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Last name

Mathieu Lemaire

TitleStaff Physician
InstitutionThe Hospital for Sick Children
Address555 University Avenue
Toronto ON M5G 1X8
ORCID ORCID Icon0000-0001-7593-6418 Additional info
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    Collapse Biography 
    Collapse education and training
    Yale University School of Medicine, New Haven, CT, USA.Ph.D. Investigative Medicine09/2014Genomics of Rare Renal Diseases
    School of Public Health, Harvard University, Boston, MA, USACertificate, Summer Program in Clinical Effectiveness09/2008Study design and biostatistics
    Pediatric Nephrology Training Program, Nephrology Division, Department of Paediatrics, The Hospital for Sick Children, Toronto, CAClinical fellow09/2009Medicine
    General Paediatrics Training Program, Department of Paediatrics,, The Hospital for Sick Children, Toronto, CAPaediatric Resident09/2007Medicine
    Medicine Program, Department of Medicine, McGill University, Montreal, QC, CAMDCM09/2004Medicine
    Department of Biology, McGill University, Montreal, QC, CAMSc, Biology09/2000Biology
    Department of Biology, McGill University, Montreal, QC, CABSc, Biology09/1997Biology
    Collapse awards and honors
    2018 - 2020New Investigator Career Enhancement Award, The Canadian Child Health Clinician Scientist Program (CCHCSP)
    2017 - 2020New Investigator Award, KRESCENT (Kidney Research Scientist Core Education and National Training Program), Canada
    2017 - 2017Fellow, American Society of Nephrology (FASN)
    2017 - 2017Fellow, Society for Pediatric Research (SPR)
    2017 - 2017Fellow, University of Toronto Science Leadership Program
    2017 - 2017Fellow, University of Toronto Science Leadership Program
    2016 - 2016Affiliate Specialist, American College Medical Genetics & Genomics (ACMG)
    2015 - 2015Fellow, EUREKA’s 6th Institute for Translational Medicine (certificate program)
    2014 - 2014Fellow, American Academy of Pediatrics (FAAP)
    2014 - 2015Associate scientific advisor, Science Translational Medicine
    2013 - 2013Top Oral Abstracts by Trainees, American Society of Nephrology Kidney Week 2013 Annual Meeting, November 7-10, 2013 in Atlanta, GA,
    2010 - 2012Post-doctoral Fellowship Award, KRESCENT (Kidney Research Scientist Core Education and National Training Program), Canada
    2018 - 2018Poster winner (oral presentation) for the (CCHCSP) annual symposium 2018 , Canadian Child Health Clinician Scientist Program

    Collapse Overview 
    Collapse overview
    Dr. Mathieu Lemaire finished his medical training at McGill University in 2004 and then moved to Toronto to learn Paediatrics at The Hospital for Sick Children. After completing his fellowship in Paediatric Nephrology in Toronto, he went to Yale University (New Haven, CT) to pursue a PhD in Investigative Medicine under the guidance of Dr Richard P. Lifton, with a focus on the genetics of rare paediatric kidney diseases. Dr Lemaire returned to the University of Toronto in 2014 as Assistant Professor of Paediatrics: he joined the Division of Nephrology at The Hospital for Sick Children as a Staff Physician, and the Cell biology Department within the SickKids Research Institute as Scientist-Track Investigator. He was cross-appointed to the Department of Biochemistry and to the Institute of Medical Sciences in 2015.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wang L, Aschenbrenner D, Zeng Z, Cao X, Mayr D, Mehta M, Capitani M, Warner N, Pan J, Wang L, Li Q, Zuo T, Cohen-Kedar S, Lu J, Ardy RC, Mulder DJ, Dissanayake D, Peng K, Huang Z, Li X, Wang Y, Wang X, Li S, Bullers S, Gammage AN, Warnatz K, Schiefer AI, Krivan G, Goda V, Kahr WHA, Lemaire M, Lu CY, Siddiqui I, Surette MG, Kotlarz D, Engelhardt KR, Griffin HR, Rottapel R, Decaluwe H, Laxer RM, Proietti M, Hambleton S, Elcombe S, Guo CH, Grimbacher B, Dotan I, Ng SC, Freeman SA, Snapper SB, Klein C, Boztug K, Huang Y, Li D, Uhlig HH, Muise AM. Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice. Nat Genet. 2021 04; 53(4):500-510. PMID: 33782605.
