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Mark Friedberg

TitleStaff Cardiologist, Echocardiography
InstitutionThe Hospital for Sick Children
DepartmentHeart Centre - Cardiology Div. Physicians Fellows & Secretaries
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Yamamura K, Yuen D, Hickey EJ, He X, Chaturvedi RR, Friedberg MK, Grosse-Wortmann L, Hanneman K, Billia F, Farkouh ME, Wald RM. Right ventricular fibrosis is associated with cardiac remodelling after pulmonary valve replacement. Heart. 2018 Dec 04. PMID: 30514732.
      View in: PubMed
    2. Grotenhuis HB, Dallaire F, Verpalen IM, van den Akker MJE, Mertens L, Friedberg MK. Aortic Root Dilatation and Aortic-Related Complications in Children After Tetralogy of Fallot Repair. Circ Cardiovasc Imaging. 2018 Dec; 11(12):e007611. PMID: 30562107.
      View in: PubMed
    3. Driessen MMP, Leiner T, Sieswerda GT, van Dijk APJ, Post MC, Friedberg MK, Mertens L, Doevendans PA, Snijder RJ, Hulzebos EH, Meijboom FJ. RV adaptation to increased afterload in congenital heart disease and pulmonary hypertension. PLoS One. 2018; 13(10):e0205196. PMID: 30356250.
      View in: PubMed
    4. Rösner A, Khalapyan T, Pedrosa J, Dalen H, McElhinney DB, Friedberg MK, Lui GK. Ventricular mechanics in adolescent and adult patients with a Fontan circulation: Relation to geometry and wall stress. Echocardiography. 2018 12; 35(12):2035-2046. PMID: 30350438.
      View in: PubMed
    5. Lopez C, Mertens L, Dragulescu A, Landeck B, Younoszai A, Friedberg MK, Hunter K, Di Maria MV. Strain and Rotational Mechanics in Children With Single Left Ventricles After Fontan. J Am Soc Echocardiogr. 2018 Oct 18. PMID: 30344011.
      View in: PubMed
    6. Grattan M, Mertens L, Grosse-Wortmann L, Friedberg MK, Cifra B, Dragulescu A. Ventricular Torsion in Young Patients With Single-Ventricle Anatomy. J Am Soc Echocardiogr. 2018 Oct 17. PMID: 30340887.
      View in: PubMed
    7. Traister A, Patel R, Huang A, Patel S, Plakhotnik J, Lee JE, Medina MG, Welsh C, Ruparel P, Zhang L, Friedberg M, Maynes J, Coles J. Cardiac regenerative capacity is age- and disease-dependent in childhood heart disease. PLoS One. 2018; 13(7):e0200342. PMID: 30044800.
      View in: PubMed
    8. Yim D, Hui W, Larios G, Dragulescu A, Grosse-Wortmann L, Bijnens B, Mertens L, Friedberg MK. Quantification of Right Ventricular Electromechanical Dyssynchrony in Relation to Right Ventricular Function and Clinical Outcomes in Children with Repaired Tetralogy of Fallot. J Am Soc Echocardiogr. 2018 Jul; 31(7):822-830. PMID: 29976349.
      View in: PubMed
    9. Son JS, James A, Fan CS, Mertens L, McCrindle BW, Manlhiot C, Friedberg MK. Prognostic Value of Serial Echocardiography in Hypoplastic Left Heart Syndrome. Circ Cardiovasc Imaging. 2018 Jul; 11(7):e006983. PMID: 30012823.
      View in: PubMed
    10. Cifra B, Morgan CT, Dragulescu A, Guerra VC, Slorach C, Friedberg MK, Manlhiot C, McCrindle BW, Dipchand AI, Mertens L. Right ventricular function during exercise in children after heart transplantation. Eur Heart J Cardiovasc Imaging. 2018 06 01; 19(6):647-653. PMID: 28655190.
      View in: PubMed
    11. Friedberg MK. Imaging Right-Left Ventricular Interactions. JACC Cardiovasc Imaging. 2018 May; 11(5):755-771. PMID: 29747850.
      View in: PubMed
    12. Roldan Ramos S, Pieles G, Hui W, Slorach C, Redington AN, Friedberg MK. A rabbit model of progressive chronic right ventricular pressure overload. Interact Cardiovasc Thorac Surg. 2018 Apr 01; 26(4):673-680. PMID: 29211855.
      View in: PubMed
    13. Cifra B, Chen CK, Fan CS, Slorach C, Manlhiot C, McCrindle BW, Dragulescu A, Redington AN, Friedberg MK, Nathan PC, Mertens L. Dynamic Myocardial Response to Exercise in Childhood Cancer Survivors Treated with Anthracyclines. J Am Soc Echocardiogr. 2018 Aug; 31(8):933-942. PMID: 29615292.
      View in: PubMed
    14. Hui W, Slorach C, Friedberg MK. Apical Transverse Motion Is Associated with Interventricular Mechanical Delay and Decreased Left Ventricular Function in Children with Dilated Cardiomyopathy. J Am Soc Echocardiogr. 2018 Aug; 31(8):943-950. PMID: 29606334.
      View in: PubMed
    15. Friedberg MK. Longitudinal Doppler Assessment of Congenital Aortic Stenosis: It Is About Time! Circ Cardiovasc Imaging. 2018 Mar; 11(3):e007622. PMID: 29555839.
      View in: PubMed
    16. Guirado L, Crispi F, Masoller N, Bennasar M, Marimon E, Carretero J, Gratacós E, Martínez JM, Friedberg MK, Gómez O. Biventricular impact of mild to moderate fetal pulmonary valve stenosis. Ultrasound Obstet Gynecol. 2018 Mar; 51(3):349-356. PMID: 28295792.
      View in: PubMed
    17. Ramos SR, Pieles G, Sun M, Slorach C, Hui W, Friedberg MK. Early versus late cardiac remodeling during right ventricular pressure load and impact of preventive versus rescue therapy with endothelin-1 receptor blockers. J Appl Physiol (1985). 2018 May 01; 124(5):1349-1362. PMID: 29446710.
      View in: PubMed
    18. Kuebler WM, Friedberg MK. Letter by Kuebler and Friedberg Regarding Article, "Pulmonary Artery Denervation by Determining Targeted Ablation Sites for Treatment of Pulmonary Arterial Hypertension". Circ Cardiovasc Interv. 2018 Feb; 11(2):e006148. PMID: 29371213.
