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Felix Ratjen

TitleDivision Head
InstitutionThe Hospital for Sick Children
DepartmentRespiratory Medicine
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
ORCID ORCID Icon0000-0003-4057-6592 Additional info
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    Collapse Biography 
    Collapse education and training
    Johann Wolfgang Goethe University , GermanyMD1986
    University of Essen, GermanyMD1994Paediatrics
    University of Essen, GermanyPhD1996Habilitation Paediatrics
    Harvard Medical School, United StatesResearch Fellowship1989

    Collapse Overview 
    Collapse overview
    Dr. Felix Ratjen is the Division Chief of Paediatric Respiratory Medicine at The Hospital for Sick Children, Professor of Paediatrics at The University of Toronto, Program Head and Senior Scientist at the Research Institute in the Translational Medicine research program and the H.E. Seller’s Chair in Cystic Fibrosis. He is co-leading the CF Centre at SickKids and Medical Director of the Clinical Research Unit.

    Dr. Ratjen completed a majority of his medical education in Germany, along with a research fellowship at the Children's Hospital in Boston. He subsequently worked at the University of Essen, where he was appointed Deputy Chief of the Department of Paediatrics in 1998 and Professor of Paediatrics in 2001. Until 2005 he was the chief executive of the scientific board of the German CF foundation before relocating in Canada in the same year. He is an the organizing committees of the major respiratory meetings (American Thoracic Society, European Respiratory Society and the North American CF conference), works on multiple grant review panels is a member of the several editorial boards including the American Journal of Respiratory and Critical Care Medicine, Thorax, Pediatric Pulmonology and the Journal of Cystic Fibrosis.

    Dr. Ratjen is conducting multiple clinical trials addressing cystic fibrosis lung disease including new therapeutic strategies to target the underlying defect, treatment of airway infections such as first infection with Pseudomonas aeruginosa, airway inflammation and other important aspects of the disease. While some of these studies are single centre studies within the CF centre at SickKids or in collaboration with the adult centre at St. Michael’s Hospital, many of them include both national and international collaborations with centres in Canada, the US, Europe and Australia. In addition, he is involved in developing and validating new outcome measures to quantify important aspects of CF lung disease that can be utilized in clinical trials. He also studies other lung diseases and over the recent years has developed an interest in the clinical evaluation of Hereditary Hemorrhagic Telangiectasia (HHT), for which he is leading one of the largest dedicated pediatric clinics.


    Collapse Research 
    Collapse research activities and funding
         (Margaret Rosenfeld)
    Cystic Fibrosis Foundation Therapeutics
    Saline Hypertonic in Preschoolers (SHIP-CT) – Study
    Role: Co-PI

         (Felix Ratjen)
    Cystic Fibrosis Foundation Therapeutics
    Tracking CF lung disease through the early years: Utility of the LCI
    Role: PI

         (Felix Ratjen)
    Sick Kids Foundation – Cystic Fibrosis Canada
    Program for Individualized CF Therapy
    Role: Co-PI

         (Felix Ratjen)
    Cystic Fibrosis Canada
    LCI to monitor treatment response for pulmonary exacerbations
    Role: PI

         (Felix Ratjen)Apr 1, 2018 - Mar 31, 2022
    Genome Canada
    Personalized Therapy for Individuals with Cystic Fibrosis
    Role: PI

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Hebestreit H, Hulzebos EHJ, Schneiderman JE, Karila C, Boas SR, Kriemler S, Dwyer T, Sahlberg M, Urquhart DS, Lands LC, Ratjen F, Takken T, Varanistkaya L, Rücker V, Hebestreit A, Usemann J, Radtke T. Cardiopulmonary Exercise Testing Provides Additional Prognostic Information in Cystic Fibrosis. Am J Respir Crit Care Med. 2019 Apr 15; 199(8):987-995. PMID: 30321487.
      View in: PubMed
    2. Perrem L, Ratjen F. Letting It All Out: Neutrophils in Early Cystic Fibrosis Airway Inflammation. Am J Respir Crit Care Med. 2019 Apr 01; 199(7):816-817. PMID: 30395720.
      View in: PubMed
    3. Couch MJ, Thomen R, Kanhere N, Hu R, Ratjen F, Woods J, Santyr G. A two-center analysis of hyperpolarized 129Xe lung MRI in stable pediatric cystic fibrosis: Potential as a biomarker for multi-site trials. J Cyst Fibros. 2019 Mar 25. PMID: 30922812.
      View in: PubMed
    4. Klingel M, Stanojevic S, Tullis E, Ratjen F, Waters V. The Effect of Oral Azithromycin on the Response to Pulmonary Exacerbations Treated with Intravenous Tobramycin in Children with Cystic Fibrosis. Ann Am Thorac Soc. 2019 Mar 15. PMID: 30874447.
      View in: PubMed
    5. Ratjen A, Au J, Carpenter S, John P, Ratjen F. Growth of Pulmonary Arteriovenous Malformations in Pediatric Patients with Hereditary Hemorrhagic Telangiectasia. J Pediatr. 2019 Mar 07. PMID: 30853205.
      View in: PubMed
    6. Rayment JH, Couch MJ, McDonald N, Kanhere N, Manson D, Santyr G, Ratjen F. Hyperpolarised 129Xe MRI to monitor treatment response in children with cystic fibrosis. Eur Respir J. 2019 Feb 28. PMID: 30819815.
      View in: PubMed
    7. Au JWY, McDonald R, Stanojevic S, Ratjen F. Does the multiple-breath washout test need to be measured before spirometry? ERJ Open Res. 2019 Feb; 5(1). PMID: 30740459.
      View in: PubMed
    8. Klostranec JM, Chen L, Mathur S, McDonald J, Faughnan ME, Ratjen F, Krings T. A theory for polymicrogyria and brain arteriovenous malformations in HHT. Neurology. 2019 Jan 01; 92(1):34-42. PMID: 30584075.
      View in: PubMed
    9. Perrem L, Rayment JH, Ratjen F. The lung clearance index as a monitoring tool in cystic fibrosis: ready for the clinic? Curr Opin Pulm Med. 2018 Nov; 24(6):579-585. PMID: 30095491.
      View in: PubMed
    10. Eckford PDW, McCormack J, Munsie L, He G, Stanojevic S, Pereira SL, Ho K, Avolio J, Bartlett C, Yang JY, Wong AP, Wellhauser L, Huan LJ, Jiang JX, Ouyang H, Du K, Klingel M, Kyriakopoulou L, Gonska T, Moraes TJ, Strug LJ, Rossant J, Ratjen F, Bear CE. The CF Canada-Sick Kids Program in individual CF therapy: A resource for the advancement of personalized medicine in CF. J Cyst Fibros. 2019 Jan; 18(1):35-43. PMID: 29685812.
      View in: PubMed
    11. Ratjen F, Klingel M, Black P, Powers MR, Grasemann H, Solomon M, Sagel SD, Donaldson SH, Rowe SM, Rosenfeld M. Changes in Lung Clearance Index in Preschool-aged Patients with Cystic Fibrosis Treated with Ivacaftor (GOAL): A Clinical Trial. Am J Respir Crit Care Med. 2018 Aug 15; 198(4):526-528. PMID: 29614238.
      View in: PubMed
    12. Santyr G, Kanhere N, Morgado F, Rayment JH, Ratjen F, Couch MJ. Hyperpolarized Gas Magnetic Resonance Imaging of Pediatric Cystic Fibrosis Lung Disease. Acad Radiol. 2019 Mar; 26(3):344-354. PMID: 30087066.
      View in: PubMed
    13. Middleton MA, Layeghifard M, Klingel M, Stanojevic S, Yau YCW, Zlosnik JEA, Coriati A, Ratjen FA, Tullis ED, Stephenson A, Wilcox P, Freitag A, Chilvers M, McKinney M, Lavoie A, Wang PW, Guttman DS, Waters VJ. Epidemiology of Clonal Pseudomonas aeruginosa Infection in a Canadian Cystic Fibrosis Population. Ann Am Thorac Soc. 2018 Jul; 15(7):827-836. PMID: 29911888.
      View in: PubMed
    14. Racette C, Lu Z, Kowalik K, Cheng O, Bendiak G, Amin R, Dubeau A, Jensen R, Balkovec S, Gustafsson P, Ratjen F, Subbarao P. Lung clearance index is elevated in young children with symptom-controlled asthma. Health Sci Rep. 2018 Aug; 1(8):e58. PMID: 30623093.
      View in: PubMed
    15. Lu Z, Foong RE, Kowalik K, Moraes TJ, Boyce A, Dubeau A, Balkovec S, Gustafsson PM, Becker AB, Mandhane PJ, Turvey SE, Lou W, Ratjen F, Sears M, Subbarao P. Ventilation inhomogeneity in infants with recurrent wheezing. Thorax. 2018 10; 73(10):936-941. PMID: 29907664.