      View in: PubMed
    2. Alabbas A, Kirpalani A, Morgan C, Mammen C, Licht C, Phan V, Wade A, Harvey E, Zappitelli M, Clark EG, Hiremath S, Soroka SD, Wald R, Weir MA, Chanchlani R, Lemaire M. Canadian Association of Paediatric Nephrologists COVID-19 Rapid Response: Guidelines for Management of Acute Kidney Injury in Children. Can J Kidney Health Dis. 2021; 8:2054358121990135. PMID: 33614056.
      View in: PubMed
    3. Lemaire M, Noone D, Lapeyraque AL, Licht C, Frémeaux-Bacchi V. Inherited Kidney Complement Diseases. Clin J Am Soc Nephrol. 2021 Feb 03. PMID: 33536243.
      View in: PubMed
    4. Li Q, Gulati A, Lemaire M, Nottoli T, Bale A, Tufro A. Rho-GTPase Activating Protein myosin MYO9A identified as a novel candidate gene for monogenic focal segmental glomerulosclerosis. Kidney Int. 2021 May; 99(5):1102-1117. PMID: 33412162.
      View in: PubMed
    5. Lemaire M. Novel Fanconi renotubular syndromes provide insights in proximal tubule pathophysiology. Am J Physiol Renal Physiol. 2021 02 01; 320(2):F145-F160. PMID: 33283647.
      View in: PubMed
    6. Robinson C, Ruhl M, Kirpalani A, Alabbas A, Noone D, Teoh CW, Langlois V, Phan V, Lemaire M, Chanchlani R. Management of Canadian Pediatric Patients With Glomerular Diseases During the COVID-19 Pandemic: Recommendations From the Canadian Association of Pediatric Nephrologists COVID-19 Rapid Response Team. Can J Kidney Health Dis. 2020; 7:2054358120970713. PMID: 33240518.
      View in: PubMed
    7. Betcherman L, Lemaire M, Licht C, Chitayat D, Harrington J, Noone D. Helping nephrologists find answers: hyperinsulinism and tubular dysfunction: Answers. Pediatr Nephrol. 2020 02; 35(2):257-260. PMID: 31529156.
      View in: PubMed
    8. Betcherman L, Lemaire M, Licht C, Chitayat D, Harrington J, Noone D. Helping nephrologists find answers: hyperinsulinism and tubular dysfunction: Questions. Pediatr Nephrol. 2020 02; 35(2):253-255. PMID: 31529154.
      View in: PubMed
    9. Kim JH, Park EY, Chitayat D, Stachura DL, Schaper J, Lindstrom K, Jewett T, Wieczorek D, Draaisma JM, Sinnema M, Hoeberigs C, Hempel M, Bachman KK, Seeley AH, Stone JK, Kong HK, Vukadin L, Richard A, Shinde DN, McWalter K, Si YC, Douglas G, Lim ST, Vissers LELM, Lemaire M, Ahn EE. SON haploinsufficiency causes impaired pre-mRNA splicing of CAKUT genes and heterogeneous renal phenotypes. Kidney Int. 2019 06; 95(6):1494-1504. PMID: 31005274.
      View in: PubMed
    10. Kalatharan V, Lemaire M, Lanktree MB. Opportunities and Challenges for Genetic Studies of End-Stage Renal Disease in Canada. Can J Kidney Health Dis. 2018; 5:2054358118789368. PMID: 30046452.
      View in: PubMed
    11. Lemaire M, Parekh RS. A Perspective on Inherited Kidney Disease: Lessons for Practicing Nephrologists. Clin J Am Soc Nephrol. 2017 12 07; 12(12):1914-1916. PMID: 29146703.
      View in: PubMed
    12. Gaudreault-Tremblay MM, Faqeehi H, Langlois V, Hébert D, Parra DA, Annich G, Harvey E, Lemaire M. Management of Severe Hyponatremia With a Custom Continuous Renal Replacement Therapy in an Infant With Newly Diagnosed Chronic Kidney Disease. Kidney Int Rep. 2017 Nov; 2(6):1254-1258. PMID: 29270536.
      View in: PubMed
    13. Kellett S, Lemaire M, Miller SP, Licht C, Yoon G, Dlamini N, Noone D. Neonatal stroke and haematuria: Questions. Pediatr Nephrol. 2018 05; 33(5):805-806. PMID: 28717936.
      View in: PubMed
    14. Kellett S, Lemaire M, Miller SP, Licht C, Yoon G, Dlamini N, Noone D. Neonatal stroke and haematuria: Answers. Pediatr Nephrol. 2018 05; 33(5):807-811. PMID: 28717939.
