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Isaac Odame

TitleStaff Physician
InstitutionThe Hospital for Sick Children
DepartmentHaematology/Oncology
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ware RE, Odame I. Newborn Screening With Sickle Cell Point of Care: A Valuable Resource in Low-Income Settings. Pediatrics. 2019 Oct; 144(4). PMID: 31530718.
      View in: PubMed
    2. Kapustin D, Leung J, Odame I, Williams S, Shroff M, Kassner A. Hydroxycarbamide treatment in children with Sickle Cell Anaemia is associated with more intact white matter integrity: a quantitative MRI study. Br J Haematol. 2019 Oct; 187(2):238-245. PMID: 31215028.
      View in: PubMed
    3. Allemang B, Allan K, Johnson C, Cheong M, Cheung P, Odame I, Ward R, Williams S, Mukerji G, Kuo KHM. Impact of a transition program with navigator on loss to follow-up, medication adherence, and appointment attendance in hemoglobinopathies. Pediatr Blood Cancer. 2019 Aug; 66(8):e27781. PMID: 31045326.
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    4. Mburu J, Odame I. Sickle cell disease: Reducing the global disease burden. Int J Lab Hematol. 2019 May; 41 Suppl 1:82-88. PMID: 31069977.
      View in: PubMed
    5. Steele C, Sinski A, Asibey J, Hardy-Dessources MD, Elana G, Brennan C, Odame I, Hoppe C, Geisberg M, Serrao E, Quinn CT. Point-of-care screening for sickle cell disease in low-resource settings: A multi-center evaluation of HemoTypeSC, a novel rapid test. Am J Hematol. 2019 Jan; 94(1):39-45. PMID: 30290004.
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    6. Kulandaivelu Y, Lalloo C, Ward R, Zempsky WT, Kirby-Allen M, Breakey VR, Odame I, Campbell F, Amaria K, Simpson EA, Nguyen C, George T, Stinson JN. Exploring the Needs of Adolescents With Sickle Cell Disease to Inform a Digital Self-Management and Transitional Care Program: Qualitative Study. JMIR Pediatr Parent. 2018 Sep 25; 1(2):e11058. PMID: 31518307.
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    7. Compernolle V, Chou ST, Tanael S, Savage W, Howard J, Josephson CD, Odame I, Hogan C, Denomme G, Shehata N. Red blood cell specifications for patients with hemoglobinopathies: a systematic review and guideline. Transfusion. 2018 06; 58(6):1555-1566. PMID: 29697146.
      View in: PubMed
    8. Meier ER, Johnson T, Pinkney K, Velez MC, Kamani N, Odame I. Access to hematopoietic stem cell transplant for patients with sickle cell anemia. Pediatr Blood Cancer. 2018 09; 65(9):e27105. PMID: 29693782.
      View in: PubMed
    9. Zipursky A, Bhutani VK, Odame I. Rhesus disease: a global prevention strategy. Lancet Child Adolesc Health. 2018 07; 2(7):536-542. PMID: 30169325.
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    10. Amid A, Chen S, Athale U, Charpentier K, Merelles-Pulcini M, Odame I, Kirby-Allen M. Iron overload in transfusion-dependent survivors of hemoglobin Bart's hydrops fetalis. Haematologica. 2018 05; 103(5):e184-e187. PMID: 29371322.
      View in: PubMed
    11. Odame I. Hydroxyurea for SCA in Africa: no malaria harm. Blood. 2017 12 14; 130(24):2575-2576. PMID: 29242203.
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    12. Bendiak GN, Mateos-Corral D, Sallam A, Atenafu EG, Kirby M, Odame I, Bikangaga P, Subbarao P, Grasemann H. Association of wheeze with lung function decline in children with sickle cell disease. Eur Respir J. 2017 11; 50(5). PMID: 29191949.
      View in: PubMed
    13. Croal PL, Leung J, Kosinski P, Shroff M, Odame I, Kassner A. Assessment of cerebral blood flow with magnetic resonance imaging in children with sickle cell disease: A quantitative comparison with transcranial Doppler ultrasonography. Brain Behav. 2017 11; 7(11):e00811. PMID: 29201539.
