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Ian Scott

TitleSenior Scientist
InstitutionThe Hospital for Sick Children
DepartmentDevelopmental & Stem Cell Biology
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
ORCID ORCID Icon0000-0001-6665-141 Additional info
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    Collapse Biography 
    Collapse education and training
    Queen's University, Kingston, ONBScH (hons)04/1994Biochemistry
    University of Toronto, Toronto, ONPhD02/2002Developmental biology
    UCSF, San Francisco, CAPostdoc10/2005Developmental biology

    Collapse Overview 
    Collapse overview
    Research in the Scott lab is focused on how cardiac fate is first established, and how the heart later grows and develops. Using the advantages of the zebrafish embryo, we employ genetic, embryological, live imaging and genomics approaches to study in real time the earliest events of cardiovascular development. Current research topics include: 1) role of Aplnr signalling in migration of cardiac progenitors to the heart-forming region; 2) transcriptional control of early cardiac fate and migration; 3) deciphering the gene regulatory networks that govern vertebrate heart development and regeneration; 4) regulation of second heart field (SHF) development; and 5) role of CCM3 signalling in cranial vasculature development.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Yuan X, Song M, Devine P, Bruneau BG, Scott IC, Wilson MD. Heart enhancers with deeply conserved regulatory activity are established early in zebrafish development. Nat Commun. 2018 11 26; 9(1):4977. PMID: 30478328.
      View in: PubMed
    2. Gibb N, Lazic S, Yuan X, Deshwar AR, Leslie M, Wilson MD, Scott IC. Hey2 regulates the size of the cardiac progenitor pool during vertebrate heart development. Development. 2018 Nov 21; 145(22). PMID: 30355727.
      View in: PubMed
    3. Zhang L, Yang Y, Li B, Scott IC, Lou X. The DEAD-box RNA helicase Ddx39ab is essential for myocyte and lens development in zebrafish. Development. 2018 04 23; 145(8). PMID: 29636379.
      View in: PubMed
    4. Ma D, Tu C, Sheng Q, Yang Y, Kan Z, Guo Y, Shyr Y, Scott IC, Lou X. Dynamics of Zebrafish Heart Regeneration Using an HPLC-ESI-MS/MS Approach. J Proteome Res. 2018 03 02; 17(3):1300-1308. PMID: 29369637.
      View in: PubMed
    5. Kenney JW, Scott IC, Josselyn SA, Frankland PW. Contextual fear conditioning in zebrafish. Learn Mem. 2017 10; 24(10):516-523. PMID: 28916626.
      View in: PubMed
    6. Hou N, Yang Y, Scott IC, Lou X. The Sec domain protein Scfd1 facilitates trafficking of ECM components during chondrogenesis. Dev Biol. 2017 Jan 01; 421(1):8-15. PMID: 27851892.
      View in: PubMed
    7. Deshwar AR, Onderisin JC, Aleksandrova A, Yuan X, Burrows JTA, Scott IC. Mespaa can potently induce cardiac fates in zebrafish. Dev Biol. 2016 10 01; 418(1):17-27. PMID: 27554166.
      View in: PubMed
    8. Hanwell D, Hutchinson SA, Collymore C, Bruce AE, Louis R, Ghalami A, Allison WT, Ekker M, Eames BF, Childs S, Kurrasch DM, Gerlai R, Thiele T, Scott I, Ciruna B, Dowling JJ, McFarlane S, Huang P, Wen XY, Akimenko MA, Waskiewicz AJ, Drapeau P, Babiuk LA, Dragon D, Smida A, Buret AG, O'Grady E, Wilson J, Sowden-Plunkett L, Tropepe V. Restrictions on the Importation of Zebrafish into Canada Associated with Spring Viremia of Carp Virus. Zebrafish. 2016 07; 13 Suppl 1:S153-63. PMID: 27248438.
      View in: PubMed
    9. Deshwar AR, Chng SC, Ho L, Reversade B, Scott IC. The Apelin receptor enhances Nodal/TGFß signaling to ensure proper cardiac development. Elife. 2016 04 14; 5. PMID: 27077952; PMCID: PMC4859801.
    10. Lou X, Burrows JT, Scott IC. Med14 cooperates with brg1 in the differentiation of skeletogenic neural crest. BMC Dev Biol. 2015 Nov 09; 15:41. PMID: 26553192; PMCID: PMC4640375.
    11. Sharma P, Abbasi C, Lazic S, Teng AC, Wang D, Dubois N, Ignatchenko V, Wong V, Liu J, Araki T, Tiburcy M, Ackerley C, Zimmermann WH, Hamilton R, Sun Y, Liu PP, Keller G, Stagljar I, Scott IC, Kislinger T, Gramolini AO. Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function. Nat Commun. 2015 Sep 25; 6:8391. PMID: 26403541.
