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Hartmut Grasemann

TitleStaff Physician
InstitutionThe Hospital for Sick Children
DepartmentRespiratory Medicine
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Duan W, Cen Y, Lin C, Ouyang H, Du K, Kumar A, Wang B, Avolio J, Grasemann H, Moraes TJ. Inflammatory epithelial cytokines after in vitro respiratory syncytial viral infection are associated with reduced lung function. ERJ Open Res. 2021 Jul; 7(3). PMID: 34527729.
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    2. Stanojevic S, Davis SD, Perrem L, Shaw M, Retsch-Bogart G, Davis M, Jensen R, Clem CC, Isaac SM, Guido J, Jara S, France L, McDonald N, Solomon M, Sweezey N, Grasemann H, Waters V, Sanders DB, Ratjen FA. Determinants of lung disease progression measured by lung clearance index in children with cystic fibrosis. Eur Respir J. 2021 07; 58(1). PMID: 33542049.
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    3. Pollak M, Shaw M, Wilson D, Solomon M, Ratjen F, Grasemann H. Bronchodilator responsiveness in cystic fibrosis children treated for pulmonary exacerbations. Pediatr Pulmonol. 2021 Jul; 56(7):2036-2042. PMID: 33830642.
      View in: PubMed
    4. Perrem L, Stanojevic S, Shaw M, Jensen R, McDonald N, Isaac SM, Davis M, Clem C, Guido J, Jara S, France L, Solomon M, Grasemann H, Waters V, Sweezey N, Sanders DB, Davis SD, Ratjen F. Lung Clearance Index to Track Acute Respiratory Events in School-Age Children with Cystic Fibrosis. Am J Respir Crit Care Med. 2021 04 15; 203(8):977-986. PMID: 33030967.
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    5. Grasemann H, Holguin F. An association of the arginase 1 gene with preschool wheezing phenotypes. Pediatr Pulmonol. 2021 Jul; 56(7):1821-1822. PMID: 33823086.
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    6. Scott JA, Maarsingh H, Holguin F, Grasemann H. Arginine Therapy for Lung Diseases. Front Pharmacol. 2021; 12:627503. PMID: 33833679.
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    7. Martin I, Waters V, Grasemann H. Approaches to Targeting Bacterial Biofilms in Cystic Fibrosis Airways. Int J Mol Sci. 2021 Feb 22; 22(4). PMID: 33671516.
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    8. Min S, Papaz T, Lambert AN, Allen U, Birk P, Blydt-Hansen T, Foster BJ, Grasemann H, Hamiwka L, Litalien C, Ng V, Berka N, Campbell P, Claude D, Saw CL, Tinckham K, Urschel S, Van Driest SL, Parekh R, Mital S. An Integrated Clinical and Genetic Prediction Model for Tacrolimus Levels in Pediatric Solid Organ Transplant Recipients. Transplantation. 2021 02 22. PMID: 33755393.
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    9. Licht JC, Grasemann H. Potential of the Electronic Nose for the Detection of Respiratory Diseases with and without Infection. Int J Mol Sci. 2020 Dec 10; 21(24). PMID: 33321951.
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    10. Pollak M, Shaw M, Wilson D, Grasemann H, Ratjen F. Bronchodilator responsiveness in children with cystic fibrosis and allergic bronchopulmonary aspergillosis. Eur Respir J. 2020 08; 56(2). PMID: 32269091.
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    11. Gold A, Young JM, Solomon M, Grasemann H. Neuropsychological outcomes following pediatric lung transplantation. Pediatr Pulmonol. 2020 09; 55(9):2427-2436. PMID: 32567252.
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    12. Grasemann H, Holguin F. Oxidative stress and obesity-related asthma. Paediatr Respir Rev. 2021 Mar; 37:18-21. PMID: 32660723.
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    13. Avdimiretz N, Wilson D, Grasemann H. Comparison of a handheld turbine spirometer to conventional spirometry in children with cystic fibrosis. Pediatr Pulmonol. 2020 06; 55(6):1394-1399. PMID: 32203645.
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    14. Yeung JC, Machuca TN, Chaparro C, Cypel M, Stephenson AL, Solomon M, Saito T, Binnie M, Chow CW, Grasemann H, Pierre AF, Yasufuku K, de Perrot M, Donahoe LL, Tikkanen J, Martinu T, Waddell TK, Tullis E, Singer LG, Keshavjee S. Lung transplantation for cystic fibrosis. J Heart Lung Transplant. 2020 06; 39(6):553-560. PMID: 32147452.
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    15. Tavasoli F, Liu M, Machuca T, Bonato R, Grant DR, Cypel M, Keshavjee S, Grasemann H. Increased Arginase Expression and Decreased Nitric Oxide in Pig Donor Lungs after Normothermic Ex Vivo Lung Perfusion. Biomolecules. 2020 02 14; 10(2). PMID: 32075026.
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    16. Grasemann H, Klingel M, Avolio J, Prentice C, Gonska T, Tullis E, Ratjen F. Long-term effect of CFTR modulator therapy on airway nitric oxide. Eur Respir J. 2020 01; 55(1). PMID: 31601715.
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    17. Holguin F, Grasemann H, Sharma S, Winnica D, Wasil K, Smith V, Cruse MH, Perez N, Coleman E, Scialla TJ, Que LG. L-Citrulline increases nitric oxide and improves control in obese asthmatics. JCI Insight. 2019 12 19; 4(24). PMID: 31714895.
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    18. Carden MA, Brousseau DC, Ahmad FA, Bennett J, Bhatt S, Bogie A, Brown K, Casper TC, Chapman LL, Chumpitazi CE, Cohen D, Dampier C, Ellison AM, Grasemann H, Hickey RW, Hsu LL, Leibovich S, Powell E, Richards R, Sarnaik S, Weiner DL, Morris CR. Normal saline bolus use in pediatric emergency departments is associated with poorer pain control in children with sickle cell anemia and vaso-occlusive pain. Am J Hematol. 2019 06; 94(6):689-696. PMID: 30916794.