      View in: PubMed
    14. McLaren A, Klingel M, Behera S, Odame I, Kirby-Allen M, Grasemann H. Effect of Hydroxyurea Therapy on Pulmonary Function in Children with Sickle Cell Anemia. Am J Respir Crit Care Med. 2017 03 01; 195(5):689-691. PMID: 28248149.
      View in: PubMed
    15. Kosinski PD, Croal PL, Leung J, Williams S, Odame I, Hare GM, Shroff M, Kassner A. The severity of anaemia depletes cerebrovascular dilatory reserve in children with sickle cell disease: a quantitative magnetic resonance imaging study. Br J Haematol. 2017 Jan; 176(2):280-287. PMID: 27905100.
      View in: PubMed
    16. Alapan Y, Fraiwan A, Kucukal E, Hasan MN, Ung R, Kim M, Odame I, Little JA, Gurkan UA. Emerging point-of-care technologies for sickle cell disease screening and monitoring. Expert Rev Med Devices. 2016 Dec; 13(12):1073-1093. PMID: 27785945.
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    17. Hayeems RZ, Moore Hepburn C, Chakraborty P, Odame I, Clarke J, Miller FA, Brown AD. Managing sickle cell carrier results generated through newborn screening in Ontario: a precedent-setting policy story. Genet Med. 2017 06; 19(6):625-627. PMID: 27763632.
      View in: PubMed
    18. Amid A, Chen S, Brien W, Kirby-Allen M, Odame I. Optimizing chronic transfusion therapy for survivors of hemoglobin Barts hydrops fetalis. Blood. 2016 Mar 03; 127(9):1208-11. PMID: 26732098.
      View in: PubMed
    19. Ware RE, Davis BR, Schultz WH, Brown RC, Aygun B, Sarnaik S, Odame I, Fuh B, George A, Owen W, Luchtman-Jones L, Rogers ZR, Hilliard L, Gauger C, Piccone C, Lee MT, Kwiatkowski JL, Jackson S, Miller ST, Roberts C, Heeney MM, Kalfa TA, Nelson S, Imran H, Nottage K, Alvarez O, Rhodes M, Thompson AA, Rothman JA, Helton KJ, Roberts D, Coleman J, Bonner MJ, Kutlar A, Patel N, Wood J, Piller L, Wei P, Luden J, Mortier NA, Stuber SE, Luban NL, Cohen AR, Pressel S, Adams RJ. Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia-TCD With Transfusions Changing to Hydroxyurea (TWiTCH): a multicentre, open-label, phase 3, non-inferiority trial. Lancet. 2016 Feb 13; 387(10019):661-70. PMID: 26670617.
      View in: PubMed
    20. Wood JC, Pressel S, Rogers ZR, Odame I, Kwiatkowski JL, Lee MT, Owen WC, Cohen AR, St Pierre T, Heeney MM, Schultz WH, Davis BR, Ware RE. Liver iron concentration measurements by MRI in chronically transfused children with sickle cell anemia: baseline results from the TWiTCH trial. Am J Hematol. 2015 Sep; 90(9):806-10. PMID: 26087998.
      View in: PubMed
    21. McGann PT, Tshilolo L, Santos B, Tomlinson GA, Stuber S, Latham T, Aygun B, Obaro SK, Olupot-Olupot P, Williams TN, Odame I, Ware RE. Hydroxyurea Therapy for Children With Sickle Cell Anemia in Sub-Saharan Africa: Rationale and Design of the REACH Trial. Pediatr Blood Cancer. 2016 Jan; 63(1):98-104. PMID: 26275071.
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    22. Narang I, Kadmon G, Lai D, Dhanju S, Kirby-Allen M, Odame I, Amin R, Lu Z, Al-Saleh S. Higher nocturnal and awake oxygen saturations in children with sickle cell disease receiving hydroxyurea therapy. Ann Am Thorac Soc. 2015 Jul; 12(7):1044-9. PMID: 25970812.
