ, Orr KS, Moran M, White SJ, McQuaid S, Lappin TR, Thompson A, James JA. POU2F1 activity regulates HOXD10 and HOXD11 promoting a proliferative and invasive phenotype in head and neck cancer. Oncotarget. 2014 Sep 30; 5(18):8803-15. PMID: 25301728.
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    37. Tong J, Taylor P, Moran MF. Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress. Mol Cell Proteomics. 2014 Jul; 13(7):1644-58. PMID: 24797263.
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    38. Zhang W, Wei Y, Ignatchenko V, Li L, Sakashita S, Pham NA, Taylor P, Tsao MS, Kislinger T, Moran MF. Proteomic profiles of human lung adeno and squamous cell carcinoma using super-SILAC and label-free quantification approaches. Proteomics. 2014 Mar; 14(6):795-803. PMID: 24453208.
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    39. Wills MK, Tong J, Tremblay SL, Moran MF, Jones N. The ShcD signaling adaptor facilitates ligand-independent phosphorylation of the EGF receptor. Mol Biol Cell. 2014 Mar; 25(6):739-52. PMID: 24430869.
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    40. Vojvodic M, Hansford LM, Morozova O, Blakely KM, Taylor P, Fathers KE, Moffat J, Marra M, Smith KM, Moran MF, Kaplan DR. A phosphoproteomics approach to identify candidate kinase inhibitor pathway targets in lymphoma-like primary cell lines. Curr Drug Discov Technol. 2013 Dec; 10(4):283-304. PMID: 23701117.
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    41. Tong J, Sydorskyy Y, St-Germain JR, Taylor P, Tsao MS, Moran MF. Odin (ANKS1A) modulates EGF receptor recycling and stability. PLoS One. 2013; 8(6):e64817. PMID: 23825523.
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    42. Ernst A, Avvakumov G, Tong J, Fan Y, Zhao Y, Alberts P, Persaud A, Walker JR, Neculai AM, Neculai D, Vorobyov A, Garg P, Beatty L, Chan PK, Juang YC, Landry MC, Yeh C, Zeqiraj E, Karamboulas K, Allali-Hassani A, Vedadi M, Tyers M, Moffat J, Sicheri F, Pelletier L, Durocher D, Raught B, Rotin D, Yang J, Moran MF, Dhe-Paganon S, Sidhu SS. A strategy for modulation of enzymes in the ubiquitin system. Science. 2013 Feb 01; 339(6119):590-5. PMID: 23287719.
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    43. Krieger JR, Taylor P, Gajadhar AS, Guha A, Moran MF, McGlade CJ. Identification and selected reaction monitoring (SRM) quantification of endocytosis factors associated with Numb. Mol Cell Proteomics. 2013 Feb; 12(2):499-514. PMID: 23211419.
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    44. Yu C, Ali S, St-Germain J, Liu Y, Yu X, Jaye DL, Moran MF, Cooper MD, Ehrhardt GR. Purification and identification of cell surface antigens using lamprey monoclonal antibodies. J Immunol Methods. 2012 Dec 14; 386(1-2):43-9. PMID: 22964555.
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    45. Bocchinfuso DG, Taylor P, Ross E, Ignatchenko A, Ignatchenko V, Kislinger T, Pearson BJ, Moran MF. Proteomic profiling of the planarian Schmidtea mediterranea and its mucous reveals similarities with human secretions and those predicted for parasitic flatworms. Mol Cell Proteomics. 2012 Sep; 11(9):681-91. PMID: 22653920.
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    46. Hembrough T, Thyparambil S, Liao WL, Darfler MM, Abdo J, Bengali KM, Taylor P, Tong J, Lara-Guerra H, Waddell TK, Moran MF, Tsao MS, Krizman DB, Burrows J. Selected Reaction Monitoring (SRM) Analysis of Epidermal Growth Factor Receptor (EGFR) in Formalin Fixed Tumor Tissue. Clin Proteomics. 2012 May 03; 9(1):5. PMID: 22554165.
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    47. Li L, Tibiche C, Fu C, Kaneko T, Moran MF, Schiller MR, Li SS, Wang E. The human phosphotyrosine signaling network: evolution and hotspots of hijacking in cancer. Genome Res. 2012 Jul; 22(7):1222-30. PMID: 22194470.
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    48. Karisch R, Fernandez M, Taylor P, Virtanen C, St-Germain JR, Jin LL, Harris IS, Mori J, Mak TW, Senis YA, Östman A, Moran MF, Neel BG. Global proteomic assessment of the classical protein-tyrosine phosphatome and "Redoxome". Cell. 2011 Sep 02; 146(5):826-40. PMID: 21884940.