      View in: PubMed
    19. Rösner A, Khalapyan T, Dalen H, McElhinney DB, Friedberg MK, Lui GK. Classic-Pattern Dyssynchrony in Adolescents and Adults With a Fontan Circulation. J Am Soc Echocardiogr. 2018 Feb; 31(2):211-219. PMID: 29229494.
      View in: PubMed
    20. Gomez O, Okumura K, Honjo O, Sun M, Ishii R, Bijnens B, Friedberg MK. Heart rate reduction improves biventricular function and interactions in experimental pulmonary hypertension. Am J Physiol Heart Circ Physiol. 2018 03 01; 314(3):H542-H551. PMID: 29146614.
      View in: PubMed
    21. Larios G, Friedberg MK. Imaging in repaired tetralogy of Fallot with a focus on recent advances in echocardiography. Curr Opin Cardiol. 2017 Sep; 32(5):490-502. PMID: 28639972.
      View in: PubMed
    22. Friedberg MK. Another Step in the Right Direction: Resynchronizing the Dyssynchronous Right Ventricle Improves Its Efficiency and Function. Circ Cardiovasc Imaging. 2017 Sep; 10(9). PMID: 28877887.
      View in: PubMed
    23. Ramos SR, Pieles G, Hui W, Ishii R, Slorach C, Friedberg MK. Comprehensive echocardiographic assessment of biventricular function in the rabbit, animal model in cardiovascular research: feasibility and normal values. Int J Cardiovasc Imaging. 2018 Mar; 34(3):367-375. PMID: 28840383.
      View in: PubMed
    24. Nielsen EA, Okumura K, Sun M, Hjortdal VE, Redington AN, Friedberg MK. Regional septal hinge-point injury contributes to adverse biventricular interactions in pulmonary hypertension. Physiol Rep. 2017 Jul; 5(14). PMID: 28733311.
      View in: PubMed
    25. Timbie JW, Setodji CM, Kress A, Lavelle TA, Friedberg MW, Mendel PJ, Chen EK, Weidmer BA, Buttorff C, Malsberger R, Kommareddi M, Rastegar A, Kofner A, Hiatt L, Mahmud A, Giuriceo K, Kahn KL. Implementation of Medical Homes in Federally Qualified Health Centers. N Engl J Med. 2017 07 20; 377(3):246-256. PMID: 28636834.
      View in: PubMed
    26. Driessen MMP, Meijboom FJ, Hui W, Dragulescu A, Mertens L, Friedberg MK. Regional right ventricular remodeling and function in children with idiopathic pulmonary arterial hypertension vs those with pulmonary valve stenosis: Insights into mechanics of right ventricular dysfunction. Echocardiography. 2017 Jun; 34(6):888-897. PMID: 28370259.
      View in: PubMed
    27. Mawad W, Friedberg MK. The continuing challenge of evaluating diastolic function by echocardiography in children: developing concepts and newer modalities. Curr Opin Cardiol. 2017 01; 32(1):93-100. PMID: 27898434.
      View in: PubMed
    28. Yim D, Mertens L, Morgan CT, Friedberg MK, Grosse-Wortmann L, Dragulescu A. Impact of surgical pulmonary valve replacement on ventricular mechanics in children with repaired tetralogy of Fallot. Int J Cardiovasc Imaging. 2017 May; 33(5):711-720. PMID: 28005218.
      View in: PubMed
    29. Simpson J, Lopez L, Acar P, Friedberg MK, Khoo NS, Ko HH, Marek J, Marx G, McGhie JS, Meijboom F, Roberson D, Van den Bosch A, Miller O, Shirali G. Three-dimensional Echocardiography in Congenital Heart Disease: An Expert Consensus Document from the European Association of Cardiovascular Imaging and the American Society of Echocardiography. J Am Soc Echocardiogr. 2017 01; 30(1):1-27. PMID: 27838227.
      View in: PubMed
    30. Simpson J, Lopez L, Acar P, Friedberg M, Khoo N, Ko H, Marek J, Marx G, McGhie J, Meijboom F, Roberson D, Van den Bosch A, Miller O, Shirali G. Three-dimensional echocardiography in congenital heart disease: an expert consensus document from the European Association of Cardiovascular Imaging and the American Society of Echocardiography. Eur Heart J Cardiovasc Imaging. 2016 Oct; 17(10):1071-97. PMID: 27655864.
      View in: PubMed
    31. Ban KA, Cohen ME, Ko CY, Friedberg MW, Stulberg JJ, Zhou L, Hall BL, Hoyt DB, Bilimoria KY. Evaluation of the ProPublica Surgeon Scorecard "Adjusted Complication Rate" Measure Specifications. Ann Surg. 2016 10; 264(4):566-74. PMID: 27433895.
      View in: PubMed
    32. Friedberg MK, Schwartz SM, Zhang H, Chiu-Man C, Manlhiot C, Ilina MV, Arsdell GV, Kirsh JA, McCrindle BW, Stephenson EA. Hemodynamic effects of sustained postoperative cardiac resynchronization therapy in infants after repair of congenital heart disease: Results of a randomized clinical trial. Heart Rhythm. 2017 02; 14(2):240-247. PMID: 27687644.
      View in: PubMed
    33. Chowdhury SM, Goudar SP, Baker GH, Taylor CL, Shirali GS, Friedberg MK, Dragulescu A, Chessa KS, Mertens L. Speckle-Tracking Echocardiographic Measures of Right Ventricular Diastolic Function Correlate with Reference Standard Measures Before and After Preload Alteration in Children. Pediatr Cardiol. 2017 Jan; 38(1):27-35. PMID: 27655413.
      View in: PubMed
    34. Burkett DA, Slorach C, Patel SS, Redington AN, Ivy DD, Mertens L, Younoszai AK, Friedberg MK. Impact of Pulmonary Hemodynamics and Ventricular Interdependence on Left Ventricular Diastolic Function in Children With Pulmonary Hypertension. Circ Cardiovasc Imaging. 2016 Sep; 9(9). PMID: 27581953.
      View in: PubMed
    35. Friedberg MK. Echocardiographic Detection of Heart Transplant Graft Dysfunction: A New Twist on an Old Theme. Circ Cardiovasc Imaging. 2016 09; 9(9). PMID: 27609821.
