Loading...
Reach Banner
Keywords
Last name
Institution

Seema Mital

TitleStaff Cardiologist, Heart Function & Transplant Program
InstitutionThe Hospital for Sick Children
DepartmentHeart Centre - Cardiology Div. Physicians Fellows & Secretaries
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
vCardDownload vCard

    Collapse Biography 
    Collapse education and training
    Columbia University, New YorkMD06/1999Pediatric Cardiology
    Children's Hospital of Michigan, MichiganMD06/1996Pediatrics

    Collapse Overview 
    Collapse overview
    Dr. Seema Mital is a Heart Failure and Transplant Cardiologist and Head of Cardiovascular Research at the Hospital for Sick Children, Toronto. She is Professor of Paediatrics at the University of Toronto and a Senior Scientist at the SickKids Research Institute. She is also the Heart and Stroke Foundation of Ontario Chair of Cardiovascular Science, and the Scientific Co-Lead of the Ted Rogers Centre for Heart Research.

    Mital has a strong translational research program focused on genomics, pharmacogenomics and stem cell applications to model childhood heart disease and discover new therapies. She has extensive experience in the genetics/genomics of congenital heart disease and heart failure, personalized medicine and clinical trials. She established the SickKids Heart Centre Biobank, a multi-centre biorepository of children and adults with childhood onset heart disease for genomics research, one of the largest international repositories of its kind. She is the Scientific Co-lead of the Ted Rogers Centre for Heart Research Cardiac Precision Medicine Program established in November 2014.
    Mital is a Principal Investigator of the CIHR-funded Canadian National Transplant Research Program, and the NIH-funded Pediatric Heart Network. She serves on the Leadership Committee of the Functional Genomics and Translational Biology Council of the American Heart Association, American Heart Association National Peer Review Steering Committee, and the Heart and Stroke Foundation of Ontario Research Advisory Committee. She is Vice-Chair of the American Heart Association Council on Cardiovascular Disease in the Young.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Gould RA, Aziz H, Woods CE, Seman-Senderos MA, Sparks E, Preuss C, Wünnemann F, Bedja D, Moats CR, McClymont SA, Rose R, Sobreira N, Ling H, MacCarrick G, Kumar AA, Luyckx I, Cannaerts E, Verstraeten A, Björk HM, Lehsau AC, Jaskula-Ranga V, Lauridsen H, Shah AA, Bennett CL, Ellinor PT, Lin H, Isselbacher EM, Cardenas CLL, Butcher JT, Hughes GC, Lindsay ME, Mertens L, Franco-Cereceda A, Verhagen JMA, Wessels M, Mohamed SA, Eriksson P, Mital S, Van Laer L, Loeys BL, Andelfinger G, McCallion AS, Dietz HC. ROBO4 variants predispose individuals to bicuspid aortic valve and thoracic aortic aneurysm. Nat Genet. 2018 Nov 19. PMID: 30455415.
      View in: PubMed
    2. Zahavich L, Tarnopolsky M, Yao R, Mital S. Novel Association of a De Novo CALM2 Mutation With Long QT Syndrome and Hypertrophic Cardiomyopathy. Circ Genom Precis Med. 2018 Oct; 11(10):e002255. PMID: 30354306.
      View in: PubMed
    3. Min S, Papaz T, Lafreniere-Roula M, Nalli N, Grasemann H, Schwartz SM, Kamath BM, Ng V, Parekh RS, Manlhiot C, Mital S. A randomized clinical trial of age and genotype-guided tacrolimus dosing after pediatric solid organ transplantation. Pediatr Transplant. 2018 11; 22(7):e13285. PMID: 30178515.
      View in: PubMed
    4. Newburger JW, Sleeper LA, Gaynor JW, Hollenbeck-Pringle D, Frommelt PC, Li JS, Mahle WT, Williams IA, Atz AM, Burns KM, Chen S, Cnota J, Dunbar-Masterson C, Ghanayem NS, Goldberg CS, Jacobs JP, Lewis AB, Mital S, Pizarro C, Eckhauser A, Stark P, Ohye RG. Transplant-Free Survival and Interventions at 6 Years in the SVR Trial. Circulation. 2018 May 22; 137(21):2246-2253. PMID: 29437119.