      View in: PubMed
    23. Amid A, Cheong M, Eng B, Hanna M, Hohenadel BA, Nakamura LM, Walker L, Odame I, Kirby-Allen M, Waye JS. Hb S/ß+-thalassemia due to Hb sickle and a novel deletion of DNase I hypersensitive sites HS3 and HS4 of the ß locus control region. Haematologica. 2015 May; 100(5):e166-8. PMID: 25682598.
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    24. Odame I. Perspective: we need a global solution. Nature. 2014 Nov 13; 515(7526):S10. PMID: 25390135.
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    25. Amid A, Odame I. Improving outcomes in children with sickle cell disease: treatment considerations and strategies. Paediatr Drugs. 2014 Aug; 16(4):255-66. PMID: 24797542.
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    26. Savlov D, Beck CE, DeGroot J, Odame I, Friedman JN. Predictors of bacteremia among children with sickle cell disease presenting with fever. J Pediatr Hematol Oncol. 2014 Jul; 36(5):384-8. PMID: 24309605.
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    27. van den Akker M, Dror Y, Odame I. Transient erythroblastopenia of childhood is an underdiagnosed and self-limiting disease. Acta Paediatr. 2014 Jul; 103(7):e288-94. PMID: 24635829.
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    28. O'Leary JD, Crawford MW, Odame I, Shorten GD, McGrath PA. Thermal pain and sensory processing in children with sickle cell disease. Clin J Pain. 2014 Mar; 30(3):244-50. PMID: 23629596.
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    29. Birken CS, Khambalia A, Dupuis A, Pastor A, Lee M, Padavattan K, Mekky M, Odame I, Parkin PC. Morphine is associated with acute chest syndrome in children hospitalized with sickle cell disease. Hosp Pediatr. 2013 Apr; 3(2):149-55. PMID: 24340416.
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    30. O'Leary JD, Odame I, Pehora C, Chakraborty P, Crawford MW. Effectiveness of preoperative screening for sickle cell disease in a population with a newborn screening program: a cohort study. Can J Anaesth. 2013 Jan; 60(1):54-9. PMID: 23104576.
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    31. Grosse SD, Atrash HK, Odame I, Amendah D, Piel FB, Williams TN. The Jamaican historical experience of the impact of educational interventions on sickle cell disease child mortality. Am J Prev Med. 2012 Jun; 42(6):e101-3. PMID: 22608387.
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    32. Fung EB, Xu Y, Trachtenberg F, Odame I, Kwiatkowski JL, Neufeld EJ, Thompson AA, Boudreaux J, Quinn CT, Vichinsky EP. Inadequate dietary intake in patients with thalassemia. J Acad Nutr Diet. 2012 Jul; 112(7):980-90. PMID: 22551675.
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    33. Aygun B, Odame I. A global perspective on sickle cell disease. Pediatr Blood Cancer. 2012 Aug; 59(2):386-90. PMID: 22535620.
      View in: PubMed
    34. Cheng HL, Holowka S, Moineddin R, Odame I. Liver iron overload assessment by T?*2 magnetic resonance imaging in pediatric patients: an accuracy and reproducibility study. Am J Hematol. 2012 Apr; 87(4):435-7. PMID: 22286974.
      View in: PubMed
    35. Kwiatkowski JL, Kim HY, Thompson AA, Quinn CT, Mueller BU, Odame I, Giardina PJ, Vichinsky EP, Boudreaux JM, Cohen AR, Porter JB, Coates T, Olivieri NF, Neufeld EJ. Chelation use and iron burden in North American and British thalassemia patients: a report from the Thalassemia Longitudinal Cohort. Blood. 2012 Mar 22; 119(12):2746-53. PMID: 22279056.
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    36. Grosse SD, Odame I, Atrash HK, Amendah DD, Piel FB, Williams TN. Sickle cell disease in Africa: a neglected cause of early childhood mortality. Am J Prev Med. 2011 Dec; 41(6 Suppl 4):S398-405. PMID: 22099364.
      View in: PubMed
    37. Odame I, Kulkarni R, Ohene-Frempong K. Concerted global effort to combat sickle cell disease: the first global congress on sickle cell disease in Accra, Ghana. Am J Prev Med. 2011 Dec; 41(6 Suppl 4):S417-21. PMID: 22099367.