      View in: PubMed
    36. Tretter JT, Friedberg MK, Wald RM, McElhinney DB. Defining and refining indications for transcatheter pulmonary valve replacement in patients with repaired tetralogy of Fallot: Contributions from anatomical and functional imaging. Int J Cardiol. 2016 Oct 15; 221:916-25. PMID: 27441469.
      View in: PubMed
    37. Shahian DM, Normand SL, Friedberg MW, Hutter MM, Pronovost PJ. Rating the Raters: The Inconsistent Quality of Health Care Performance Measurement. Ann Surg. 2016 07; 264(1):36-8. PMID: 26756770.
      View in: PubMed
    38. Driessen MM, Hui W, Bijnens BH, Dragulescu A, Mertens L, Meijboom FJ, Friedberg MK. Adverse ventricular-ventricular interactions in right ventricular pressure load: Insights from pediatric pulmonary hypertension versus pulmonary stenosis. Physiol Rep. 2016 Jun; 4(11). PMID: 27302992.
      View in: PubMed
    39. Dallaire F, Slorach C, Bradley T, Hui W, Sarkola T, Friedberg MK, Jaeggi E, Dragulescu A, Mahmud FH, Daneman D, Mertens L. Pediatric Reference Values and Z Score Equations for Left Ventricular Systolic Strain Measured by Two-Dimensional Speckle-Tracking Echocardiography. J Am Soc Echocardiogr. 2016 08; 29(8):786-793.e8. PMID: 27185223.
      View in: PubMed
    40. Cifra B, Mertens L, Mirkhani M, Slorach C, Hui W, Manlhiot C, Friedberg MK, Dragulescu A. Systolic and Diastolic Myocardial Response to Exercise in a Healthy Pediatric Cohort. J Am Soc Echocardiogr. 2016 07; 29(7):648-54. PMID: 27038512.
      View in: PubMed
    41. Schantz D, Benson L, Windram J, Wong D, Dragulescu A, Yoo SJ, Mertens L, Friedberg M, Al Nafisi B, Grosse-Wortmann L. Abnormal Mitral Valve Dimensions in Pediatric Patients with Hypertrophic Cardiomyopathy. Pediatr Cardiol. 2016 Apr; 37(4):784-8. PMID: 26961572.
      View in: PubMed
    42. Friedberg MK, Margossian R, Lu M, Mercer-Rosa L, Henderson HT, Nutting A, Friedman K, Molina KM, Altmann K, Canter C, Sleeper LA, Colan SD. Systolic-diastolic functional coupling in healthy children and in those with dilated cardiomyopathy. J Appl Physiol (1985). 2016 Jun 01; 120(11):1301-18. PMID: 26940654; PMCID: PMC4891930 [Available on 06/01/17].
      View in: PubMed, PubMed Central
    43. Koestenberger M, Friedberg MK, Nestaas E, Michel-Behnke I, Hansmann G. Transthoracic echocardiography in the evaluation of pediatric pulmonary hypertension and ventricular dysfunction. Pulm Circ. 2016 Mar; 6(1):15-29. PMID: 27162612; PMCID: PMC4860554.
      View in: PubMed, PubMed Central
    44. Grotenhuis HB, Ruijsink B, Chetan D, Dragulescu A, Friedberg MK, Kotani Y, Caldarone CA, Honjo O, Mertens LL. Impact of Norwood versus hybrid palliation on cardiac size and function in hypoplastic left heart syndrome. Heart. 2016 06 15; 102(12):966-74. PMID: 26908097.
      View in: PubMed
    45. Nielsen EA, Sun M, Honjo O, Hjortdal VE, Redington AN, Friedberg MK. Dual Endothelin Receptor Blockade Abrogates Right Ventricular Remodeling and Biventricular Fibrosis in Isolated Elevated Right Ventricular Afterload. PLoS One. 2016; 11(1):e0146767. PMID: 26765263; PMCID: PMC4713098.
      View in: PubMed, PubMed Central
    46. Li J, Cai S, Peng J, Friedberg MK, Redington AN. Time Dependent Distribution of MicroRNA 144 after Intravenous Delivery. Microrna. 2016; 5(1):36-49. PMID: 27001183.
      View in: PubMed
    47. Forsha D, Slorach C, Chen CK, Sherman A, Mertens L, Barker P, Kisslo J, Friedberg MK. Patterns of Mechanical Inefficiency in Pediatric Dilated Cardiomyopathy and Their Relation to Left Ventricular Function and Clinical Outcomes. J Am Soc Echocardiogr. 2016 Mar; 29(3):226-36. PMID: 26711366.
      View in: PubMed
    48. Breitling S, Krauszman A, Parihar R, Walther T, Friedberg MK, Kuebler WM. Dose-dependent, therapeutic potential of angiotensin-(1-7) for the treatment of pulmonary arterial hypertension. Pulm Circ. 2015 Dec; 5(4):649-57. PMID: 26697172; PMCID: PMC4671739.
      View in: PubMed, PubMed Central
    49. Abman SH, Hansmann G, Archer SL, Ivy DD, Adatia I, Chung WK, Hanna BD, Rosenzweig EB, Raj JU, Cornfield D, Stenmark KR, Steinhorn R, Thébaud B, Fineman JR, Kuehne T, Feinstein JA, Friedberg MK, Earing M, Barst RJ, Keller RL, Kinsella JP, Mullen M, Deterding R, Kulik T, Mallory G, Humpl T, Wessel DL. Pediatric Pulmonary Hypertension: Guidelines From the American Heart Association and American Thoracic Society. Circulation. 2015 Nov 24; 132(21):2037-99. PMID: 26534956.
      View in: PubMed
    50. Di Maria MV, Burkett DA, Younoszai AK, Landeck BF, Mertens L, Ivy DD, Friedberg MK, Hunter KS. Echocardiographic estimation of right ventricular stroke work in children with pulmonary arterial hypertension: comparison with invasive measurements. J Am Soc Echocardiogr. 2015 Nov; 28(11):1350-7. PMID: 26299333.
      View in: PubMed
    51. Burkett DA, Slorach C, Patel SS, Redington AN, Ivy DD, Mertens L, Younoszai AK, Friedberg MK. Left Ventricular Myocardial Function in Children With Pulmonary Hypertension: Relation to Right Ventricular Performance and Hemodynamics. Circ Cardiovasc Imaging. 2015 Aug; 8(8). PMID: 26259580; PMCID: PMC4535191.