      View in: PubMed
    5. Mathew J, Zahavich L, Lafreniere-Roula M, Wilson J, George K, Benson L, Bowdin S, Mital S. Utility of genetics for risk stratification in pediatric hypertrophic cardiomyopathy. Clin Genet. 2018 Feb; 93(2):310-319. PMID: 29053178.
      View in: PubMed
    6. Chen CK, Manlhiot C, Mital S, Schwartz SM, Van Arsdell GS, Caldarone C, McCrindle BW, Dipchand AI. Prelisting predictions of early postoperative survival in infant heart transplantation using classification and regression tree analysis. Pediatr Transplant. 2018 03; 22(2). PMID: 29271030.
      View in: PubMed
    7. Jin SC, Homsy J, Zaidi S, Lu Q, Morton S, DePalma SR, Zeng X, Qi H, Chang W, Sierant MC, Hung WC, Haider S, Zhang J, Knight J, Bjornson RD, Castaldi C, Tikhonoa IR, Bilguvar K, Mane SM, Sanders SJ, Mital S, Russell MW, Gaynor JW, Deanfield J, Giardini A, Porter GA, Srivastava D, Lo CW, Shen Y, Watkins WS, Yandell M, Yost HJ, Tristani-Firouzi M, Newburger JW, Roberts AE, Kim R, Zhao H, Kaltman JR, Goldmuntz E, Chung WK, Seidman JG, Gelb BD, Seidman CE, Lifton RP, Brueckner M. Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands. Nat Genet. 2017 Nov; 49(11):1593-1601. PMID: 28991257.
      View in: PubMed
    8. Gillis E, Kumar AA, Luyckx I, Preuss C, Cannaerts E, van de Beek G, Wieschendorf B, Alaerts M, Bolar N, Vandeweyer G, Meester J, Wünnemann F, Gould RA, Zhurayev R, Zerbino D, Mohamed SA, Mital S, Mertens L, Björck HM, Franco-Cereceda A, McCallion AS, Van Laer L, Verhagen JMA, van de Laar IMBH, Wessels MW, Messas E, Goudot G, Nemcikova M, Krebsova A, Kempers M, Salemink S, Duijnhouwer T, Jeunemaitre X, Albuisson J, Eriksson P, Andelfinger G, Dietz HC, Verstraeten A, Loeys BL. Corrigendum: Candidate Gene Resequencing in a Large Bicuspid Aortic Valve-Associated Thoracic Aortic Aneurysm Cohort: SMAD6 as an Important Contributor. Front Physiol. 2017; 8:730. PMID: 28974934.
      View in: PubMed
    9. Skitch A, Mital S, Mertens L, Liu P, Kantor P, Grosse-Wortmann L, Manlhiot C, Greenberg M, Nathan PC. Novel approaches to the prediction, diagnosis and treatment of cardiac late effects in survivors of childhood cancer: a multi-centre observational study. BMC Cancer. 2017 Aug 03; 17(1):519. PMID: 28774277.
      View in: PubMed
    10. Ouellette AC, Mathew J, Manickaraj AK, Manase G, Zahavich L, Wilson J, George K, Benson L, Bowdin S, Mital S. Clinical genetic testing in pediatric cardiomyopathy: Is bigger better? Clin Genet. 2018 Jan; 93(1):33-40. PMID: 28369760.
      View in: PubMed
    11. Ramroop R, Manase G, Lu D, Manase D, Chen S, Kim R, Lee T, Mahle WT, McHugh K, Mitchell M, Tristani-Firouzi M, Wechsler SB, Wilder NS, Zak V, Lafreniere-Roula M, Newburger JW, Gaynor JW, Russell MW, Mital S. Adrenergic receptor genotypes influence postoperative outcomes in infants in the Single-Ventricle Reconstruction Trial. J Thorac Cardiovasc Surg. 2017 Nov; 154(5):1703-1710.e3. PMID: 28734628.