      View in: PubMed
    12. Lau K, Tao H, Liu H, Wen J, Sturgeon K, Sorfazlian N, Lazic S, Burrows JT, Wong MD, Li D, Deimling S, Ciruna B, Scott I, Simmons C, Henkelman RM, Williams T, Hadjantonakis AK, Fernandez-Gonzalez R, Sun Y, Hopyan S. Anisotropic stress orients remodelling of mammalian limb bud ectoderm. Nat Cell Biol. 2015 May; 17(5):569-79. PMID: 25893915; PMCID: PMC4955842.
    13. Burrows JT, Pearson BJ, Scott IC. An in vivo requirement for the mediator subunit med14 in the maintenance of stem cell populations. Stem Cell Reports. 2015 Apr 14; 4(4):670-84. PMID: 25772472; PMCID: PMC4400641.
    14. Liu YC, Couzens AL, Deshwar AR, B McBroom-Cerajewski LD, Zhang X, Puviindran V, Scott IC, Gingras AC, Hui CC, Angers S. The PPFIA1-PP2A protein complex promotes trafficking of Kif7 to the ciliary tip and Hedgehog signaling. Sci Signal. 2014 Dec 09; 7(355):ra117. PMID: 25492966.
      View in: PubMed
    15. Hu D, Scott IC, Snider F, Geary-Joo C, Zhao X, Simmons DG, Cross JC. The basic helix-loop-helix transcription factor Hand1 regulates mouse development as a homodimer. Dev Biol. 2013 Oct 15; 382(2):470-81. PMID: 23911935.
      View in: PubMed
    16. Kelsey L, Flenniken AM, Qu D, Funnell AP, Pearson R, Zhou YQ, Voronina I, Berberovic Z, Wood G, Newbigging S, Weiss ES, Wong M, Quach I, Yeh SY, Deshwar AR, Scott IC, McKerlie C, Henkelman M, Backx P, Simpson J, Osborne L, Rossant J, Crossley M, Bruneau B, Adamson SL. ENU-induced mutation in the DNA-binding domain of KLF3 reveals important roles for KLF3 in cardiovascular development and function in mice. PLoS Genet. 2013; 9(7):e1003612. PMID: 23874215; PMCID: PMC3708807.
    17. Paskaradevan S, Scott IC. The Aplnr GPCR regulates myocardial progenitor development via a novel cell-non-autonomous, Ga(i/o) protein-independent pathway. Biol Open. 2012 Mar 15; 1(3):275-85. PMID: 23213418; PMCID: PMC3507289.
    18. Nesan D, Kamkar M, Burrows J, Scott IC, Marsden M, Vijayan MM. Glucocorticoid receptor signaling is essential for mesoderm formation and muscle development in zebrafish. Endocrinology. 2012 Mar; 153(3):1288-300. PMID: 22234471.
      View in: PubMed
    19. Scott IC. Life before Nkx2.5: cardiovascular progenitor cells: embryonic origins and development. Curr Top Dev Biol. 2012; 100:1-31. PMID: 22449839.
      View in: PubMed
    20. Yoruk B, Gillers BS, Chi NC, Scott IC. Ccm3 functions in a manner distinct from Ccm1 and Ccm2 in a zebrafish model of CCM vascular disease. Dev Biol. 2012 Feb 15; 362(2):121-31. PMID: 22182521.
      View in: PubMed
    21. Lou X, Deshwar AR, Crump JG, Scott IC. Smarcd3b and Gata5 promote a cardiac progenitor fate in the zebrafish embryo. Development. 2011 Aug; 138(15):3113-23. PMID: 21715426.
      View in: PubMed
    22. Kean MJ, Ceccarelli DF, Goudreault M, Sanches M, Tate S, Larsen B, Gibson LC, Derry WB, Scott IC, Pelletier L, Baillie GS, Sicheri F, Gingras AC. Structure-function analysis of core STRIPAK Proteins: a signaling complex implicated in Golgi polarization. J Biol Chem. 2011 Jul 15; 286(28):25065-75. PMID: 21561862; PMCID: PMC3137080.
    23. Ceccarelli DF, Laister RC, Mulligan VK, Kean MJ, Goudreault M, Scott IC, Derry WB, Chakrabartty A, Gingras AC, Sicheri F. CCM3/PDCD10 heterodimerizes with germinal center kinase III (GCKIII) proteins using a mechanism analogous to CCM3 homodimerization. J Biol Chem. 2011 Jul 15; 286(28):25056-64. PMID: 21561863; PMCID: PMC3137079.
