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Andrea Kassner

TitleSenior Scientist
InstitutionThe Hospital for Sick Children
DepartmentTranslational Medicine
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Cahill LS, Pilmeyer J, Yu LX, Steinman J, Hare GMT, Kassner A, Macgowan CK, Sled JG. Ultrasound Detection of Abnormal Cerebrovascular Morphology in a Mouse Model of Sickle Cell Disease Based on Wave Reflection. Ultrasound Med Biol. 2019 Sep 26. PMID: 31563480.
      View in: PubMed
    2. Kapustin D, Leung J, Odame I, Williams S, Shroff M, Kassner A. Hydroxycarbamide treatment in children with Sickle Cell Anaemia is associated with more intact white matter integrity: a quantitative MRI study. Br J Haematol. 2019 Oct; 187(2):238-245. PMID: 31215028.
      View in: PubMed
    3. Croal PL, Leung J, Phillips CL, Serafin MG, Kassner A. Quantification of pathophysiological alterations in venous oxygen saturation: A comparison of global MR susceptometry techniques. Magn Reson Imaging. 2019 05; 58:18-23. PMID: 30639755.
      View in: PubMed
    4. Dlamini N, Shah-Basak P, Leung J, Kirkham F, Shroff M, Kassner A, Robertson A, Dirks P, Westmacott R, deVeber G, Logan W. Breath-Hold Blood Oxygen Level-Dependent MRI: A Tool for the Assessment of Cerebrovascular Reserve in Children with Moyamoya Disease. AJNR Am J Neuroradiol. 2018 09; 39(9):1717-1723. PMID: 30139753.
      View in: PubMed
    5. Croal PL, Leung J, Kosinski P, Shroff M, Odame I, Kassner A. Assessment of cerebral blood flow with magnetic resonance imaging in children with sickle cell disease: A quantitative comparison with transcranial Doppler ultrasonography. Brain Behav. 2017 11; 7(11):e00811. PMID: 29201539.
      View in: PubMed
    6. Eftekhari E, Hojjat SP, Vitorino R, Carroll TJ, Cantrell CG, Lee L, Taylor MW, Morrow SA, Benhabib H, Aviv RI, Kassner A. Normal appearing white matter permeability: a marker of inflammation and information processing speed deficit among relapsing remitting multiple sclerosis patients. Neuroradiology. 2017 Aug; 59(8):771-780. PMID: 28623483.
      View in: PubMed
    7. Merali Z, Huang K, Mikulis D, Silver F, Kassner A. Evolution of blood-brain-barrier permeability after acute ischemic stroke. PLoS One. 2017; 12(2):e0171558. PMID: 28207745.
      View in: PubMed
    8. Domi T, Vossough A, Stence NV, Felling RJ, Leung J, Krishnan P, Watson CG, Grant PE, Kassner A. The Potential for Advanced Magnetic Resonance Neuroimaging Techniques in Pediatric Stroke Research. Pediatr Neurol. 2017 04; 69:24-36. PMID: 28237248.
      View in: PubMed
    9. Dlamini N, Yau I, Westmacott R, Shroff M, Armstrong D, Logan W, Mikulis D, deVeber G, Kassner A. Cerebrovascular Reactivity and Intellectual Outcome in Childhood Stroke With Transient Cerebral Arteriopathy. Pediatr Neurol. 2017 04; 69:71-78. PMID: 28258787.
      View in: PubMed
    10. Kosinski PD, Croal PL, Leung J, Williams S, Odame I, Hare GM, Shroff M, Kassner A. The severity of anaemia depletes cerebrovascular dilatory reserve in children with sickle cell disease: a quantitative magnetic resonance imaging study. Br J Haematol. 2017 Jan; 176(2):280-287. PMID: 27905100.
      View in: PubMed
    11. Leung J, Duffin J, Fisher JA, Kassner A. MRI-based cerebrovascular reactivity using transfer function analysis reveals temporal group differences between patients with sickle cell disease and healthy controls. Neuroimage Clin. 2016; 12:624-630. PMID: 27722086.
      View in: PubMed
    12. Cahill LS, Gazdzinski LM, Tsui AK, Zhou YQ, Portnoy S, Liu E, Mazer CD, Hare GM, Kassner A, Sled JG. Functional and anatomical evidence of cerebral tissue hypoxia in young sickle cell anemia mice. J Cereb Blood Flow Metab. 2017 Mar; 37(3):994-1005. PMID: 27165012.