      View in: PubMed
    12. Gillis E, Kumar AA, Luyckx I, Preuss C, Cannaerts E, van de Beek G, Wieschendorf B, Alaerts M, Bolar N, Vandeweyer G, Meester J, Wünnemann F, Gould RA, Zhurayev R, Zerbino D, Mohamed SA, Mital S, Mertens L, Björck HM, Franco-Cereceda A, McCallion AS, Van Laer L, Verhagen JMA, van de Laar IMBH, Wessels MW, Messas E, Goudot G, Nemcikova M, Krebsova A, Kempers M, Salemink S, Duijnhouwer T, Jeunemaitre X, Albuisson J, Eriksson P, Andelfinger G, Dietz HC, Verstraeten A, Loeys BL. Candidate Gene Resequencing in a Large Bicuspid Aortic Valve-Associated Thoracic Aortic Aneurysm Cohort: SMAD6 as an Important Contributor. Front Physiol. 2017; 8:400. PMID: 28659821.
      View in: PubMed
    13. Zahavich L, Bowdin S, Mital S. Use of Clinical Exome Sequencing in Isolated Congenital Heart Disease. Circ Cardiovasc Genet. 2017 Jun; 10(3). PMID: 28473349.
      View in: PubMed
    14. Goldberg DJ, Zak V, Goldstein BH, Chen S, Hamstra MS, Radojewski EA, Maunsell E, Mital S, Menon SC, Schumacher KR, Payne RM, Stylianou M, Kaltman JR, deVries TM, Yeager JL, Paridon SM. Results of a phase I/II multi-center investigation of udenafil in adolescents after fontan palliation. Am Heart J. 2017 Jun; 188:42-52. PMID: 28577680.
      View in: PubMed
    15. Fridman MD, Mital S. Perspective on precision medicine in paediatric heart failure. Clin Sci (Lond). 2017 Mar 01; 131(6):439-448. PMID: 28265035.
      View in: PubMed
    16. Canobbio MM, Warnes CA, Aboulhosn J, Connolly HM, Khanna A, Koos BJ, Mital S, Rose C, Silversides C, Stout K. Management of Pregnancy in Patients With Complex Congenital Heart Disease: A Scientific Statement for Healthcare Professionals From the American Heart Association. Circulation. 2017 02 21; 135(8):e50-e87. PMID: 28082385.
      View in: PubMed
    17. Mital S, Musunuru K, Garg V, Russell MW, Lanfear DE, Gupta RM, Hickey KT, Ackerman MJ, Perez MV, Roden DM, Woo D, Fox CS, Ware S. Enhancing Literacy in Cardiovascular Genetics: A Scientific Statement From the American Heart Association. Circ Cardiovasc Genet. 2016 Oct; 9(5):448-467. PMID: 27672144.
      View in: PubMed
    18. Sifrim A, Hitz MP, Wilsdon A, Breckpot J, Turki SH, Thienpont B, McRae J, Fitzgerald TW, Singh T, Swaminathan GJ, Prigmore E, Rajan D, Abdul-Khaliq H, Banka S, Bauer UM, Bentham J, Berger F, Bhattacharya S, Bu'Lock F, Canham N, Colgiu IG, Cosgrove C, Cox H, Daehnert I, Daly A, Danesh J, Fryer A, Gewillig M, Hobson E, Hoff K, Homfray T, Kahlert AK, Ketley A, Kramer HH, Lachlan K, Lampe AK, Louw JJ, Manickara AK, Manase D, McCarthy KP, Metcalfe K, Moore C, Newbury-Ecob R, Omer SO, Ouwehand WH, Park SM, Parker MJ, Pickardt T, Pollard MO, Robert L, Roberts DJ, Sambrook J, Setchfield K, Stiller B, Thornborough C, Toka O, Watkins H, Williams D, Wright M, Mital S, Daubeney PE, Keavney B, Goodship J, Abu-Sulaiman RM, Klaassen S, Wright CF, Firth HV, Barrett JC, Devriendt K, FitzPatrick DR, Brook JD, Hurles ME. Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing. Nat Genet. 2016 09; 48(9):1060-5. PMID: 27479907.
      View in: PubMed
    19. Patel P, Kuzmanov U, Mital S. Avoiding false discovery in biomarker research. BMC Biochem. 2016 07 30; 17(1):17. PMID: 27474398.
