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Christoph Licht

TitleNephrologist
InstitutionThe Hospital for Sick Children
DepartmentNephrology
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Biography 
    Collapse education and training
    Albert-Ludwigs-University, Freiburg, GermanyM.D.05/1992Medicine
    Ruprecht-Karls-University, Heidelberg, GermanyDr. Med. (Doctorate in Medicine)01/1995Internal Medicine/Nephrology
    University of Cologne, Cologne, GermanyHabilitation11/2005Novel aspects of chronic kidney disease. Role of endothelin-1 and complement dysregulation
    Children's Hospital of the University of Cologne, Cologne, GermanyClinical Fellowship10/2005Pediatric Nephrology
    University of Texas, Southwestern Medical Center at Dallas, Dallas, USAPostdoctoral Research Fellowship07/2002Nephrology
    Children's Hospital of the University of Cologne, Cologne, GermanyClinical Fellowship06/1999Pediatric Nephrology
    Children's Hospital of the University of Cologne, Cologne, Cologne, GermanyPostgraduate Training06/1998Pediatrics
    FRCPC – Fellow of the Royal College of Physicians and Surgeons of Canada, Ottawa, ONAcademic Certification in Pediatrics and Pediatric Nephrology01/2012Pediatric Nephrology
    Eureka Institute for Translational Medicine, Syracuse, ItalyInaugural Certificate Program in Translational Medicine05/2009Translational Medicine
    Board Certification, Düsseldorf, GermanyBoard Certification in Pediatric Nephrology12/2006Pediatric Nephrology
    College of Physicians and Surgeons of Ontario, Toronto, CanadaLicense in Paediatrics and Paediatric Nephrology05/2006Paediatric Nephrology
    Paediatric Healthcare Board, Düsseldorf, GermanyCertification in Pediatrics08/1998Pediatrics
    Physician Board of Germany , Stuttgart, GermanyCertificate of Approbation as Physician12/1993Medicine
    The Hospital for Sick Children Department of Paediatrics, Paediatrics Leadership Program06/2015Rotman School of Management
    Collapse awards and honors
    2004 - 2004Else-Kröner-Fresenius (Best Poster Award), Working Group for Pediatric Nephrology
    2002 - 2002First Prize, National KFOC Research Fellow and Young Investigators Research Presentation, Clinical Nephrology Meetings
    2014 - 2014CORD (Canadian Organization for Rare Disorders) Rarity Scientific Award, Canadian Organization for Rare Disorders

    Collapse Overview 
    Collapse overview
    I am a Professor of Paediatrics at the University of Toronto and Staff Physician in the Division of Nephrology, The Hospital for Sick Children (SickKids). In addition, I am Senior Associate Scientist in the Cell Biology Program of the SickKids Research Institute. I am also cross appointed as Associate Member to the Institute of Medical Science (IMS) and Laboratory Medicine and Pathobiology (LMP) of the University of Toronto.

    My research focuses on complement-mediated renal diseases such as atypical hemolytic-uremic syndrome (aHUS) and membranoproliferative glomerulonephritis (MPGN) / C3 glomerulopathy (C3G). My research has translational character and includes both clinical and basic research: I have established an international registry with biorepository (www.kidcom.ca). In addition, I have also established a basic research program focusing on the pathogenesis of complement-mediated thrombotic microangiopathy (TMA). In particular, I am investigating the consequences of complement activation on endothelial cells, platelets and neutrophils, and the interaction of these cells in TMA pathogenesis. The results of my research can change our understanding of the pathophysiology of aHUS and may ultimately allow for the development of new treatment strategies not only for aHUS but also other complement-mediated diseases.

    I am the chair of HUS International (HUSi), and chair of the International aHUS Registry. I serve on the editorial board of Kidney International, Nephrology Dialysis and Transplantation and Pediatric Nephrology, and have published numerous peer-reviewed articles and book chapters related to my research focus.

    Innovations

    Advancing diagnosis and treatment of aHUS and related conditions
    We reported the successful use of eculizumab in aHUS, DEAP HUS, refractory MPGN, antibody-medicated kidney transplant rejection, and post HSCT TMA in children.

    Modelling vascular endothelium and TMA and aHUS pathology
    We established blood outgrowth endothelial cells (BOECs) from normal donors and aHUS patients as an approach to study vascular endothelium, in particular the response to complement activation. By using the BioFlux microfluidic system we established a model system to study interactions of endothelium, platelets, neutrophils and complement. A major contribution relates to the investigating of complement and von Willebrand Factor (VWF) identifying VWF as new complement regulator on ECs.

    Investigating platelet-complement interactions
    Platelets interact with the AP regulator Factor H (CFH), which is also synthesized by megakaryocytes and can be taken up by platelets in vivo and in vitro. We demonstrated that platelet CFH is functional, bioavailabel and released from stimulated platelets.

    Investigating neutrophil-endothelium-complement interactions
    We recently observed that several complement proteins are present in neutrophils and that CRP/properdin mediates complement deposition on NETs and that NETs trap bacteria while complement kills them. We also studied the interaction of neutrophils with complement-challenged endothelial cells, neutrophils and platelets, observing that complement dysregulation stimulates neutrophil adhesion to endothelial cells with subsequent platelet aggregation.

    Establishing a registry and biorepository for patients with complement-mediated diseases
    We took a leadership role in establishing an international registry with biorepository that maintains for patients with complement-mediated diseases such as aHUS and C3G (www.kidcom.ca).


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Wilbur C, Yea C, Licht C, Irwin MS, Yeh EA. An upfront immunomodulatory therapy protocol for pediatric opsoclonus-myoclonus syndrome. Pediatr Blood Cancer. 2019 Aug; 66(8):e27776. PMID: 31033188.
      View in: PubMed
    2. Konstantelos N, Banh T, Patel V, Vasilevska-Ristovska J, Borges K, Hussain-Shamsy N, Noone D, Hebert D, Radhakrishnan S, Licht CPB, Langlois V, Pearl RJ, Parekh RS. Association of low birth weight and prematurity with clinical outcomes of childhood nephrotic syndrome: a prospective cohort study. Pediatr Nephrol. 2019 Apr 11. PMID: 30976899.
