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Simon Sharpe

TitleSenior Scientist & Associate Chief, Research Training and Career
InstitutionThe Hospital for Sick Children
DepartmentMolecular Medicine
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Muiznieks LD, Sharpe S, Pomès R, Keeley FW. Role of Liquid-Liquid Phase Separation in Assembly of Elastin and Other Extracellular Matrix Proteins. J Mol Biol. 2018 Nov 02; 430(23):4741-4753. PMID: 29886015.
      View in: PubMed
    2. Cole GB, Reichheld SE, Sharpe S. FRET Analysis of the Promiscuous yet Specific Interactions of the HIV-1 Vpu Transmembrane Domain. Biophys J. 2017 Nov 07; 113(9):1992-2003. PMID: 29117523.
      View in: PubMed
    3. Stone TA, Cole GB, Nguyen HQ, Sharpe S, Deber CM. Influence of hydrocarbon-stapling on membrane interactions of synthetic antimicrobial peptides. Bioorg Med Chem. 2018 03 15; 26(6):1189-1196. PMID: 29275987.
      View in: PubMed
    4. Wang H, Muiznieks LD, Ghosh P, Williams D, Solarski M, Fang A, Ruiz-Riquelme A, Pomès R, Watts JC, Chakrabartty A, Wille H, Sharpe S, Schmitt-Ulms G. Somatostatin binds to the human amyloid ß peptide and favors the formation of distinct oligomers. Elife. 2017 06 26; 6. PMID: 28650319.
      View in: PubMed
    5. Reichheld SE, Muiznieks LD, Keeley FW, Sharpe S. Direct observation of structure and dynamics during phase separation of an elastomeric protein. Proc Natl Acad Sci U S A. 2017 05 30; 114(22):E4408-E4415. PMID: 28507126.
      View in: PubMed
    6. Miao M, Reichheld SE, Muiznieks LD, Sitarz EE, Sharpe S, Keeley FW. Single nucleotide polymorphisms and domain/splice variants modulate assembly and elastomeric properties of human elastin. Implications for tissue specificity and durability of elastic tissue. Biopolymers. 2017 May; 107(5). PMID: 27997981.
      View in: PubMed
    7. Chan SW, Yau J, Ing C, Liu K, Farber P, Won A, Bhandari V, Kara-Yacoubian N, Seraphim TV, Chakrabarti N, Kay LE, Yip CM, Pomès R, Sharpe S, Houry WA. Mechanism of Amyloidogenesis of a Bacterial AAA+ Chaperone. Structure. 2016 07 06; 24(7):1095-109. PMID: 27265850.
      View in: PubMed
    8. Galant NJ, Bugyei-Twum A, Rakhit R, Walsh P, Sharpe S, Arslan PE, Westermark P, Higaki JN, Torres R, Tapia J, Chakrabartty A. Substoichiometric inhibition of transthyretin misfolding by immune-targeting sparsely populated misfolding intermediates: a potential diagnostic and therapeutic for TTR amyloidoses. Sci Rep. 2016 04 28; 6:25080. PMID: 27122057.
      View in: PubMed
    9. Walsh P, Vanderlee G, Yau J, Campeau J, Sim VL, Yip CM, Sharpe S. The mechanism of membrane disruption by cytotoxic amyloid oligomers formed by prion protein(106-126) is dependent on bilayer composition. J Biol Chem. 2014 Apr 11; 289(15):10419-30. PMID: 24554723.
      View in: PubMed
    10. Reichheld SE, Muiznieks LD, Stahl R, Simonetti K, Sharpe S, Keeley FW. Conformational transitions of the cross-linking domains of elastin during self-assembly. J Biol Chem. 2014 Apr 04; 289(14):10057-68. PMID: 24550393.
      View in: PubMed
    11. Larda ST, Simonetti K, Al-Abdul-Wahid MS, Sharpe S, Prosser RS. Dynamic equilibria between monomeric and oligomeric misfolded states of the mammalian prion protein measured by 19F NMR. J Am Chem Soc. 2013 Jul 17; 135(28):10533-41. PMID: 23781904.
      View in: PubMed
    12. Baldwin AJ, Walsh P, Hansen DF, Hilton GR, Benesch JL, Sharpe S, Kay LE. Probing dynamic conformations of the high-molecular-weight aB-crystallin heat shock protein ensemble by NMR spectroscopy. J Am Chem Soc. 2012 Sep 19; 134(37):15343-50. PMID: 22916679.