      View in: PubMed
    16. Lu Z, Foong RE, Kowalik K, Moraes TJ, Dubeau A, Lefebvre D, Davis SD, Balkovec S, Becker A, Mandhane P, Turvey SE, Lou W, Sears MR, Ratjen F, Subbarao P. Reference equations for the interpretation of forced expiratory and plethysmographic measurements in infants. Pediatr Pulmonol. 2018 Jul; 53(7):907-916. PMID: 29790670.
      View in: PubMed
    17. Ratjen F, Moeller A, McKinney ML, Asherova I, Alon N, Maykut R, Angyalosi G. Eradication of early P. aeruginosa infection in children <7?years of age with cystic fibrosis: The early study. J Cyst Fibros. 2019 Jan; 18(1):78-85. PMID: 29685813.
      View in: PubMed
    18. Blanchard AC, Rooney AM, Yau Y, Zhang Y, Stapleton PJ, Horton E, Klingel M, Stanojevic S, Ratjen F, Coburn B, Waters V. Early detection using qPCR of Pseudomonas aeruginosa infection in children with cystic fibrosis undergoing eradication treatment. J Cyst Fibros. 2018 Nov; 17(6):723-728. PMID: 29525410.
      View in: PubMed
    19. Castellani C, Duff AJA, Bell SC, Heijerman HGM, Munck A, Ratjen F, Sermet-Gaudelus I, Southern KW, Barben J, Flume PA, Hodková P, Kashirskaya N, Kirszenbaum MN, Madge S, Oxley H, Plant B, Schwarzenberg SJ, Smyth AR, Taccetti G, Wagner TOF, Wolfe SP, Drevinek P. ECFS best practice guidelines: the 2018 revision. J Cyst Fibros. 2018 Mar; 17(2):153-178. PMID: 29506920.
      View in: PubMed
    20. Robinson PD, Lum S, Moore C, Hardaker KM, Benseler N, Aurora P, Cooper P, Fitzgerald D, Jensen R, McDonald R, Selvadurai H, Ratjen F, Stanojevic S. Comparison of facemask and mouthpiece interfaces for multiple breath washout measurements. J Cyst Fibros. 2018 Jul; 17(4):511-517. PMID: 29483003.
      View in: PubMed
    21. Robinson PD, Latzin P, Ramsey KA, Stanojevic S, Aurora P, Davis SD, Gappa M, Hall GL, Horsley A, Jensen R, Lum S, Milla C, Nielsen KG, Pittman JE, Rosenfeld M, Singer F, Subbarao P, Gustafsson PM, Ratjen F. Preschool Multiple-Breath Washout Testing. An Official American Thoracic Society Technical Statement. Am J Respir Crit Care Med. 2018 Mar 01; 197(5):e1-e19. PMID: 29493315.
      View in: PubMed
    22. Rayment JH, Stanojevic S, Davis SD, Retsch-Bogart G, Ratjen F. Lung clearance index to monitor treatment response in pulmonary exacerbations in preschool children with cystic fibrosis. Thorax. 2018 05; 73(5):451-458. PMID: 29449440.
      View in: PubMed
    23. Kanhere N, Couch MJ, Rayment JH, Ratjen F, Santyr G. Reply to Verbanck and Vanderhelst: The Respective Roles of Lung Clearance Index and Magnetic Resonance Imaging in the Clinical Management of Patients with Cystic Fibrosis. Am J Respir Crit Care Med. 2018 02 01; 197(3):411-412. PMID: 28800249.
      View in: PubMed
    24. Moore C, Horton E, Benseler N, Jensen R, Ratjen F. The effects of 100% oxygen on breathing pattern are not limited to young children. Eur Respir J. 2018 01; 51(1). PMID: 29301913.
      View in: PubMed
    25. Fernandopulle N, Mertens L, Klingel M, Manson D, Ratjen F. Echocardiography Grading for Pulmonary Arteriovenous Malformation Screening in Children with Hereditary Hemorrhagic Telangiectasia. J Pediatr. 2018 04; 195:288-291.e1. PMID: 29274888.
      View in: PubMed
    26. Radtke T, Hebestreit H, Gallati S, Schneiderman JE, Braun J, Stevens D, Hulzebos EH, Takken T, Boas SR, Urquhart DS, Lands LC, Tejero S, Sovtic A, Dwyer T, Petrovic M, Harris RA, Karila C, Savi D, Usemann J, Mei-Zahav M, Hatziagorou E, Ratjen F, Kriemler S. CFTR Genotype and Maximal Exercise Capacity in Cystic Fibrosis: A Cross-sectional Study. Ann Am Thorac Soc. 2018 02; 15(2):209-216. PMID: 29140739.
      View in: PubMed
    27. Ramsey K, Ratjen F, Latzin P. Elucidating progression of early cystic fibrosis lung disease. Eur Respir J. 2017 11; 50(5). PMID: 29122922.
      View in: PubMed
    28. Kanhere N, Couch MJ, Kowalik K, Zanette B, Rayment JH, Manson D, Subbarao P, Ratjen F, Santyr G. Correlation of Lung Clearance Index with Hyperpolarized 129Xe Magnetic Resonance Imaging in Pediatric Subjects with Cystic Fibrosis. Am J Respir Crit Care Med. 2017 10 15; 196(8):1073-1075. PMID: 28245140.
      View in: PubMed
    29. Hayeems RZ, Miller FA, Vermeulen M, Potter BK, Chakraborty P, Davies C, Carroll JC, Ratjen F, Guttmann A. False-Positive Newborn Screening for Cystic Fibrosis and Health Care Use. Pediatrics. 2017 Nov; 140(5). PMID: 29025964.
      View in: PubMed
    30. Kane M, Rayment JH, Jensen R, McDonald R, Stanojevic S, Ratjen F. Correcting for tissue nitrogen excretion in multiple breath washout measurements. PLoS One. 2017; 12(10):e0185553. PMID: 29020072.
      View in: PubMed
    31. Waters V, Ratjen F. Standard versus biofilm antimicrobial susceptibility testing to guide antibiotic therapy in cystic fibrosis. Cochrane Database Syst Rev. 2017 10 05; 10:CD009528. PMID: 28981972.
      View in: PubMed
    32. Oude Engberink E, Ratjen F, Davis SD, Retsch-Bogart G, Amin R, Stanojevic S. Inter-test reproducibility of the lung clearance index measured by multiple breath washout. Eur Respir J. 2017 10; 50(4). PMID: 28982773.
      View in: PubMed
    33. Rayment JH, Ratjen F. Another Brick in the Wall: Lung Clearance Index and Lower Airways Pathology in Preschool Cystic Fibrosis. Ann Am Thorac Soc. 2017 Sep; 14(9):1389-1390. PMID: 28862497.
      View in: PubMed
    34. Somayaji R, Stanojevic S, Tullis DE, Stephenson AL, Ratjen F, Waters V. Clinical Outcomes Associated with Achromobacter Species Infection in Patients with Cystic Fibrosis. Ann Am Thorac Soc. 2017 Sep; 14(9):1412-1418. PMID: 28406714.
      View in: PubMed
    35. Molinski SV, Ahmadi S, Ip W, Ouyang H, Villella A, Miller JP, Lee PS, Kulleperuma K, Du K, Di Paola M, Eckford PD, Laselva O, Huan LJ, Wellhauser L, Li E, Ray PN, Pomès R, Moraes TJ, Gonska T, Ratjen F, Bear CE. Orkambi® and amplifier co-therapy improves function from a rare CFTR mutation in gene-edited cells and patient tissue. EMBO Mol Med. 2017 09; 9(9):1224-1243. PMID: 28667089.
      View in: PubMed
    36. Grasemann H, Ciet P, Amin R, McDonald N, Klingel M, Tiddens HAWM, Ratjen F, Grosse-Wortmann L. Changes in magnetic resonance imaging scores and ventilation inhomogeneity in children with cystic fibrosis pulmonary exacerbations. Eur Respir J. 2017 08; 50(2). PMID: 28838978.
      View in: PubMed
    37. Rayment JH, Ahmareen O, John PR, Ratjen F. Chronic Hypoxemia in a 2-Year-Old Boy. Ann Am Thorac Soc. 2017 Aug; 14(8):1348-1352. PMID: 28763268.
      View in: PubMed
    38. Livingston MH, Mahant S, Ratjen F, Connolly BL, Thorpe K, Mamdani M, Maclusky I, Laberge S, Giglia L, Walton JM, Yang CL, Roberts A, Shawyer AC, Brindle M, Parsons SJ, Stoian CA, Cohen E. Intrapleural Dornase and Tissue Plasminogen Activator in pediatric empyema (DTPA): a study protocol for a randomized controlled trial. Trials. 2017 06 24; 18(1):293. PMID: 28646887.
      View in: PubMed
    39. Waters V, Ratjen F. Combination antimicrobial susceptibility testing for acute exacerbations in chronic infection of Pseudomonas aeruginosa in cystic fibrosis. Cochrane Database Syst Rev. 2017 06 19; 6:CD006961. PMID: 28628280.
