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Brian Nieman

TitleSenior Scientist
InstitutionThe Hospital for Sick Children
DepartmentResearch Operations
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Yuen N, Szulc-Lerch KU, Li YQ, Morshead CM, Mabbott DJ, Wong CS, Nieman BJ. Metformin effects on brain development following cranial irradiation in a mouse model. Neuro Oncol. 2021 Sep 01; 23(9):1523-1536. PMID: 34042964.
      View in: PubMed
    2. Ayoub R, Lau K, Yuen N, Fernandes D, Elder M, Yeung J, Wong SC, Nieman BJ. Spatiotemporal Mapping of Early Volume Loss in the Mouse Brain after Cranial Irradiation. Radiat Res. 2021 Jul 16. PMID: 34270782.
      View in: PubMed
    3. van der Plas E, Qiu W, Nieman BJ, Yasui Y, Liu Q, Dixon SB, Kadan-Lottick NS, Weldon CB, Weil BR, Jacola LM, Gibson TM, Leisenring W, Oeffinger K, Hudson MM, Robison LL, Armstrong GT, Krull KR. Sex-Specific Associations Between Chemotherapy, Chronic Conditions, and Neurocognitive Impairment in Acute Lymphoblastic Leukemia Survivors: A Report From the Childhood Cancer Survivor Study. J Natl Cancer Inst. 2021 May 04; 113(5):588-596. PMID: 32882041.
      View in: PubMed
    4. Kesler SR, Sleurs C, McDonald BC, Deprez S, van der Plas E, Nieman BJ. Brain Imaging in Pediatric Cancer Survivors: Correlates of Cognitive Impairment. J Clin Oncol. 2021 Jun 01; 39(16):1775-1785. PMID: 33886371.
      View in: PubMed
    5. Fernandes DJ, Spring S, Roy AR, Qiu LR, Yee Y, Nieman BJ, Lerch JP, Palmert MR. Exposure to maternal high-fat diet induces extensive changes in the brain of adult offspring. Transl Psychiatry. 2021 03 02; 11(1):149. PMID: 33654064.
      View in: PubMed
    6. Richmond CR, Ballantyne LL, de Guzman AE, Nieman BJ, Funk CD, Ghasemlou N. Arginase-1 deficiency in neural cells does not contribute to neurodevelopment or functional outcomes after sciatic nerve injury. Neurochem Int. 2021 05; 145:104984. PMID: 33561495.
      View in: PubMed
    7. van der Plas E, Spencer Noakes TL, Butcher DT, Weksberg R, Galin-Corini L, Wanstall EA, Te P, Hopf L, Guger S, Hitzler J, Schachar RJ, Ito S, Nieman BJ. Cognitive and behavioral risk factors for low quality of life in survivors of childhood acute lymphoblastic leukemia. Pediatr Res. 2020 Nov 17. PMID: 33203967.
      View in: PubMed
    8. van der Plas E, Spencer Noakes TL, Butcher DT, Weksberg R, Galin-Corini L, Wanstall EA, Te P, Hopf L, Guger S, Spiegler BJ, Hitzler J, Schachar RJ, Ito S, Nieman BJ. Quantitative MRI outcomes in child and adolescent leukemia survivors: Evidence for global alterations in gray and white matter. Neuroimage Clin. 2020; 28:102428. PMID: 32980598.
      View in: PubMed
    9. Gazdzinski LM, Mellerup M, Wang T, Adel SAA, Lerch JP, Sled JG, Nieman BJ, Wheeler AL. White Matter Changes Caused by Mild Traumatic Brain Injury in Mice Evaluated Using Neurite Orientation Dispersion and Density Imaging. J Neurotrauma. 2020 08 15; 37(16):1818-1828. PMID: 32242488.
      View in: PubMed
    10. Berg EL, Pride MC, Petkova SP, Lee RD, Copping NA, Shen Y, Adhikari A, Fenton TA, Pedersen LR, Noakes LS, Nieman BJ, Lerch JP, Harris S, Born HA, Peters MM, Deng P, Cameron DL, Fink KD, Beitnere U, O'Geen H, Anderson AE, Dindot SV, Nash KR, Weeber EJ, Wöhr M, Ellegood J, Segal DJ, Silverman JL. Translational outcomes in a full gene deletion of ubiquitin protein ligase E3A rat model of Angelman syndrome. Transl Psychiatry. 2020 01 27; 10(1):39. PMID: 32066685.