      View in: PubMed
    3. Menne J, Delmas Y, Fakhouri F, Licht C, Lommelé Å, Minetti EE, Provôt F, Rondeau E, Sheerin NS, Wang J, Weekers LE, Greenbaum LA. Outcomes in patients with atypical hemolytic uremic syndrome treated with eculizumab in a long-term observational study. BMC Nephrol. 2019 Apr 10; 20(1):125. PMID: 30971227.
      View in: PubMed
    4. Shroff R, Smith C, Ranchin B, Bayazit AK, Stefanidis CJ, Askiti V, Azukaitis K, Canpolat N, Agbas A, Aitkenhead H, Anarat A, Aoun B, Aofolaju D, Bakkaloglu SA, Bhowruth D, Borzych-Duzalka D, Bulut IK, Büscher R, Deanfield J, Dempster C, Duzova A, Habbig S, Hayes W, Hegde S, Krid S, Licht C, Litwin M, Mayes M, Mir S, Nemec R, Obrycki L, Paglialonga F, Picca S, Samaille C, Shenoy M, Sinha MD, Spasojevic B, Stronach L, Vidal E, Vondrák K, Yilmaz A, Zaloszyc A, Fischbach M, Schmitt CP, Schaefer F. Effects of Hemodiafiltration versus Conventional Hemodialysis in Children with ESKD: The HDF, Heart and Height Study. J Am Soc Nephrol. 2019 Apr; 30(4):678-691. PMID: 30846560.
      View in: PubMed
    5. Pelletier JH, Kumar KR, Engen R, Bensimhon A, Varner JD, Rheault MN, Srivastava T, Straatmann C, Silva C, Davis TK, Wenderfer SE, Gibson K, Selewski D, Barcia J, Weng P, Licht C, Jawa N, Kallash M, Foreman JW, Wigfall DR, Chua AN, Chambers E, Hornik CP, Brewer ED, Nagaraj SK, Greenbaum LA, Gbadegesin RA. Correction to: Recurrence of nephrotic syndrome following kidney transplantation is associated with initial native kidney biopsy findings : A Midwest Pediatric Nephrology Consortium (MWPNC) study. Pediatr Nephrol. 2019 Mar; 34(3):539. PMID: 30443740.
      View in: PubMed
    6. Riar SS, Banh THM, Borges K, Subbarao P, Patel V, Vasilevska-Ristovska J, Chanchlani R, Hussain-Shamsy N, Noone D, Hebert D, Licht CPB, Langlois V, Pearl RJ, Parekh RS. Prevalence of Asthma and Allergies and Risk of Relapse in Childhood Nephrotic Syndrome: Insight into Nephrotic Syndrome Cohort. J Pediatr. 2019 May; 208:251-257.e1. PMID: 30732999.
      View in: PubMed
    7. Feitz WJC, van de Kar NCAJ, Orth-Höller D, van den Heuvel LPJW, Licht C. The genetics of atypical hemolytic uremic syndrome. Med Genet. 2018; 30(4):400-409. PMID: 30930551.
      View in: PubMed
    8. Shuster S, Ankawi G, Licht C, Reiser J, Wang X, Wei C, Chitayat D, Hladunewich M. Fetal Renal Echogenicity Associated with Maternal Focal Segmental Glomerulosclerosis: The Effect of Transplacental Transmission of Permeability Factor suPAR. J Clin Med. 2018 Oct 04; 7(10). PMID: 30287750.
      View in: PubMed
    9. Shroff R, Bayazit A, Stefanidis CJ, Askiti V, Azukaitis K, Canpolat N, Agbas A, Anarat A, Aoun B, Bakkaloglu S, Bhowruth D, Borzych-Duzalka D, Bulut IK, Büscher R, Dempster C, Duzova A, Habbig S, Hayes W, Hegde S, Krid S, Licht C, Litwin M, Mayes M, Mir S, Nemec R, Obrycki L, Paglialonga F, Picca S, Ranchin B, Samaille C, Shenoy M, Sinha M, Smith C, Spasojevic B, Vidal E, Vondrák K, Yilmaz A, Zaloszyc A, Fischbach M, Schaefer F, Schmitt CP. Effect of haemodiafiltration vs conventional haemodialysis on growth and cardiovascular outcomes in children - the HDF, heart and height (3H) study. BMC Nephrol. 2018 08 10; 19(1):199. PMID: 30097064.
      View in: PubMed
    10. Pelletier JH, Kumar KR, Engen R, Bensimhon A, Varner JD, Rheault MN, Srivastava T, Straatmann C, Silva C, Davis TK, Wenderfer SE, Gibson K, Selewski D, Barcia J, Weng P, Licht C, Jawa N, Kallash M, Foreman JW, Wigfall DR, Chua AN, Chambers E, Hornik CP, Brewer ED, Nagaraj SK, Greenbaum LA, Gbadegesin RA. Recurrence of nephrotic syndrome following kidney transplantation is associated with initial native kidney biopsy findings. Pediatr Nephrol. 2018 10; 33(10):1773-1780. PMID: 29982878.
      View in: PubMed
    11. Schaefer F, Ardissino G, Ariceta G, Fakhouri F, Scully M, Isbel N, Lommelé Å, Kupelian V, Gasteyger C, Greenbaum LA, Johnson S, Ogawa M, Licht C, Vande Walle J, Frémeaux-Bacchi V. Clinical and genetic predictors of atypical hemolytic uremic syndrome phenotype and outcome. Kidney Int. 2018 08; 94(2):408-418. PMID: 29907460.
      View in: PubMed
    12. Menne J, Delmas Y, Fakhouri F, Kincaid JF, Licht C, Minetti EE, Mix C, Provôt F, Rondeau E, Sheerin NS, Wang J, Weekers LE, Greenbaum LA. Eculizumab prevents thrombotic microangiopathy in patients with atypical haemolytic uraemic syndrome in a long-term observational study. Clin Kidney J. 2019 Apr; 12(2):196-205. PMID: 30976396.