      View in: PubMed
    40. Ratjen F, Hug C, Marigowda G, Tian S, Huang X, Stanojevic S, Milla CE, Robinson PD, Waltz D, Davies JC. Efficacy and safety of lumacaftor and ivacaftor in patients aged 6-11 years with cystic fibrosis homozygous for F508del-CFTR: a randomised, placebo-controlled phase 3 trial. Lancet Respir Med. 2017 07; 5(7):557-567. PMID: 28606620.
      View in: PubMed
    41. Stanojevic S, Davis SD, Retsch-Bogart G, Webster H, Davis M, Johnson RC, Jensen R, Pizarro ME, Kane M, Clem CC, Schornick L, Subbarao P, Ratjen FA. Progression of Lung Disease in Preschool Patients with Cystic Fibrosis. Am J Respir Crit Care Med. 2017 05 01; 195(9):1216-1225. PMID: 27943680.
      View in: PubMed
    42. Ahmadi S, Bozoky Z, Di Paola M, Xia S, Li C, Wong AP, Wellhauser L, Molinski SV, Ip W, Ouyang H, Avolio J, Forman-Kay JD, Ratjen F, Hirota JA, Rommens J, Rossant J, Gonska T, Moraes TJ, Bear CE. Phenotypic profiling of CFTR modulators in patient-derived respiratory epithelia. NPJ Genom Med. 2017 Apr 14; 2:12. PMID: 28649446.
      View in: PubMed
    43. Milla CE, Ratjen F, Marigowda G, Liu F, Waltz D, Rosenfeld M. Lumacaftor/Ivacaftor in Patients Aged 6-11 Years with Cystic Fibrosis and Homozygous for F508del-CFTR. Am J Respir Crit Care Med. 2017 04 01; 195(7):912-920. PMID: 27805836.
      View in: PubMed
    44. Hayeems RZ, Miller FA, Barg CJ, Bombard Y, Carroll JC, Tam K, Kerr E, Chakraborty P, Potter BK, Patton S, Bytautas JP, Taylor L, Davies C, Milburn J, Price A, Gonska T, Keenan K, Ratjen F, Guttmann A. Psychosocial Response to Uncertain Newborn Screening Results for Cystic Fibrosis. J Pediatr. 2017 05; 184:165-171.e1. PMID: 28279431.
      View in: PubMed
    45. Waters V, Yau Y, Beaudoin T, Wettlaufer J, Tom SK, McDonald N, Rizvi L, Klingel M, Ratjen F, Tullis E. Pilot trial of tobramycin inhalation powder in cystic fibrosis patients with chronic Burkholderia cepacia complex infection. J Cyst Fibros. 2017 Jul; 16(4):492-495. PMID: 28262569.
      View in: PubMed
    46. Blanchard AC, Horton E, Stanojevic S, Taylor L, Waters V, Ratjen F. Effectiveness of a stepwise Pseudomonas aeruginosa eradication protocol in children with cystic fibrosis. J Cyst Fibros. 2017 May; 16(3):395-400. PMID: 28189634.
      View in: PubMed
    47. Raaijmakers L, Jensen R, Stanojevic S, Ratjen F. Validation of multiple breath washout devices. J Cyst Fibros. 2017 11; 16(6):e22-e23. PMID: 28185888.
      View in: PubMed
    48. Ratjen F. How Best to Capture Early Cystic Fibrosis Lung Disease? Am J Respir Crit Care Med. 2017 02 01; 195(3):283-284. PMID: 28145764.
      View in: PubMed
    49. Subbarao P, Milla CE, Morgan WJ, Ratjen F. Corrections to an ATS Workshop Report on Multiple-Breath Washout Testing for Patients with Cystic Fibrosis. Ann Am Thorac Soc. 2017 Jan; 14(1):145. PMID: 28035881.
      View in: PubMed
    50. Waters V, Ratjen F. Antibiotic treatment for nontuberculous mycobacteria lung infection in people with cystic fibrosis. Cochrane Database Syst Rev. 2016 12 19; 12:CD010004. PMID: 28000919.
      View in: PubMed
    51. Rayment JH, Ratjen F. Constrictive Bronchiolitis: A Distinct Phenotype of Cystic Fibrosis Lung Disease? Ann Am Thorac Soc. 2016 12; 13(12):2111-2112. PMID: 27925783.
      View in: PubMed
    52. Oude Engberink E, Stanojevic S, Ratjen F. Clinimetric Properties of the Lung Clearance Index in Adults and Children With Cystic Fibrosis. Chest. 2016 12; 150(6):1412-1413. PMID: 27938756.
      View in: PubMed
    53. Waters V, Stanojevic S, Ratjen F. Special considerations for the treatment of pulmonary exacerbations in children with cystic fibrosis. Expert Rev Respir Med. 2016 Nov; 10(11):1221-1228. PMID: 27718754.
      View in: PubMed
    54. Strug LJ, Gonska T, He G, Keenan K, Ip W, Boëlle PY, Lin F, Panjwani N, Gong J, Li W, Soave D, Xiao B, Tullis E, Rabin H, Parkins MD, Price A, Zuberbuhler PC, Corvol H, Ratjen F, Sun L, Bear CE, Rommens JM. Cystic fibrosis gene modifier SLC26A9 modulates airway response to CFTR-directed therapeutics. Hum Mol Genet. 2016 10 15; 25(20):4590-4600. PMID: 28171547.
      View in: PubMed
    55. Bombard Y, Miller FA, Barg CJ, Patton SJ, Carroll JC, Chakraborty P, Potter BK, Tam K, Taylor L, Kerr E, Davies C, Milburn J, Ratjen F, Guttmann A, Hayeems RZ. A secondary benefit: the reproductive impact of carrier results from newborn screening for cystic fibrosis. Genet Med. 2017 04; 19(4):403-411. PMID: 27608173.
      View in: PubMed
    56. Stanojevic S, McDonald A, Waters V, MacDonald S, Horton E, Tullis E, Ratjen F. Effect of pulmonary exacerbations treated with oral antibiotics on clinical outcomes in cystic fibrosis. Thorax. 2017 04; 72(4):327-332. PMID: 27539619.
      View in: PubMed
    57. Hayeems RZ, Miller FA, Barg CJ, Bombard Y, Kerr E, Tam K, Carroll JC, Potter BK, Chakraborty P, Davies C, Milburn J, Patton S, Bytautas JP, Taylor L, Price A, Gonska T, Keenan K, Ratjen F, Guttmann A. Parent Experience With False-Positive Newborn Screening Results for Cystic Fibrosis. Pediatrics. 2016 09; 138(3). PMID: 27485696.
      View in: PubMed
    58. Wettlaufer J, Klingel M, Yau Y, Stanojevic S, Tullis E, Ratjen F, Waters V. Longitudinal study of Stenotrophomonas maltophilia antibody levels and outcomes in cystic fibrosis patients. J Cyst Fibros. 2017 01; 16(1):58-63. PMID: 27346471.
      View in: PubMed
    59. Jensen R, Stanojevic S, Klingel M, Pizarro ME, Hall GL, Ramsey K, Foong R, Saunders C, Robinson PD, Webster H, Hardaker K, Kane M, Ratjen F. A Systematic Approach to Multiple Breath Nitrogen Washout Test Quality. PLoS One. 2016; 11(6):e0157523. PMID: 27304432.
      View in: PubMed
    60. Stanojevic S, Ratjen F. Physiologic endpoints for clinical studies for cystic fibrosis. J Cyst Fibros. 2016 07; 15(4):416-23. PMID: 27316663.
      View in: PubMed
    61. Ratjen F. Pulmonary artery hypertension: an underrated disease manifestation in cystic fibrosis? Lancet Respir Med. 2016 08; 4(8):596-598. PMID: 27298018.
      View in: PubMed
    62. Inarejos Clemente EJ, Ratjen F, Manson DE. Utility of MDCT MIP Postprocessing Reconstruction Images in Children With Hereditary Hemorrhagic Telangiectasia. J Comput Assist Tomogr. 2016 May-Jun; 40(3):375-9. PMID: 26953767.
      View in: PubMed
    63. Kane M, Gonska T, Jensen R, Avolio J, Klingel M, Stanojevic S, Ratjen F. Lung clearance index response in patients with CF with class III CFTR mutations. Thorax. 2016 May; 71(5):476-7. PMID: 26944510.
      View in: PubMed
    64. Amin R, Stanojevic S, Kane M, Webster H, Ratjen F. A randomized controlled trial to evaluate the lung clearance index as an outcome measure for early phase studies in patients with cystic fibrosis. Respir Med. 2016 Mar; 112:59-64. PMID: 26856191.
      View in: PubMed
    65. Zuo L, Pannell BK, Horsley A, Bell N, Kane M, Ratjen F, Thompson BR, Nilsen K. Commentaries on Viewpoint: Using the same cut-off for sulfur hexafluoride and nitrogen multiple-breath washout may not be appropriate. J Appl Physiol (1985). 2015 Dec 15; 119(12):1513-4. PMID: 26670341.