      View in: PubMed
    13. Kim JA, Leung J, Lerch JP, Kassner A. Reduced cerebrovascular reserve is regionally associated with cortical thickness reductions in children with sickle cell disease. Brain Res. 2016 07 01; 1642:263-269. PMID: 27026656.
      View in: PubMed
    14. Leung J, Kosinski PD, Croal PL, Kassner A. Developmental trajectories of cerebrovascular reactivity in healthy children and young adults assessed with magnetic resonance imaging. J Physiol. 2016 05 15; 594(10):2681-9. PMID: 26847953.
      View in: PubMed
    15. Kassner A, Merali Z. Assessment of Blood-Brain Barrier Disruption in Stroke. Stroke. 2015 Nov; 46(11):3310-5. PMID: 26463696.
      View in: PubMed
    16. Leung J, Kim JA, Kassner A. Reproducibility of cerebrovascular reactivity measures in children using BOLD MRI. J Magn Reson Imaging. 2016 May; 43(5):1191-5. PMID: 26435493.
      View in: PubMed
    17. Merali Z, Wong T, Leung J, Gao MM, Mikulis D, Kassner A. Dynamic contrast-enhanced MRI and CT provide comparable measurement of blood-brain barrier permeability in a rodent stroke model. Magn Reson Imaging. 2015 Oct; 33(8):1007-12. PMID: 26117703.
      View in: PubMed
    18. Nasui OC, Chan MW, Nathanael G, Crawley A, Miller E, Belik J, Cheng HL, Kassner A, Rayner T, Weiss R, Detzler G, Zhong A, Moineddin R, Jong R, Rogers M, Doria AS. Physiologic characterization of inflammatory arthritis in a rabbit model with BOLD and DCE MRI at 1.5 Tesla. Eur Radiol. 2014 Nov; 24(11):2766-78. PMID: 25187381.
      View in: PubMed
    19. Merali Z, Leung J, Mikulis D, Silver F, Kassner A. Longitudinal assessment of imatinib's effect on the blood-brain barrier after ischemia/reperfusion injury with permeability MRI. Transl Stroke Res. 2015 Feb; 6(1):39-49. PMID: 25146090.
      View in: PubMed
    20. Merali Z, Gao MM, Bowes T, Chen J, Evans K, Kassner A. Neuroproteome changes after ischemia/reperfusion injury and tissue plasminogen activator administration in rats: a quantitative iTRAQ proteomics study. PLoS One. 2014; 9(5):e98706. PMID: 24879061.
      View in: PubMed
    21. Behpour AM, Shah PS, Mikulis DJ, Kassner A. Cerebral blood flow abnormalities in children with sickle cell disease: a systematic review. Pediatr Neurol. 2013 Mar; 48(3):188-99. PMID: 23419469.
      View in: PubMed
    22. Leung J, Behpour A, Sokol N, Mohanta A, Kassner A. Assessment of intracranial blood flow velocities using a computer controlled vasoactive stimulus: a comparison between phase contrast magnetic resonance angiography and transcranial Doppler ultrasonography. J Magn Reson Imaging. 2013 Sep; 38(3):733-8. PMID: 23148038.
      View in: PubMed
    23. Fierstra J, Winter JD, Machina M, Lukovic J, Duffin J, Kassner A, Fisher JA. Non-invasive accurate measurement of arterial PCO2 in a pediatric animal model. J Clin Monit Comput. 2013 Apr; 27(2):147-55. PMID: 23100168.
      View in: PubMed
    24. Winter JD, Dorner S, Lukovic J, Fisher JA, St Lawrence KS, Kassner A. Noninvasive MRI measures of microstructural and cerebrovascular changes during normal swine brain development. Pediatr Res. 2011 May; 69(5 Pt 1):418-24. PMID: 21258264.
      View in: PubMed
    25. Han JS, Mikulis DJ, Mardimae A, Kassner A, Poublanc J, Crawley AP, deVeber GA, Fisher JA, Logan WJ. Measurement of cerebrovascular reactivity in pediatric patients with cerebral vasculopathy using blood oxygen level-dependent MRI. Stroke. 2011 May; 42(5):1261-9. PMID: 21493907.