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    19. Khan MA, Ali ZS, Sweezey N, Grasemann H, Palaniyar N. Progression of Cystic Fibrosis Lung Disease from Childhood to Adulthood: Neutrophils, Neutrophil Extracellular Trap (NET) Formation, and NET Degradation. Genes (Basel). 2019 02 26; 10(3). PMID: 30813645.
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    20. Xia E, Duan R, Shi F, Seigel KE, Grasemann H, Hu J. Overcoming the Undesirable CRISPR-Cas9 Expression in Gene Correction. Mol Ther Nucleic Acids. 2018 Dec 07; 13:699-709. PMID: 30513454.
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    21. Beaudoin T, Stone TA, Glibowicka M, Adams C, Yau Y, Ahmadi S, Bear CE, Grasemann H, Waters V, Deber CM. Activity of a novel antimicrobial peptide against Pseudomonas aeruginosa biofilms. Sci Rep. 2018 10 03; 8(1):14728. PMID: 30283025.
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    22. Min S, Papaz T, Lafreniere-Roula M, Nalli N, Grasemann H, Schwartz SM, Kamath BM, Ng V, Parekh RS, Manlhiot C, Mital S. A randomized clinical trial of age and genotype-guided tacrolimus dosing after pediatric solid organ transplantation. Pediatr Transplant. 2018 11; 22(7):e13285. PMID: 30178515.
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    23. Ratjen F, Klingel M, Black P, Powers MR, Grasemann H, Solomon M, Sagel SD, Donaldson SH, Rowe SM, Rosenfeld M. Changes in Lung Clearance Index in Preschool-aged Patients with Cystic Fibrosis Treated with Ivacaftor (GOAL): A Clinical Trial. Am J Respir Crit Care Med. 2018 08 15; 198(4):526-528. PMID: 29614238.
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    24. Cao H, Ouyang H, Grasemann H, Bartlett C, Du K, Duan R, Shi F, Estrada M, Seigel KE, Coates AL, Yeger H, Bear CE, Gonska T, Moraes TJ, Hu J. Transducing Airway Basal Cells with a Helper-Dependent Adenoviral Vector for Lung Gene Therapy. Hum Gene Ther. 2018 06; 29(6):643-652. PMID: 29320887.
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    25. Khan MA, Philip LM, Cheung G, Vadakepeedika S, Grasemann H, Sweezey N, Palaniyar N. Regulating NETosis: Increasing pH Promotes NADPH Oxidase-Dependent NETosis. Front Med (Lausanne). 2018; 5:19. PMID: 29487850.
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    26. Bendiak GN, Mateos-Corral D, Sallam A, Atenafu EG, Kirby M, Odame I, Bikangaga P, Subbarao P, Grasemann H. Association of wheeze with lung function decline in children with sickle cell disease. Eur Respir J. 2017 11; 50(5). PMID: 29191949.
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    27. Grasemann H. CFTR Modulator Therapy for Cystic Fibrosis. N Engl J Med. 2017 11 23; 377(21):2085-2088. PMID: 29099349.
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    28. Lazor T, Grasemann H, Solomon M, Anthony SJ. Quality of life outcomes following pediatric lung transplantation. Pediatr Pulmonol. 2017 Nov; 52(11):1495-1501. PMID: 28910513.
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    29. Grasemann H, Ciet P, Amin R, McDonald N, Klingel M, Tiddens HAWM, Ratjen F, Grosse-Wortmann L. Changes in magnetic resonance imaging scores and ventilation inhomogeneity in children with cystic fibrosis pulmonary exacerbations. Eur Respir J. 2017 08; 50(2). PMID: 28838978.
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    30. Khan MA, Farahvash A, Douda DN, Licht JC, Grasemann H, Sweezey N, Palaniyar N. JNK Activation Turns on LPS- and Gram-Negative Bacteria-Induced NADPH Oxidase-Dependent Suicidal NETosis. Sci Rep. 2017 06 13; 7(1):3409. PMID: 28611461.
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    31. McLaren A, Klingel M, Behera S, Odame I, Kirby-Allen M, Grasemann H. Effect of Hydroxyurea Therapy on Pulmonary Function in Children with Sickle Cell Anemia. Am J Respir Crit Care Med. 2017 03 01; 195(5):689-691. PMID: 28248149.
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    32. Grasemann C, Herrmann R, Starschinova J, Gertsen M, Palmert MR, Grasemann H. Effects of fetal exposure to high-fat diet or maternal hyperglycemia on L-arginine and nitric oxide metabolism in lung. Nutr Diabetes. 2017 02 20; 7(2):e244. PMID: 28218737.
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    33. McGeachie MJ, Yates KP, Zhou X, Guo F, Sternberg AL, Van Natta ML, Wise RA, Szefler SJ, Sharma S, Kho AT, Cho MH, Croteau-Chonka DC, Castaldi PJ, Jain G, Sanyal A, Zhan Y, Lajoie BR, Dekker J, Stamatoyannopoulos J, Covar RA, Zeiger RS, Adkinson NF, Williams PV, Kelly HW, Grasemann H, Vonk JM, Koppelman GH, Postma DS, Raby BA, Houston I, Lu Q, Fuhlbrigge AL, Tantisira KG, Silverman EK, Tonascia J, Strunk RC, Weiss ST. Genetics and Genomics of Longitudinal Lung Function Patterns in Individuals with Asthma. Am J Respir Crit Care Med. 2016 12 15; 194(12):1465-1474. PMID: 27367781.