      View in: PubMed
    66. Ratjen F, Waters V, Klingel M, McDonald N, Dell S, Leahy TR, Yau Y, Grasemann H. Changes in airway inflammation during pulmonary exacerbations in patients with cystic fibrosis and primary ciliary dyskinesia. Eur Respir J. 2016 Mar; 47(3):829-36. PMID: 26585432.
      View in: PubMed
    67. Davis SD, Ratjen F, Brumback LC, Johnson RC, Filbrun AG, Kerby GS, Panitch HB, Donaldson SH, Rosenfeld M. Infant lung function tests as endpoints in the ISIS multicenter clinical trial in cystic fibrosis. J Cyst Fibros. 2016 05; 15(3):386-91. PMID: 26547590.
      View in: PubMed
    68. Waters V, Ratjen F. Combination antimicrobial susceptibility testing for acute exacerbations in chronic infection of Pseudomonas aeruginosa in cystic fibrosis. Cochrane Database Syst Rev. 2015 Nov 02; (11):CD006961. PMID: 26522473.
      View in: PubMed
    69. Ooi CY, Ratjen F, Gonska T. Author's Response: Re: Stratifying Cystic Fibrosis Risk for Newborn Screen Infants With Equivocal Sweat Chloride Levels. Pediatrics. 2015 Nov; 136(5):e1490-1. PMID: 26527092.
      View in: PubMed
    70. Waters V, Ratjen F. Pulmonary Exacerbations in Children with Cystic Fibrosis. Ann Am Thorac Soc. 2015 Nov; 12 Suppl 2:S200-6. PMID: 26595740.
      View in: PubMed
    71. Gonska T, Ratjen F. Newborn screening for cystic fibrosis. Expert Rev Respir Med. 2015 Oct; 9(5):619-31. PMID: 26366807.
      View in: PubMed
    72. Subbarao P, Lu Z, Kowalik K, Brown M, Balkovec S, Gustafsson P, Lou W, Ratjen F. Changes in multiple breath washout measures after raised volume rapid thoracoabdominal compression maneuvers in infants. Pediatr Pulmonol. 2016 Feb; 51(2):183-8. PMID: 26383784.
      View in: PubMed
    73. Torphy TJ, Allen J, Cantin AM, Konstan MW, Accurso FJ, Joseloff E, Ratjen FA, Chmiel JF. Considerations for the Conduct of Clinical Trials with Antiinflammatory Agents in Cystic Fibrosis. A Cystic Fibrosis Foundation Workshop Report. Ann Am Thorac Soc. 2015 Sep; 12(9):1398-406. PMID: 26146892.
      View in: PubMed
    74. Waters V, Stanojevic S, Klingel M, Chiang J, Sonneveld N, Kukkar R, Tullis E, Ratjen F. Prolongation of antibiotic treatment for cystic fibrosis pulmonary exacerbations. J Cyst Fibros. 2015 Nov; 14(6):770-6. PMID: 26265220.
      View in: PubMed
    75. Grasemann H, Gonska T, Avolio J, Klingel M, Tullis E, Ratjen F. Effect of ivacaftor therapy on exhaled nitric oxide in patients with cystic fibrosis. J Cyst Fibros. 2015 Nov; 14(6):727-32. PMID: 26168933.
      View in: PubMed
    76. Sonneveld N, Stanojevic S, Amin R, Aurora P, Davies J, Elborn JS, Horsley A, Latzin P, O'Neill K, Robinson P, Scrase E, Selvadurai H, Subbarao P, Welsh L, Yammine S, Ratjen F. Lung clearance index in cystic fibrosis subjects treated for pulmonary exacerbations. Eur Respir J. 2015 Oct; 46(4):1055-64. PMID: 26160868.
      View in: PubMed
    77. Subbarao P, Milla C, Aurora P, Davies JC, Davis SD, Hall GL, Heltshe S, Latzin P, Lindblad A, Pittman JE, Robinson PD, Rosenfeld M, Singer F, Starner TD, Ratjen F, Morgan W. Multiple-Breath Washout as a Lung Function Test in Cystic Fibrosis. A Cystic Fibrosis Foundation Workshop Report. Ann Am Thorac Soc. 2015 Jun; 12(6):932-9. PMID: 26075554.
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    148. Ratjen F, Grasemann H. New therapies in cystic fibrosis. Curr Pharm Des. 2012; 18(5):614-27. PMID: 22229570.
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    157. Osborn AJ, Leung R, Ratjen F, James AL. Effect of endoscopic sinus surgery on pulmonary function and microbial pathogens in a pediatric population with cystic fibrosis. Arch Otolaryngol Head Neck Surg. 2011 Jun; 137(6):542-7. PMID: 21690506.
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    164. Amin R, Lam M, Dupuis A, Ratjen F. The effect of early Pseudomonas aeruginosa treatment on lung function in pediatric cystic fibrosis. Pediatr Pulmonol. 2011 Jun; 46(6):554-8. PMID: 21337727.
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    165. Leahy TR, Yau YC, Atenafu E, Corey M, Ratjen F, Waters V. Epidemiology of borderline oxacillin-resistant Staphylococcus aureus in pediatric cystic fibrosis. Pediatr Pulmonol. 2011 May; 46(5):489-96. PMID: 21337531.
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    166. Grasemann H, Al-Saleh S, Scott JA, Shehnaz D, Mehl A, Amin R, Rafii M, Pencharz P, Belik J, Ratjen F. Asymmetric dimethylarginine contributes to airway nitric oxide deficiency in patients with cystic fibrosis. Am J Respir Crit Care Med. 2011 May 15; 183(10):1363-8. PMID: 21278301.
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    167. Wells GD, Wilkes DL, Schneiderman JE, Rayner T, Elmi M, Selvadurai H, Dell SD, Noseworthy MD, Ratjen F, Tein I, Coates AL. Skeletal muscle metabolism in cystic fibrosis and primary ciliary dyskinesia. Pediatr Res. 2011 Jan; 69(1):40-5. PMID: 20938370.
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    169. Grasemann H, Ratjen F. Emerging therapies for cystic fibrosis lung disease. Expert Opin Emerg Drugs. 2010 Dec; 15(4):653-9. PMID: 20812885.
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    170. Barnes PJ, Dweik RA, Gelb AF, Gibson PG, George SC, Grasemann H, Pavord ID, Ratjen F, Silkoff PE, Taylor DR, Zamel N. Exhaled nitric oxide in pulmonary diseases: a comprehensive review. Chest. 2010 Sep; 138(3):682-92. PMID: 20822990.
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    171. Amin R, Subbarao P, Lou W, Jabar A, Balkovec S, Jensen R, Kerrigan S, Gustafsson P, Ratjen F. The effect of dornase alfa on ventilation inhomogeneity in patients with cystic fibrosis. Eur Respir J. 2011 Apr; 37(4):806-12. PMID: 20693248.
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    172. Hedlin G, Eber E, Aurora P, Lødrup Carlsen KC, Ratjen F, Dankert-Roelse JE, Ross-Russell RI, Turner S, Midulla F, Baraldi E, Bush A. Paediatric respiratory disease: past, present and future. Eur Respir J. 2010 Aug; 36(2):225-8. PMID: 20675775.
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    173. Al-Saleh S, Dell SD, Grasemann H, Yau YC, Waters V, Martin S, Ratjen F. Sputum induction in routine clinical care of children with cystic fibrosis. J Pediatr. 2010 Dec; 157(6):1006-1011.e1. PMID: 20630539.
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    174. Saiman L, Anstead M, Mayer-Hamblett N, Lands LC, Kloster M, Hocevar-Trnka J, Goss CH, Rose LM, Burns JL, Marshall BC, Ratjen F. Effect of azithromycin on pulmonary function in patients with cystic fibrosis uninfected with Pseudomonas aeruginosa: a randomized controlled trial. JAMA. 2010 May 05; 303(17):1707-15. PMID: 20442386.
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    175. Amin R, Subbarao P, Jabar A, Balkovec S, Jensen R, Kerrigan S, Gustafsson P, Ratjen F. Hypertonic saline improves the LCI in paediatric patients with CF with normal lung function. Thorax. 2010 May; 65(5):379-83. PMID: 20435858.
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    176. Ulrich M, Worlitzsch D, Viglio S, Siegmann N, Iadarola P, Shute JK, Geiser M, Pier GB, Friedel G, Barr ML, Schuster A, Meyer KC, Ratjen F, Bjarnsholt T, Gulbins E, Döring G. Alveolar inflammation in cystic fibrosis. J Cyst Fibros. 2010 May; 9(3):217-27. PMID: 20347403.
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    177. Lands LC, Tanswell AK, Laberge S, McCusker C, Ratjen F. Pediatric Respiratory Assembly. Mini symposium on lung inflammation. Can Respir J. 2010 Mar-Apr; 17(2):e35-41. PMID: 20422066.