      View in: PubMed, PubMed Central
    52. Roche SL, Kantor PF, Friedberg MK. Comments on the assessment of biventricular function in children after tetralogy of fallot repair. J Am Soc Echocardiogr. 2015 Apr; 28(4):495-6. PMID: 25839153.
      View in: PubMed
    53. Dallaire F, Slorach C, Hui W, Sarkola T, Friedberg MK, Bradley TJ, Jaeggi E, Dragulescu A, Har RL, Cherney DZ, Mertens L. Reference values for pulse wave Doppler and tissue Doppler imaging in pediatric echocardiography. Circ Cardiovasc Imaging. 2015 Feb; 8(2):e002167. PMID: 25632029.
      View in: PubMed
    54. Borik S, Crean A, Horlick E, Osten M, Lee KJ, Chaturvedi R, Friedberg MK, McCrindle BW, Manlhiot C, Benson L. Percutaneous pulmonary valve implantation: 5 years of follow-up: does age influence outcomes? Circ Cardiovasc Interv. 2015 Feb; 8(2):e001745. PMID: 25652317.
      View in: PubMed
    55. Hussain T, Dragulescu A, Benson L, Yoo SJ, Meng H, Windram J, Wong D, Greiser A, Friedberg M, Mertens L, Seed M, Redington A, Grosse-Wortmann L. Quantification and significance of diffuse myocardial fibrosis and diastolic dysfunction in childhood hypertrophic cardiomyopathy. Pediatr Cardiol. 2015 Jun; 36(5):970-8. PMID: 25605038.
      View in: PubMed
    56. Okumura K, Kato H, Honjo O, Breitling S, Kuebler WM, Sun M, Friedberg MK. Carvedilol improves biventricular fibrosis and function in experimental pulmonary hypertension. J Mol Med (Berl). 2015 Jun; 93(6):663-74. PMID: 25595602.
      View in: PubMed
    57. Roche SL, Grosse-Wortmann L, Friedberg MK, Redington AN, Stephens D, Kantor PF. Exercise echocardiography demonstrates biventricular systolic dysfunction and reveals decreased left ventricular contractile reserve in children after tetralogy of Fallot repair. J Am Soc Echocardiogr. 2015 Mar; 28(3):294-301. PMID: 25459500.
      View in: PubMed
    58. Okumura K, Humpl T, Dragulescu A, Mertens L, Friedberg MK. Longitudinal assessment of right ventricular myocardial strain in relation to transplant-free survival in children with idiopathic pulmonary hypertension. J Am Soc Echocardiogr. 2014 Dec; 27(12):1344-51. PMID: 25306221.
      View in: PubMed
    59. Mah K, Friedberg MK. Congenitally corrected transposition of the great arteries: situs solitus or inversus. Circ Cardiovasc Imaging. 2014 Sep; 7(5):849-51. PMID: 25227238.
      View in: PubMed
    60. Mondal T, Slorach C, Manlhiot C, Hui W, Kantor PF, McCrindle BW, Mertens L, Friedberg MK. Prognostic implications of the systolic to diastolic duration ratio in children with idiopathic or familial dilated cardiomyopathy. Circ Cardiovasc Imaging. 2014 Sep; 7(5):773-80. PMID: 25140066.
      View in: PubMed
    61. Forsha D, Slorach C, Chen CK, Stephenson EA, Risum N, Hornik C, Wagner G, Mertens L, Barker P, Kisslo J, Friedberg MK. Classic-pattern dyssynchrony and electrical activation delays in pediatric dilated cardiomyopathy. J Am Soc Echocardiogr. 2014 Sep; 27(9):956-64. PMID: 25063467.
      View in: PubMed
    62. Cifra B, Dragulescu A, Brun H, Slorach C, Friedberg MK, Manlhiot C, McCrindle BW, Dipchand A, Mertens L. Left ventricular myocardial response to exercise in children after heart transplant. J Heart Lung Transplant. 2014 Dec; 33(12):1241-7. PMID: 25130553.
      View in: PubMed
    63. Weber R, Kantor P, Chitayat D, Friedberg MK, Golding F, Mertens L, Nield LE, Ryan G, Seed M, Yoo SJ, Manlhiot C, Jaeggi E. Spectrum and outcome of primary cardiomyopathies diagnosed during fetal life. JACC Heart Fail. 2014 Aug; 2(4):403-11. PMID: 25023818.
      View in: PubMed
    64. Dragulescu A, Friedberg MK, Grosse-Wortmann L, Redington A, Mertens L. Effect of chronic right ventricular volume overload on ventricular interaction in patients after tetralogy of Fallot repair. J Am Soc Echocardiogr. 2014 Aug; 27(8):896-902. PMID: 24846007.
      View in: PubMed
    65. Hui W, Slorach C, Dragulescu A, Mertens L, Bijnens B, Friedberg MK. Mechanisms of right ventricular electromechanical dyssynchrony and mechanical inefficiency in children after repair of tetralogy of fallot. Circ Cardiovasc Imaging. 2014 Jul; 7(4):610-8. PMID: 24785673.
      View in: PubMed
    66. Di Maria MV, Younoszai AK, Mertens L, Landeck BF, Ivy DD, Hunter KS, Friedberg MK. RV stroke work in children with pulmonary arterial hypertension: estimation based on invasive haemodynamic assessment and correlation with outcomes. Heart. 2014 Sep; 100(17):1342-7. PMID: 24780910.
      View in: PubMed
    67. Friedberg MK, Redington AN. Right versus left ventricular failure: differences, similarities, and interactions. Circulation. 2014 Mar 04; 129(9):1033-44. PMID: 24589696.
      View in: PubMed
    68. Okumura K, Slorach C, Mroczek D, Dragulescu A, Mertens L, Redington AN, Friedberg MK. Right ventricular diastolic performance in children with pulmonary arterial hypertension associated with congenital heart disease: correlation of echocardiographic parameters with invasive reference standards by high-fidelity micromanometer catheter. Circ Cardiovasc Imaging. 2014 May; 7(3):491-501. PMID: 24577356.