      View in: PubMed
    13. Yau J, Sharpe S. Structures of amyloid fibrils formed by the prion protein derived peptides PrP(244-249) and PrP(245-250). J Struct Biol. 2012 Nov; 180(2):290-302. PMID: 22929126.
      View in: PubMed
    14. Cole G, Simonetti K, Ademi I, Sharpe S. Dimerization of the transmembrane domain of human tetherin in membrane mimetic environments. Biochemistry. 2012 Jun 26; 51(25):5033-40. PMID: 22667354.
      View in: PubMed
    15. Neudecker P, Robustelli P, Cavalli A, Walsh P, Lundström P, Zarrine-Afsar A, Sharpe S, Vendruscolo M, Kay LE. Structure of an intermediate state in protein folding and aggregation. Science. 2012 Apr 20; 336(6079):362-6. PMID: 22517863.
      View in: PubMed
    16. Sharpe S, Simonetti K, Yau J, Walsh P. Solid-State NMR characterization of autofluorescent fibrils formed by the elastin-derived peptide GVGVAGVG. Biomacromolecules. 2011 May 09; 12(5):1546-55. PMID: 21456595.
      View in: PubMed
    17. Lu JX, Sharpe S, Ghirlando R, Yau WM, Tycko R. Oligomerization state and supramolecular structure of the HIV-1 Vpu protein transmembrane segment in phospholipid bilayers. Protein Sci. 2010 Oct; 19(10):1877-96. PMID: 20669237.
      View in: PubMed
    18. Walsh P, Neudecker P, Sharpe S. Structural properties and dynamic behavior of nonfibrillar oligomers formed by PrP(106-126). J Am Chem Soc. 2010 Jun 09; 132(22):7684-95. PMID: 20465257.
      View in: PubMed
    19. Walsh P, Yau J, Simonetti K, Sharpe S. Morphology and secondary structure of stable beta-oligomers formed by amyloid peptide PrP(106-126). Biochemistry. 2009 Jun 30; 48(25):5779-81. PMID: 19476383.
      View in: PubMed
    20. Walsh P, Simonetti K, Sharpe S. Core structure of amyloid fibrils formed by residues 106-126 of the human prion protein. Structure. 2009 Mar 11; 17(3):417-26. PMID: 19278656.
      View in: PubMed
    21. Sharpe S, Yau WM, Tycko R. Structure and dynamics of the HIV-1 Vpu transmembrane domain revealed by solid-state NMR with magic-angle spinning. Biochemistry. 2006 Jan 24; 45(3):918-33. PMID: 16411768.
      View in: PubMed
    22. Sharpe S, Yau WM, Tycko R. Expression and purification of a recombinant peptide from the Alzheimer's beta-amyloid protein for solid-state NMR. Protein Expr Purif. 2005 Jul; 42(1):200-10. PMID: 15939307.
      View in: PubMed
    23. Goodyear DJ, Sharpe S, Grant CW, Morrow MR. Molecular dynamics simulation of transmembrane polypeptide orientational fluctuations. Biophys J. 2005 Jan; 88(1):105-17. PMID: 15489306.
      View in: PubMed
    24. Sharpe S, Kessler N, Anglister JA, Yau WM, Tycko R. Solid-state NMR yields structural constraints on the V3 loop from HIV-1 Gp120 bound to the 447-52D antibody Fv fragment. J Am Chem Soc. 2004 Apr 21; 126(15):4979-90. PMID: 15080704.
      View in: PubMed
    25. Sharpe S, Barber KR, Grant CW, Goodyear D, Morrow MR. Organization of model helical peptides in lipid bilayers: insight into the behavior of single-span protein transmembrane domains. Biophys J. 2002 Jul; 83(1):345-58. PMID: 12080125.
      View in: PubMed
    26. Sharpe S, Barber KR, Grant CW. Interaction between ErbB-1 and ErbB-2 transmembrane domains in bilayer membranes. FEBS Lett. 2002 May 22; 519(1-3):103-7. PMID: 12023026.
      View in: PubMed
    27. Sharpe S, Barber KR, Grant CW. Evidence of a tendency to self-association of the transmembrane domain of ErbB-2 in fluid phospholipid bilayers. Biochemistry. 2002 Feb 19; 41(7):2341-52. PMID: 11841227.
      View in: PubMed
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