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    178. Brand PL, Ratjen F, Aurora P, Dankert-Roelse JE, Ross-Russell RI, Kuehni CE, Midulla F, Hedlin G. Paediatrics in Vienna. Eur Respir J. 2010 May; 35(5):1172-8. PMID: 20075043.
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    179. Grasemann H, Ratjen F. Editorial: leukocyte trafficking and matrix metalloproteinase-8 in obliterative bronchiolitis. J Leukoc Biol. 2010 Jan; 87(1):23-4. PMID: 20047888.
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    180. Ratjen F, Munck A, Kho P, Angyalosi G. Treatment of early Pseudomonas aeruginosa infection in patients with cystic fibrosis: the ELITE trial. Thorax. 2010 Apr; 65(4):286-91. PMID: 19996339.
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    181. Smyth AR, Barbato A, Beydon N, Bisgaard H, de Boeck K, Brand P, Bush A, Fauroux B, de Jongste J, Korppi M, O'Callaghan C, Pijnenburg M, Ratjen F, Southern K, Spencer D, Thomson A, Vyas H, Warris A, Merkus PJ. Respiratory medicines for children: current evidence, unlicensed use and research priorities. Eur Respir J. 2010 Feb; 35(2):247-65. PMID: 19840958.
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    182. Bendiak GN, Ratjen F. The approach to Pseudomonas aeruginosa in cystic fibrosis. Semin Respir Crit Care Med. 2009 Oct; 30(5):587-95. PMID: 19760546.
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    183. Ratjen F, Brockhaus F, Angyalosi G. Aminoglycoside therapy against Pseudomonas aeruginosa in cystic fibrosis: a review. J Cyst Fibros. 2009 Dec; 8(6):361-9. PMID: 19747887.
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    184. Mateos-Corral D, Cutz E, Solomon M, Ratjen F. Plastic bronchitis as an unusual cause of mucus plugging in cystic fibrosis. Pediatr Pulmonol. 2009 Sep; 44(9):939-40. PMID: 19658112.
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    185. Barbato A, Bertuola F, Kuehni C, Korppi M, Kotecha S, Pijnenburg MW, Ratjen F, Seddon P, Bush A. Paediatrics in Berlin. Eur Respir J. 2009 Aug; 34(2):436-43. PMID: 19648520.
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    186. Wilkes DL, Schneiderman JE, Nguyen T, Heale L, Moola F, Ratjen F, Coates AL, Wells GD. Exercise and physical activity in children with cystic fibrosis. Paediatr Respir Rev. 2009 Sep; 10(3):105-9. PMID: 19651380.
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    187. Amin R, Dupuis A, Aaron SD, Ratjen F. The effect of chronic infection with Aspergillus fumigatus on lung function and hospitalization in patients with cystic fibrosis. Chest. 2010 Jan; 137(1):171-6. PMID: 19567494.
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    188. Ratjen FA. Cystic fibrosis: pathogenesis and future treatment strategies. Respir Care. 2009 May; 54(5):595-605. PMID: 19393104.
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    189. Keijzer R, Chiu PP, Ratjen F, Langer JC. Pulmonary function after early vs late lobectomy during childhood: a preliminary study. J Pediatr Surg. 2009 May; 44(5):893-5. PMID: 19433164.
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    190. Al-Saleh S, Mei-Zahav M, Faughnan ME, MacLusky IB, Carpenter S, Letarte M, Ratjen F. Screening for pulmonary and cerebral arteriovenous malformations in children with hereditary haemorrhagic telangiectasia. Eur Respir J. 2009 Oct; 34(4):875-81. PMID: 19386691.
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    191. Amin R, Noone PG, Ratjen F. Chemical pleurodesis versus surgical intervention for persistent and recurrent pneumothoraces in cystic fibrosis. Cochrane Database Syst Rev. 2009 Apr 15; (2):CD007481. PMID: 19370689.
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    192. Ratjen F. Update in cystic fibrosis 2008. Am J Respir Crit Care Med. 2009 Mar 15; 179(6):445-8. PMID: 19264980.
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    193. Nash EF, Stephenson A, Ratjen F, Tullis E. Nebulized and oral thiol derivatives for pulmonary disease in cystic fibrosis. Cochrane Database Syst Rev. 2009 Jan 21; (1):CD007168. PMID: 19160327.
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    194. Ratjen F, Bush A. Amiloride: still a viable treatment option in cystic fibrosis? Am J Respir Crit Care Med. 2008 Dec 15; 178(12):1191-2. PMID: 19050201.
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    195. Corvol H, Boelle PY, Brouard J, Knauer N, Chadelat K, Henrion-Caude A, Flamant C, Muselet-Charlier C, Boule M, Fauroux B, Vallet C, Feingold J, Ratjen F, Grasemann H, Clement A. Genetic variations in inflammatory mediators influence lung disease progression in cystic fibrosis. Pediatr Pulmonol. 2008 Dec; 43(12):1224-32. PMID: 19009622.
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    196. Wells GD, Heale L, Schneiderman JE, Wilkes DL, Atenafu E, Coates AL, Ratjen F. Assessment of body composition in pediatric patients with cystic fibrosis. Pediatr Pulmonol. 2008 Oct; 43(10):1025-32. PMID: 18781652.
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    197. Coates AL, Green M, Leung K, Chan J, Ribeiro N, Louca E, Ratjen F, Charron M, Tservistas M, Keller M. Rapid pulmonary delivery of inhaled tobramycin for Pseudomonas infection in cystic fibrosis: a pilot project. Pediatr Pulmonol. 2008 Aug; 43(8):753-9. PMID: 18613006.
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    198. Waters V, Ratjen F. Combination antimicrobial susceptibility testing for acute exacerbations in chronic infection of Pseudomonas aeruginosa in cystic fibrosis. Cochrane Database Syst Rev. 2008 Jul 16; (3):CD006961. PMID: 18646176.
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    199. Nikolaizik WH, Vietzke D, Ratjen F. A pilot study to compare tobramycin 80 mg injectable preparation with 300 mg solution for inhalation in cystic fibrosis patients. Can Respir J. 2008 Jul-Aug; 15(5):259-62. PMID: 18716688.
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    200. Davis SD, Ratjen F. Reduced lung function in cystic fibrosis: a primary or secondary phenotype? Am J Respir Crit Care Med. 2008 Jul 01; 178(1):2-3. PMID: 18565959.
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    201. Ratjen F. Recent advances in cystic fibrosis. Paediatr Respir Rev. 2008 Jun; 9(2):144-8. PMID: 18513677.
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    202. Wells GD, Wilkes DL, Schneiderman-Walker J, Elmi M, Tullis E, Lands LC, Ratjen F, Coates AL. Reliability and validity of the habitual activity estimation scale (HAES) in patients with cystic fibrosis. Pediatr Pulmonol. 2008 Apr; 43(4):345-53. PMID: 18306334.
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    203. Amin R, Ratjen F. MRI: the next frontier for cystic fibrosis clinicians? Expert Rev Respir Med. 2008 Apr; 2(2):179-82. PMID: 20477247.
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    204. Amin R, Ratjen F. Cystic fibrosis: a review of pulmonary and nutritional therapies. Adv Pediatr. 2008; 55:99-121. PMID: 19048729.
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    205. Grasemann C, Ratjen F, Schnabel D, Reutershahn E, Vester U, Grasemann H. Effect of growth hormone therapy on nitric oxide formation in cystic fibrosis patients. Eur Respir J. 2008 Apr; 31(4):815-21. PMID: 18094013.
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    206. Ratjen F. New pulmonary therapies for cystic fibrosis. Curr Opin Pulm Med. 2007 Nov; 13(6):541-6. PMID: 17901762.
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    207. Grasemann H, Tschiedel E, Groch M, Klepper J, Ratjen F. Exhaled nitric oxide in children after accidental exposure to chlorine gas. Inhal Toxicol. 2007 Aug; 19(10):895-8. PMID: 17687720.
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    208. Ridder-Schaphorn S, Ratjen F, Dübbers A, Häberle J, Falk S, Küster P, Schuster A, Mellies U, Löwe B, Reintjes R, Peters G, Kahl BC. Nasal Staphylococcus aureus carriage is not a risk factor for lower-airway infection in young cystic fibrosis patients. J Clin Microbiol. 2007 Sep; 45(9):2979-84. PMID: 17652474.
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    209. Schnabel D, Grasemann C, Staab D, Wollmann H, Ratjen F. A multicenter, randomized, double-blind, placebo-controlled trial to evaluate the metabolic and respiratory effects of growth hormone in children with cystic fibrosis. Pediatrics. 2007 Jun; 119(6):e1230-8. PMID: 17545356.
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    210. Subbarao P, Balkovec S, Solomon M, Ratjen F. Pilot study of safety and tolerability of inhaled hypertonic saline in infants with cystic fibrosis. Pediatr Pulmonol. 2007 May; 42(5):471-6. PMID: 17436328.