      View in: PubMed
    11. Cox MA, Duncan GS, Lin GHY, Steinberg BE, Yu LX, Brenner D, Buckler LN, Elia AJ, Wakeham AC, Nieman B, Dominguez-Brauer C, Elford AR, Gill KT, Kubli SP, Haight J, Berger T, Ohashi PS, Tracey KJ, Olofsson PS, Mak TW. Choline acetyltransferase-expressing T cells are required to control chronic viral infection. Science. 2019 02 08; 363(6427):639-644. PMID: 30733420.
      View in: PubMed
    12. de Guzman AE, Ahmed M, Li YQ, Wong CS, Nieman BJ. p53 Loss Mitigates Early Volume Deficits in the Brains of Irradiated Young Mice. Int J Radiat Oncol Biol Phys. 2019 02 01; 103(2):511-520. PMID: 30243572.
      View in: PubMed
    13. Spencer Noakes TL, Przybycien TS, Forwell A, Nicholls C, Zhou YQ, Butcher DT, Weksberg R, Guger SL, Spiegler BJ, Schachar RJ, Hitzler J, Ito S, van der Plas E, Nieman BJ. Brain Development and Heart Function after Systemic Single-Agent Chemotherapy in a Mouse Model of Childhood Leukemia Treatment. Clin Cancer Res. 2018 12 01; 24(23):6040-6052. PMID: 30054283.
      View in: PubMed
    14. Qiu LR, Fernandes DJ, Szulc-Lerch KU, Dazai J, Nieman BJ, Turnbull DH, Foster JA, Palmert MR, Lerch JP. Mouse MRI shows brain areas relatively larger in males emerge before those larger in females. Nat Commun. 2018 07 05; 9(1):2615. PMID: 29976930.
      View in: PubMed
    15. Nieman BJ, van Eede MC, Spring S, Dazai J, Henkelman RM, Lerch JP. MRI to Assess Neurological Function. Curr Protoc Mouse Biol. 2018 Jun; 8(2):e44. PMID: 29927554.
      View in: PubMed
    16. Beera KG, Li YQ, Dazai J, Stewart J, Egan S, Ahmed M, Wong CS, Jaffray DA, Nieman BJ. Altered brain morphology after focal radiation reveals impact of off-target effects: implications for white matter development and neurogenesis. Neuro Oncol. 2018 05 18; 20(6):788-798. PMID: 29228390.
      View in: PubMed
    17. Yee Y, Fernandes DJ, French L, Ellegood J, Cahill LS, Vousden DA, Spencer Noakes L, Scholz J, van Eede MC, Nieman BJ, Sled JG, Lerch JP. Structural covariance of brain region volumes is associated with both structural connectivity and transcriptomic similarity. Neuroimage. 2018 10 01; 179:357-372. PMID: 29782994.
      View in: PubMed
    18. Vousden DA, Cox E, Allemang-Grand R, Laliberté C, Qiu LR, Lindenmaier Z, Nieman BJ, Lerch JP. Continuous manganese delivery via osmotic pumps for manganese-enhanced mouse MRI does not impair spatial learning but leads to skin ulceration. Neuroimage. 2018 06; 173:411-420. PMID: 29505831.
      View in: PubMed
    19. Sheybani-Deloui S, Chi L, Staite MV, Cain JE, Nieman BJ, Henkelman RM, Wainwright BJ, Potter SS, Bagli DJ, Lorenzo AJ, Rosenblum ND. Activated Hedgehog-GLI Signaling Causes Congenital Ureteropelvic Junction Obstruction. J Am Soc Nephrol. 2018 02; 29(2):532-544. PMID: 29109083.
      View in: PubMed
    20. Van Der Plas E, Erdman L, Nieman BJ, Weksberg R, Butcher DT, O'connor DL, Aufreiter S, Hitzler J, Guger SL, Schachar RJ, Ito S, Spiegler BJ. Characterizing neurocognitive late effects in childhood leukemia survivors using a combination of neuropsychological and cognitive neuroscience measures. Child Neuropsychol. 2018 11; 24(8):999-1014. PMID: 29017430.
      View in: PubMed
    21. Spencer Noakes TL, Henkelman RM, Nieman BJ. Partitioning k-space for cylindrical three-dimensional rapid acquisition with relaxation enhancement imaging in the mouse brain. NMR Biomed. 2017 Nov; 30(11). PMID: 28902423.