      View in: PubMed
    26. Kassner A, Mandell DM, Mikulis DJ. Measuring permeability in acute ischemic stroke. Neuroimaging Clin N Am. 2011 May; 21(2):315-25, x-xi. PMID: 21640302.
      View in: PubMed
    27. Kassner A, Thornhill R. Measuring the integrity of the human blood-brain barrier using magnetic resonance imaging. Methods Mol Biol. 2011; 686:229-45. PMID: 21082374.
      View in: PubMed
    28. Winter JD, Fierstra J, Dorner S, Fisher JA, St Lawrence KS, Kassner A. Feasibility and precision of cerebral blood flow and cerebrovascular reactivity MRI measurements using a computer-controlled gas delivery system in an anesthetised juvenile animal model. J Magn Reson Imaging. 2010 Nov; 32(5):1068-75. PMID: 21031510.
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    29. Mahmoodabadi SZ, Alirezaie J, Babyn P, Kassner A, Widjaja E. Wavelets and fuzzy relational classifiers: a novel diffusion-weighted image analysis system for pediatric metabolic brain diseases. Comput Methods Programs Biomed. 2011 Aug; 103(2):74-86. PMID: 20674064.
      View in: PubMed
    30. Liu F, Vidarsson L, Winter JD, Tran H, Kassner A. Sex differences in the human corpus callosum microstructure: a combined T2 myelin-water and diffusion tensor magnetic resonance imaging study. Brain Res. 2010 Jul 09; 1343:37-45. PMID: 20435024.
      View in: PubMed
    31. Kassner A, Thornhill RE, Liu F, Winter PM, Caruthers SD, Wickline SA, Lanza GM. Assessment of tumor angiogenesis: dynamic contrast-enhanced MRI with paramagnetic nanoparticles compared with Gd-DTPA in a rabbit Vx-2 tumor model. Contrast Media Mol Imaging. 2010 May-Jun; 5(3):155-61. PMID: 20586031.
      View in: PubMed
    32. Kassner A, Thornhill RE. Texture analysis: a review of neurologic MR imaging applications. AJNR Am J Neuroradiol. 2010 May; 31(5):809-16. PMID: 20395383.
      View in: PubMed
    33. Thornhill RE, Chen S, Rammo W, Mikulis DJ, Kassner A. Contrast-enhanced MR imaging in acute ischemic stroke: T2* measures of blood-brain barrier permeability and their relationship to T1 estimates and hemorrhagic transformation. AJNR Am J Neuroradiol. 2010 Jun; 31(6):1015-22. PMID: 20190209.
      View in: PubMed
    34. Kassner A, Winter JD, Poublanc J, Mikulis DJ, Crawley AP. Blood-oxygen level dependent MRI measures of cerebrovascular reactivity using a controlled respiratory challenge: reproducibility and gender differences. J Magn Reson Imaging. 2010 Feb; 31(2):298-304. PMID: 20099341.
      View in: PubMed
    35. Andreisek G, White LM, Kassner A, Sussman MS. Evaluation of diffusion tensor imaging and fiber tractography of the median nerve: preliminary results on intrasubject variability and precision of measurements. AJR Am J Roentgenol. 2010 Jan; 194(1):W65-72. PMID: 20028893.
      View in: PubMed
    36. Kassner A, Liu F, Thornhill RE, Tomlinson G, Mikulis DJ. Prediction of hemorrhagic transformation in acute ischemic stroke using texture analysis of postcontrast T1-weighted MR images. J Magn Reson Imaging. 2009 Nov; 30(5):933-41. PMID: 19856407.
      View in: PubMed
    37. Wu S, Thornhill RE, Chen S, Rammo W, Mikulis DJ, Kassner A. Relative recirculation: a fast, model-free surrogate for the measurement of blood-brain barrier permeability and the prediction of hemorrhagic transformation in acute ischemic stroke. Invest Radiol. 2009 Oct; 44(10):662-8. PMID: 19724234.
      View in: PubMed
    38. Vidarsson L, Thornhill RE, Liu F, Mikulis DJ, Kassner A. Quantitative permeability magnetic resonance imaging in acute ischemic stroke: how long do we need to scan? Magn Reson Imaging. 2009 Nov; 27(9):1216-22. PMID: 19695816.