      View in: PubMed
    13. Azzouz L, Cherry A, Riedl M, Khan M, Pluthero FG, Kahr WHA, Palaniyar N, Licht C. Relative antibacterial functions of complement and NETs: NETs trap and complement effectively kills bacteria. Mol Immunol. 2018 05; 97:71-81. PMID: 29571059.
      View in: PubMed
    14. Filler G, Licht C, Huang SS. Is there a case for eculizumab for pediatric renal transplantation? Pediatr Transplant. 2018 03; 22(2). PMID: 29417722.
      View in: PubMed
    15. Petropoulos TE, Ramirez ME, Granton J, Licht C, John R, Moayedi Y, Morel CF, McQuillan RF. Renal thrombotic microangiopathy and pulmonary arterial hypertension in a patient with late-onset cobalamin C deficiency. Clin Kidney J. 2018 Jun; 11(3):310-314. PMID: 29942494.
      View in: PubMed
    16. Chanchlani R, Thorner P, Radhakrishnan S, Hebert D, Langlois V, Arora S, Barth D, Cattran D, Kirschfink M, Licht C. Long-term Eculizumab Therapy in a Child With Refractory Immune Complex-Mediated Membranoproliferative Glomerulonephritis. Kidney Int Rep. 2018 Mar; 3(2):482-485. PMID: 29725653.
      View in: PubMed
    17. Lionel AC, Costain G, Monfared N, Walker S, Reuter MS, Hosseini SM, Thiruvahindrapuram B, Merico D, Jobling R, Nalpathamkalam T, Pellecchia G, Sung WWL, Wang Z, Bikangaga P, Boelman C, Carter MT, Cordeiro D, Cytrynbaum C, Dell SD, Dhir P, Dowling JJ, Heon E, Hewson S, Hiraki L, Inbar-Feigenberg M, Klatt R, Kronick J, Laxer RM, Licht C, MacDonald H, Mercimek-Andrews S, Mendoza-Londono R, Piscione T, Schneider R, Schulze A, Silverman E, Siriwardena K, Snead OC, Sondheimer N, Sutherland J, Vincent A, Wasserman JD, Weksberg R, Shuman C, Carew C, Szego MJ, Hayeems RZ, Basran R, Stavropoulos DJ, Ray PN, Bowdin S, Meyn MS, Cohn RD, Scherer SW, Marshall CR. Improved diagnostic yield compared with targeted gene sequencing panels suggests a role for whole-genome sequencing as a first-tier genetic test. Genet Med. 2018 04; 20(4):435-443. PMID: 28771251.
      View in: PubMed
    18. Noone DG, Riedl M, Licht C. The role of von Willebrand factor in thrombotic microangiopathy. Pediatr Nephrol. 2018 08; 33(8):1297-1307. PMID: 28748411.
      View in: PubMed
    19. Kellett S, Lemaire M, Miller SP, Licht C, Yoon G, Dlamini N, Noone D. Neonatal stroke and haematuria: Questions. Pediatr Nephrol. 2018 05; 33(5):805-806. PMID: 28717936.
      View in: PubMed
    20. Kellett S, Lemaire M, Miller SP, Licht C, Yoon G, Dlamini N, Noone D. Neonatal stroke and haematuria: Answers. Pediatr Nephrol. 2018 05; 33(5):807-811. PMID: 28717939.
      View in: PubMed
    21. Carter S, van de Hoef D, Temple M, Harvey E, Al-Saleh S, Licht C, Noone D. Plastic bronchitis: a rare complication of long-term haemodialysis catheter placement in a child. Pediatr Nephrol. 2017 09; 32(9):1635-1638. PMID: 28642998.
      View in: PubMed
    22. Even-Or E, Di Mola M, Ali M, Courtney S, McDougall E, Alexander S, Schechter T, Whitlock JA, Licht C, Krueger J. Optimizing autologous nonmobilized mononuclear cell collections for cellular therapy in pediatric patients with high-risk leukemia. Transfusion. 2017 06; 57(6):1536-1542. PMID: 28439898.
      View in: PubMed
    23. Laskin BL, Huang G, King E, Geary DF, Licht C, Metlay JP, Furth SL, Kimball T, Mitsnefes M. Short, frequent, 5-days-per-week, in-center hemodialysis versus 3-days-per week treatment: a randomized crossover pilot trial through the Midwest Pediatric Nephrology Consortium. Pediatr Nephrol. 2017 Aug; 32(8):1423-1432. PMID: 28389745.
      View in: PubMed
    24. Borges K, Sibbald C, Hussain-Shamsy N, Vasilevska-Ristovska J, Banh T, Patel V, Brooke J, Piekut M, Reddon M, Aitken-Menezes K, McNaughton A, Pearl RJ, Langlois V, Radhakrishnan S, Licht CPB, Piscione TD, Levin L, Noone D, Hebert D, Parekh RS. Parental Health Literacy and Outcomes of Childhood Nephrotic Syndrome. Pediatrics. 2017 Mar; 139(3). PMID: 28213606.
      View in: PubMed
    25. Clark WF, Patriquin C, Licht C, Huang SH, Rock G. Simple diagnosis and treatment algorithm for adult thrombotic microangiopathy. Transfus Apher Sci. 2017 02; 56(1):50-51. PMID: 28139433.
      View in: PubMed
    26. Yea C, Bitnun A, Robinson J, Mineyko A, Barton M, Mah JK, Vajsar J, Richardson S, Licht C, Brophy J, Crone M, Desai S, Hukin J, Jones K, Muir K, Pernica JM, Pless R, Pohl D, Rafay MF, Selby K, Venkateswaran S, Bernard G, Yeh EA. Longitudinal Outcomes in the 2014 Acute Flaccid Paralysis Cluster in Canada. J Child Neurol. 2017 03; 32(3):301-307. PMID: 28193112.
