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Simon Sharpe

TitleSenior Scientist
InstitutionThe Hospital for Sick Children
DepartmentMolecular Medicine
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Gourgas O, Cole GB, Muiznieks LD, Sharpe S, Cerruti M. Effect of the Ionic Concentration of Simulated Body Fluid on the Minerals Formed on Cross-Linked Elastin-Like Polypeptide Membranes. Langmuir. 2019 Nov 26; 35(47):15364-15375. PMID: 31729882.
      View in: PubMed
    2. Cole GB, Sharpe S. Hydrophobic matching of HIV-1 Vpu transmembrane helix-helix interactions is optimized for subcellular location. Biochim Biophys Acta Biomembr. 2019 Oct 01; 1861(10):183022. PMID: 31302078.
      View in: PubMed
    3. Stone TA, Cole GB, Ravamehr-Lake D, Nguyen HQ, Khan F, Sharpe S, Deber CM. Positive Charge Patterning and Hydrophobicity of Membrane-Active Antimicrobial Peptides as Determinants of Activity, Toxicity, and Pharmacokinetic Stability. J Med Chem. 2019 Jul 11; 62(13):6276-6286. PMID: 31194548.
      View in: PubMed
    4. Reichheld SE, Muiznieks LD, Lu R, Sharpe S, Keeley FW. Sequence variants of human tropoelastin affecting assembly, structural characteristics and functional properties of polymeric elastin in health and disease. Matrix Biol. 2019 Jun 26. PMID: 31254613.
      View in: PubMed
    5. Gourgas O, Muiznieks LD, Bello DG, Nanci A, Sharpe S, Cerruti M. Cross-Linked Elastin-like Polypeptide Membranes as a Model for Medial Arterial Calcification. Biomacromolecules. 2019 Jul 08; 20(7):2625-2636. PMID: 31244014.
      View in: PubMed
    6. Muiznieks LD, Sharpe S, Pomès R, Keeley FW. Role of Liquid-Liquid Phase Separation in Assembly of Elastin and Other Extracellular Matrix Proteins. J Mol Biol. 2018 11 02; 430(23):4741-4753. PMID: 29886015.
      View in: PubMed
    7. Cole GB, Reichheld SE, Sharpe S. FRET Analysis of the Promiscuous yet Specific Interactions of the HIV-1 Vpu Transmembrane Domain. Biophys J. 2017 Nov 07; 113(9):1992-2003. PMID: 29117523.
      View in: PubMed
    8. Stone TA, Cole GB, Nguyen HQ, Sharpe S, Deber CM. Influence of hydrocarbon-stapling on membrane interactions of synthetic antimicrobial peptides. Bioorg Med Chem. 2018 03 15; 26(6):1189-1196. PMID: 29275987.
      View in: PubMed
    9. Wang H, Muiznieks LD, Ghosh P, Williams D, Solarski M, Fang A, Ruiz-Riquelme A, Pomès R, Watts JC, Chakrabartty A, Wille H, Sharpe S, Schmitt-Ulms G. Somatostatin binds to the human amyloid ß peptide and favors the formation of distinct oligomers. Elife. 2017 06 26; 6. PMID: 28650319.
      View in: PubMed
    10. Reichheld SE, Muiznieks LD, Keeley FW, Sharpe S. Direct observation of structure and dynamics during phase separation of an elastomeric protein. Proc Natl Acad Sci U S A. 2017 05 30; 114(22):E4408-E4415. PMID: 28507126.
      View in: PubMed
    11. Miao M, Reichheld SE, Muiznieks LD, Sitarz EE, Sharpe S, Keeley FW. Single nucleotide polymorphisms and domain/splice variants modulate assembly and elastomeric properties of human elastin. Implications for tissue specificity and durability of elastic tissue. Biopolymers. 2017 May; 107(5). PMID: 27997981.
      View in: PubMed
    12. Chan SW, Yau J, Ing C, Liu K, Farber P, Won A, Bhandari V, Kara-Yacoubian N, Seraphim TV, Chakrabarti N, Kay LE, Yip CM, Pomès R, Sharpe S, Houry WA. Mechanism of Amyloidogenesis of a Bacterial AAA+ Chaperone. Structure. 2016 07 06; 24(7):1095-109. PMID: 27265850.
      View in: PubMed
    13. Galant NJ, Bugyei-Twum A, Rakhit R, Walsh P, Sharpe S, Arslan PE, Westermark P, Higaki JN, Torres R, Tapia J, Chakrabartty A. Substoichiometric inhibition of transthyretin misfolding by immune-targeting sparsely populated misfolding intermediates: a potential diagnostic and therapeutic for TTR amyloidoses. Sci Rep. 2016 04 28; 6:25080. PMID: 27122057.
      View in: PubMed
    14. Walsh P, Vanderlee G, Yau J, Campeau J, Sim VL, Yip CM, Sharpe S. The mechanism of membrane disruption by cytotoxic amyloid oligomers formed by prion protein(106-126) is dependent on bilayer composition. J Biol Chem. 2014 Apr 11; 289(15):10419-30. PMID: 24554723.