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    211. Grasemann H, Stehling F, Brunar H, Widmann R, Laliberte TW, Molina L, Döring G, Ratjen F. Inhalation of Moli1901 in patients with cystic fibrosis. Chest. 2007 May; 131(5):1461-6. PMID: 17494794.
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    212. Lam W, Tjon J, Seto W, Dekker A, Wong C, Atenafu E, Bitnun A, Waters V, Yau Y, Solomon M, Ratjen F. Pharmacokinetic modelling of a once-daily dosing regimen for intravenous tobramycin in paediatric cystic fibrosis patients. J Antimicrob Chemother. 2007 Jun; 59(6):1135-40. PMID: 17446242.
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    213. Henke MO, Ratjen F. Mucolytics in cystic fibrosis. Paediatr Respir Rev. 2007 Mar; 8(1):24-9. PMID: 17419975.
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    214. Ratjen F, Walter H, Haug M, Meisner C, Grasemann H, Döring G. Diagnostic value of serum antibodies in early Pseudomonas aeruginosa infection in cystic fibrosis patients. Pediatr Pulmonol. 2007 Mar; 42(3):249-55. PMID: 17243185.
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    215. Chan EY, Avcin T, Dell S, Manson D, Cutz E, Schneider R, Ratjen F. Massive hemoptysis in an 11-year-old girl with isolated pulmonary arteritis. Pediatr Pulmonol. 2007 Feb; 42(2):177-80. PMID: 17186544.
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    216. Ratjen F. Treatment of early Pseudomonas aeruginosa infection in patients with cystic fibrosis. Curr Opin Pulm Med. 2006 Nov; 12(6):428-32. PMID: 17053493.
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    217. Subbarao P, Ratjen F. Beta2-agonists for asthma: the pediatric perspective. Clin Rev Allergy Immunol. 2006 Oct-Dec; 31(2-3):209-18. PMID: 17085794.
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    218. Waters V, Ratjen F. Multidrug-resistant organisms in cystic fibrosis: management and infection-control issues. Expert Rev Anti Infect Ther. 2006 Oct; 4(5):807-19. PMID: 17140357.
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    219. Taylor L, Corey M, Matlow A, Sweezey NB, Ratjen F. Comparison of throat swabs and nasopharyngeal suction specimens in non-sputum-producing patients with cystic fibrosis. Pediatr Pulmonol. 2006 Sep; 41(9):839-43. PMID: 16850448.
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    220. Ratjen F. Inhaled hypertonic saline produces small increases in lung function in patients with cystic fibrosis. J Pediatr. 2006 Jul; 149(1):142. PMID: 17243308.
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    221. Starosta V, Ratjen F, Rietschel E, Paul K, Griese M. Anti-inflammatory cytokines in cystic fibrosis lung disease. Eur Respir J. 2006 Sep; 28(3):581-7. PMID: 16807263.
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    222. Grasemann H, Schwiertz R, Grasemann C, Vester U, Racké K, Ratjen F. Decreased systemic bioavailability of L-arginine in patients with cystic fibrosis. Respir Res. 2006 Jun 09; 7:87. PMID: 16764721.
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    223. Ratjen F. Diagnosing and managing infection in CF. Paediatr Respir Rev. 2006; 7 Suppl 1:S151-3. PMID: 16798546.
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    224. Ratjen F. What's new in CF airway inflammation: an update. Paediatr Respir Rev. 2006; 7 Suppl 1:S70-2. PMID: 16798601.
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    225. Stehling F, Roll C, Ratjen F, Grasemann H. Nasal nitric oxide to diagnose primary ciliary dyskinesia in newborns. Arch Dis Child Fetal Neonatal Ed. 2006 May; 91(3):F233. PMID: 16632655.
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    226. Grasemann H, Kurtz F, Ratjen F. Inhaled L-arginine improves exhaled nitric oxide and pulmonary function in patients with cystic fibrosis. Am J Respir Crit Care Med. 2006 Jul 15; 174(2):208-12. PMID: 16627863.
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    227. Büscher R, Hoerning A, Patel HH, Zhang S, Arthur DB, Grasemann H, Ratjen F, Insel PA. P2Y2 receptor polymorphisms and haplotypes in cystic fibrosis and their impact on Ca2+ influx. Pharmacogenet Genomics. 2006 Mar; 16(3):199-205. PMID: 16495779.
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    228. Ratjen F. Restoring airway surface liquid in cystic fibrosis. N Engl J Med. 2006 Jan 19; 354(3):291-3. PMID: 16421371.
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    229. Ratjen F, Rietschel E, Kasel D, Schwiertz R, Starke K, Beier H, van Koningsbruggen S, Grasemann H. Pharmacokinetics of inhaled colistin in patients with cystic fibrosis. J Antimicrob Chemother. 2006 Feb; 57(2):306-11. PMID: 16396919.
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    230. Tschiedel E, Grasemann H, Ratjen F. Mycobacterium chelonae in a CF patient with anaplastic large cell lymphoma. J Cyst Fibros. 2006 May; 5(2):133-6. PMID: 16403492.
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    231. Griese M, Essl R, Schmidt R, Ballmann M, Paul K, Rietschel E, Ratjen F. Sequential analysis of surfactant, lung function and inflammation in cystic fibrosis patients. Respir Res. 2005 Nov 07; 6:133. PMID: 16274485.
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    232. Grasemann H, Schwiertz R, Matthiesen S, Racké K, Ratjen F. Increased arginase activity in cystic fibrosis airways. Am J Respir Crit Care Med. 2005 Dec 15; 172(12):1523-8. PMID: 16166623.
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    233. Ratjen F, Rjabko O, Kremens B. High-dose corticosteroid therapy for bronchiolitis obliterans after bone marrow transplantation in children. Bone Marrow Transplant. 2005 Jul; 36(2):135-8. PMID: 15908967.
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    234. Knauer N, Ratjen F, Grasemann H. [Cystic fibrosis modifying genes]. Pneumologie. 2005 Jun; 59(6):395-404. PMID: 15991075.
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    235. Tang CM, Hoerning A, Büscher R, O'Connor DT, Ratjen F, Grasemann H, Insel PA. Human adenosine 2B receptor: SNP discovery and evaluation of expression in patients with cystic fibrosis. Pharmacogenet Genomics. 2005 May; 15(5):321-7. PMID: 15864133.
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    236. Brouard J, Knauer N, Boelle PY, Corvol H, Henrion-Caude A, Flamant C, Bremont F, Delaisi B, Duhamel JF, Marguet C, Roussey M, Miesch MC, Chadelat K, Boule M, Fauroux B, Ratjen F, Grasemann H, Clement A. Influence of interleukin-10 on Aspergillus fumigatus infection in patients with cystic fibrosis. J Infect Dis. 2005 Jun 01; 191(11):1988-91. PMID: 15871134.
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    237. Hartl D, Starosta V, Maier K, Beck-Speier I, Rebhan C, Becker BF, Latzin P, Fischer R, Ratjen F, Huber RM, Rietschel E, Krauss-Etschmann S, Griese M. Inhaled glutathione decreases PGE2 and increases lymphocytes in cystic fibrosis lungs. Free Radic Biol Med. 2005 Aug 15; 39(4):463-72. PMID: 16043018.
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    238. Steinkamp G, Wiedemann B, Rietschel E, Krahl A, Gielen J, Bärmeier H, Ratjen F. Prospective evaluation of emerging bacteria in cystic fibrosis. J Cyst Fibros. 2005 Mar; 4(1):41-8. PMID: 15752680.
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    239. Ratjen F, Paul K, van Koningsbruggen S, Breitenstein S, Rietschel E, Nikolaizik W. DNA concentrations in BAL fluid of cystic fibrosis patients with early lung disease: influence of treatment with dornase alpha. Pediatr Pulmonol. 2005 Jan; 39(1):1-4. PMID: 15532079.
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    240. Grasemann H, Grasemann C, Kurtz F, Tietze-Schillings G, Vester U, Ratjen F. Oral L-arginine supplementation in cystic fibrosis patients: a placebo-controlled study. Eur Respir J. 2005 Jan; 25(1):62-8. PMID: 15640324.
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    241. Midulla F, Guidi R, Tancredi G, Quattrucci S, Ratjen F, Bottero S, Vestiti K, Francalanci P, Cutrera R. Microaspiration in infants with laryngomalacia. Laryngoscope. 2004 Sep; 114(9):1592-6. PMID: 15475788.
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    242. Griese M, Essl R, Schmidt R, Rietschel E, Ratjen F, Ballmann M, Paul K. Pulmonary surfactant, lung function, and endobronchial inflammation in cystic fibrosis. Am J Respir Crit Care Med. 2004 Nov 01; 170(9):1000-5. PMID: 15271694.
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    243. Grasemann H, Ratjen F. Gender-specific disease modification by NOS3. Br J Haematol. 2004 Jul; 126(1):160; author reply 161. PMID: 15198747.