      View in: PubMed
    22. Heyn CC, Bishop J, Duffin K, Lee W, Dazai J, Spring S, Nieman BJ, Sled JG. Magnetic resonance thermometry of flowing blood. NMR Biomed. 2017 Nov; 30(11). PMID: 28686319.
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    23. Allemang-Grand R, Ellegood J, Spencer Noakes L, Ruston J, Justice M, Nieman BJ, Lerch JP. Neuroanatomy in mouse models of Rett syndrome is related to the severity of Mecp2 mutation and behavioral phenotypes. Mol Autism. 2017; 8:32. PMID: 28670438.
      View in: PubMed
    24. van der Plas E, Schachar RJ, Hitzler J, Crosbie J, Guger SL, Spiegler BJ, Ito S, Nieman BJ. Brain structure, working memory and response inhibition in childhood leukemia survivors. Brain Behav. 2017 02; 7(2):e00621. PMID: 28239531.
      View in: PubMed
    25. de Guzman AE, Wong MD, Gleave JA, Nieman BJ. Variations in post-perfusion immersion fixation and storage alter MRI measurements of mouse brain morphometry. Neuroimage. 2016 Nov 15; 142:687-695. PMID: 27335314.
      View in: PubMed
    26. Nieman BJ, de Guzman AE, Gazdzinski LM, Lerch JP, Chakravarty MM, Pipitone J, Strother D, Fryer C, Bouffet E, Laughlin S, Laperriere N, Riggs L, Skocic J, Mabbott DJ. White and Gray Matter Abnormalities After Cranial Radiation in Children and Mice. Int J Radiat Oncol Biol Phys. 2015 Nov 15; 93(4):882-91. PMID: 26530758.
      View in: PubMed
    27. Szulc KU, Lerch JP, Nieman BJ, Bartelle BB, Friedel M, Suero-Abreu GA, Watson C, Joyner AL, Turnbull DH. 4D MEMRI atlas of neonatal FVB/N mouse brain development. Neuroimage. 2015 Sep; 118:49-62. PMID: 26037053.
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    28. de Guzman AE, Gazdzinski LM, Alsop RJ, Stewart JM, Jaffray DA, Wong CS, Nieman BJ. Treatment age, dose and sex determine neuroanatomical outcome in irradiated juvenile mice. Radiat Res. 2015 May; 183(5):541-9. PMID: 25938769.
      View in: PubMed
    29. van der Plas E, Nieman BJ, Butcher DT, Hitzler JK, Weksberg R, Ito S, Schachar R. Neurocognitive Late Effects of Chemotherapy in Survivors of Acute Lymphoblastic Leukemia: Focus on Methotrexate. J Can Acad Child Adolesc Psychiatry. 2015; 24(1):25-32. PMID: 26336377.
      View in: PubMed
    30. Cahill LS, Laliberté CL, Liu XJ, Bishop J, Nieman BJ, Mogil JS, Sorge RE, Jones CD, Salter MW, Henkelman RM. Quantifying blood-spinal cord barrier permeability after peripheral nerve injury in the living mouse. Mol Pain. 2014 Sep 13; 10:60. PMID: 25216623.
      View in: PubMed
    31. Vousden DA, Epp J, Okuno H, Nieman BJ, van Eede M, Dazai J, Ragan T, Bito H, Frankland PW, Lerch JP, Henkelman RM. Whole-brain mapping of behaviourally induced neural activation in mice. Brain Struct Funct. 2015 Jul; 220(4):2043-57. PMID: 24760545.
      View in: PubMed
    32. Gleave JA, Lerch JP, Henkelman RM, Nieman BJ. A method for 3D immunostaining and optical imaging of the mouse brain demonstrated in neural progenitor cells. PLoS One. 2013; 8(8):e72039. PMID: 23936537.
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    33. Gazdzinski LM, Nieman BJ. Cellular imaging and texture analysis distinguish differences in cellular dynamics in mouse brain tumors. Magn Reson Med. 2014 Apr; 71(4):1531-41. PMID: 23661610.
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    34. Szulc KU, Nieman BJ, Houston EJ, Bartelle BB, Lerch JP, Joyner AL, Turnbull DH. MRI analysis of cerebellar and vestibular developmental phenotypes in Gbx2 conditional knockout mice. Magn Reson Med. 2013 Dec; 70(6):1707-17. PMID: 23400959.
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    35. Gazdzinski LM, Cormier K, Lu FG, Lerch JP, Wong CS, Nieman BJ. Radiation-induced alterations in mouse brain development characterized by magnetic resonance imaging. Int J Radiat Oncol Biol Phys. 2012 Dec 01; 84(5):e631-8. PMID: 22975609.