      View in: PubMed
    69. Dragulescu A, Friedberg MK. A tale of two ventricles: ventricular-ventricular interactions and LV dysfunction after surgical repair of Tetralogy of Fallot. Eur Heart J Cardiovasc Imaging. 2014 May; 15(5):498-9. PMID: 24375562.
      View in: PubMed
    70. Forsey J, Benson L, Rozenblyum E, Friedberg MK, Mertens L. Early changes in apical rotation in genotype positive children with hypertrophic cardiomyopathy mutations without hypertrophic changes on two-dimensional imaging. J Am Soc Echocardiogr. 2014 Feb; 27(2):215-21. PMID: 24325958.
      View in: PubMed
    71. Friedberg MK, Cho MY, Li J, Assad RS, Sun M, Rohailla S, Honjo O, Apitz C, Redington AN. Adverse biventricular remodeling in isolated right ventricular hypertension is mediated by increased transforming growth factor-ß1 signaling and is abrogated by angiotensin receptor blockade. Am J Respir Cell Mol Biol. 2013 Dec; 49(6):1019-28. PMID: 23841477.
      View in: PubMed
    72. Marx GR, Shirali G, Levine JC, Guey LT, Cnota JF, Baffa JM, Border WL, Colan S, Ensing G, Friedberg MK, Goldberg DJ, Idriss SF, John JB, Lai WW, Lu M, Menon SC, Ohye RG, Saudek D, Wong PC, Pearson GD. Multicenter study comparing shunt type in the norwood procedure for single-ventricle lesions: three-dimensional echocardiographic analysis. Circ Cardiovasc Imaging. 2013 Nov; 6(6):934-42. PMID: 24097422.
      View in: PubMed
    73. Friedberg MK, Kassem E. Reply to Koestenberger and Ravekes. Am Heart J. 2013 Oct; 166(4):e35. PMID: 24093870.
      View in: PubMed
    74. Chetan D, Kotani Y, Jacques F, Poynter JA, Benson LN, Lee KJ, Chaturvedi RR, Friedberg MK, Van Arsdell GS, Caldarone CA, Honjo O. Surgical palliation strategy does not affect interstage ventricular dysfunction or atrioventricular valve regurgitation in children with hypoplastic left heart syndrome and variants. Circulation. 2013 Sep 10; 128(11 Suppl 1):S205-12. PMID: 24030408.
      View in: PubMed
    75. Bharucha T, Khan R, Mertens L, Friedberg MK. Right ventricular mechanical dyssynchrony and asymmetric contraction in hypoplastic heart syndrome are associated with tricuspid regurgitation. J Am Soc Echocardiogr. 2013 Oct; 26(10):1214-1220. PMID: 23876994.
      View in: PubMed
    76. Kassem E, Humpl T, Friedberg MK. Prognostic significance of 2-dimensional, M-mode, and Doppler echo indices of right ventricular function in children with pulmonary arterial hypertension. Am Heart J. 2013 Jun; 165(6):1024-31. PMID: 23708176.
      View in: PubMed
    77. Forsey J, Friedberg MK, Mertens L. Speckle tracking echocardiography in pediatric and congenital heart disease. Echocardiography. 2013 Apr; 30(4):447-59. PMID: 23551605.
      View in: PubMed
    78. Friedberg MK, Mertens L. Echocardiographic assessment of ventricular synchrony in congenital and acquired heart disease in children. Echocardiography. 2013 Apr; 30(4):460-71. PMID: 23551606.
      View in: PubMed
    79. Friedberg MK, Fernandes FP, Roche SL, Slorach C, Grosse-Wortmann L, Manlhiot C, Fackoury C, McCrindle BW, Mertens L, Kantor PF. Relation of right ventricular mechanics to exercise tolerance in children after tetralogy of Fallot repair. Am Heart J. 2013 Apr; 165(4):551-7. PMID: 23537972.
      View in: PubMed
    80. Friedberg MK. Squeezing better function out of the systemic right ventricle by optimizing its pacing site. Heart Rhythm. 2013 May; 10(5):683-4. PMID: 23391887.
      View in: PubMed
    81. Friedberg MK. Echocardiography for assessment of mechanical dyssynchrony in children: the search must go on. J Am Soc Echocardiogr. 2013 Feb; 26(2):160-4. PMID: 23352085.
      View in: PubMed
    82. Dragulescu A, Mertens L, Friedberg MK. Interpretation of left ventricular diastolic dysfunction in children with cardiomyopathy by echocardiography: problems and limitations. Circ Cardiovasc Imaging. 2013 Mar 01; 6(2):254-61. PMID: 23343514.
      View in: PubMed
    83. Friedberg MK, Wu S, Slorach C. Left-right ventricular interactions in pediatric aortic stenosis: right ventricular myocardial strain before and after aortic valvuloplasty. J Am Soc Echocardiogr. 2013 Apr; 26(4):390-7. PMID: 23337736.
      View in: PubMed
    84. Janoušek J, van Geldorp IE, Krupicková S, Rosenthal E, Nugent K, Tomaske M, Früh A, Elders J, Hiippala A, Kerst G, Gebauer RA, Kubuš P, Frias P, Gabbarini F, Clur SA, Nagel B, Ganame J, Papagiannis J, Marek J, Tisma-Dupanovic S, Tsao S, Nürnberg JH, Wren C, Friedberg M, de Guillebon M, Volaufova J, Prinzen FW, Delhaas T. Permanent cardiac pacing in children: choosing the optimal pacing site: a multicenter study. Circulation. 2013 Feb 05; 127(5):613-23. PMID: 23275383.
      View in: PubMed
    85. Dragulescu A, Grosse-Wortmann L, Redington A, Friedberg MK, Mertens L. Differential effect of right ventricular dilatation on myocardial deformation in patients with atrial septal defects and patients after tetralogy of Fallot repair. Int J Cardiol. 2013 Sep 30; 168(2):803-10. PMID: 23122548.
      View in: PubMed
    86. Mertens L, Friedberg MK. Echocardiography and cardiac resynchronization therapy in children and patients with congenital heart disease. Minerva Pediatr. 2012 Oct; 64(5):451-60. PMID: 22992528.
      View in: PubMed
    87. Alkon J, Friedberg MK, Manlhiot C, Manickaraj AK, Kinnear C, McCrindle BW, Benson LN, Addonizio LJ, Colan SD, Mital S. Genetic variations in hypoxia response genes influence hypertrophic cardiomyopathy phenotype. Pediatr Res. 2012 Dec; 72(6):583-92. PMID: 23007030.