      View in: PubMed
    27. Woodward L, Johnson S, Walle JV, Beck J, Gasteyger C, Licht C, Ariceta G. An innovative and collaborative partnership between patients with rare disease and industry-supported registries: the Global aHUS Registry. Orphanet J Rare Dis. 2016 11 21; 11(1):154. PMID: 27871301.
      View in: PubMed
    28. Even-Or E, Eden-Walker A, Di Mola M, McDougall E, Schechter T, Ali M, Svajger G, Gassas A, Licht C, Krueger J. Comparison of two apheresis systems for autologous stem cell collections in pediatric oncology patients. Transfusion. 2017 01; 57(1):122-130. PMID: 27696435.
      View in: PubMed
    29. Noone D, Hebert D, Licht C. Pathogenesis and treatment of ANCA-associated vasculitis-a role for complement. Pediatr Nephrol. 2018 Jan; 33(1):1-11. PMID: 27596099.
      View in: PubMed
    30. Riedl M, Noone DG, Khan MA, Pluthero FG, Kahr WHA, Palaniyar N, Licht C. Complement Activation Induces Neutrophil Adhesion and Neutrophil-Platelet Aggregate Formation on Vascular Endothelial Cells. Kidney Int Rep. 2017 Jan; 2(1):66-75. PMID: 29142942.
      View in: PubMed
    31. Banh TH, Hussain-Shamsy N, Patel V, Vasilevska-Ristovska J, Borges K, Sibbald C, Lipszyc D, Brooke J, Geary D, Langlois V, Reddon M, Pearl R, Levin L, Piekut M, Licht CP, Radhakrishnan S, Aitken-Menezes K, Harvey E, Hebert D, Piscione TD, Parekh RS. Ethnic Differences in Incidence and Outcomes of Childhood Nephrotic Syndrome. Clin J Am Soc Nephrol. 2016 10 07; 11(10):1760-1768. PMID: 27445165.
      View in: PubMed
    32. Noone DG, Riedl M, Pluthero FG, Bowman ML, Liszewski MK, Lu L, Quan Y, Balgobin S, Schneppenheim R, Schneppenheim S, Budde U, James P, Atkinson JP, Palaniyar N, Kahr WH, Licht C. Von Willebrand factor regulates complement on endothelial cells. Kidney Int. 2016 07; 90(1):123-34. PMID: 27236750.
      View in: PubMed
    33. Rousso S, Banh TM, Ackerman S, Piva E, Licht C, Harvey EA. Impact of fill volume on ultrafiltration with icodextrin in children on chronic peritoneal dialysis. Pediatr Nephrol. 2016 10; 31(10):1673-9. PMID: 27178072.
      View in: PubMed
    34. Teoh CW, Riedl M, Licht C. The alternative pathway of complement and the thrombotic microangiopathies. Transfus Apher Sci. 2016 Apr; 54(2):220-31. PMID: 27160864.
      View in: PubMed
    35. Yuen J, Pluthero FG, Douda DN, Riedl M, Cherry A, Ulanova M, Kahr WH, Palaniyar N, Licht C. NETosing Neutrophils Activate Complement Both on Their Own NETs and Bacteria via Alternative and Non-alternative Pathways. Front Immunol. 2016; 7:137. PMID: 27148258.
      View in: PubMed
    36. Riedl M, Thorner P, Licht C. C3 Glomerulopathy. Pediatr Nephrol. 2017 01; 32(1):43-57. PMID: 27056062.
      View in: PubMed
    37. Al-Ghaithi B, Chanchlani R, Riedl M, Thorner P, Licht C. C3 Glomerulopathy and post-infectious glomerulonephritis define a disease spectrum. Pediatr Nephrol. 2016 11; 31(11):2079-86. PMID: 27008643.
      View in: PubMed
    38. Borges K, Vasilevska-Ristovska J, Hussain-Shamsy N, Patel V, Banh T, Hebert D, Pearl RJ, Radhakrishnan S, Piscione TD, Licht CP, Langlois V, Levin L, Strug L, Parekh RS. Parental attitudes to genetic testing differ by ethnicity and immigration in childhood nephrotic syndrome: a cross-sectional study. Can J Kidney Health Dis. 2016; 3:16. PMID: 26998310.
      View in: PubMed
    39. Greenbaum LA, Fila M, Ardissino G, Al-Akash SI, Evans J, Henning P, Lieberman KV, Maringhini S, Pape L, Rees L, van de Kar NC, Vande Walle J, Ogawa M, Bedrosian CL, Licht C. Eculizumab is a safe and effective treatment in pediatric patients with atypical hemolytic uremic syndrome. Kidney Int. 2016 Mar; 89(3):701-11. PMID: 26880462.
      View in: PubMed
    40. Licht C, Ardissino G, Ariceta G, Cohen D, Cole JA, Gasteyger C, Greenbaum LA, Johnson S, Ogawa M, Schaefer F, Vande Walle J, Frémeaux-Bacchi V. The global aHUS registry: methodology and initial patient characteristics. BMC Nephrol. 2015 Dec 10; 16:207. PMID: 26654630.
      View in: PubMed
    41. Gipson DS, Troost JP, Lafayette RA, Hladunewich MA, Trachtman H, Gadegbeku CA, Sedor JR, Holzman LB, Moxey-Mims MM, Perumal K, Kaskel FJ, Nelson PJ, Tuttle KR, Bagnasco SM, Hogan MC, Dell KM, Appel GB, Lieske JC, Ilori TO, Sethna CB, Fervenza FC, Hogan SL, Nachman PH, Rosenberg AZ, Greenbaum LA, Meyers KE, Hewitt SM, Choi MJ, Kopp JB, Zhdanova O, Hodgin JB, Johnstone DB, Adler SG, Avila-Casado C, Neu AM, Hingorani SR, Lemley KV, Nast CC, Brady TM, Barisoni-Thomas L, Fornoni A, Jennette JC, Cattran DC, Palmer MB, Gibson KL, Reich HN, Mokrzycki MH, Sambandam KK, Zilleruelo GE, Licht C, Sampson MG, Song P, Mariani LH, Kretzler M. Complete Remission in the Nephrotic Syndrome Study Network. Clin J Am Soc Nephrol. 2016 Jan 07; 11(1):81-9. PMID: 26656320.