      View in: PubMed
    39. Kassner A, Roberts TP, Moran B, Silver FL, Mikulis DJ. Recombinant tissue plasminogen activator increases blood-brain barrier disruption in acute ischemic stroke: an MR imaging permeability study. AJNR Am J Neuroradiol. 2009 Nov; 30(10):1864-9. PMID: 19661169.
      View in: PubMed
    40. Winter JD, Poublanc J, Crawley AP, Kassner A. Comparison of spiral imaging and SENSE-EPI at 1.5 and 3.0 T using a controlled cerebrovascular challenge. J Magn Reson Imaging. 2009 May; 29(5):1206-10. PMID: 19388098.
      View in: PubMed
    41. Andreisek G, White LM, Kassner A, Tomlinson G, Sussman MS. Diffusion tensor imaging and fiber tractography of the median nerve at 1.5T: optimization of b value. Skeletal Radiol. 2009 Jan; 38(1):51-9. PMID: 18773203.
      View in: PubMed
    42. Saupe N, White LM, Sussman MS, Kassner A, Tomlinson G, Noseworthy MD. Diffusion tensor magnetic resonance imaging of the human calf: comparison between 1.5 T and 3.0 T-preliminary results. Invest Radiol. 2008 Sep; 43(9):612-8. PMID: 18708854.
      View in: PubMed
    43. Mandell DM, Han JS, Poublanc J, Crawley AP, Kassner A, Fisher JA, Mikulis DJ. Selective reduction of blood flow to white matter during hypercapnia corresponds with leukoaraiosis. Stroke. 2008 Jul; 39(7):1993-8. PMID: 18451357.
      View in: PubMed
    44. Widjaja E, Blaser S, Miller E, Kassner A, Shannon P, Chuang SH, Snead OC, Raybaud CR. Evaluation of subcortical white matter and deep white matter tracts in malformations of cortical development. Epilepsia. 2007 Aug; 48(8):1460-9. PMID: 17441991.
      View in: PubMed
    45. Roberts TP, Liu F, Kassner A, Mori S, Guha A. Fiber density index correlates with reduced fractional anisotropy in white matter of patients with glioblastoma. AJNR Am J Neuroradiol. 2005 Oct; 26(9):2183-6. PMID: 16219820.
      View in: PubMed
    46. Kassner A, Roberts T, Taylor K, Silver F, Mikulis D. Prediction of hemorrhage in acute ischemic stroke using permeability MR imaging. AJNR Am J Neuroradiol. 2005 Oct; 26(9):2213-7. PMID: 16219824.
      View in: PubMed
    47. Mikulis DJ, Krolczyk G, Desal H, Logan W, Deveber G, Dirks P, Tymianski M, Crawley A, Vesely A, Kassner A, Preiss D, Somogyi R, Fisher JA. Preoperative and postoperative mapping of cerebrovascular reactivity in moyamoya disease by using blood oxygen level-dependent magnetic resonance imaging. J Neurosurg. 2005 Aug; 103(2):347-55. PMID: 16175867.
      View in: PubMed
    48. Kassner A, Roberts TP. Beyond perfusion: cerebral vascular reactivity and assessment of microvascular permeability. Top Magn Reson Imaging. 2004 Feb; 15(1):58-65. PMID: 15057173.
      View in: PubMed
    49. Winter PM, Caruthers SD, Kassner A, Harris TD, Chinen LK, Allen JS, Lacy EK, Zhang H, Robertson JD, Wickline SA, Lanza GM. Molecular imaging of angiogenesis in nascent Vx-2 rabbit tumors using a novel alpha(nu)beta3-targeted nanoparticle and 1.5 tesla magnetic resonance imaging. Cancer Res. 2003 Sep 15; 63(18):5838-43. PMID: 14522907.
      View in: PubMed
    50. Kassner A, Zhu XP, Li KL, Jackson A. Neoangiogenesis in association with moyamoya syndrome shown by estimation of relative recirculation based on dynamic contrast-enhanced MR images. AJNR Am J Neuroradiol. 2003 May; 24(5):810-8. PMID: 12748076.
      View in: PubMed
    51. Jackson A, Kassner A, Annesley-Williams D, Reid H, Zhu XP, Li KL. Abnormalities in the recirculation phase of contrast agent bolus passage in cerebral gliomas: comparison with relative blood volume and tumor grade. AJNR Am J Neuroradiol. 2002 Jan; 23(1):7-14. PMID: 11827869.
      View in: PubMed
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