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    244. Borchers T, Dirsch O, Schaper J, Kreuzfelder E, Jakob H, Ratjen F. Nodular pulmonary vasculitis in a twelve-year-old boy. Pediatr Pulmonol. 2004 Feb; 37(2):181-5. PMID: 14730665.
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    245. Griese M, Ramakers J, Krasselt A, Starosta V, Van Koningsbruggen S, Fischer R, Ratjen F, Müllinger B, Huber RM, Maier K, Rietschel E, Scheuch G. Improvement of alveolar glutathione and lung function but not oxidative state in cystic fibrosis. Am J Respir Crit Care Med. 2004 Apr 01; 169(7):822-8. PMID: 14726422.
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    246. Ratjen F, Konietzko N. [Diabetes mellitus in cystic fibrosis]. Pneumologie. 2004 Jan; 58(1):5-6. PMID: 14732892.
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    247. Ratjen F, Nicolai T. Paediatric bronchoscopy. Paediatr Respir Rev. 2004; 5 Suppl A:S21-2. PMID: 14980237.
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    248. Ratjen F. The infant with cystic fibrosis: inflammatory markers. Paediatr Respir Rev. 2004; 5 Suppl A:S365-6. PMID: 14980297.
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    249. Ratjen F. Early interventions in CF. Pediatr Pulmonol Suppl. 2004; 26:88-90. PMID: 15029609.
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    250. Ratjen F. Dornase in non-CF. Pediatr Pulmonol Suppl. 2004; 26:154-5. PMID: 15029636.
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    251. Paul K, Rietschel E, Ballmann M, Griese M, Worlitzsch D, Shute J, Chen C, Schink T, Döring G, van Koningsbruggen S, Wahn U, Ratjen F. Effect of treatment with dornase alpha on airway inflammation in patients with cystic fibrosis. Am J Respir Crit Care Med. 2004 Mar 15; 169(6):719-25. PMID: 14684561.
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    252. Midulla F, de Blic J, Barbato A, Bush A, Eber E, Kotecha S, Haxby E, Moretti C, Pohunek P, Ratjen F. Flexible endoscopy of paediatric airways. Eur Respir J. 2003 Oct; 22(4):698-708. PMID: 14582925.
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    253. Viazov S, Ratjen F, Scheidhauer R, Fiedler M, Roggendorf M. High prevalence of human metapneumovirus infection in young children and genetic heterogeneity of the viral isolates. J Clin Microbiol. 2003 Jul; 41(7):3043-5. PMID: 12843040.
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    254. Ratjen F, Döring G. Cystic fibrosis. Lancet. 2003 Feb 22; 361(9358):681-9. PMID: 12606185.
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    255. Grasemann H, Storm van's Gravesande K, Buscher R, Drazen JM, Ratjen F. Effects of sex and of gene variants in constitutive nitric oxide synthases on exhaled nitric oxide. Am J Respir Crit Care Med. 2003 Apr 15; 167(8):1113-6. PMID: 12531780.
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    256. Ratjen F, Costabel U, Griese M, Paul K. Bronchoalveolar lavage fluid findings in children with hypersensitivity pneumonitis. Eur Respir J. 2003 Jan; 21(1):144-8. PMID: 12570123.
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    257. Dalhoff K, Ewig S, Höffken G, Lorenz J, Maass M, Niedermeyer J, Ratjen F, Welte T, Wilkens H. [Recommendations for the diagnosis, therapy and prevention of pneumonia in the immunocompromised host]. Pneumologie. 2002 Dec; 56(12):807-31. PMID: 12486620.
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    258. Griese M, Neumann M, von Bredow T, Schmidt R, Ratjen F. Surfactant in children with malignancies, immunosuppression, fever and pulmonary infiltrates. Eur Respir J. 2002 Nov; 20(5):1284-91. PMID: 12449186.
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    259. Ratjen F, Hartog CM, Paul K, Wermelt J, Braun J. Matrix metalloproteases in BAL fluid of patients with cystic fibrosis and their modulation by treatment with dornase alpha. Thorax. 2002 Nov; 57(11):930-4. PMID: 12403873.
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    260. Grasemann H, Storm van's Gravesande K, Buscher R, Knauer N, Silverman ES, Palmer LJ, Drazen JM, Ratjen F. Endothelial nitric oxide synthase variants in cystic fibrosis lung disease. Am J Respir Crit Care Med. 2003 Feb 01; 167(3):390-4. PMID: 12406848.
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    261. Büscher R, Eilmes KJ, Grasemann H, Torres B, Knauer N, Sroka K, Insel PA, Ratjen F. beta2 adrenoceptor gene polymorphisms in cystic fibrosis lung disease. Pharmacogenetics. 2002 Jul; 12(5):347-53. PMID: 12142724.
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    262. Nikolaizik WH, Trociewicz K, Ratjen F. Bronchial reactions to the inhalation of high-dose tobramycin in cystic fibrosis. Eur Respir J. 2002 Jul; 20(1):122-6. PMID: 12166559.
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    263. Straub V, Ratjen F, Amthor H, Voit T, Grasemann H. Airway nitric oxide in Duchenne muscular dystrophy. J Pediatr. 2002 Jul; 141(1):132-4. PMID: 12091865.
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    264. Neumann M, von Bredow C, Ratjen F, Griese M. Bronchoalveolar lavage protein patterns in children with malignancies, immunosuppression, fever and pulmonary infiltrates. Proteomics. 2002 Jun; 2(6):683-9. PMID: 12112849.
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    265. Grasemann H, Ratjen F. [Pulmonary metabolism of nitric oxide (NO) in patients with cystic fibrosis]. Pneumologie. 2002 Jun; 56(6):376-81. PMID: 12063621.
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    266. Grasemann H, Storm van's Gravesande K, Gärtig S, Kirsch M, Büscher R, Drazen JM, Ratjen F. Nasal nitric oxide levels in cystic fibrosis patients are associated with a neuronal NO synthase (NOS1) gene polymorphism. Nitric Oxide. 2002 Mar; 6(2):236-41. PMID: 11890749.
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    267. Gaston B, Ratjen F, Vaughan JW, Malhotra NR, Canady RG, Snyder AH, Hunt JF, Gaertig S, Goldberg JB. Nitrogen redox balance in the cystic fibrosis airway: effects of antipseudomonal therapy. Am J Respir Crit Care Med. 2002 Feb 01; 165(3):387-90. PMID: 11818326.
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    268. Grasemann H, Ratjen F. Different subgroups of difficult asthma in children. Thorax. 2001 Nov; 56(11):895. PMID: 11641518.
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    269. Ratjen F, Döring G, Nikolaizik WH. Effect of inhaled tobramycin on early Pseudomonas aeruginosa colonisation in patients with cystic fibrosis. Lancet. 2001 Sep 22; 358(9286):983-4. PMID: 11583754.
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    270. Bald M, Ratjen F, Nikolaizik W, Wingen AM. Ciprofloxacin-induced acute renal failure in a patient with cystic fibrosis. Pediatr Infect Dis J. 2001 Mar; 20(3):320-1. PMID: 11303842.
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    271. Ratjen F. Changes in strategies for optimal antibacterial therapy in cystic fibrosis. Int J Antimicrob Agents. 2001 Feb; 17(2):93-6. PMID: 11165111.
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    272. Ratjen F, Comes G, Paul K, Posselt HG, Wagner TO, Harms K. Effect of continuous antistaphylococcal therapy on the rate of P. aeruginosa acquisition in patients with cystic fibrosis. Pediatr Pulmonol. 2001 Jan; 31(1):13-6. PMID: 11180669.
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    273. Grasemann H, Knauer N, Büscher R, Hübner K, Drazen JM, Ratjen F. Airway nitric oxide levels in cystic fibrosis patients are related to a polymorphism in the neuronal nitric oxide synthase gene. Am J Respir Crit Care Med. 2000 Dec; 162(6):2172-6. PMID: 11112133.
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    274. Ratjen F, Kavuk I, Gärtig S, Wiesemann HG, Grasemann H. Airway nitric oxide in infants with acute wheezy bronchitis. Pediatr Allergy Immunol. 2000 Nov; 11(4):230-5. PMID: 11110577.
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    275. Ratjen F. Reference values for bronchoalveolar lavage in children. Monaldi Arch Chest Dis. 2000 Jun; 55(3):247-50. PMID: 10948675.
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    276. Ratjen F, Rietschel E, Griese M, Ballmann M, Kleinau I, Döring G, Reinhardt D, Paul K. Fractional analysis of bronchoalveolar lavage fluid cytology in cystic fibrosis patients with normal lung function. Bronchoalveolar lavage for the evaluation of anti-inflammatory treatment (BEAT) study group. Eur Respir J. 2000 Jan; 15(1):141-5. PMID: 10678636.
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    277. de Blic J, Midulla F, Barbato A, Clement A, Dab I, Eber E, Green C, Grigg J, Kotecha S, Kurland G, Pohunek P, Ratjen F, Rossi G. Bronchoalveolar lavage in children. ERS Task Force on bronchoalveolar lavage in children. European Respiratory Society. Eur Respir J. 2000 Jan; 15(1):217-31. PMID: 10678650.