      View in: PubMed
    42. Caillaud C, Zaloszyc A, Licht C, Pichault V, Frémeaux-Bacchi V, Fischbach M. CFH gene mutation in a case of Shiga toxin-associated hemolytic uremic syndrome (STEC-HUS). Pediatr Nephrol. 2016 Jan; 31(1):157-61. PMID: 26399238.
      View in: PubMed
    43. Levy I, Licht C, Daneman A, Sochett E, Harrington J. The Impact of Hypoparathyroidism Treatment on the Kidney in Children: Long-Term Retrospective Follow-Up Study. J Clin Endocrinol Metab. 2015 Nov; 100(11):4106-13. PMID: 26323021.
      View in: PubMed
    44. Weisser C, Feber J, Tsampalieros A, Licht C. An atypical case of acute kidney injury: Hemolytic uremic syndrome (HUS). Pediatr Nephrol. 2016 Jun; 31(6):917, 919-21. PMID: 25877918.
      View in: PubMed
    45. Loirat C, Fakhouri F, Ariceta G, Besbas N, Bitzan M, Bjerre A, Coppo R, Emma F, Johnson S, Karpman D, Landau D, Langman CB, Lapeyraque AL, Licht C, Nester C, Pecoraro C, Riedl M, van de Kar NC, Van de Walle J, Vivarelli M, Frémeaux-Bacchi V. An international consensus approach to the management of atypical hemolytic uremic syndrome in children. Pediatr Nephrol. 2016 Jan; 31(1):15-39. PMID: 25859752.
      View in: PubMed
    46. Luzzatto L, Hollak CE, Cox TM, Schieppati A, Licht C, Kääriäinen H, Merlini G, Schaefer F, Simoens S, Pani L, Garattini S, Remuzzi G. Rare diseases and effective treatments: are we delivering? Lancet. 2015 Feb 28; 385(9970):750-2. PMID: 25752159.
      View in: PubMed
    47. Licht C, Greenbaum LA, Muus P, Babu S, Bedrosian CL, Cohen DJ, Delmas Y, Douglas K, Furman RR, Gaber OA, Goodship T, Herthelius M, Hourmant M, Legendre CM, Remuzzi G, Sheerin N, Trivelli A, Loirat C. Efficacy and safety of eculizumab in atypical hemolytic uremic syndrome from 2-year extensions of phase 2 studies. Kidney Int. 2015 May; 87(5):1061-73. PMID: 25651368.
      View in: PubMed
    48. Hayes W, Tschumi S, Ling SC, Feber J, Kirschfink M, Licht C. Eculizumab hepatotoxicity in pediatric aHUS. Pediatr Nephrol. 2015 May; 30(5):775-81. PMID: 25416628.
      View in: PubMed
    49. Chaturvedi S, Lipszyc DH, Licht C, Craig JC, Parekh R. Pharmacological interventions for hypertension in children. Evid Based Child Health. 2014 Sep; 9(3):498-580. PMID: 25236305.
      View in: PubMed
    50. Chaturvedi S, Lipszyc DH, Licht C, Craig JC, Parekh RS. Cochrane in context: pharmacological interventions for hypertension in children. Evid Based Child Health. 2014 Sep; 9(3):581-3. PMID: 25236306.
      View in: PubMed
    51. Riedl M, Fakhouri F, Le Quintrec M, Noone DG, Jungraithmayr TC, Fremeaux-Bacchi V, Licht C. Spectrum of complement-mediated thrombotic microangiopathies: pathogenetic insights identifying novel treatment approaches. Semin Thromb Hemost. 2014 Jun; 40(4):444-64. PMID: 24911558.
      View in: PubMed
    52. Johnson S, Stojanovic J, Ariceta G, Bitzan M, Besbas N, Frieling M, Karpman D, Landau D, Langman C, Licht C, Pecoraro C, Riedl M, Siomou E, van de Kar N, Walle JV, Loirat C, Taylor CM. An audit analysis of a guideline for the investigation and initial therapy of diarrhea negative (atypical) hemolytic uremic syndrome. Pediatr Nephrol. 2014 Oct; 29(10):1967-78. PMID: 24817340.
      View in: PubMed
    53. Licht C, Noone D. Treatment of DEAP-HUS--seeking the best strategy. Pediatr Nephrol. 2014 May; 29(5):941-2. PMID: 24526096.
      View in: PubMed
    54. Chaturvedi S, Lipszyc DH, Licht C, Craig JC, Parekh R. Pharmacological interventions for hypertension in children. Cochrane Database Syst Rev. 2014 Feb 01; (2):CD008117. PMID: 24488616.
      View in: PubMed
    55. Jodele S, Fukuda T, Vinks A, Mizuno K, Laskin BL, Goebel J, Dixon BP, Teusink A, Pluthero FG, Lu L, Licht C, Davies SM. Eculizumab therapy in children with severe hematopoietic stem cell transplantation-associated thrombotic microangiopathy. Biol Blood Marrow Transplant. 2014 Apr; 20(4):518-25. PMID: 24370861.
      View in: PubMed
    56. Noone D, Waters A, Pluthero FG, Geary DF, Kirschfink M, Zipfel PF, Licht C. Successful treatment of DEAP-HUS with eculizumab. Pediatr Nephrol. 2014 May; 29(5):841-51. PMID: 24249282.
      View in: PubMed
    57. Legendre CM, Licht C, Loirat C. Eculizumab in atypical hemolytic-uremic syndrome. N Engl J Med. 2013 10 03; 369(14):1379-80. PMID: 24088105.
      View in: PubMed
    58. Jobling RK, Kannu P, Licht C, Carter MT. The first report of nephrocalcinosis in a patient with a 16q23.1-16q23.3 deletion, global developmental delay, trigonocephaly, and portocaval shunt. Clin Dysmorphol. 2013 Oct; 22(4):152-5. PMID: 24326958.