    24. Lazic S, Scott IC. Mef2cb regulates late myocardial cell addition from a second heart field-like population of progenitors in zebrafish. Dev Biol. 2011 Jun 01; 354(1):123-33. PMID: 21466801.
      View in: PubMed
    25. Takeuchi JK, Lou X, Alexander JM, Sugizaki H, Delgado-Olguín P, Holloway AK, Mori AD, Wylie JN, Munson C, Zhu Y, Zhou YQ, Yeh RF, Henkelman RM, Harvey RP, Metzger D, Chambon P, Stainier DY, Pollard KS, Scott IC, Bruneau BG. Chromatin remodelling complex dosage modulates transcription factor function in heart development. Nat Commun. 2011 Feb 08; 2:187. PMID: 21304516; PMCID: PMC3096875.
    26. Delgado-Olguín P, Brand-Arzamendi K, Scott IC, Jungblut B, Stainier DY, Bruneau BG, Recillas-Targa F. CTCF promotes muscle differentiation by modulating the activity of myogenic regulatory factors. J Biol Chem. 2011 Apr 08; 286(14):12483-94. PMID: 21288905; PMCID: PMC3069451.
    27. Chi NC, Shaw RM, Jungblut B, Huisken J, Ferrer T, Arnaout R, Scott I, Beis D, Xiao T, Baier H, Jan LY, Tristani-Firouzi M, Stainier DY. Genetic and physiologic dissection of the vertebrate cardiac conduction system. PLoS Biol. 2008 May 13; 6(5):e109. PMID: 18479184; PMCID: PMC2430899.
    28. Davis JL, Long X, Georger MA, Scott IC, Rich A, Miano JM. Expression and comparative genomics of two serum response factor genes in zebrafish. Int J Dev Biol. 2008; 52(4):389-96. PMID: 18415940.
      View in: PubMed
    29. Jin SW, Herzog W, Santoro MM, Mitchell TS, Frantsve J, Jungblut B, Beis D, Scott IC, D'Amico LA, Ober EA, Verkade H, Field HA, Chi NC, Wehman AM, Baier H, Stainier DY. A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryos. Dev Biol. 2007 Jul 01; 307(1):29-42. PMID: 17531218; PMCID: PMC2695512.
    30. Scott IC, Masri B, D'Amico LA, Jin SW, Jungblut B, Wehman AM, Baier H, Audigier Y, Stainier DY. The g protein-coupled receptor agtrl1b regulates early development of myocardial progenitors. Dev Cell. 2007 Mar; 12(3):403-13. PMID: 17336906.
      View in: PubMed
    31. D'Amico L, Scott IC, Jungblut B, Stainier DY. A mutation in zebrafish hmgcr1b reveals a role for isoprenoids in vertebrate heart-tube formation. Curr Biol. 2007 Feb 06; 17(3):252-9. PMID: 17276918.
      View in: PubMed
    32. Beis D, Bartman T, Jin SW, Scott IC, D'Amico LA, Ober EA, Verkade H, Frantsve J, Field HA, Wehman A, Baier H, Tallafuss A, Bally-Cuif L, Chen JN, Stainier DY, Jungblut B. Genetic and cellular analyses of zebrafish atrioventricular cushion and valve development. Development. 2005 Sep; 132(18):4193-204. PMID: 16107477.
      View in: PubMed
    33. Hughes M, Dobric N, Scott IC, Su L, Starovic M, St-Pierre B, Egan SE, Kingdom JC, Cross JC. The Hand1, Stra13 and Gcm1 transcription factors override FGF signaling to promote terminal differentiation of trophoblast stem cells. Dev Biol. 2004 Jul 01; 271(1):26-37. PMID: 15196947.
      View in: PubMed
    34. Scott IC, Stainier DY. Developmental biology: twisting the body into shape. Nature. 2003 Oct 02; 425(6957):461-3. PMID: 14523426.
      View in: PubMed
    35. Scott IC, Stainier DY. Development. Fishing out a new heart. Science. 2002 Dec 13; 298(5601):2141-2. PMID: 12481123.
      View in: PubMed
    36. Scott IC, Anson-Cartwright L, Riley P, Reda D, Cross JC. The HAND1 basic helix-loop-helix transcription factor regulates trophoblast differentiation via multiple mechanisms. Mol Cell Biol. 2000 Jan; 20(2):530-41. PMID: 10611232; PMCID: PMC85124.
    37. Nakayama H, Scott IC, Cross JC. The transition to endoreduplication in trophoblast giant cells is regulated by the mSNA zinc finger transcription factor. Dev Biol. 1998 Jul 01; 199(1):150-63. PMID: 9676199.
      View in: PubMed
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