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    34. Winnica D, Que LG, Baffi C, Grasemann H, Fiedler K, Yang Z, Etling E, Wasil K, Wenzel SE, Freeman B, Holguin F. l-citrulline prevents asymmetric dimethylarginine-mediated reductions in nitric oxide and nitrosative stress in primary human airway epithelial cells. Clin Exp Allergy. 2017 Feb; 47(2):190-199. PMID: 27562295.
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    35. McGeachie MJ, Yates KP, Zhou X, Guo F, Sternberg AL, Van Natta ML, Wise RA, Szefler SJ, Sharma S, Kho AT, Cho MH, Croteau-Chonka DC, Castaldi PJ, Jain G, Sanyal A, Zhan Y, Lajoie BR, Dekker J, Stamatoyannopoulos J, Covar RA, Zeiger RS, Adkinson NF, Williams PV, Kelly HW, Grasemann H, Vonk JM, Koppelman GH, Postma DS, Raby BA, Houston I, Lu Q, Fuhlbrigge AL, Tantisira KG, Silverman EK, Tonascia J, Weiss ST, Strunk RC. Patterns of Growth and Decline in Lung Function in Persistent Childhood Asthma. N Engl J Med. 2016 May 12; 374(19):1842-1852. PMID: 27168434.
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    36. Ratjen F, Waters V, Klingel M, McDonald N, Dell S, Leahy TR, Yau Y, Grasemann H. Changes in airway inflammation during pulmonary exacerbations in patients with cystic fibrosis and primary ciliary dyskinesia. Eur Respir J. 2016 Mar; 47(3):829-36. PMID: 26585432.
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    37. Grasemann H, Gonska T, Avolio J, Klingel M, Tullis E, Ratjen F. Effect of ivacaftor therapy on exhaled nitric oxide in patients with cystic fibrosis. J Cyst Fibros. 2015 Nov; 14(6):727-32. PMID: 26168933.
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    38. Palaniyar N, Mall MA, Taube C, Worgall S, Grasemann H. New Developments in Cystic Fibrosis Airway Inflammation. Mediators Inflamm. 2015; 2015:769425. PMID: 26221065.
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    39. Ghorbani P, Santhakumar P, Hu Q, Djiadeu P, Wolever TM, Palaniyar N, Grasemann H. Short-chain fatty acids affect cystic fibrosis airway inflammation and bacterial growth. Eur Respir J. 2015 Oct; 46(4):1033-45. PMID: 26022954.
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    40. Scott JA, North ML, Rafii M, Huang H, Pencharz P, Grasemann H. Plasma arginine metabolites reflect airway dysfunction in a murine model of allergic airway inflammation. J Appl Physiol (1985). 2015 May 15; 118(10):1229-33. PMID: 25979935.
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    41. Grasemann H. Metabolic origins of childhood asthma. Mol Cell Pediatr. 2015 Dec; 2(1):6. PMID: 26542296.
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    42. Douda DN, Khan MA, Grasemann H, Palaniyar N. SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx. Proc Natl Acad Sci U S A. 2015 Mar 03; 112(9):2817-22. PMID: 25730848.
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    43. Douda DN, Grasemann H, Pace-Asciak C, Palaniyar N. A lipid mediator hepoxilin A3 is a natural inducer of neutrophil extracellular traps in human neutrophils. Mediators Inflamm. 2015; 2015:520871. PMID: 25784781.
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    44. Waters VJ, Stanojevic S, Sonneveld N, Klingel M, Grasemann H, Yau YC, Tullis E, Wilcox P, Freitag A, Chilvers M, Ratjen FA. Factors associated with response to treatment of pulmonary exacerbations in cystic fibrosis patients. J Cyst Fibros. 2015 Nov; 14(6):755-62. PMID: 25690407.
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    45. Machuca TN, Cypel M, Zhao Y, Grasemann H, Tavasoli F, Yeung JC, Bonato R, Chen M, Zamel R, Chun YM, Guan Z, de Perrot M, Waddell TK, Liu M, Keshavjee S. The role of the endothelin-1 pathway as a biomarker for donor lung assessment in clinical ex vivo lung perfusion. J Heart Lung Transplant. 2015 Jun; 34(6):849-57. PMID: 25907141.
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    46. Grasemann H, Dhaliwal R, Ivanovska J, Kantores C, McNamara PJ, Scott JA, Belik J, Jankov RP. Arginase inhibition prevents bleomycin-induced pulmonary hypertension, vascular remodeling, and collagen deposition in neonatal rat lungs. . 2015 Mar 15; 308(6):L503-10. PMID: 25595650.
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    47. Yau YC, Ratjen F, Tullis E, Wilcox P, Freitag A, Chilvers M, Grasemann H, Zlosnik J, Speert D, Corey M, Stanojevic S, Matukas L, Leahy TR, Shih S, Waters V. Randomized controlled trial of biofilm antimicrobial susceptibility testing in cystic fibrosis patients. J Cyst Fibros. 2015 Mar; 14(2):262-6. PMID: 25453872.
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    48. Scott JA, Grasemann H. Arginine metabolism in asthma. Immunol Allergy Clin North Am. 2014 Nov; 34(4):767-75. PMID: 25282289.
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    49. Grasemann H, Jaecklin T, Mehl A, Huang H, Rafii M, Pencharz P, Ratjen F. Multitracer stable isotope quantification of arginase and nitric oxide synthase activity in a mouse model of pseudomonas lung infection. Mediators Inflamm. 2014; 2014:323526. PMID: 25177109.
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    50. Woerner C, Cutz E, Yoo SJ, Grasemann H, Humpl T. Pulmonary venoocclusive disease in childhood. Chest. 2014 Jul; 146(1):167-174. PMID: 24503954.