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    59. Zhan X, Larson DE, Wang C, Koboldt DC, Sergeev YV, Fulton RS, Fulton LL, Fronick CC, Branham KE, Bragg-Gresham J, Jun G, Hu Y, Kang HM, Liu D, Othman M, Brooks M, Ratnapriya R, Boleda A, Grassmann F, von Strachwitz C, Olson LM, Buitendijk GH, Hofman A, van Duijn CM, Cipriani V, Moore AT, Shahid H, Jiang Y, Conley YP, Morgan DJ, Kim IK, Johnson MP, Cantsilieris S, Richardson AJ, Guymer RH, Luo H, Ouyang H, Licht C, Pluthero FG, Zhang MM, Zhang K, Baird PN, Blangero J, Klein ML, Farrer LA, DeAngelis MM, Weeks DE, Gorin MB, Yates JR, Klaver CC, Pericak-Vance MA, Haines JL, Weber BH, Wilson RK, Heckenlively JR, Chew EY, Stambolian D, Mardis ER, Swaroop A, Abecasis GR. Identification of a rare coding variant in complement 3 associated with age-related macular degeneration. Nat Genet. 2013 Nov; 45(11):1375-9. PMID: 24036949.
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    60. Samuel S, Morgan CJ, Bitzan M, Mammen C, Dart AB, Manns BJ, Alexander RT, Erickson RL, Grisaru S, Wade AW, Blydt-Hansen T, Feber J, Arora S, Licht C, Zappitelli M. Substantial practice variation exists in the management of childhood nephrotic syndrome. Pediatr Nephrol. 2013 Dec; 28(12):2289-98. PMID: 23917450.
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    61. Tati R, Kristoffersson AC, Ståhl AL, Rebetz J, Wang L, Licht C, Motto D, Karpman D. Complement activation associated with ADAMTS13 deficiency in human and murine thrombotic microangiopathy. J Immunol. 2013 Sep 01; 191(5):2184-93. PMID: 23878316.
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    62. Jodele S, Licht C, Goebel J, Dixon BP, Zhang K, Sivakumaran TA, Davies SM, Pluthero FG, Lu L, Laskin BL. Abnormalities in the alternative pathway of complement in children with hematopoietic stem cell transplant-associated thrombotic microangiopathy. Blood. 2013 Sep 19; 122(12):2003-7. PMID: 23814021.
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    63. Legendre CM, Licht C, Muus P, Greenbaum LA, Babu S, Bedrosian C, Bingham C, Cohen DJ, Delmas Y, Douglas K, Eitner F, Feldkamp T, Fouque D, Furman RR, Gaber O, Herthelius M, Hourmant M, Karpman D, Lebranchu Y, Mariat C, Menne J, Moulin B, Nürnberger J, Ogawa M, Remuzzi G, Richard T, Sberro-Soussan R, Severino B, Sheerin NS, Trivelli A, Zimmerhackl LB, Goodship T, Loirat C. Terminal complement inhibitor eculizumab in atypical hemolytic-uremic syndrome. N Engl J Med. 2013 Jun 06; 368(23):2169-81. PMID: 23738544.
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    64. Weitz M, Licht C, Müller M, Haber P. Renal ultrasound volume in children with primary vesicoureteral reflux allows functional assessment. J Pediatr Urol. 2013 Dec; 9(6 Pt B):1077-83. PMID: 23639632.
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    65. Noone D, Licht C. Chronic kidney disease: a new look at pathogenetic mechanisms and treatment options. Pediatr Nephrol. 2014 May; 29(5):779-92. PMID: 23471475.
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    66. Gibson P, Shammas A, Cada M, Licht C, Gupta AA. The role of Tc-99m-DTPA nuclear medicine GFR studies in pediatric solid tumor patients. J Pediatr Hematol Oncol. 2013 Mar; 35(2):108-11. PMID: 22767127.
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    67. Filler G, Licht C, Haig A. Native kidney BK virus nephropathy associated with acute lymphocytic leukemia. Pediatr Nephrol. 2013 Jun; 28(6):979-81. PMID: 23443506.
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    68. Hussain N, Zello JA, Vasilevska-Ristovska J, Banh TM, Patel VP, Patel P, Battiston CD, Hebert D, Licht CP, Piscione TD, Parekh RS. The rationale and design of Insight into Nephrotic Syndrome: Investigating Genes, Health and Therapeutics (INSIGHT): a prospective cohort study of childhood nephrotic syndrome. BMC Nephrol. 2013 Jan 26; 14:25. PMID: 23351121.
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    69. Heinen S, Pluthero FG, van Eimeren VF, Quaggin SE, Licht C. Monitoring and modeling treatment of atypical hemolytic uremic syndrome. Mol Immunol. 2013 May; 54(1):84-8. PMID: 23220071.
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    70. Noone D, Licht C. An update on the pathomechanisms and future therapies of Alport syndrome. Pediatr Nephrol. 2013 Jul; 28(7):1025-36. PMID: 22903660.
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    71. Wei CC, Wang W, Smoyer WE, Licht C. Trends in pediatric primary membranoproliferative glomerulonephritis costs and complications. Pediatr Nephrol. 2012 Dec; 27(12):2243-50. PMID: 22802081.
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    72. Noone D, Al-Matrafi J, Tinckam K, Zipfel PF, Herzenberg AM, Thorner PS, Pluthero FG, Kahr WH, Filler G, Hebert D, Harvey E, Licht C. Antibody mediated rejection associated with complement factor h-related protein 3/1 deficiency successfully treated with eculizumab. Am J Transplant. 2012 Sep; 12(9):2546-53. PMID: 22681773.
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    73. Radhakrishnan S, Lunn A, Kirschfink M, Thorner P, Hebert D, Langlois V, Pluthero F, Licht C. Eculizumab and refractory membranoproliferative glomerulonephritis. N Engl J Med. 2012 Mar 22; 366(12):1165-6. PMID: 22435384.
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    74. Temme J, Peters F, Lange K, Pirson Y, Heidet L, Torra R, Grunfeld JP, Weber M, Licht C, Müller GA, Gross O. Incidence of renal failure and nephroprotection by RAAS inhibition in heterozygous carriers of X-chromosomal and autosomal recessive Alport mutations. Kidney Int. 2012 Apr; 81(8):779-83. PMID: 22237748.