      View in: PubMed
    20. Al Teneiji A, Siriwardena K, George K, Mital S, Mercimek-Mahmutoglu S. Progressive Cerebellar Atrophy and a Novel Homozygous Pathogenic DNAJC19 Variant as a Cause of Dilated Cardiomyopathy Ataxia Syndrome. Pediatr Neurol. 2016 09; 62:58-61. PMID: 27426421.
      View in: PubMed
    21. Priest JR, Osoegawa K, Mohammed N, Nanda V, Kundu R, Schultz K, Lammer EJ, Girirajan S, Scheetz T, Waggott D, Haddad F, Reddy S, Bernstein D, Burns T, Steimle JD, Yang XH, Moskowitz IP, Hurles M, Lifton RP, Nickerson D, Bamshad M, Eichler EE, Mital S, Sheffield V, Quertermous T, Gelb BD, Portman M, Ashley EA. De Novo and Rare Variants at Multiple Loci Support the Oligogenic Origins of Atrioventricular Septal Heart Defects. PLoS Genet. 2016 Apr; 12(4):e1005963. PMID: 27058611.
      View in: PubMed
    22. Shah SH, Arnett D, Houser SR, Ginsburg GS, MacRae C, Mital S, Loscalzo J, Hall JL. Opportunities for the Cardiovascular Community in the Precision Medicine Initiative. Circulation. 2016 Jan 12; 133(2):226-31. PMID: 27028435.
      View in: PubMed
    23. Homsy J, Zaidi S, Shen Y, Ware JS, Samocha KE, Karczewski KJ, DePalma SR, McKean D, Wakimoto H, Gorham J, Jin SC, Deanfield J, Giardini A, Porter GA, Kim R, Bilguvar K, López-Giráldez F, Tikhonova I, Mane S, Romano-Adesman A, Qi H, Vardarajan B, Ma L, Daly M, Roberts AE, Russell MW, Mital S, Newburger JW, Gaynor JW, Breitbart RE, Iossifov I, Ronemus M, Sanders SJ, Kaltman JR, Seidman JG, Brueckner M, Gelb BD, Goldmuntz E, Lifton RP, Seidman CE, Chung WK. De novo mutations in congenital heart disease with neurodevelopmental and other congenital anomalies. Science. 2015 Dec 04; 350(6265):1262-6. PMID: 26785492; PMCID: PMC4890146.
    24. Khattak S, Brimble E, Zhang W, Zaslavsky K, Strong E, Ross PJ, Hendry J, Mital S, Salter MW, Osborne LR, Ellis J. Human induced pluripotent stem cell derived neurons as a model for Williams-Beuren syndrome. Mol Brain. 2015 Nov 24; 8(1):77. PMID: 26603386; PMCID: PMC4657290.
    25. Burchill LJ, Redington AN, Silversides CK, Ross HJ, Jimenez-Juan L, Mital S, Oechslin EN, Dragulescu A, Slorach C, Mertens L, Wald RM. Renin-angiotensin-aldosterone system genotype and serum BNP in a contemporary cohort of adults late after Fontan palliation. Int J Cardiol. 2015 Oct 15; 197:209-15. PMID: 26142965.
      View in: PubMed
    26. D'Alessandro LC, Al Turki S, Manickaraj AK, Manase D, Mulder BJ, Bergin L, Rosenberg HC, Mondal T, Gordon E, Lougheed J, Smythe J, Devriendt K, Bhattacharya S, Watkins H, Bentham J, Bowdin S, Hurles ME, Mital S. Exome sequencing identifies rare variants in multiple genes in atrioventricular septal defect. Genet Med. 2016 Feb; 18(2):189-98. PMID: 25996639.
      View in: PubMed
    27. Bhatt AB, Foster E, Kuehl K, Alpert J, Brabeck S, Crumb S, Davidson WR, Earing MG, Ghoshhajra BB, Karamlou T, Mital S, Ting J, Tseng ZH. Congenital heart disease in the older adult: a scientific statement from the American Heart Association. Circulation. 2015 May 26; 131(21):1884-931. PMID: 25896865.
      View in: PubMed
    28. Manase D, D'Alessandro LC, Manickaraj AK, Al Turki S, Hurles ME, Mital S. High throughput exome coverage of clinically relevant cardiac genes. BMC Med Genomics. 2014 Dec 11; 7:67. PMID: 25496018; PMCID: PMC4272796.