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    88. Apitz C, Honjo O, Humpl T, Li J, Assad RS, Cho MY, Hong J, Friedberg MK, Redington AN. Biventricular structural and functional responses to aortic constriction in a rabbit model of chronic right ventricular pressure overload. J Thorac Cardiovasc Surg. 2012 Dec; 144(6):1494-501. PMID: 22818124.
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    89. Friedberg MK, Mertens L. Deformation imaging in selected congenital heart disease: is it evolving to clinical use? J Am Soc Echocardiogr. 2012 Sep; 25(9):919-31. PMID: 22766028.
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    90. Ahmad N, Kantor PF, Grosse-Wortmann L, Seller N, Jaeggi ET, Friedberg MK, Mertens L. Influence of RV restrictive physiology on LV diastolic function in children after tetralogy of Fallot repair. J Am Soc Echocardiogr. 2012 Aug; 25(8):866-73. PMID: 22727200.
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    91. Friedberg MK, Fernandes FP, Roche SL, Grosse-Wortmann L, Manlhiot C, Fackoury C, Slorach C, McCrindle BW, Mertens L, Kantor PF. Impaired right and left ventricular diastolic myocardial mechanics and filling in asymptomatic children and adolescents after repair of tetralogy of Fallot. Eur Heart J Cardiovasc Imaging. 2012 Nov; 13(11):905-13. PMID: 22467442.
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    92. Alghamdi MH, Grosse-Wortmann L, Ahmad N, Mertens L, Friedberg MK. Can simple echocardiographic measures reduce the number of cardiac magnetic resonance imaging studies to diagnose right ventricular enlargement in congenital heart disease? J Am Soc Echocardiogr. 2012 May; 25(5):518-23. PMID: 22365707.
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    93. Fernandes FP, Manlhiot C, Roche SL, Grosse-Wortmann L, Slorach C, McCrindle BW, Mertens L, Kantor PF, Friedberg MK. Impaired left ventricular myocardial mechanics and their relation to pulmonary regurgitation, right ventricular enlargement and exercise capacity in asymptomatic children after repair of tetralogy of Fallot. J Am Soc Echocardiogr. 2012 May; 25(5):494-503. PMID: 22326134.
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    94. Koestenberger M, Friedberg MK, Ravekes W, Nestaas E, Hansmann G. Non-Invasive Imaging for Congenital Heart Disease: Recent Innovations in Transthoracic Echocardiography. J Clin Exp Cardiolog. 2012 Jan 22; Suppl 8:2. PMID: 24163784.
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    95. Apitz C, Honjo O, Friedberg MK, Assad RS, Van Arsdell G, Humpl T, Redington AN. Beneficial effects of vasopressors on right ventricular function in experimental acute right ventricular failure in a rabbit model. Thorac Cardiovasc Surg. 2012 Feb; 60(1):17-23. PMID: 22222683.
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    96. Bharucha T, Fernandes F, Slorach C, Mertens L, Friedberg MK. Measurement of effective aortic valve area using three-dimensional echocardiography in children undergoing aortic balloon valvuloplasty for aortic stenosis. Echocardiography. 2012 Apr; 29(4):484-91. PMID: 22150633.
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    97. Dragulescu A, Grosse-Wortmann L, Fackoury C, Riffle S, Waiss M, Jaeggi E, Yoo SJ, Friedberg MK, Mertens L. Echocardiographic assessment of right ventricular volumes after surgical repair of tetralogy of Fallot: clinical validation of a new echocardiographic method. J Am Soc Echocardiogr. 2011 Nov; 24(11):1191-8. PMID: 21920701.
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    98. van Geldorp IE, Delhaas T, Gebauer RA, Frias P, Tomaske M, Friedberg MK, Tisma-Dupanovic S, Elders J, Früh A, Gabbarini F, Kubus P, Illikova V, Tsao S, Blank AC, Hiippala A, Sluysmans T, Karpawich P, Clur SA, Ganame X, Collins KK, Dann G, Thambo JB, Trigo C, Nagel B, Papagiannis J, Rackowitz A, Marek J, Nürnberg JH, Vanagt WY, Prinzen FW, Janousek J. Impact of the permanent ventricular pacing site on left ventricular function in children: a retrospective multicentre survey. Heart. 2011 Dec; 97(24):2051-5. PMID: 21917655.
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    99. Jegatheeswaran A, Oliveira C, Batsos C, Moon-Grady AJ, Silverman NH, Hornberger LK, Coyte P, Friedberg MK. Costs of prenatal detection of congenital heart disease. Am J Cardiol. 2011 Dec 15; 108(12):1808-14. PMID: 21907953.
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    100. Sajan I, Manlhiot C, Reyes J, McCrindle BW, Humpl T, Friedberg MK. Pulmonary arterial capacitance in children with idiopathic pulmonary arterial hypertension and pulmonary arterial hypertension associated with congenital heart disease: relation to pulmonary vascular resistance, exercise capacity, and survival. Am Heart J. 2011 Sep; 162(3):562-8. PMID: 21884877.
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    101. Fernandes FP, Manlhiot C, McCrindle BW, Mertens L, Kantor PF, Friedberg MK. Usefulness of mitral regurgitation as a marker of increased risk for death or cardiac transplantation in idiopathic dilated cardiomyopathy in children. Am J Cardiol. 2011 May 15; 107(10):1517-21. PMID: 21377646.
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    102. Roche SL, Grosse-Wortmann L, Redington AN, Slorach C, Smith G, Kantor PF, Friedberg MK. Exercise induces biventricular mechanical dyssynchrony in children with repaired tetralogy of Fallot. Heart. 2010 Dec; 96(24):2010-5. PMID: 21088123.
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    103. Koopman LP, Slorach C, Manlhiot C, McCrindle BW, Jaeggi ET, Mertens L, Friedberg MK. Assessment of myocardial deformation in children using Digital Imaging and Communications in Medicine (DICOM) data and vendor independent speckle tracking software. J Am Soc Echocardiogr. 2011 Jan; 24(1):37-44. PMID: 21095099.
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    104. Hui W, Slorach C, Bradley TJ, Jaeggi ET, Mertens L, Friedberg MK. Measurement of right ventricular mechanical synchrony in children using tissue Doppler velocity and two-dimensional strain imaging. J Am Soc Echocardiogr. 2010 Dec; 23(12):1289-96. PMID: 20952161.