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    75. Gross O, Licht C, Anders HJ, Hoppe B, Beck B, Tönshoff B, Höcker B, Wygoda S, Ehrich JH, Pape L, Konrad M, Rascher W, Dötsch J, Müller-Wiefel DE, Hoyer P, Knebelmann B, Pirson Y, Grunfeld JP, Niaudet P, Cochat P, Heidet L, Lebbah S, Torra R, Friede T, Lange K, Müller GA, Weber M. Early angiotensin-converting enzyme inhibition in Alport syndrome delays renal failure and improves life expectancy. Kidney Int. 2012 Mar; 81(5):494-501. PMID: 22166847.
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    76. Piscione TD, Licht C. Genetics of proteinuria: an overview of gene mutations associated with nonsyndromic proteinuric glomerulopathies. Adv Chronic Kidney Dis. 2011 Jul; 18(4):273-89. PMID: 21782134.
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    77. Kanbur N, Pinhas L, Lorenzo A, Farhat W, Licht C, Katzman DK. Nocturnal enuresis in adolescents with anorexia nervosa: prevalence, potential causes, and pathophysiology. Int J Eat Disord. 2011 May; 44(4):349-55. PMID: 20354997.
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    78. Chaturvedi S, Brandao L, Geary D, Licht C. Primary antiphospholipid syndrome presenting as renal vein thrombosis and membranous nephropathy. Pediatr Nephrol. 2011 Jun; 26(6):979-85. PMID: 21431428.
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    79. Allen U, Licht C. Pandemic H1N1 influenza A infection and (atypical) HUS--more than just another trigger? Pediatr Nephrol. 2011 Jan; 26(1):3-5. PMID: 21057815.
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    80. El-Hout Y, Licht C, Pippi Salle JL, Ngan BY, Bagli DJ, Lorenzo AJ, Farhat WA. Hypertension in children with poorly functioning unilateral kidneys: predictors of resolution after nephrectomy. BJU Int. 2010 Nov; 106(9):1376-80. PMID: 20394620.
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    81. Wine E, Shen-Tu G, Gareau MG, Goldberg HA, Licht C, Ngan BY, Sorensen ES, Greenaway J, Sodek J, Zohar R, Sherman PM. Osteopontin mediates Citrobacter rodentium-induced colonic epithelial cell hyperplasia and attaching-effacing lesions. Am J Pathol. 2010 Sep; 177(3):1320-32. PMID: 20651246.
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    82. Neuhaus TJ, Langlois V, Licht C. Behavioural abnormalities in children with nephrotic syndrome--an underappreciated complication of a standard treatment? Nephrol Dial Transplant. 2010 Aug; 25(8):2397-9. PMID: 20573807.
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    83. Waters AM, Licht C. aHUS caused by complement dysregulation: new therapies on the horizon. Pediatr Nephrol. 2011 Jan; 26(1):41-57. PMID: 20556434.
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    84. Lemaire M, Connolly B, Harvey E, Licht C. Treatment of paediatric vancomycin intoxication: a case report and review of the literature. NDT Plus. 2010 Jun; 3(3):260-264. PMID: 28657057.
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    85. Zipfel PF, Mache C, Müller D, Licht C, Wigger M, Skerka C. DEAP-HUS: deficiency of CFHR plasma proteins and autoantibody-positive form of hemolytic uremic syndrome. Pediatr Nephrol. 2010 Oct; 25(10):2009-19. PMID: 20157737.
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    86. Chaturvedi S, Licht C, Langlois V. Hemolytic uremic syndrome caused by Bordetella pertussis infection. Pediatr Nephrol. 2010 Jul; 25(7):1361-4. PMID: 20145955.
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    87. De S, Waters AM, Segal AO, Trautmann A, Harvey EA, Licht C. Severe atypical HUS caused by CFH S1191L--case presentation and review of treatment options. Pediatr Nephrol. 2010 Jan; 25(1):97-104. PMID: 19856002.
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    88. Licht C, Pluthero FG, Li L, Christensen H, Habbig S, Hoppe B, Geary DF, Zipfel PF, Kahr WH. Platelet-associated complement factor H in healthy persons and patients with atypical HUS. Blood. 2009 Nov 12; 114(20):4538-45. PMID: 19704120.
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    89. Skerka C, Licht C, Mengel M, Uzonyi B, Strobel S, Zipfel PF, Józsi M. Autoimmune forms of thrombotic microangiopathy and membranoproliferative glomerulonephritis: Indications for a disease spectrum and common pathogenic principles. Mol Immunol. 2009 Sep; 46(14):2801-7. PMID: 19640589.
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    90. Licht C, Fremeaux-Bacchi V. Hereditary and acquired complement dysregulation in membranoproliferative glomerulonephritis. Thromb Haemost. 2009 Feb; 101(2):271-8. PMID: 19190809.
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    91. Gross O, Borza DB, Anders HJ, Licht C, Weber M, Segerer S, Torra R, Gubler MC, Heidet L, Harvey S, Cosgrove D, Lees G, Kashtan C, Gregory M, Savige J, Ding J, Thorner P, Abrahamson DR, Antignac C, Tryggvason K, Hudson B, Miner JH. Stem cell therapy for Alport syndrome: the hope beyond the hype. Nephrol Dial Transplant. 2009 Mar; 24(3):731-4. PMID: 19110486.
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    92. Lemaire M, Chitayat D, Geary DF, Bichet DG, Licht C. A novel disease-causing mutation in AVPR2: Q96H. NDT Plus. 2009 Feb; 2(1):20-2. PMID: 25949277.
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    93. De S, Al-Nabhani D, Thorner P, Cattran D, Piscione TD, Licht C. Remission of resistant MPGN type I with mycophenolate mofetil and steroids. Pediatr Nephrol. 2009 Mar; 24(3):597-600. PMID: 18972137.