    29. Buske OJ, Manickaraj A, Mital S, Ray PN, Brudno M. Identification of deleterious synonymous variants in human genomes. Bioinformatics. 2015 Mar 01; 31(5):799. PMID: 25488928.
      View in: PubMed
    30. Reddy S, Fung A, Manlhiot C, Tierney ES, Chung WK, Blume E, Kaufman BD, Goldmuntz E, Colan S, Mital S. Adrenergic receptor genotype influences heart failure severity and ß-blocker response in children with dilated cardiomyopathy. Pediatr Res. 2015 Feb; 77(2):363-9. PMID: 25406899; PMCID: PMC4298011.
    31. Gaynor JW, Kim DS, Arrington CB, Atz AM, Bellinger DC, Burt AA, Ghanayem NS, Jacobs JP, Lee TM, Lewis AB, Mahle WT, Marino BS, Miller SG, Newburger JW, Pizarro C, Ravishankar C, Santani AB, Wilder NS, Jarvik GP, Mital S, Russell MW. Validation of association of the apolipoprotein E e2 allele with neurodevelopmental dysfunction after cardiac surgery in neonates and infants. J Thorac Cardiovasc Surg. 2014 Dec; 148(6):2560-6. PMID: 25282659; PMCID: PMC4376113.
    32. Burns KM, Byrne BJ, Gelb BD, Kühn B, Leinwand LA, Mital S, Pearson GD, Rodefeld M, Rossano JW, Stauffer BL, Taylor MD, Towbin JA, Redington AN. New mechanistic and therapeutic targets for pediatric heart failure: report from a National Heart, Lung, and Blood Institute working group. Circulation. 2014 Jul 01; 130(1):79-86. PMID: 24982119.
      View in: PubMed
    33. Newburger JW, Sleeper LA, Frommelt PC, Pearson GD, Mahle WT, Chen S, Dunbar-Masterson C, Mital S, Williams IA, Ghanayem NS, Goldberg CS, Jacobs JP, Krawczeski CD, Lewis AB, Pasquali SK, Pizarro C, Gruber PJ, Atz AM, Khaikin S, Gaynor JW, Ohye RG. Transplantation-free survival and interventions at 3 years in the single ventricle reconstruction trial. Circulation. 2014 May 20; 129(20):2013-20. PMID: 24705119; PMCID: PMC4029928.
    34. Al Turki S, Manickaraj AK, Mercer CL, Gerety SS, Hitz MP, Lindsay S, D'Alessandro LC, Swaminathan GJ, Bentham J, Arndt AK, Louw J, Low J, Breckpot J, Gewillig M, Thienpont B, Abdul-Khaliq H, Harnack C, Hoff K, Kramer HH, Schubert S, Siebert R, Toka O, Cosgrove C, Watkins H, Lucassen AM, O'Kelly IM, Salmon AP, Bu'lock FA, Granados-Riveron J, Setchfield K, Thornborough C, Brook JD, Mulder B, Klaassen S, Bhattacharya S, Devriendt K, Fitzpatrick DF, Wilson DI, Mital S, Hurles ME. Rare variants in NR2F2 cause congenital heart defects in humans. Am J Hum Genet. 2014 Apr 03; 94(4):574-85. PMID: 24702954.
      View in: PubMed
    35. Fahed AC, Roberts AE, Mital S, Lakdawala NK. Heart failure in congenital heart disease: a confluence of acquired and congenital. Heart Fail Clin. 2014 Jan; 10(1):219-27. PMID: 24275306; PMCID: PMC3874878.
    36. Jeewa A, Manlhiot C, Kantor PF, Mital S, McCrindle BW, Dipchand AI. Risk factors for mortality or delisting of patients from the pediatric heart transplant waiting list. J Thorac Cardiovasc Surg. 2014 Jan; 147(1):462-8. PMID: 24183905.