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    49. Organ SL, Tong J, Taylor P, St-Germain JR, Navab R, Moran MF, Tsao MS. Quantitative phospho-proteomic profiling of hepatocyte growth factor (HGF)-MET signaling in colorectal cancer. J Proteome Res. 2011 Jul 01; 10(7):3200-11. PMID: 21609022.
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    50. Mao X, Cao B, Wood TE, Hurren R, Tong J, Wang X, Wang W, Li J, Jin Y, Sun W, Spagnuolo PA, MacLean N, Moran MF, Datti A, Wrana J, Batey RA, Schimmer AD. A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway. Blood. 2011 Feb 10; 117(6):1986-97. PMID: 21135258.
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    51. Wei Y, Tong J, Taylor P, Strumpf D, Ignatchenko V, Pham NA, Yanagawa N, Liu G, Jurisica I, Shepherd FA, Tsao MS, Kislinger T, Moran MF. Primary tumor xenografts of human lung adeno and squamous cell carcinoma express distinct proteomic signatures. J Proteome Res. 2011 Jan 07; 10(1):161-74. PMID: 20815376.
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    52. Morozova O, Vojvodic M, Grinshtein N, Hansford LM, Blakely KM, Maslova A, Hirst M, Cezard T, Morin RD, Moore R, Smith KM, Miller F, Taylor P, Thiessen N, Varhol R, Zhao Y, Jones S, Moffat J, Kislinger T, Moran MF, Kaplan DR, Marra MA. System-level analysis of neuroblastoma tumor-initiating cells implicates AURKB as a novel drug target for neuroblastoma. Clin Cancer Res. 2010 Sep 15; 16(18):4572-82. PMID: 20651058.
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    53. Jin LL, Tong J, Prakash A, Peterman SM, St-Germain JR, Taylor P, Trudel S, Moran MF. Measurement of protein phosphorylation stoichiometry by selected reaction monitoring mass spectrometry. J Proteome Res. 2010 May 07; 9(5):2752-61. PMID: 20205385.
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    54. St-Germain JR, Taylor P, Tong J, Jin LL, Nikolic A, Stewart II, Ewing RM, Dharsee M, Li Z, Trudel S, Moran MF. Multiple myeloma phosphotyrosine proteomic profile associated with FGFR3 expression, ligand activation, and drug inhibition. Proc Natl Acad Sci U S A. 2009 Nov 24; 106(47):20127-32. PMID: 19901323.
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    55. Micallef J, Taccone M, Mukherjee J, Croul S, Busby J, Moran MF, Guha A. Epidermal growth factor receptor variant III-induced glioma invasion is mediated through myristoylated alanine-rich protein kinase C substrate overexpression. Cancer Res. 2009 Oct 01; 69(19):7548-56. PMID: 19773446.
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    56. Tong J, Taylor P, Peterman SM, Prakash A, Moran MF. Epidermal growth factor receptor phosphorylation sites Ser991 and Tyr998 are implicated in the regulation of receptor endocytosis and phosphorylations at Ser1039 and Thr1041. Mol Cell Proteomics. 2009 Sep; 8(9):2131-44. PMID: 19531499.
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    57. Ju YH, Guzzo A, Chiu MW, Taylor P, Moran MF, Gurd JW, MacDonald JF, Orser BA. Distinct properties of murine alpha 5 gamma-aminobutyric acid type a receptors revealed by biochemical fractionation and mass spectroscopy. J Neurosci Res. 2009 Jun; 87(8):1737-47. PMID: 19156871.
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    58. Taylor P, Nielsen PA, Trelle MB, Hørning OB, Andersen MB, Vorm O, Moran MF, Kislinger T. Automated 2D peptide separation on a 1D nano-LC-MS system. J Proteome Res. 2009 Mar; 8(3):1610-6. PMID: 19178303.
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    59. Iliadi KG, Avivi A, Iliadi NN, Knight D, Korol AB, Nevo E, Taylor P, Moran MF, Kamyshev NG, Boulianne GL. nemy encodes a cytochrome b561 that is required for Drosophila learning and memory. Proc Natl Acad Sci U S A. 2008 Dec 16; 105(50):19986-91. PMID: 19064935.