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    278. Grasemann H, Gaston B, Fang K, Paul K, Ratjen F. Decreased levels of nitrosothiols in the lower airways of patients with cystic fibrosis and normal pulmonary function. J Pediatr. 1999 Dec; 135(6):770-2. PMID: 10586185.
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    279. Grasemann H, Ratjen F. Cystic fibrosis lung disease: the role of nitric oxide. Pediatr Pulmonol. 1999 Dec; 28(6):442-8. PMID: 10587420.
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    280. Ratjen F, Gärtig S, Wiesemann HG, Grasemann H. Effect of inhaled nitric oxide on pulmonary function in cystic fibrosis. Respir Med. 1999 Aug; 93(8):579-83. PMID: 10542992.
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    281. Knauer-Fischer S, Ratjen F. Lipid-laden macrophages in bronchoalveolar lavage fluid as a marker for pulmonary aspiration. Pediatr Pulmonol. 1999 Jun; 27(6):419-22. PMID: 10380094.
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    282. Ratjen F, Havers W, Braun J. Intrapulmonary protein leakage in immunocompromised children and adults with pneumonia. Thorax. 1999 May; 54(5):432-6. PMID: 10212109.
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    283. Ratjen F, Tummler B. Comparison of the in vitro and in vivo response to inhaled DNase in patients with cystic fibrosis. Thorax. 1999 Jan; 54(1):91. PMID: 10343641.
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    284. Knauer-Fischer S, Schaper J, Janssen HT, Ratjen F. Tuberculoma of the pons. Pediatr Neurol. 1999 Jan; 20(1):57-9. PMID: 10029262.
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    285. Grasemann H, Gärtig SS, Wiesemann HG, Teschler H, Konietzko N, Ratjen F. Effect of L-arginine infusion on airway NO in cystic fibrosis and primary ciliary dyskinesia syndrome. Eur Respir J. 1999 Jan; 13(1):114-8. PMID: 10836334.
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    286. Ratjen F, Grasemann H, Wolstein R, Wiesemann HG. Isovolume pressure/flow curves of rapid thoracoabdominal compressions in infants without respiratory disease. Pediatr Pulmonol. 1998 Sep; 26(3):197-203. PMID: 9773915.
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    287. Wiesemann HG, Steinkamp G, Ratjen F, Bauernfeind A, Przyklenk B, Döring G, von der Hardt H. Placebo-controlled, double-blind, randomized study of aerosolized tobramycin for early treatment of Pseudomonas aeruginosa colonization in cystic fibrosis. Pediatr Pulmonol. 1998 Feb; 25(2):88-92. PMID: 9516091.
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    288. Grasemann H, Ioannidis I, Tomkiewicz RP, de Groot H, Rubin BK, Ratjen F. Nitric oxide metabolites in cystic fibrosis lung disease. Arch Dis Child. 1998 Jan; 78(1):49-53. PMID: 9534676.
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    289. Piotrowski JA, Splittgerber FH, Donovan TJ, Ratjen F, Zerkowski HR. Single-lung transplantation in a patient with cystic fibrosis and an asymmetric thorax. Ann Thorac Surg. 1997 Nov; 64(5):1456-8; discussion 1458-9. PMID: 9386721.
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    290. Dörk T, Dworniczak B, Aulehla-Scholz C, Wieczorek D, Böhm I, Mayerova A, Seydewitz HH, Nieschlag E, Meschede D, Horst J, Pander HJ, Sperling H, Ratjen F, Passarge E, Schmidtke J, Stuhrmann M. Distinct spectrum of CFTR gene mutations in congenital absence of vas deferens. Hum Genet. 1997 Sep; 100(3-4):365-77. PMID: 9272157.
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    291. Grasemann H, Michler E, Wallot M, Ratjen F. Decreased concentration of exhaled nitric oxide (NO) in patients with cystic fibrosis. Pediatr Pulmonol. 1997 Sep; 24(3):173-7. PMID: 9330413.
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    292. Grasemann H, Ioannidis I, de Groot H, Ratjen F. Metabolites of nitric oxide in the lower respiratory tract of children. Eur J Pediatr. 1997 Jul; 156(7):575-8. PMID: 9243246.
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    293. Rath PM, Ratjen F, Ansorg R. Genetic diversity among isolates of Aspergillus fumigatus in patients with cystic fibrosis. Zentralbl Bakteriol. 1997 Feb; 285(3):450-5. PMID: 9084119.
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    294. Ratjen F, Costabel U. [Bronchoalveolar lavage in childhood: technical aspects and reference values]. Pneumologie. 1997 Feb; 51(2):93-8. PMID: 9157457.
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    295. Braun J, Mehnert A, Dalhoff K, Wiessmann KJ, Ratjen F. Different BALF protein composition in normal children and adults. Respiration. 1997; 64(5):350-7. PMID: 9311051.
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    296. Ratjen F. Normal values of bronchoalveolar lavage. Pediatr Pulmonol Suppl. 1997; 16:101-2. PMID: 9443225.
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    297. Ratjen F, Costabel U, Havers W. Differential cytology of bronchoalveolar lavage fluid in immunosuppressed children with pulmonary infiltrates. Arch Dis Child. 1996 Jun; 74(6):507-11. PMID: 8758126.
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    298. Ratjen F, Bruch J. Adjustment of bronchoalveolar lavage volume to body weight in children. Pediatr Pulmonol. 1996 Mar; 21(3):184-8. PMID: 8860074.
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    299. Ratjen F, Rehn B, Costabel U, Bruch J. Age-dependency of surfactant phospholipids and surfactant protein A in bronchoalveolar lavage fluid of children without bronchopulmonary disease. Eur Respir J. 1996 Feb; 9(2):328-33. PMID: 8777972.
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    300. Ratjen F, Kreuzfelder E. Immunoglobulin and beta 2-microglobulin concentrations in bronchoalveolar lavage of children and adults. Lung. 1996; 174(6):383-91. PMID: 8887933.
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    301. Ratjen F, Trost A, Welker J, Spangenberg P, Wiesemann HG. The effect of rapid thoracoabdominal compressions on intracranial pressure in newborn lambs. Pediatr Res. 1995 Nov; 38(5):664-7. PMID: 8552431.
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    302. Grasemann H, Wiesemann HG, Ratjen F. [The importance of lung function as a predictor of 2-year mortality in mucoviscidosis]. Pneumologie. 1995 Aug; 49(8):466-9. PMID: 7479641.
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    303. Ratjen F, Bredendiek M, Zheng L, Brendel M, Costabel U. Lymphocyte subsets in bronchoalveolar lavage fluid of children without bronchopulmonary disease. Am J Respir Crit Care Med. 1995 Jul; 152(1):174-8. PMID: 7599820.
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    304. Ratjen F, Bredendiek M, Brendel M, Meltzer J, Costabel U. Differential cytology of bronchoalveolar lavage fluid in normal children. Eur Respir J. 1994 Oct; 7(10):1865-70. PMID: 7828697.
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    305. Ratjen FA, Schoenfeld B, Wiesemann HG. Pulmonary alveolar microlithiasis and lymphocytic interstitial pneumonitis in a ten year old girl. Eur Respir J. 1992 Nov; 5(10):1283-5. PMID: 1486977.
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    306. Ratjen FA, Wiesemann HG. Variability of dynamic compliance measurements in spontaneously breathing and ventilated newborn infants. Pediatr Pulmonol. 1992 Feb; 12(2):73-80. PMID: 1570192.
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    307. Colin AA, Wohl ME, Mead J, Ratjen FA, Glass G, Stark AR. Transition from dynamically maintained to relaxed end-expiratory volume in human infants. J Appl Physiol (1985). 1989 Nov; 67(5):2107-11. PMID: 2600036.
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    308. Ratjen FA, Colin AA, Stark AR, Mead J, Wohl ME. Changes of time constants during infancy and early childhood. J Appl Physiol (1985). 1989 Nov; 67(5):2112-5. PMID: 2600037.
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    309. Ratjen F, Zinman R, Wohl ME. A new technique to demonstrate flow limitation in partial expiratory flow-volume curves in infants. J Appl Physiol (1985). 1989 Oct; 67(4):1662-9. PMID: 2793766.
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    310. Ratjen F, Zinman R, Stark AR, Leszczynski LE, Wohl ME. Effect of changes in lung volume on respiratory system compliance in newborn infants. J Appl Physiol (1985). 1989 Sep; 67(3):1192-7. PMID: 2793712.
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    311. Ratjen F, Wönne R, Posselt HG, Stöver B, Hofmann D, Bender SW. A double-blind placebo controlled trial with oral ambroxol and N-acetylcysteine for mucolytic treatment in cystic fibrosis. Eur J Pediatr. 1985 Nov; 144(4):374-8. PMID: 3908111.
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