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    38. Tsangaris E, Klaassen R, Fernandez CV, Yanofsky R, Shereck E, Champagne J, Silva M, Lipton JH, Brossard J, Michon B, Abish S, Steele M, Ali K, Dower N, Athale U, Jardine L, Hand JP, Odame I, Canning P, Allen C, Carcao M, Beyene J, Roifman CM, Dror Y. Genetic analysis of inherited bone marrow failure syndromes from one prospective, comprehensive and population-based cohort and identification of novel mutations. J Med Genet. 2011 Sep; 48(9):618-28. PMID: 21659346.
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    39. Scantlebury N, Mabbott D, Janzen L, Rockel C, Widjaja E, Jones G, Kirby M, Odame I. White matter integrity and core cognitive function in children diagnosed with sickle cell disease. J Pediatr Hematol Oncol. 2011 Apr; 33(3):163-71. PMID: 21325970.
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    40. Odame I. Developing a global agenda for sickle cell disease: report of an international symposium and workshop in Cotonou, Republic of Benin. Am J Prev Med. 2010 Apr; 38(4 Suppl):S571-5. PMID: 20331960.
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    41. Athale UH, Duckworth J, Odame I, Barr R. Childhood atypical teratoid rhabdoid tumor of the central nervous system: a meta-analysis of observational studies. J Pediatr Hematol Oncol. 2009 Sep; 31(9):651-63. PMID: 19707161.
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    42. Beaumont M, Odame I, Babyn PS, Vidarsson L, Kirby-Allen M, Cheng HL. Accurate liver T2 measurement of iron overload: a simulations investigation and in vivo study. J Magn Reson Imaging. 2009 Aug; 30(2):313-20. PMID: 19629985.
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    43. Baruchel S, Sharp JR, Bartels U, Hukin J, Odame I, Portwine C, Strother D, Fryer C, Halton J, Egorin MJ, Reis RM, Martinho O, Stempak D, Hawkins C, Gammon J, Bouffet E. A Canadian paediatric brain tumour consortium (CPBTC) phase II molecularly targeted study of imatinib in recurrent and refractory paediatric central nervous system tumours. Eur J Cancer. 2009 Sep; 45(13):2352-9. PMID: 19505817.
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    44. Macartney C, Freilich M, Odame I, Charpentier K, Dror Y. Complete response to tacrolimus in a child with severe aplastic anemia resistant to cyclosporin A. Pediatr Blood Cancer. 2009 Apr; 52(4):525-7. PMID: 19058202.
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    45. Teo JT, Klaassen R, Fernandez CV, Yanofsky R, Wu J, Champagne J, Silva M, Lipton JH, Brossard J, Samson Y, Abish S, Steele M, Ali K, Athale U, Jardine L, Hand JP, Tsangaris E, Odame I, Beyene J, Dror Y. Clinical and genetic analysis of unclassifiable inherited bone marrow failure syndromes. Pediatrics. 2008 Jul; 122(1):e139-48. PMID: 18595958.
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    46. Lafay-Cousin L, Sung L, Carret AS, Hukin J, Wilson B, Johnston DL, Zelcer S, Silva M, Odame I, Mpofu C, Strother D, Bouffet E. Carboplatin hypersensitivity reaction in pediatric patients with low-grade glioma: a Canadian Pediatric Brain Tumor Consortium experience. Cancer. 2008 Feb 15; 112(4):892-9. PMID: 18098210.
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    47. Johnston DL, Keene DL, Lafay-Cousin L, Steinbok P, Sung L, Carret AS, Crooks B, Strother D, Wilson B, Odame I, Eisenstat DD, Mpofu C, Zelcer S, Huang A, Bouffet E. Supratentorial primitive neuroectodermal tumors: a Canadian pediatric brain tumor consortium report. J Neurooncol. 2008 Jan; 86(1):101-8. PMID: 17619825.
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    48. Odame I, Li P, Lau L, Doda W, Noseworthy M, Babyn P, Weitzman S. Pulmonary Langerhans cell histiocytosis: a variable disease in childhood. Pediatr Blood Cancer. 2006 Dec; 47(7):889-93. PMID: 16276522.