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    60. Tong J, Taylor P, Jovceva E, St-Germain JR, Jin LL, Nikolic A, Gu X, Li ZH, Trudel S, Moran MF. Tandem immunoprecipitation of phosphotyrosine-mass spectrometry (TIPY-MS) indicates C19ORF19 becomes tyrosine-phosphorylated and associated with activated epidermal growth factor receptor. J Proteome Res. 2008 Mar; 7(3):1067-77. PMID: 18271526.
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    61. Mathivanan S, Ahmed M, Ahn NG, Alexandre H, Amanchy R, Andrews PC, Bader JS, Balgley BM, Bantscheff M, Bennett KL, Björling E, Blagoev B, Bose R, Brahmachari SK, Burlingame AS, Bustelo XR, Cagney G, Cantin GT, Cardasis HL, Celis JE, Chaerkady R, Chu F, Cole PA, Costello CE, Cotter RJ, Crockett D, DeLany JP, De Marzo AM, DeSouza LV, Deutsch EW, Dransfield E, Drewes G, Droit A, Dunn MJ, Elenitoba-Johnson K, Ewing RM, Van Eyk J, Faca V, Falkner J, Fang X, Fenselau C, Figeys D, Gagné P, Gelfi C, Gevaert K, Gimble JM, Gnad F, Goel R, Gromov P, Hanash SM, Hancock WS, Harsha HC, Hart G, Hays F, He F, Hebbar P, Helsens K, Hermeking H, Hide W, Hjernø K, Hochstrasser DF, Hofmann O, Horn DM, Hruban RH, Ibarrola N, James P, Jensen ON, Jensen PH, Jung P, Kandasamy K, Kheterpal I, Kikuno RF, Korf U, Körner R, Kuster B, Kwon MS, Lee HJ, Lee YJ, Lefevre M, Lehvaslaiho M, Lescuyer P, Levander F, Lim MS, Löbke C, Loo JA, Mann M, Martens L, Martinez-Heredia J, McComb M, McRedmond J, Mehrle A, Menon R, Miller CA, Mischak H, Mohan SS, Mohmood R, Molina H, Moran MF, Morgan JD, Moritz R, Morzel M, Muddiman DC, Nalli A, Navarro JD, Neubert TA, Ohara O, Oliva R, Omenn GS, Oyama M, Paik YK, Pennington K, Pepperkok R, Periaswamy B, Petricoin EF, Poirier GG, Prasad TS, Purvine SO, Rahiman BA, Ramachandran P, Ramachandra YL, Rice RH, Rick J, Ronnholm RH, Salonen J, Sanchez JC, Sayd T, Seshi B, Shankari K, Sheng SJ, Shetty V, Shivakumar K, Simpson RJ, Sirdeshmukh R, Siu KW, Smith JC, Smith RD, States DJ, Sugano S, Sullivan M, Superti-Furga G, Takatalo M, Thongboonkerd V, Trinidad JC, Uhlen M, Vandekerckhove J, Vasilescu J, Veenstra TD, Vidal-Taboada JM, Vihinen M, Wait R, Wang X, Wiemann S, Wu B, Xu T, Yates JR, Zhong J, Zhou M, Zhu Y, Zurbig P, Pandey A. Human Proteinpedia enables sharing of human protein data. Nat Biotechnol. 2008 Feb; 26(2):164-7. PMID: 18259167.
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    62. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D. Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol. 2007; 3:89. PMID: 17353931.
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    63. Moran MF, Tong J, Taylor P, Ewing RM. Emerging applications for phospho-proteomics in cancer molecular therapeutics. Biochim Biophys Acta. 2006 Dec; 1766(2):230-41. PMID: 16889898.
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    64. Wang G, Barrett JW, Nazarian SH, Everett H, Gao X, Bleackley C, Colwill K, Moran MF, McFadden G. Myxoma virus M11L prevents apoptosis through constitutive interaction with Bak. J Virol. 2004 Jul; 78(13):7097-111. PMID: 15194786.
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    65. Sydor JR, Scalf M, Sideris S, Mao GD, Pandey Y, Tan M, Mariano M, Moran MF, Nock S, Wagner P. Chip-based analysis of protein-protein interactions by fluorescence detection and on-chip immunoprecipitation combined with microLC-MS/MS analysis. Anal Chem. 2003 Nov 15; 75(22):6163-70. PMID: 14615996.
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    66. Wang Z, Moran MF. Phospholipase C-gamma1: a phospholipase and guanine nucleotide exchange factor. Mol Interv. 2002 Oct; 2(6):352-5,338. PMID: 14993410.