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    105. Lagopoulos ME, Manlhiot C, McCrindle BW, Jaeggi ET, Friedberg MK, Nield LE. Impact of prenatal diagnosis and anatomical subtype on outcome in double outlet right ventricle. Am Heart J. 2010 Oct; 160(4):692-700. PMID: 20934564.
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    106. Friedberg MK, Su X, Tworetzky W, Soriano BD, Powell AJ, Marx GR. Validation of 3D echocardiographic assessment of left ventricular volumes, mass, and ejection fraction in neonates and infants with congenital heart disease: a comparison study with cardiac MRI. Circ Cardiovasc Imaging. 2010 Nov; 3(6):735-42. PMID: 20855861.
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    107. Mertens LL, Friedberg MK. Imaging the right ventricle--current state of the art. Nat Rev Cardiol. 2010 Oct; 7(10):551-63. PMID: 20697412.
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    108. Koopman LP, Slorach C, Manlhiot C, McCrindle BW, Friedberg MK, Mertens L, Jaeggi ET. Myocardial tissue Doppler velocity imaging in children: comparative study between two ultrasound systems. J Am Soc Echocardiogr. 2010 Sep; 23(9):929-37. PMID: 20688469.
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    109. Koopman LP, Slorach C, Hui W, Manlhiot C, McCrindle BW, Friedberg MK, Jaeggi ET, Mertens L. Comparison between different speckle tracking and color tissue Doppler techniques to measure global and regional myocardial deformation in children. J Am Soc Echocardiogr. 2010 Sep; 23(9):919-28. PMID: 20655173.
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    110. Alkon J, Humpl T, Manlhiot C, McCrindle BW, Reyes JT, Friedberg MK. Usefulness of the right ventricular systolic to diastolic duration ratio to predict functional capacity and survival in children with pulmonary arterial hypertension. Am J Cardiol. 2010 Aug 01; 106(3):430-6. PMID: 20643259.
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    111. Singer SJ, Burgers J, Friedberg M, Rosenthal MB, Leape L, Schneider E. Defining and measuring integrated patient care: promoting the next frontier in health care delivery. Med Care Res Rev. 2011 Feb; 68(1):112-27. PMID: 20555018.
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    112. Moiduddin N, Asoh K, Slorach C, Benson LN, Friedberg MK. Effect of transcatheter pulmonary valve implantation on short-term right ventricular function as determined by two-dimensional speckle tracking strain and strain rate imaging. Am J Cardiol. 2009 Sep 15; 104(6):862-7. PMID: 19733725.
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    113. Friedberg MK, Dubin AM, Van Hare GF, McDaniel G, Niksch A, Rosenthal DN. Acute effects of single-site pacing from the left and right ventricle on ventricular function and ventricular-ventricular interactions in children with normal hearts. Congenit Heart Dis. 2009 Sep-Oct; 4(5):356-61. PMID: 19740190.
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    114. Sarnari R, Kamal RY, Friedberg MK, Silverman NH. Doppler assessment of the ratio of the systolic to diastolic duration in normal children: relation to heart rate, age and body surface area. J Am Soc Echocardiogr. 2009 Aug; 22(8):928-32. PMID: 19553081.
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    115. Kim S, Al-Radi O, Friedberg MK, Caldarone CA, Coles JG, Oechslin E, Williams WG, Van Arsdell GS. Superior vena cava to pulmonary artery anastomosis as an adjunct to biventricular repair: 38-year follow-up. Ann Thorac Surg. 2009 May; 87(5):1475-82; discussion 1482-3. PMID: 19379888.
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    116. Friedberg MK, Mertens L. Tissue velocities, strain, and strain rate for echocardiographic assessment of ventricular function in congenital heart disease. Eur J Echocardiogr. 2009 Jul; 10(5):585-93. PMID: 19401299.
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    117. Friedberg MK, Silverman NH, Moon-Grady AJ, Tong E, Nourse J, Sorenson B, Lee J, Hornberger LK. Prenatal detection of congenital heart disease. J Pediatr. 2009 Jul; 155(1):26-31, 31.e1. PMID: 19394031.
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    118. Mertens L, Friedberg MK. Selecting pacing sites in children with complete heart block: is it time to avoid the right ventricular free wall? Eur Heart J. 2009 May; 30(9):1033-4. PMID: 19342393.
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    119. Mertens L, Friedberg MK. The gold standard for noninvasive imaging in congenital heart disease: echocardiography. Curr Opin Cardiol. 2009 Mar; 24(2):119-24. PMID: 19225295.
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    120. Mohammed A, Mertens L, Friedberg MK. Relations between systolic and diastolic function in children with dilated and hypertrophic cardiomyopathy as assessed by tissue Doppler imaging. J Am Soc Echocardiogr. 2009 Feb; 22(2):145-51. PMID: 19101113.
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    121. Friedberg MK, Dubin AM, Van Hare GF, McDaniel GM, Niksch A, Rosenthal DN. Pacing-induced electromechanical ventricular dyssynchrony does not acutely influence right ventricular function and global hemodynamics in children with normal hearts. J Cardiovasc Electrophysiol. 2009 May; 20(5):539-44. PMID: 19017336.
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    122. Grosse-Wortmann L, Friedberg MK. Images in cardiovascular medicine. Bilateral vertical veins from a common confluence in supracardiac total anomalous pulmonary venous connection. Circulation. 2008 Aug 05; 118(6):e103-4. PMID: 18678777.
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    123. Mohammed A, Friedberg MK. Feasibility of a new tissue Doppler based method for comprehensive evaluation of left-ventricular intra-ventricular mechanical dyssynchrony in children with dilated cardiomyopathy. J Am Soc Echocardiogr. 2008 Sep; 21(9):1062-7. PMID: 18650062.
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    124. Friedberg MK, Roche SL, Mohammed AF, Balasingam M, Atenafu EG, Kantor PF. Left ventricular diastolic mechanical dyssynchrony and associated clinical outcomes in children with dilated cardiomyopathy. Circ Cardiovasc Imaging. 2008 Jul; 1(1):50-7. PMID: 19808514.