      View in: PubMed
    36. Nieman BJ, Blank MC, Roman BB, Henkelman RM, Millen KJ. If the skull fits: magnetic resonance imaging and microcomputed tomography for combined analysis of brain and skull phenotypes in the mouse. Physiol Genomics. 2012 Oct 17; 44(20):992-1002. PMID: 22947655.
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    37. Parasoglou P, Berrios-Otero CA, Nieman BJ, Turnbull DH. High-resolution MRI of early-stage mouse embryos. NMR Biomed. 2013 Feb; 26(2):224-31. PMID: 22915475.
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    38. Gleave JA, Wong MD, Dazai J, Altaf M, Henkelman RM, Lerch JP, Nieman BJ. Neuroanatomical phenotyping of the mouse brain with three-dimensional autofluorescence imaging. Physiol Genomics. 2012 Aug 01; 44(15):778-85. PMID: 22718750.
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    39. Lerch JP, Gazdzinski L, Germann J, Sled JG, Henkelman RM, Nieman BJ. Wanted dead or alive? The tradeoff between in-vivo versus ex-vivo MR brain imaging in the mouse. Front Neuroinform. 2012; 6:6. PMID: 22470335.
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    40. Nieman BJ, Wong MD, Henkelman RM. Genes into geometry: imaging for mouse development in 3D. Curr Opin Genet Dev. 2011 Oct; 21(5):638-46. PMID: 21907568.
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    41. Berrios-Otero CA, Nieman BJ, Parasoglou P, Turnbull DH. In utero phenotyping of mouse embryonic vasculature with MRI. Magn Reson Med. 2012 Jan; 67(1):251-7. PMID: 21590728.
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    42. Yu X, Nieman BJ, Sudarov A, Szulc KU, Abdollahian DJ, Bhatia N, Lalwani AK, Joyner AL, Turnbull DH. Morphological and functional midbrain phenotypes in Fibroblast Growth Factor 17 mutant mice detected by Mn-enhanced MRI. Neuroimage. 2011 Jun 01; 56(3):1251-8. PMID: 21356319.
      View in: PubMed
    43. Chen XJ, Nieman BJ. Mouse phenotyping with MRI. Methods Mol Biol. 2011; 771:595-631. PMID: 21874500.
      View in: PubMed
    44. Nieman BJ, Shyu JY, Rodriguez JJ, Garcia AD, Joyner AL, Turnbull DH. In vivo MRI of neural cell migration dynamics in the mouse brain. Neuroimage. 2010 Apr 01; 50(2):456-64. PMID: 20053381.
      View in: PubMed
    45. Nieman BJ, Turnbull DH. Ultrasound and magnetic resonance microimaging of mouse development. Methods Enzymol. 2010; 476:379-400. PMID: 20691877.
      View in: PubMed
    46. Berrios-Otero CA, Wadghiri YZ, Nieman BJ, Joyner AL, Turnbull DH. Three-dimensional micro-MRI analysis of cerebral artery development in mouse embryos. Magn Reson Med. 2009 Dec; 62(6):1431-9. PMID: 19859945.
      View in: PubMed
    47. Nieman BJ, Szulc KU, Turnbull DH. Three-dimensional, in vivo MRI with self-gating and image coregistration in the mouse. Magn Reson Med. 2009 May; 61(5):1148-57. PMID: 19253389.
      View in: PubMed
    48. Watt KN, Bishop J, Nieman BJ, Henkelman RM, Chen XJ. Oxygen-enhanced MR imaging of mice lungs. Magn Reson Med. 2008 Jun; 59(6):1412-21. PMID: 18421693.
      View in: PubMed
    49. Nieman BJ, Lerch JP, Bock NA, Chen XJ, Sled JG, Henkelman RM. Mouse behavioral mutants have neuroimaging abnormalities. Hum Brain Mapp. 2007 Jun; 28(6):567-75. PMID: 17437292.
      View in: PubMed
    50. Nieman BJ, Bishop J, Dazai J, Bock NA, Lerch JP, Feintuch A, Chen XJ, Sled JG, Henkelman RM. MR technology for biological studies in mice. NMR Biomed. 2007 May; 20(3):291-303. PMID: 17451169.