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    51. Jaecklin T, Duerr J, Huang H, Rafii M, Bear CE, Ratjen F, Pencharz P, Kavanagh BP, Mall MA, Grasemann H. Lung arginase expression and activity is increased in cystic fibrosis mouse models. J Appl Physiol (1985). 2014 Aug 01; 117(3):284-8. PMID: 24925982.
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    52. Scott JA, Duongh M, Young AW, Subbarao P, Gauvreau GM, Grasemann H. Asymmetric dimethylarginine in chronic obstructive pulmonary disease (ADMA in COPD). Int J Mol Sci. 2014 Apr 10; 15(4):6062-71. PMID: 24727374.
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    53. Mehl A, Ghorbani P, Douda D, Huang H, Palaniyar N, Ratjen F, Grasemann H. Effect of arginase inhibition on pulmonary L-arginine metabolism in murine Pseudomonas pneumonia. PLoS One. 2014; 9(3):e90232. PMID: 24595185.
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    54. Scott JA, Gauvreau GM, Grasemann H. Asymmetric dimethylarginine and asthma. Eur Respir J. 2014 Feb; 43(2):647-8. PMID: 24488993.
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    55. Douda DN, Yip L, Khan MA, Grasemann H, Palaniyar N. Akt is essential to induce NADPH-dependent NETosis and to switch the neutrophil death to apoptosis. Blood. 2014 Jan 23; 123(4):597-600. PMID: 24458280.
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    56. Grasemann H, Ratjen F, Solomon M. Aquagenic wrinkling of the palms in a patient with cystic fibrosis. N Engl J Med. 2013 Dec 12; 369(24):2362-3. PMID: 24328486.
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    57. Scott JA, Grasemann H. Asymmetric dimethylarginine: a disease marker for asthma? Chest. 2013 Aug; 144(2):367-368. PMID: 23918098.
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    58. Kalnins D, Pencharz PB, Grasemann H, Solomon M. Energy expenditure and nutritional status in pediatric patients before and after lung transplantation. J Pediatr. 2013 Nov; 163(5):1500-2. PMID: 23870785.
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    59. North ML, Grasemann H, Khanna N, Inman MD, Gauvreau GM, Scott JA. Increased ornithine-derived polyamines cause airway hyperresponsiveness in a mouse model of asthma. Am J Respir Cell Mol Biol. 2013 Jun; 48(6):694-702. PMID: 23470627.
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    60. Grasemann H, Pencharz PB. Arginine metabolism in patients with cystic fibrosis. J Pediatr. 2013 Aug; 163(2):317-9. PMID: 23541774.
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    61. Grasemann H, Ratjen F. Early lung disease in cystic fibrosis. Lancet Respir Med. 2013 Apr; 1(2):148-57. PMID: 24429095.
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    62. O'Gorman CS, Shulman R, Lara-Corrales I, Pope E, Marcon M, Grasemann H, Schneider R, Upton J, Sochett EB, Koltin D, Cohen E. A child with autoimmune polyendocrinopathy candidiasis and ectodermal dysplasia treated with immunosuppression: a case report. J Med Case Rep. 2013 Feb 14; 7:44. PMID: 23409957.
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    63. Grasemann H, Tullis E, Ratjen F. A randomized controlled trial of inhaled L-arginine in patients with cystic fibrosis. J Cyst Fibros. 2013 Sep; 12(5):468-74. PMID: 23333044.
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    64. Grasemann H, Shehnaz D, Enomoto M, Leadley M, Belik J, Ratjen F. L-ornithine derived polyamines in cystic fibrosis airways. PLoS One. 2012; 7(10):e46618. PMID: 23071598.
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    65. Amin R, Charron M, Grinblat L, Shammas A, Grasemann H, Graniel K, Ciet P, Tiddens H, Ratjen F. Cystic fibrosis: detecting changes in airway inflammation with FDG PET/CT. Radiology. 2012 Sep; 264(3):868-75. PMID: 22829680.
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    66. Asner S, Waters V, Solomon M, Yau Y, Richardson SE, Grasemann H, Gharabaghi F, Tran D. Role of respiratory viruses in pulmonary exacerbations in children with cystic fibrosis. J Cyst Fibros. 2012 Sep; 11(5):433-9. PMID: 22579414.
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    67. Duong M, Amin R, Baatjes AJ, Kritzinger F, Qi Y, Meghji Z, Lou W, Grasemann H, O'Byrne PM, Subbarao P. The effect of montelukast, budesonide alone, and in combination on exercise-induced bronchoconstriction. J Allergy Clin Immunol. 2012 Aug; 130(2):535-9.e3. PMID: 22534533.
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    68. Grasemann H. New developments in pharmaceutical treatments for cystic fibrosis. Curr Pharm Des. 2012; 18(5):613. PMID: 22229569.
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    69. Ratjen F, Grasemann H. New therapies in cystic fibrosis. Curr Pharm Des. 2012; 18(5):614-27. PMID: 22229570.
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    70. Grasemann H, Ratjen F. Nitric oxide and L-arginine deficiency in cystic fibrosis. Curr Pharm Des. 2012; 18(5):726-36. PMID: 22229575.
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    71. Grasemann H, de Perrot M, Bendiak GN, Cox P, van Arsdell GS, Keshavjee S, Solomon M. ABO-incompatible lung transplantation in an infant. Am J Transplant. 2012 Mar; 12(3):779-81. PMID: 22152044.
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    72. Grosse-Wortmann L, Yoo SJ, Solomon M, Macgowan CK, Keshavjee S, Grasemann H. Cardiopulmonary magnetic resonance imaging in children after lung transplantation: preliminary observations. J Heart Lung Transplant. 2011 Nov; 30(11):1294-8. PMID: 21856174.
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    73. Corvol H, Beucher J, Boëlle PY, Busson PF, Muselet-Charlier C, Clement A, Ratjen F, Grasemann H, Laki J, Palmer CN, Elborn JS, Mehta A. Ancestral haplotype 8.1 and lung disease severity in European cystic fibrosis patients. J Cyst Fibros. 2012 Jan; 11(1):63-7. PMID: 21993476.