      View in: PubMed
    15. Azukaitis K, Simkova E, Majid MA, Galiano M, Benz K, Amann K, Bockmeyer C, Gajjar R, Meyers KE, Cheong HI, Lange-Sperandio B, Jungraithmayr T, Frémeaux-Bacchi V, Bergmann C, Bereczki C, Miklaszewska M, Csuka D, Prohászka Z, Killen P, Gipson P, Sampson MG, Lemaire M, Schaefer F. The Phenotypic Spectrum of Nephropathies Associated with Mutations in Diacylglycerol Kinase e. J Am Soc Nephrol. 2017 10; 28(10):3066-3075. PMID: 28526779.
      View in: PubMed
    16. Epand RM, So V, Jennings W, Khadka B, Gupta RS, Lemaire M. Diacylglycerol Kinase-e: Properties and Biological Roles. Front Cell Dev Biol. 2016; 4:112. PMID: 27803897.
      View in: PubMed
    17. So V, Jalan D, Lemaire M, Topham MK, Hatch GM, Epand RM. Diacylglycerol kinase epsilon suppresses expression of p53 and glycerol kinase in mouse embryo fibroblasts. Biochim Biophys Acta. 2016 12; 1861(12 Pt A):1993-1999. PMID: 27713003.
      View in: PubMed
    18. Mele C, Lemaire M, Iatropoulos P, Piras R, Bresin E, Bettoni S, Bick D, Helbling D, Veith R, Valoti E, Donadelli R, Murer L, Neunhäuserer M, Breno M, Frémeaux-Bacchi V, Lifton R, Remuzzi G, Noris M. Characterization of a New DGKE Intronic Mutation in Genetically Unsolved Cases of Familial Atypical Hemolytic Uremic Syndrome. Clin J Am Soc Nephrol. 2015 Jun 05; 10(6):1011-9. PMID: 25854283.
      View in: PubMed
    19. Lemaire M, Frémeaux-Bacchi V, Schaefer F, Choi M, Tang WH, Le Quintrec M, Fakhouri F, Taque S, Nobili F, Martinez F, Ji W, Overton JD, Mane SM, Nürnberg G, Altmüller J, Thiele H, Morin D, Deschenes G, Baudouin V, Llanas B, Collard L, Majid MA, Simkova E, Nürnberg P, Rioux-Leclerc N, Moeckel GW, Gubler MC, Hwa J, Loirat C, Lifton RP. Recessive mutations in DGKE cause atypical hemolytic-uremic syndrome. Nat Genet. 2013 May; 45(5):531-6. PMID: 23542698.
      View in: PubMed
    20. Lemaire M, Islam QS, Shen H, Khan MA, Parveen M, Abedin F, Haseen F, Hyder Z, Cook RJ, Zlotkin SH. Iron-containing micronutrient powder provided to children with moderate-to-severe malnutrition increases hemoglobin concentrations but not the risk of infectious morbidity: a randomized, double-blind, placebo-controlled, noninferiority safety trial. Am J Clin Nutr. 2011 Aug; 94(2):585-93. PMID: 21715512.
      View in: PubMed
    21. Lemaire M, Connolly B, Harvey E, Licht C. Treatment of paediatric vancomycin intoxication: a case report and review of the literature. NDT Plus. 2010 Jun; 3(3):260-264. PMID: 28657057.
      View in: PubMed
    22. Lemaire M, Diamond IR, Langer JC. Whole or parts--the fate of hemoperitoneum. Surgery. 2009 Nov; 146(5):947-9. PMID: 19744438.
      View in: PubMed
    23. Lemaire M, Kantor P, Manson D, Grasemann H, Ely BA, Nield LS, Michalik DE, Michalik D, Batra J. Index of suspicion. Pediatr Rev. 2008 Nov; 29(11):399-406. PMID: 18977858.
      View in: PubMed
    24. Lemaire M, Chitayat D, Geary DF, Bichet DG, Licht C. A novel disease-causing mutation in AVPR2: Q96H. NDT Plus. 2009 Feb; 2(1):20-2. PMID: 25949277.
      View in: PubMed
    25. Lemaire M. Subgroup analysis: at best suggestive (rather than conclusive). Pediatr Nephrol. 2008 Jul; 23(7):1189-90; author reply 1191-2. PMID: 18401599.
      View in: PubMed
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