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    94. Ariceta G, Besbas N, Johnson S, Karpman D, Landau D, Licht C, Loirat C, Pecoraro C, Taylor CM, Van de Kar N, Vandewalle J, Zimmerhackl LB. Guideline for the investigation and initial therapy of diarrhea-negative hemolytic uremic syndrome. Pediatr Nephrol. 2009 Apr; 24(4):687-96. PMID: 18800230.
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    95. Gerth C, Zawadzki RJ, Licht C, Werner JS, Héon E. A microstructural retinal analysis of membrano-proliferative glomerulonephritis type II. Br J Ophthalmol. 2008 Aug; 92(8):1150-1. PMID: 18653610.
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    96. Habbig S, Mihatsch MJ, Heinen S, Beck B, Emmel M, Skerka C, Kirschfink M, Hoppe B, Zipfel PF, Licht C. C3 deposition glomerulopathy due to a functional factor H defect. Kidney Int. 2009 Jun; 75(11):1230-1234. PMID: 18633337.
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    97. Józsi M, Licht C, Strobel S, Zipfel SL, Richter H, Heinen S, Zipfel PF, Skerka C. Factor H autoantibodies in atypical hemolytic uremic syndrome correlate with CFHR1/CFHR3 deficiency. Blood. 2008 Feb 01; 111(3):1512-4. PMID: 18006700.
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    98. Smith RJ, Alexander J, Barlow PN, Botto M, Cassavant TL, Cook HT, de Córdoba SR, Hageman GS, Jokiranta TS, Kimberling WJ, Lambris JD, Lanning LD, Levidiotis V, Licht C, Lutz HU, Meri S, Pickering MC, Quigg RJ, Rops AL, Salant DJ, Sethi S, Thurman JM, Tully HF, Tully SP, van der Vlag J, Walker PD, Würzner R, Zipfel PF. New approaches to the treatment of dense deposit disease. J Am Soc Nephrol. 2007 Sep; 18(9):2447-56. PMID: 17675665.
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    99. Zipfel PF, Edey M, Heinen S, Józsi M, Richter H, Misselwitz J, Hoppe B, Routledge D, Strain L, Hughes AE, Goodship JA, Licht C, Goodship TH, Skerka C. Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome. PLoS Genet. 2007 Mar 16; 3(3):e41. PMID: 17367211.
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    100. Wolf MT, Beck BB, Zaucke F, Kunze A, Misselwitz J, Ruley J, Ronda T, Fischer A, Eifinger F, Licht C, Otto E, Hoppe B, Hildebrandt F. The Uromodulin C744G mutation causes MCKD2 and FJHN in children and adults and may be due to a possible founder effect. Kidney Int. 2007 Mar; 71(6):574-81. PMID: 17245395.
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    101. Dörbecker C, Licht C, Körber F, Plum G, Haefs C, Hoppe B, Seifert H. Community-acquired pneumonia due to Bordetella holmesii in a patient with frequently relapsing nephrotic syndrome. J Infect. 2007 Apr; 54(4):e203-5. PMID: 17174401.
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    102. Licht C, Schlötzer-Schrehardt U, Kirschfink M, Zipfel PF, Hoppe B. MPGN II--genetically determined by defective complement regulation? Pediatr Nephrol. 2007 Jan; 22(1):2-9. PMID: 17024390.
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    103. Licht C, Heinen S, Józsi M, Löschmann I, Saunders RE, Perkins SJ, Waldherr R, Skerka C, Kirschfink M, Hoppe B, Zipfel PF. Deletion of Lys224 in regulatory domain 4 of Factor H reveals a novel pathomechanism for dense deposit disease (MPGN II). Kidney Int. 2006 Jul; 70(1):42-50. PMID: 16612335.
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    104. Zipfel PF, Misselwitz J, Licht C, Skerka C. The role of defective complement control in hemolytic uremic syndrome. Semin Thromb Hemost. 2006 Mar; 32(2):146-54. PMID: 16575689.
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    105. von Schnakenburg C, Feneberg R, Plank C, Zimmering M, Arbeiter K, Bald M, Fehrenbach H, Griebel M, Licht C, Konrad M, Timmermann K, Kemper MJ. Percutaneous endoscopic gastrostomy in children on peritoneal dialysis. Perit Dial Int. 2006 Jan-Feb; 26(1):69-77. PMID: 16538878.
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    106. Józsi M, Heinen S, Hartmann A, Ostrowicz CW, Hälbich S, Richter H, Kunert A, Licht C, Saunders RE, Perkins SJ, Zipfel PF, Skerka C. Factor H and atypical hemolytic uremic syndrome: mutations in the C-terminus cause structural changes and defective recognition functions. J Am Soc Nephrol. 2006 Jan; 17(1):170-7. PMID: 16338962.
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    107. Müller A, Beck B, Theilemann K, Stapenhorst L, Licht C, Michalk D, Franzen C, Hoppe B. Detection of polyomavirus BK and JC in children with kidney diseases and renal transplant recipients. Pediatr Infect Dis J. 2005 Sep; 24(9):778-81. PMID: 16148843.
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    108. Licht C, Weyersberg A, Heinen S, Stapenhorst L, Devenge J, Beck B, Waldherr R, Kirschfink M, Zipfel PF, Hoppe B. Successful plasma therapy for atypical hemolytic uremic syndrome caused by factor H deficiency owing to a novel mutation in the complement cofactor protein domain 15. Am J Kidney Dis. 2005 Feb; 45(2):415-21. PMID: 15685522.
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    109. Licht C, Stapenhorst L, Simon T, Budde U, Schneppenheim R, Hoppe B. Two novel ADAMTS13 gene mutations in thrombotic thrombocytopenic purpura/hemolytic-uremic syndrome (TTP/HUS). Kidney Int. 2004 Sep; 66(3):955-8. PMID: 15327386.
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    110. Licht C, Hell K, Eifinger F, Hoppe B, Querfeld U. Posttransplant lymphoproliferative disease in a child: clinical and molecular characterization. Pediatr Nephrol. 2002 Feb; 17(2):79-84. PMID: 11875668.
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