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    49. Steele JM, Sung L, Klaassen R, Fernandez CV, Yanofsky R, Wu J, Odame I, Silva M, Champagne J, Ali K, Brossard J, Samson Y, Abish S, Le D, Jardine L, Hand JP, Lipton JH, Charpentier K, Stephens D, Freedman M, Dror Y. Disease progression in recently diagnosed patients with inherited marrow failure syndromes: a Canadian Inherited Marrow Failure Registry (CIMFR) report. Pediatr Blood Cancer. 2006 Dec; 47(7):918-25. PMID: 16676307.
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    50. Keene D, Johnston D, Strother D, Fryer C, Carret AS, Crooks B, Eisenstat D, Moghrabi A, Wilson B, Brossard J, Mpofu C, Odame I, Zelcer S, Silva M, Samson Y, Hand J, Bouffet E. Epidemiological survey of central nervous system germ cell tumors in Canadian children. J Neurooncol. 2007 May; 82(3):289-95. PMID: 17120159.
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    51. Carret AS, Tabori U, Crooks B, Hukin J, Odame I, Johnston DL, Keene DL, Freeman C, Bouffet E. Outcome of secondary high-grade glioma in children previously treated for a malignant condition: a study of the Canadian Pediatric Brain Tumour Consortium. Radiother Oncol. 2006 Oct; 81(1):33-8. PMID: 16973227.
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    52. Odame I, Duckworth J, Talsma D, Beaumont L, Furlong W, Webber C, Barr R. Osteopenia, physical activity and health-related quality of life in survivors of brain tumors treated in childhood. Pediatr Blood Cancer. 2006 Mar; 46(3):357-62. PMID: 16035080.
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    53. Tabori U, Sung L, Hukin J, Laperriere N, Crooks B, Carret AS, Silva M, Odame I, Mpofu C, Strother D, Wilson B, Samson Y, Bouffet E. Distinctive clinical course and pattern of relapse in adolescents with medulloblastoma. Int J Radiat Oncol Biol Phys. 2006 Feb 01; 64(2):402-7. PMID: 16198067.
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    54. Tabori U, Sung L, Hukin J, Laperriere N, Crooks B, Carret AS, Silva M, Odame I, Mpofu C, Strother D, Wilson B, Samson Y, Bouffet E. Medulloblastoma in the second decade of life: a specific group with respect to toxicity and management: a Canadian Pediatric Brain Tumor Consortium Study. Cancer. 2005 May 01; 103(9):1874-80. PMID: 15770645.
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    55. Hanley C, Nagel K, Odame I, Fitzgerald P, Husain M. Immediate versus delayed access of implantable venous access devices: does the timing of access make a difference to the frequency of complications? J Pediatr Hematol Oncol. 2003 Aug; 25(8):613-5. PMID: 12902913.
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    56. Laditan AA, Odame I, Ogundipe O. Childhood meningitis at King Fahad Hospital, Hofuf, Saudi Arabia. Ann Saudi Med. 1997 Nov; 17(6):605-8. PMID: 17338005.
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    57. Reilly JJ, Odame I, Gibson BE, Wharton BA. Malnutrition as a prognosis factor in lymphoblastic leukemia: a multivariate analysis. Arch Dis Child. 1995 Jan; 72(1):98. PMID: 7717757.
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    58. Odame I, Reilly JJ, Gibson BE, Donaldson MD. Patterns of obesity in boys and girls after treatment for acute lymphoblastic leukaemia. Arch Dis Child. 1994 Aug; 71(2):147-9. PMID: 7944537.
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    59. Reilly JJ, Odame I, McColl JH, McAllister PJ, Gibson BE, Wharton BA. Does weight for height have prognostic significance in children with acute lymphoblastic leukemia? Am J Pediatr Hematol Oncol. 1994 Aug; 16(3):225-30. PMID: 8037340.
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    60. Odame I, Donaldson MD, Wallace AM, Cochran W, Smith PJ. Early diagnosis and management of 5 alpha-reductase deficiency. Arch Dis Child. 1992 Jun; 67(6):720-3. PMID: 1626992.
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