      View in: PubMed
    51. Xie G, Clapcote SJ, Nieman BJ, Tallerico T, Huang Y, Vukobradovic I, Cordes SP, Osborne LR, Rossant J, Sled JG, Henderson JT, Roder JC. Forward genetic screen of mouse reveals dominant missense mutation in the P/Q-type voltage-dependent calcium channel, CACNA1A. Genes Brain Behav. 2007 Nov; 6(8):717-27. PMID: 17376154.
      View in: PubMed
    52. Mori AD, Zhu Y, Vahora I, Nieman B, Koshiba-Takeuchi K, Davidson L, Pizard A, Seidman JG, Seidman CE, Chen XJ, Henkelman RM, Bruneau BG. Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis. Dev Biol. 2006 Sep 15; 297(2):566-86. PMID: 16870172.
      View in: PubMed
    53. Bishop J, Feintuch A, Bock NA, Nieman B, Dazai J, Davidson L, Henkelman RM. Retrospective gating for mouse cardiac MRI. Magn Reson Med. 2006 Mar; 55(3):472-7. PMID: 16450339.
      View in: PubMed
    54. Nieman BJ, Flenniken AM, Adamson SL, Henkelman RM, Sled JG. Anatomical phenotyping in the brain and skull of a mutant mouse by magnetic resonance imaging and computed tomography. Physiol Genomics. 2006 Jan 12; 24(2):154-62. PMID: 16410543.
      View in: PubMed
    55. Nieman BJ, Bock NA, Bishop J, Chen XJ, Sled JG, Rossant J, Henkelman RM. Magnetic resonance imaging for detection and analysis of mouse phenotypes. NMR Biomed. 2005 Nov; 18(7):447-68. PMID: 16206127.
      View in: PubMed
    56. Bock NA, Nieman BJ, Bishop JB, Mark Henkelman R. In vivo multiple-mouse MRI at 7 Tesla. Magn Reson Med. 2005 Nov; 54(5):1311-6. PMID: 16215960.
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    57. Flenniken AM, Osborne LR, Anderson N, Ciliberti N, Fleming C, Gittens JE, Gong XQ, Kelsey LB, Lounsbury C, Moreno L, Nieman BJ, Peterson K, Qu D, Roscoe W, Shao Q, Tong D, Veitch GI, Voronina I, Vukobradovic I, Wood GA, Zhu Y, Zirngibl RA, Aubin JE, Bai D, Bruneau BG, Grynpas M, Henderson JE, Henkelman RM, McKerlie C, Sled JG, Stanford WL, Laird DW, Kidder GM, Adamson SL, Rossant J. A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia. Development. 2005 Oct; 132(19):4375-86. PMID: 16155213.
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    58. Nieman BJ, Bishop J, Henkelman RM. Gradient hysteresis in MRI and NMR experiments. J Magn Reson. 2005 Dec; 177(2):336-40. PMID: 16188476.
      View in: PubMed
    59. Nieman BJ, Bock NA, Bishop J, Sled JG, Josette Chen X, Mark Henkelman R. Fast spin-echo for multiple mouse magnetic resonance phenotyping. Magn Reson Med. 2005 Sep; 54(3):532-7. PMID: 16086298.
      View in: PubMed
    60. Dazai J, Bock NA, Nieman BJ, Davidson LM, Henkelman RM, Chen XJ. Multiple mouse biological loading and monitoring system for MRI. Magn Reson Med. 2004 Oct; 52(4):709-15. PMID: 15389955.
      View in: PubMed
    61. Zhou YQ, Foster FS, Nieman BJ, Davidson L, Chen XJ, Henkelman RM. Comprehensive transthoracic cardiac imaging in mice using ultrasound biomicroscopy with anatomical confirmation by magnetic resonance imaging. Physiol Genomics. 2004 Jul 08; 18(2):232-44. PMID: 15114000.
      View in: PubMed
    62. Zhou YQ, Davidson L, Henkelman RM, Nieman BJ, Foster FS, Yu LX, Chen XJ. Ultrasound-guided left-ventricular catheterization: a novel method of whole mouse perfusion for microimaging. Lab Invest. 2004 Mar; 84(3):385-9. PMID: 14704721.
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    63. Peyronnet O, Nieman B, Généreux F, Vachon V, Laprade R, Schwartz JL. Estimation of the radius of the pores formed by the Bacillus thuringiensis Cry1C delta-endotoxin in planar lipid bilayers. Biochim Biophys Acta. 2002 Dec 23; 1567(1-2):113-22. PMID: 12488044.
      View in: PubMed
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