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    74. Scott JA, North ML, Rafii M, Huang H, Pencharz P, Subbarao P, Belik J, Grasemann H. Asymmetric dimethylarginine is increased in asthma. Am J Respir Crit Care Med. 2011 Oct 01; 184(7):779-85. PMID: 21719758.
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    75. Belik J, McIntyre BA, Enomoto M, Pan J, Grasemann H, Vasquez-Vivar J. Pulmonary hypertension in the newborn GTP cyclohydrolase I-deficient mouse. Free Radic Biol Med. 2011 Dec 15; 51(12):2227-33. PMID: 21982896.
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    76. Radhakrishnan DK, Bendiak GN, Mateos-Corral D, Al-Saleh S, Bhattacharjee R, Kirby-Allen M, Grasemann H. Lower airway nitric oxide is increased in children with sickle cell disease. J Pediatr. 2012 Jan; 160(1):93-7. PMID: 21868036.
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    77. Douda DN, Jackson R, Grasemann H, Palaniyar N. Innate immune collectin surfactant protein D simultaneously binds both neutrophil extracellular traps and carbohydrate ligands and promotes bacterial trapping. J Immunol. 2011 Aug 15; 187(4):1856-65. PMID: 21724991.
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    78. Bendiak GN, Kritzinger F, Dipchand AI, Ng VL, Solomon M, Grasemann H. Flow-independent exhaled nitric oxide parameters in pediatric lung and cardiac transplant recipients. Transplantation. 2011 May 27; 91(10):e75-7. PMID: 21540720.
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    79. Mateos-Corral D, Coombs R, Grasemann H, Ratjen F, Dell SD. Diagnostic value of nasal nitric oxide measured with non-velum closure techniques for children with primary ciliary dyskinesia. J Pediatr. 2011 Sep; 159(3):420-4. PMID: 21514598.
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    80. North ML, Amatullah H, Khanna N, Urch B, Grasemann H, Silverman F, Scott JA. Augmentation of arginase 1 expression by exposure to air pollution exacerbates the airways hyperresponsiveness in murine models of asthma. Respir Res. 2011 Feb 03; 12:19. PMID: 21291525.
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    81. Grasemann H, Al-Saleh S, Scott JA, Shehnaz D, Mehl A, Amin R, Rafii M, Pencharz P, Belik J, Ratjen F. Asymmetric dimethylarginine contributes to airway nitric oxide deficiency in patients with cystic fibrosis. Am J Respir Crit Care Med. 2011 May 15; 183(10):1363-8. PMID: 21278301.
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    82. Grasemann H, Kritzinger F, Dipchand A, Hebert D, Solomon M. Nasal nitric oxide is reduced in children after solid-organ transplantation. J Heart Lung Transplant. 2011 Jan; 30(1):108-9. PMID: 20934886.
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    83. Grasemann H, Ratjen F. Emerging therapies for cystic fibrosis lung disease. Expert Opin Emerg Drugs. 2010 Dec; 15(4):653-9. PMID: 20812885.
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    84. Barnes PJ, Dweik RA, Gelb AF, Gibson PG, George SC, Grasemann H, Pavord ID, Ratjen F, Silkoff PE, Taylor DR, Zamel N. Exhaled nitric oxide in pulmonary diseases: a comprehensive review. Chest. 2010 Sep; 138(3):682-92. PMID: 20822990.
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    85. Grasemann H. Do the cysteine proteinases cathepsin B and S contribute to cystic fibrosis lung disease? Pediatr Pulmonol. 2010 Sep; 45(9):845-6. PMID: 20632408.
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    86. Al-Saleh S, Dell SD, Grasemann H, Yau YC, Waters V, Martin S, Ratjen F. Sputum induction in routine clinical care of children with cystic fibrosis. J Pediatr. 2010 Dec; 157(6):1006-1011.e1. PMID: 20630539.
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    87. Solomon M, Grasemann H, Keshavjee S. Pediatric lung transplantation. Pediatr Clin North Am. 2010 Apr; 57(2):375-91, table of contents. PMID: 20371042.
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    88. Grasemann H, Ratjen F. Editorial: leukocyte trafficking and matrix metalloproteinase-8 in obliterative bronchiolitis. J Leukoc Biol. 2010 Jan; 87(1):23-4. PMID: 20047888.
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    89. Douda DN, Farmakovski N, Dell S, Grasemann H, Palaniyar N. SP-D counteracts GM-CSF-mediated increase of granuloma formation by alveolar macrophages in lysinuric protein intolerance. Orphanet J Rare Dis. 2009 Dec 23; 4:29. PMID: 20030831.
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    90. Belik J, Stevens D, Pan J, Shehnaz D, Ibrahim C, Kantores C, Ivanovska J, Grasemann H, Jankov RP. Chronic hypercapnia downregulates arginase expression and activity and increases pulmonary arterial smooth muscle relaxation in the newborn rat. . 2009 Oct; 297(4):L777-84. PMID: 19666777.
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    91. North ML, Khanna N, Marsden PA, Grasemann H, Scott JA. Functionally important role for arginase 1 in the airway hyperresponsiveness of asthma. Am J Physiol Lung Cell Mol Physiol. 2009 Jun; 296(6):L911-20. PMID: 19286931.
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    92. Corvol H, Boelle PY, Brouard J, Knauer N, Chadelat K, Henrion-Caude A, Flamant C, Muselet-Charlier C, Boule M, Fauroux B, Vallet C, Feingold J, Ratjen F, Grasemann H, Clement A. Genetic variations in inflammatory mediators influence lung disease progression in cystic fibrosis. Pediatr Pulmonol. 2008 Dec; 43(12):1224-32. PMID: 19009622.