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    125. Predescu D, Chaturvedi RR, Friedberg MK, Benson LN, Ozawa A, Lee KJ. Complete heart block associated with device closure of perimembranous ventricular septal defects. J Thorac Cardiovasc Surg. 2008 Nov; 136(5):1223-8. PMID: 19026807.
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    126. Friedberg MK, Slorach C. Relation between left ventricular regional radial function and radial wall motion abnormalities using two-dimensional speckle tracking in children with idiopathic dilated cardiomyopathy. Am J Cardiol. 2008 Aug 01; 102(3):335-9. PMID: 18638597.
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    127. Soslow JH, Friedberg MK, Silverman NH. Idiopathic premature closure of the ductus arteriosus: an indication for early delivery. Echocardiography. 2008 Jul; 25(6):650-2. PMID: 18422673.
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    128. Zhu Y, Gramolini AO, Walsh MA, Zhou YQ, Slorach C, Friedberg MK, Takeuchi JK, Sun H, Henkelman RM, Backx PH, Redington AN, Maclennan DH, Bruneau BG. Tbx5-dependent pathway regulating diastolic function in congenital heart disease. Proc Natl Acad Sci U S A. 2008 Apr 08; 105(14):5519-24. PMID: 18378906; PMCID: PMC2291114.
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    129. Friedberg MK, Roche SL, Balasingam M, Stephenson E, Slorach C, Fackoury C, Kantor PF. Evaluation of mechanical dyssynchrony in children with idiopathic dilated cardiomyopathy and associated clinical outcomes. Am J Cardiol. 2008 Apr 15; 101(8):1191-5. PMID: 18394457.
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    130. Jaeggi ET, Friedberg MK. Diagnosis and management of fetal bradyarrhythmias. Pacing Clin Electrophysiol. 2008 Feb; 31 Suppl 1:S50-3. PMID: 18226037.
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    131. Friedberg MK, Silverman NH, Dubin AM, Rosenthal DN. Right ventricular mechanical dyssynchrony in children with hypoplastic left heart syndrome. J Am Soc Echocardiogr. 2007 Sep; 20(9):1073-9. PMID: 17566698.
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    132. Friedberg MK, Silverman NH. The systolic to diastolic duration ratio in children with hypoplastic left heart syndrome: a novel Doppler index of right ventricular function. J Am Soc Echocardiogr. 2007 Jun; 20(6):749-55. PMID: 17543747.
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    133. Friedberg MK, Silverman NH, Dubin AM, Rosenthal DN. Mechanical dyssynchrony in children with systolic dysfunction secondary to cardiomyopathy: a Doppler tissue and vector velocity imaging study. J Am Soc Echocardiogr. 2007 Jun; 20(6):756-63. PMID: 17543748.
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    134. Bernheimer J, Friedberg M, Chan F, Silverman N. Echocardiographic diagnosis of persistent fifth aortic arch. Echocardiography. 2007 Mar; 24(3):258-62. PMID: 17313637.
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    135. Friedberg MK, Kim N, Silverman NH. Atrioventricular septal defect recently diagnosed by fetal echocardiography: echocardiographic features, associated anomalies, and outcomes. Congenit Heart Dis. 2007 Mar-Apr; 2(2):110-4. PMID: 18377486.
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    136. Friedberg MK, Feinstein JA, Rosenthal DN. Noninvasive assessment of pulmonary arterial capacitance by echocardiography. J Am Soc Echocardiogr. 2007 Feb; 20(2):186-90. PMID: 17275705.
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    137. Friedberg MK, Silverman NH. The systolic to diastolic duration ratio in children with heart failure secondary to restrictive cardiomyopathy. J Am Soc Echocardiogr. 2006 Nov; 19(11):1326-31. PMID: 17098134.
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    138. Kim N, Friedberg MK, Silverman NH. Diagnosis and prognosis of fetuses with double outlet right ventricle. Prenat Diagn. 2006 Aug; 26(8):740-5. PMID: 16807954.
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    139. Friedberg MK, Chang IL, Silverman NH, Ramamoorthy C, Chan FP. Images in cardiovascular medicine. Near sudden death from cardiac lipoma in an adolescent. Circulation. 2006 May 30; 113(21):e778-9. PMID: 16735681.
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    140. Friedberg MK, Feinstein JA, Rosenthal DN. A novel echocardiographic Doppler method for estimation of pulmonary arterial pressures. J Am Soc Echocardiogr. 2006 May; 19(5):559-62. PMID: 16644441.
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    141. Friedberg MK, Silverman NH. Cardiac ventricular diastolic and systolic duration in children with heart failure secondary to idiopathic dilated cardiomyopathy. Am J Cardiol. 2006 Jan 01; 97(1):101-5. PMID: 16377292.
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    142. Friedberg MK, Ursell PC, Silverman NH. Isomerism of the left atrial appendage associated with ventricular noncompaction. Am J Cardiol. 2005 Oct 01; 96(7):985-90. PMID: 16188529.
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    143. Friedberg M, Silverman NH. Right ventricular outflow tract obstruction in an infant. Heart. 2005 Jun; 91(6):748. PMID: 15894767; PMCID: PMC1768927.
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    144. Friedberg MK, Rosenthal DN. New developments in echocardiographic methods to assess right ventricular function in congenital heart disease. Curr Opin Cardiol. 2005 Mar; 20(2):84-8. PMID: 15711192.
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    145. Friedberg MK, Silverman NH. Mitral valve leaflet excursion velocity in the pediatric population: a comparable diastolic index to the color M-mode propagation velocity. J Am Soc Echocardiogr. 2005 Feb; 18(2):142-7. PMID: 15682051.
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    146. Friedberg MK, Silverman NH. Changing indications for fetal echocardiography in a University Center population. Prenat Diagn. 2004 Oct; 24(10):781-6. PMID: 15503290.
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    147. Friedberg M, Khoury A, Schwartz Y, Braver Y, Lorber A. Percutaneous transcatheter occlusion of the patent arterial duct using the pfm DuctOcclud Coil via a trans-aortic and trans-pulmonary approach. Cardiol Young. 2002 Oct; 12(5):465-9. PMID: 15773450.
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    148. Frohnert PP, Giuliani ER, Friedberg M, Johnson WJ, Tauxe WN. Statistical investigation of correlations between serum potassium levels and electrocardiographic findings in patients on intermittent hemodialysis therapy. Circulation. 1970 Apr; 41(4):667-76. PMID: 5437411.
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