      View in: PubMed
    37. Molina KM, Shrader P, Colan SD, Mital S, Margossian R, Sleeper LA, Shirali G, Barker P, Canter CE, Altmann K, Radojewski E, Tierney ES, Rychik J, Tani LY. Predictors of disease progression in pediatric dilated cardiomyopathy. Circ Heart Fail. 2013 Nov; 6(6):1214-22. PMID: 24132734; PMCID: PMC4111626.
    38. Gaber N, Gagliardi M, Patel P, Kinnear C, Zhang C, Chitayat D, Shannon P, Jaeggi E, Tabori U, Keller G, Mital S. Fetal reprogramming and senescence in hypoplastic left heart syndrome and in human pluripotent stem cells during cardiac differentiation. Am J Pathol. 2013 Sep; 183(3):720-34. PMID: 23871585.
      View in: PubMed
    39. Buske OJ, Manickaraj A, Mital S, Ray PN, Brudno M. Identification of deleterious synonymous variants in human genomes. Bioinformatics. 2013 Aug 01; 29(15):1843-50. PMID: 23736532.
      View in: PubMed
    40. D'Alessandro LC, Mital S. Pediatric transplantation: opportunities for pharmacogenomics and genomics. Per Med. 2013 Jun; 10(4):397-404. PMID: 29783417.
      View in: PubMed
    41. Fung A, Manlhiot C, Naik S, Rosenberg H, Smythe J, Lougheed J, Mondal T, Chitayat D, McCrindle BW, Mital S. Impact of prenatal risk factors on congenital heart disease in the current era. J Am Heart Assoc. 2013 May 31; 2(3):e000064. PMID: 23727699; PMCID: PMC3698764.
    42. Cordell HJ, Bentham J, Topf A, Zelenika D, Heath S, Mamasoula C, Cosgrove C, Blue G, Granados-Riveron J, Setchfield K, Thornborough C, Breckpot J, Soemedi R, Martin R, Rahman TJ, Hall D, van Engelen K, Moorman AF, Zwinderman AH, Barnett P, Koopmann TT, Adriaens ME, Varro A, George AL, dos Remedios C, Bishopric NH, Bezzina CR, O'Sullivan J, Gewillig M, Bu'Lock FA, Winlaw D, Bhattacharya S, Devriendt K, Brook JD, Mulder BJ, Mital S, Postma AV, Lathrop GM, Farrall M, Goodship JA, Keavney BD. Genome-wide association study of multiple congenital heart disease phenotypes identifies a susceptibility locus for atrial septal defect at chromosome 4p16. Nat Genet. 2013 Jul; 45(7):822-4. PMID: 23708191.
      View in: PubMed
    43. Binesh Marvasti T, D'Alessandro LC, Manase D, Papaz T, Mital S. Personalized medicine in the care of the child with congenital heart disease: discovery to application. Congenit Heart Dis. 2013 May-Jun; 8(3):266-9. PMID: 23601919.
      View in: PubMed
    44. Cordell HJ, Töpf A, Mamasoula C, Postma AV, Bentham J, Zelenika D, Heath S, Blue G, Cosgrove C, Granados Riveron J, Darlay R, Soemedi R, Wilson IJ, Ayers KL, Rahman TJ, Hall D, Mulder BJ, Zwinderman AH, van Engelen K, Brook JD, Setchfield K, Bu'Lock FA, Thornborough C, O'Sullivan J, Stuart AG, Parsons J, Bhattacharya S, Winlaw D, Mital S, Gewillig M, Breckpot J, Devriendt K, Moorman AF, Rauch A, Lathrop GM, Keavney BD, Goodship JA. Genome-wide association study identifies loci on 12q24 and 13q32 associated with tetralogy of Fallot. Hum Mol Genet. 2013 Apr 01; 22(7):1473-81. PMID: 23297363.
      View in: PubMed
    45. Patel P, Mital S. Stem cells in pediatric cardiology. Eur J Pediatr. 2013 Oct; 172(10):1287-92. PMID: 23292032.
      View in: PubMed
    46. Kinnear C, Chang WY, Khattak S, Hinek A, Thompson T, de Carvalho Rodrigues D, Kennedy K, Mahmut N, Pasceri P, Stanford WL, Ellis J, Mital S. Modeling and rescue of the vascular phenotype of Williams-Beuren syndrome in patient induced pluripotent stem cells. Stem Cells Transl Med. 2013 Jan; 2(1):2-15. PMID: 23283491; PMCID: PMC3659746.