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    93. Lemaire M, Kantor P, Manson D, Grasemann H, Ely BA, Nield LS, Michalik DE, Michalik D, Batra J. Index of suspicion. Pediatr Rev. 2008 Nov; 29(11):399-406. PMID: 18977858.
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    94. MacLean JE, Atenafu E, Kirby-Allen M, MacLusky IB, Stephens D, Grasemann H, Subbarao P. Longitudinal decline in lung volume in a population of children with sickle cell disease. Am J Respir Crit Care Med. 2008 Nov 15; 178(10):1055-9. PMID: 18776149.
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    95. Al-Saleh S, Grasemann H, Cox P. Necrotizing pneumonia complicated by early and late pneumatoceles. Can Respir J. 2008 Apr; 15(3):129-32. PMID: 18437254.
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    96. Lakeman P, Gille JJ, Dankert-Roelse JE, Heijerman HG, Munck A, Iron A, Grasemann H, Schuster A, Cornel MC, Ten Kate LP. CFTR mutations in Turkish and North African cystic fibrosis patients in Europe: implications for screening. Genet Test. 2008 Mar; 12(1):25-35. PMID: 18373402.
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    97. Belik J, Shehnaz D, Pan J, Grasemann H. Developmental changes in arginase expression and activity in the lung. . 2008 Mar; 294(3):L498-504. PMID: 18192591.
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    98. Grasemann C, Ratjen F, Schnabel D, Reutershahn E, Vester U, Grasemann H. Effect of growth hormone therapy on nitric oxide formation in cystic fibrosis patients. Eur Respir J. 2008 Apr; 31(4):815-21. PMID: 18094013.
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    99. Grasemann H, Gerard NP, De Sanctis GT. Ventilatory responses to acute hypoxia in neurokinin-1 receptor deficient mice. Respir Physiol Neurobiol. 2007 Nov 15; 159(2):227-31. PMID: 17869190.
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    100. Grasemann H, Tschiedel E, Groch M, Klepper J, Ratjen F. Exhaled nitric oxide in children after accidental exposure to chlorine gas. Inhal Toxicol. 2007 Aug; 19(10):895-8. PMID: 17687720.
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    101. Grasemann H, Stehling F, Brunar H, Widmann R, Laliberte TW, Molina L, Döring G, Ratjen F. Inhalation of Moli1901 in patients with cystic fibrosis. Chest. 2007 May; 131(5):1461-6. PMID: 17494794.
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    102. Ratjen F, Walter H, Haug M, Meisner C, Grasemann H, Döring G. Diagnostic value of serum antibodies in early Pseudomonas aeruginosa infection in cystic fibrosis patients. Pediatr Pulmonol. 2007 Mar; 42(3):249-55. PMID: 17243185.
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    103. Büscher R, Grasemann H. Disease modifying genes in cystic fibrosis: therapeutic option or one-way road? Naunyn Schmiedebergs Arch Pharmacol. 2006 Nov; 374(2):65-77. PMID: 17033796.
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    104. Grasemann H, Schwiertz R, Grasemann C, Vester U, Racké K, Ratjen F. Decreased systemic bioavailability of L-arginine in patients with cystic fibrosis. Respir Res. 2006 Jun 09; 7:87. PMID: 16764721.
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    105. Stehling F, Roll C, Ratjen F, Grasemann H. Nasal nitric oxide to diagnose primary ciliary dyskinesia in newborns. Arch Dis Child Fetal Neonatal Ed. 2006 May; 91(3):F233. PMID: 16632655.
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    106. Grasemann H, Kurtz F, Ratjen F. Inhaled L-arginine improves exhaled nitric oxide and pulmonary function in patients with cystic fibrosis. Am J Respir Crit Care Med. 2006 Jul 15; 174(2):208-12. PMID: 16627863.
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    107. Büscher R, Hoerning A, Patel HH, Zhang S, Arthur DB, Grasemann H, Ratjen F, Insel PA. P2Y2 receptor polymorphisms and haplotypes in cystic fibrosis and their impact on Ca2+ influx. Pharmacogenet Genomics. 2006 Mar; 16(3):199-205. PMID: 16495779.
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    108. Ratjen F, Rietschel E, Kasel D, Schwiertz R, Starke K, Beier H, van Koningsbruggen S, Grasemann H. Pharmacokinetics of inhaled colistin in patients with cystic fibrosis. J Antimicrob Chemother. 2006 Feb; 57(2):306-11. PMID: 16396919.
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    109. Tschiedel E, Grasemann H, Ratjen F. Mycobacterium chelonae in a CF patient with anaplastic large cell lymphoma. J Cyst Fibros. 2006 May; 5(2):133-6. PMID: 16403492.
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    110. Grasemann H, Schwiertz R, Matthiesen S, Racké K, Ratjen F. Increased arginase activity in cystic fibrosis airways. Am J Respir Crit Care Med. 2005 Dec 15; 172(12):1523-8. PMID: 16166623.
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    111. Knauer N, Ratjen F, Grasemann H. [Cystic fibrosis modifying genes]. Pneumologie. 2005 Jun; 59(6):395-404. PMID: 15991075.
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    112. Tang CM, Hoerning A, Büscher R, O'Connor DT, Ratjen F, Grasemann H, Insel PA. Human adenosine 2B receptor: SNP discovery and evaluation of expression in patients with cystic fibrosis. Pharmacogenet Genomics. 2005 May; 15(5):321-7. PMID: 15864133.
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    113. Brouard J, Knauer N, Boelle PY, Corvol H, Henrion-Caude A, Flamant C, Bremont F, Delaisi B, Duhamel JF, Marguet C, Roussey M, Miesch MC, Chadelat K, Boule M, Fauroux B, Ratjen F, Grasemann H, Clement A. Influence of interleukin-10 on Aspergillus fumigatus infection in patients with cystic fibrosis. J Infect Dis. 2005 Jun 01; 191(11):1988-91. PMID: 15871134.