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    67. Ho Y, Gruhler A, Heilbut A, Bader GD, Moore L, Adams SL, Millar A, Taylor P, Bennett K, Boutilier K, Yang L, Wolting C, Donaldson I, Schandorff S, Shewnarane J, Vo M, Taggart J, Goudreault M, Muskat B, Alfarano C, Dewar D, Lin Z, Michalickova K, Willems AR, Sassi H, Nielsen PA, Rasmussen KJ, Andersen JR, Johansen LE, Hansen LH, Jespersen H, Podtelejnikov A, Nielsen E, Crawford J, Poulsen V, Sørensen BD, Matthiesen J, Hendrickson RC, Gleeson F, Pawson T, Moran MF, Durocher D, Mann M, Hogue CW, Figeys D, Tyers M. Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10; 415(6868):180-3. PMID: 11805837.
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    68. Koehler JA, Moran MF. Regulation of extracellular signal-regulated kinase activity by p120 RasGAP does not involve its pleckstrin homology or calcium-dependent lipid binding domains but does require these domains to regulate cell proliferation. Cell Growth Differ. 2001 Nov; 12(11):551-61. PMID: 11714636.
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    69. Ashman K, Moran MF, Sicheri F, Pawson T, Tyers M. Cell signalling - the proteomics of it all. Sci STKE. 2001 Oct 09; 2001(103):pe33. PMID: 11593049.
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    70. Figeys D, McBroom LD, Moran MF. Mass spectrometry for the study of protein-protein interactions. Methods. 2001 Jul; 24(3):230-9. PMID: 11403572.
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    71. Koehler JA, Moran MF. RACK1, a protein kinase C scaffolding protein, interacts with the PH domain of p120GAP. Biochem Biophys Res Commun. 2001 May 18; 283(4):888-95. PMID: 11350068.
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    72. Dankort D, Maslikowski B, Warner N, Kanno N, Kim H, Wang Z, Moran MF, Oshima RG, Cardiff RD, Muller WJ. Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancer. Mol Cell Biol. 2001 Mar; 21(5):1540-51. PMID: 11238891.
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    73. de Hoog CL, Koehler JA, Goldstein MD, Taylor P, Figeys D, Moran MF. Ras binding triggers ubiquitination of the Ras exchange factor Ras-GRF2. Mol Cell Biol. 2001 Mar; 21(6):2107-17. PMID: 11238945.
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    74. Simon VR, Moran MF. SERCA activity is required for timely progression through G1/S. Cell Prolif. 2001 Feb; 34(1):15-30. PMID: 11284916.
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    75. Pham N, Cheglakov I, Koch CA, de Hoog CL, Moran MF, Rotin D. The guanine nucleotide exchange factor CNrasGEF activates ras in response to cAMP and cGMP. Curr Biol. 2000 May 04; 10(9):555-8. PMID: 10801446.
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    76. de Hoog CL, Fan WT, Goldstein MD, Moran MF, Koch CA. Calmodulin-independent coordination of Ras and extracellular signal-regulated kinase activation by Ras-GRF2. Mol Cell Biol. 2000 Apr; 20(8):2727-33. PMID: 10733575.
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    77. Shen Z, Batzer A, Koehler JA, Polakis P, Schlessinger J, Lydon NB, Moran MF. Evidence for SH3 domain directed binding and phosphorylation of Sam68 by Src. Oncogene. 1999 Aug 19; 18(33):4647-53. PMID: 10467411.
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    78. Fan WT, Koch CA, de Hoog CL, Fam NP, Moran MF. The exchange factor Ras-GRF2 activates Ras-dependent and Rac-dependent mitogen-activated protein kinase pathways. Curr Biol. 1998 Jul 30-Aug 13; 8(16):935-8. PMID: 9707409.
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    79. Wang Z, Glück S, Zhang L, Moran MF. Requirement for phospholipase C-gamma1 enzymatic activity in growth factor-induced mitogenesis. Mol Cell Biol. 1998 Jan; 18(1):590-7. PMID: 9418905.
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    80. Dankort DL, Wang Z, Blackmore V, Moran MF, Muller WJ. Distinct tyrosine autophosphorylation sites negatively and positively modulate neu-mediated transformation. Mol Cell Biol. 1997 Sep; 17(9):5410-25. PMID: 9271418.
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    81. Tung PS, Fam NP, Chen L, Moran MF. A 54-kDa protein related to ras-guanine nucleotide release factor expressed in the rat exocrine pancreas. Cell Tissue Res. 1997 Sep; 289(3):505-15. PMID: 9232829.