      View in: PubMed
    15. Reichheld SE, Muiznieks LD, Stahl R, Simonetti K, Sharpe S, Keeley FW. Conformational transitions of the cross-linking domains of elastin during self-assembly. J Biol Chem. 2014 Apr 04; 289(14):10057-68. PMID: 24550393.
      View in: PubMed
    16. Larda ST, Simonetti K, Al-Abdul-Wahid MS, Sharpe S, Prosser RS. Dynamic equilibria between monomeric and oligomeric misfolded states of the mammalian prion protein measured by 19F NMR. J Am Chem Soc. 2013 Jul 17; 135(28):10533-41. PMID: 23781904.
      View in: PubMed
    17. Baldwin AJ, Walsh P, Hansen DF, Hilton GR, Benesch JL, Sharpe S, Kay LE. Probing dynamic conformations of the high-molecular-weight aB-crystallin heat shock protein ensemble by NMR spectroscopy. J Am Chem Soc. 2012 Sep 19; 134(37):15343-50. PMID: 22916679.
      View in: PubMed
    18. Yau J, Sharpe S. Structures of amyloid fibrils formed by the prion protein derived peptides PrP(244-249) and PrP(245-250). J Struct Biol. 2012 Nov; 180(2):290-302. PMID: 22929126.
      View in: PubMed
    19. Cole G, Simonetti K, Ademi I, Sharpe S. Dimerization of the transmembrane domain of human tetherin in membrane mimetic environments. Biochemistry. 2012 Jun 26; 51(25):5033-40. PMID: 22667354.
      View in: PubMed
    20. Neudecker P, Robustelli P, Cavalli A, Walsh P, Lundström P, Zarrine-Afsar A, Sharpe S, Vendruscolo M, Kay LE. Structure of an intermediate state in protein folding and aggregation. Science. 2012 Apr 20; 336(6079):362-6. PMID: 22517863.
      View in: PubMed
    21. Sharpe S, Simonetti K, Yau J, Walsh P. Solid-State NMR characterization of autofluorescent fibrils formed by the elastin-derived peptide GVGVAGVG. Biomacromolecules. 2011 May 09; 12(5):1546-55. PMID: 21456595.
      View in: PubMed
    22. Lu JX, Sharpe S, Ghirlando R, Yau WM, Tycko R. Oligomerization state and supramolecular structure of the HIV-1 Vpu protein transmembrane segment in phospholipid bilayers. Protein Sci. 2010 Oct; 19(10):1877-96. PMID: 20669237.
      View in: PubMed
    23. Walsh P, Neudecker P, Sharpe S. Structural properties and dynamic behavior of nonfibrillar oligomers formed by PrP(106-126). J Am Chem Soc. 2010 Jun 09; 132(22):7684-95. PMID: 20465257.
      View in: PubMed
    24. Walsh P, Yau J, Simonetti K, Sharpe S. Morphology and secondary structure of stable beta-oligomers formed by amyloid peptide PrP(106-126). Biochemistry. 2009 Jun 30; 48(25):5779-81. PMID: 19476383.
      View in: PubMed
    25. Walsh P, Simonetti K, Sharpe S. Core structure of amyloid fibrils formed by residues 106-126 of the human prion protein. Structure. 2009 Mar 11; 17(3):417-26. PMID: 19278656.
      View in: PubMed
    26. Sharpe S, Yau WM, Tycko R. Structure and dynamics of the HIV-1 Vpu transmembrane domain revealed by solid-state NMR with magic-angle spinning. Biochemistry. 2006 Jan 24; 45(3):918-33. PMID: 16411768.
      View in: PubMed
    27. Sharpe S, Yau WM, Tycko R. Expression and purification of a recombinant peptide from the Alzheimer's beta-amyloid protein for solid-state NMR. Protein Expr Purif. 2005 Jul; 42(1):200-10. PMID: 15939307.
      View in: PubMed
    28. Goodyear DJ, Sharpe S, Grant CW, Morrow MR. Molecular dynamics simulation of transmembrane polypeptide orientational fluctuations. Biophys J. 2005 Jan; 88(1):105-17. PMID: 15489306.
      View in: PubMed
    29. Sharpe S, Kessler N, Anglister JA, Yau WM, Tycko R. Solid-state NMR yields structural constraints on the V3 loop from HIV-1 Gp120 bound to the 447-52D antibody Fv fragment. J Am Chem Soc. 2004 Apr 21; 126(15):4979-90. PMID: 15080704.
      View in: PubMed
    30. Sharpe S, Barber KR, Grant CW, Goodyear D, Morrow MR. Organization of model helical peptides in lipid bilayers: insight into the behavior of single-span protein transmembrane domains. Biophys J. 2002 Jul; 83(1):345-58. PMID: 12080125.
      View in: PubMed
    31. Sharpe S, Barber KR, Grant CW. Interaction between ErbB-1 and ErbB-2 transmembrane domains in bilayer membranes. FEBS Lett. 2002 May 22; 519(1-3):103-7. PMID: 12023026.
      View in: PubMed
    32. Sharpe S, Barber KR, Grant CW. Evidence of a tendency to self-association of the transmembrane domain of ErbB-2 in fluid phospholipid bilayers. Biochemistry. 2002 Feb 19; 41(7):2341-52. PMID: 11841227.
      View in: PubMed
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