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    114. Ackerman KG, Huang H, Grasemann H, Puma C, Singer JB, Hill AE, Lander E, Nadeau JH, Churchill GA, Drazen JM, Beier DR. Interacting genetic loci cause airway hyperresponsiveness. Physiol Genomics. 2005 Mar 21; 21(1):105-11. PMID: 15657107.
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    115. Grasemann H, Grasemann C, Kurtz F, Tietze-Schillings G, Vester U, Ratjen F. Oral L-arginine supplementation in cystic fibrosis patients: a placebo-controlled study. Eur Respir J. 2005 Jan; 25(1):62-8. PMID: 15640324.
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    116. Grasemann H, Lax H, Treseler JW, Colin AA. Dornase alpha and exhaled NO in cystic fibrosis. Pediatr Pulmonol. 2004 Nov; 38(5):379-85. PMID: 15390350.
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    117. Grasemann H, Ratjen F. Gender-specific disease modification by NOS3. Br J Haematol. 2004 Jul; 126(1):160; author reply 161. PMID: 15198747.
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    118. Storm van's Gravesande K, Wechsler ME, Grasemann H, Silverman ES, Le L, Palmer LJ, Drazen JM. Association of a missense mutation in the NOS3 gene with exhaled nitric oxide levels. Am J Respir Crit Care Med. 2003 Jul 15; 168(2):228-31. PMID: 12738608.
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    119. Grasemann H, Storm van's Gravesande K, Buscher R, Drazen JM, Ratjen F. Effects of sex and of gene variants in constitutive nitric oxide synthases on exhaled nitric oxide. Am J Respir Crit Care Med. 2003 Apr 15; 167(8):1113-6. PMID: 12531780.
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    120. Grasemann H, Storm van's Gravesande K, Buscher R, Knauer N, Silverman ES, Palmer LJ, Drazen JM, Ratjen F. Endothelial nitric oxide synthase variants in cystic fibrosis lung disease. Am J Respir Crit Care Med. 2003 Feb 01; 167(3):390-4. PMID: 12406848.
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    121. Straub V, Ratjen F, Amthor H, Voit T, Grasemann H. Airway nitric oxide in Duchenne muscular dystrophy. J Pediatr. 2002 Jul; 141(1):132-4. PMID: 12091865.
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    122. Büscher R, Eilmes KJ, Grasemann H, Torres B, Knauer N, Sroka K, Insel PA, Ratjen F. beta2 adrenoceptor gene polymorphisms in cystic fibrosis lung disease. Pharmacogenetics. 2002 Jul; 12(5):347-53. PMID: 12142724.
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    123. Grasemann H, Ratjen F. [Pulmonary metabolism of nitric oxide (NO) in patients with cystic fibrosis]. Pneumologie. 2002 Jun; 56(6):376-81. PMID: 12063621.
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    124. Grasemann H, Storm van's Gravesande K, Gärtig S, Kirsch M, Büscher R, Drazen JM, Ratjen F. Nasal nitric oxide levels in cystic fibrosis patients are associated with a neuronal NO synthase (NOS1) gene polymorphism. Nitric Oxide. 2002 Mar; 6(2):236-41. PMID: 11890749.
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    125. Grasemann H, Ratjen F. Different subgroups of difficult asthma in children. Thorax. 2001 Nov; 56(11):895. PMID: 11641518.
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    126. Baron R, Silverman ES, Grasemann H, Collins T, Drazen JM. DNA sequence variants of the platelet-derived growth factor A-chain gene. Clin Exp Allergy. 2001 Oct; 31(10):1501-8. PMID: 11678848.
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    127. Grasemann H. [Genetics of the neuronal NO synthase (NOS1) in the etiology of bronchial asthma]. Pneumologie. 2001 Aug; 55(8):390-5. PMID: 11505291.
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    128. Silverman ES, De Sanctis GT, Boyce J, Maclean JA, Jiao A, Green FH, Grasemann H, Faunce D, Fitzmaurice G, Shi GP, Stein-Streilein J, Milbrandt J, Collins T, Drazen JM. The transcription factor early growth-response factor 1 modulates tumor necrosis factor-alpha, immunoglobulin E, and airway responsiveness in mice. Am J Respir Crit Care Med. 2001 Mar; 163(3 Pt 1):778-85. PMID: 11254538.
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    129. Wechsler ME, Grasemann H, Deykin A, Silverman EK, Yandava CN, Israel E, Wand M, Drazen JM. Exhaled nitric oxide in patients with asthma: association with NOS1 genotype. Am J Respir Crit Care Med. 2000 Dec; 162(6):2043-7. PMID: 11112111.
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    130. Grasemann H, Knauer N, Büscher R, Hübner K, Drazen JM, Ratjen F. Airway nitric oxide levels in cystic fibrosis patients are related to a polymorphism in the neuronal nitric oxide synthase gene. Am J Respir Crit Care Med. 2000 Dec; 162(6):2172-6. PMID: 11112133.
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    131. Ratjen F, Kavuk I, Gärtig S, Wiesemann HG, Grasemann H. Airway nitric oxide in infants with acute wheezy bronchitis. Pediatr Allergy Immunol. 2000 Nov; 11(4):230-5. PMID: 11110577.
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    132. Grasemann H, Yandava CN, Storm van's Gravesande K, Deykin A, Pillari A, Ma J, Sonna LA, Lilly C, Stampfer MJ, Israel E, Silverman EK, Drazen JM. A neuronal NO synthase (NOS1) gene polymorphism is associated with asthma. Biochem Biophys Res Commun. 2000 Jun 07; 272(2):391-4. PMID: 10833424.