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    82. Fam NP, Fan WT, Wang Z, Zhang LJ, Chen H, Moran MF. Cloning and characterization of Ras-GRF2, a novel guanine nucleotide exchange factor for Ras. Mol Cell Biol. 1997 Mar; 17(3):1396-406. PMID: 9032266.
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    83. Fam NP, Zhang LJ, Rommens JM, Beatty BG, Moran MF. Mapping of the Ras-GRF2 gene (GRF2) to mouse chromosome 13C3-D1 and human chromosome 5q13, near the Ras-GAP gene. Genomics. 1997 Jan 01; 39(1):118-20. PMID: 9027497.
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    84. Wang Z, Moran MF. Requirement for the adapter protein GRB2 in EGF receptor endocytosis. Science. 1996 Jun 28; 272(5270):1935-9. PMID: 8658166.
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    85. Wang Z, Tung PS, Moran MF. Association of p120 ras GAP with endocytic components and colocalization with epidermal growth factor (EGF) receptor in response to EGF stimulation. Cell Growth Differ. 1996 Jan; 7(1):123-33. PMID: 8788041.
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    86. Gawler DJ, Zhang LJ, Moran MF. Mutation-deletion analysis of a Ca(2+)-dependent phospholipid binding (CaLB) domain within p120 GAP, a GTPase-activating protein for p21 ras. Biochem J. 1995 Apr 15; 307 ( Pt 2):487-91. PMID: 7733887.
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    87. Gawler DJ, Zhang LJ, Reedijk M, Tung PS, Moran MF. CaLB: a 43 amino acid calcium-dependent membrane/phospholipid binding domain in p120 Ras GTPase-activating protein. Oncogene. 1995 Mar 02; 10(5):817-25. PMID: 7898923.
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    88. Fixman ED, Naujokas MA, Rodrigues GA, Moran MF, Park M. Efficient cell transformation by the Tpr-Met oncoprotein is dependent upon tyrosine 489 in the carboxy-terminus. Oncogene. 1995 Jan 19; 10(2):237-49. PMID: 7838524.
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    89. Ellis C, Measday V, Moran MF. Phosphorylation-dependent complexes of p120 Ras-specific GTPase-activating protein with p62 and p190. Methods Enzymol. 1995; 255:179-92. PMID: 8524102.
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    90. Chen L, Zhang LJ, Greer P, Tung PS, Moran MF. A murine CDC25/ras-GRF-related protein implicated in Ras regulation. Dev Genet. 1993; 14(5):339-46. PMID: 8293576.
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    91. Khan SA, Dorrington JH, Moran MF. Steroidogenesis-inducing protein stimulates protein-tyrosine kinase activity in rat Leydig cells. Endocrinology. 1993 Jan; 132(1):109-14. PMID: 8419115.
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    92. Wong G, Müller O, Clark R, Conroy L, Moran MF, Polakis P, McCormick F. Molecular cloning and nucleic acid binding properties of the GAP-associated tyrosine phosphoprotein p62. Cell. 1992 May 01; 69(3):551-8. PMID: 1374686.
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    93. Koch CA, Moran MF, Anderson D, Liu XQ, Mbamalu G, Pawson T. Multiple SH2-mediated interactions in v-src-transformed cells. Mol Cell Biol. 1992 Mar; 12(3):1366-74. PMID: 1545818.
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    94. Koch CA, Anderson D, Moran MF, Ellis C, Pawson T. SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins. Science. 1991 May 03; 252(5006):668-74. PMID: 1708916.
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    95. Moran MF, Polakis P, McCormick F, Pawson T, Ellis C. Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein. Mol Cell Biol. 1991 Apr; 11(4):1804-12. PMID: 2005883.
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    96. Anderson D, Koch CA, Grey L, Ellis C, Moran MF, Pawson T. Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors. Science. 1990 Nov 16; 250(4983):979-82. PMID: 2173144.
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    97. Moran MF, Koch CA, Anderson D, Ellis C, England L, Martin GS, Pawson T. Src homology region 2 domains direct protein-protein interactions in signal transduction. Proc Natl Acad Sci U S A. 1990 Nov; 87(21):8622-6. PMID: 2236073.
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    98. Moran MF, Koch CA, Sadowski I, Pawson T. Mutational analysis of a phosphotransfer motif essential for v-fps tyrosine kinase activity. Oncogene. 1988 Dec; 3(6):665-72. PMID: 2577868.
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