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    133. Grasemann H, Gaston B, Fang K, Paul K, Ratjen F. Decreased levels of nitrosothiols in the lower airways of patients with cystic fibrosis and normal pulmonary function. J Pediatr. 1999 Dec; 135(6):770-2. PMID: 10586185.
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    134. Grasemann H, Ratjen F. Cystic fibrosis lung disease: the role of nitric oxide. Pediatr Pulmonol. 1999 Dec; 28(6):442-8. PMID: 10587420.
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    135. Grasemann H, Yandava CN, Drazen JM. Neuronal NO synthase (NOS1) is a major candidate gene for asthma. Clin Exp Allergy. 1999 Dec; 29 Suppl 4:39-41. PMID: 10641565.
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    136. Grasemann H, Lu B, Jiao A, Boudreau J, Gerard NP, De Sanctis GT. Targeted deletion of the neutral endopeptidase gene alters ventilatory responses to acute hypoxia in mice. J Appl Physiol (1985). 1999 Oct; 87(4):1266-71. PMID: 10517751.
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    137. Ratjen F, Gärtig S, Wiesemann HG, Grasemann H. Effect of inhaled nitric oxide on pulmonary function in cystic fibrosis. Respir Med. 1999 Aug; 93(8):579-83. PMID: 10542992.
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    138. Grasemann H, Drazen JM, Deykin A, Israel E, De Sanctis GT, Pillari A, Yandava CH. Simple tandem repeat polymorphisms in the neuronal nitric oxide synthase gene in different ethnic populations. Hum Hered. 1999 Jun; 49(3):139-41. PMID: 10364677.
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    139. De Sanctis GT, MacLean JA, Hamada K, Mehta S, Scott JA, Jiao A, Yandava CN, Kobzik L, Wolyniec WW, Fabian AJ, Venugopal CS, Grasemann H, Huang PL, Drazen JM. Contribution of nitric oxide synthases 1, 2, and 3 to airway hyperresponsiveness and inflammation in a murine model of asthma. J Exp Med. 1999 May 17; 189(10):1621-30. PMID: 10330441.
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    140. Nicolai RD, Grasemann H, Oberste-Berghaus C, Hövel M, Hauffa BP. Serum insulin-like growth factors IGF-I and IGFBP-3 in children with slipped capital femoral epiphysis. J Pediatr Orthop B. 1999 Apr; 8(2):103-6. PMID: 10218170.
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    141. De Sanctis GT, MacLean JA, Qin S, Wolyniec WW, Grasemann H, Yandava CN, Jiao A, Noonan T, Stein-Streilein J, Green FH, Drazen JM. Interleukin-8 receptor modulates IgE production and B-cell expansion and trafficking in allergen-induced pulmonary inflammation. J Clin Invest. 1999 Feb; 103(4):507-15. PMID: 10021459.
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    142. Grasemann H. Total sputum nitrate plus nitrite is raised during acute pulmonary infection in cystic fibrosis. Am J Respir Crit Care Med. 1999 Feb; 159(2):684-5. PMID: 10075477.
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    143. Grasemann H, Gärtig SS, Wiesemann HG, Teschler H, Konietzko N, Ratjen F. Effect of L-arginine infusion on airway NO in cystic fibrosis and primary ciliary dyskinesia syndrome. Eur Respir J. 1999 Jan; 13(1):114-8. PMID: 10836334.
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    144. Ratjen F, Grasemann H, Wolstein R, Wiesemann HG. Isovolume pressure/flow curves of rapid thoracoabdominal compressions in infants without respiratory disease. Pediatr Pulmonol. 1998 Sep; 26(3):197-203. PMID: 9773915.
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    145. Grasemann H, Kremens B, Passarge E. Experience treating a patient with Bloom syndrome and acute myelogenous leukemia. Med Pediatr Oncol. 1998 May; 30(5):309-10. PMID: 9544230.
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    146. Grasemann H, Ioannidis I, Tomkiewicz RP, de Groot H, Rubin BK, Ratjen F. Nitric oxide metabolites in cystic fibrosis lung disease. Arch Dis Child. 1998 Jan; 78(1):49-53. PMID: 9534676.
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    147. Grasemann H, Michler E, Wallot M, Ratjen F. Decreased concentration of exhaled nitric oxide (NO) in patients with cystic fibrosis. Pediatr Pulmonol. 1997 Sep; 24(3):173-7. PMID: 9330413.
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    148. Grasemann H, Ioannidis I, de Groot H, Ratjen F. Metabolites of nitric oxide in the lower respiratory tract of children. Eur J Pediatr. 1997 Jul; 156(7):575-8. PMID: 9243246.
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    149. Grasemann H, Drazen JM, Yandava CN. Protein sequence of the human neuronal nitric oxide synthase (Type I NOS): an error in the sequence database. Nitric Oxide. 1997; 1(6):441. PMID: 9466948.
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    150. Grasemann H, Nicolai RD, Patsalis T, Hövel M. The treatment of Legg-Calvé-Perthes disease. To contain or not to contain. Arch Orthop Trauma Surg. 1997; 116(1-2):50-4. PMID: 9006766.
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    151. Grasemann H, Nicolai RD, Hauffa BP, Reinhardt W, Nicolai H, Hövel M. Skeletal immaturity, IGF-I and IGFBP-3 serum concentrations in Legg-Calvé-Perthes disease (skeletal immaturity, IGF-I and IGFBP-3 in LCPD). Klin Padiatr. 1996 Nov-Dec; 208(6):339-43. PMID: 8962421.
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    152. Grasemann H, Wiesemann HG, Ratjen F. [The importance of lung function as a predictor of 2-year mortality in mucoviscidosis]. Pneumologie. 1995 Aug; 49(8):466-9. PMID: 7479641.
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