    47. Papaz T, Safi M, Manickaraj AK, Ogaki C, Breaton Kyryliuk J, Burrill L, Dodge C, Chant-Gambacort C, Walter LL, Rosenberg H, Mondal T, Smythe J, Lougheed J, Bergin L, Gordon E, Chitayat D, Oechslin E, Mital S. Factors influencing participation in a population-based biorepository for childhood heart disease. Pediatrics. 2012 Nov; 130(5):e1198-205. PMID: 23045559.
      View in: PubMed
    48. Manickaraj AK, Mital S. Personalized medicine in pediatric cardiology: do little changes make a big difference? Curr Opin Pediatr. 2012 Oct; 24(5):584-91. PMID: 22890065.
      View in: PubMed
    49. Alkon J, Friedberg MK, Manlhiot C, Manickaraj AK, Kinnear C, McCrindle BW, Benson LN, Addonizio LJ, Colan SD, Mital S. Genetic variations in hypoxia response genes influence hypertrophic cardiomyopathy phenotype. Pediatr Res. 2012 Dec; 72(6):583-92. PMID: 23007030.
      View in: PubMed
    50. Jeewa A, Manickaraj AK, Mertens L, Manlhiot C, Kinnear C, Mondal T, Smythe J, Rosenberg H, Lougheed J, McCrindle BW, van Arsdell G, Redington AN, Mital S. Genetic determinants of right-ventricular remodeling after tetralogy of Fallot repair. Pediatr Res. 2012 Oct; 72(4):407-13. PMID: 22797143.
      View in: PubMed
    51. Yoon G, Soman T, Wilson J, George K, Mital S, Dipchand AI, McCabe J, Logan W, Kantor P. Cardiac transplantation in Friedreich ataxia. J Child Neurol. 2012 Sep; 27(9):1193-6. PMID: 22752490; PMCID: PMC3671892.
    52. Newburger JW, Sleeper LA, Bellinger DC, Goldberg CS, Tabbutt S, Lu M, Mussatto KA, Williams IA, Gustafson KE, Mital S, Pike N, Sood E, Mahle WT, Cooper DS, Dunbar-Masterson C, Krawczeski CD, Lewis A, Menon SC, Pemberton VL, Ravishankar C, Atz TW, Ohye RG, Gaynor JW. Early developmental outcome in children with hypoplastic left heart syndrome and related anomalies: the single ventricle reconstruction trial. Circulation. 2012 May 01; 125(17):2081-91. PMID: 22456475; PMCID: PMC3341507.
    53. Farra N, Manickaraj AK, Ellis J, Mital S. Personalized Medicine in the Genomics Era: highlights from an international symposium on childhood heart disease. Future Cardiol. 2012 Mar; 8(2):157-60. PMID: 22413975.
      View in: PubMed
    54. Gijsen V, Mital S, van Schaik RH, Soldin OP, Soldin SJ, van der Heiden IP, Nulman I, Koren G, de Wildt SN. Age and CYP3A5 genotype affect tacrolimus dosing requirements after transplant in pediatric heart recipients. J Heart Lung Transplant. 2011 Dec; 30(12):1352-9. PMID: 21930396; PMCID: PMC3640375.
    55. Kantor PF, Rusconi P, Lipshultz S, Mital S, Wilkinson JD, Burch M. Current applications and Future Needs for Biomarkers in Pediatric Cardiomyopathy and Heart Failure: Summary From The Second International Conference On Pediatric Cardiomyopathy. Prog Pediatr Cardiol. 2011 Aug 01; 32(1):11-14. PMID: 21909230.
      View in: PubMed
    56. Burchill L, Greenway S, Silversides CK, Mital S. Genetic counseling in the adult with congenital heart disease: what is the role? Curr Cardiol Rep. 2011 Aug; 13(4):347-55. PMID: 21537992.
      View in: PubMed
    57. Mital S. Personalizing medicine for the child with heart disease: a path forward. J Cardiovasc Pharmacol. 2011 Jul; 58(1):1-3. PMID: 21654326.
      View in: PubMed
    58. Mital S, Chung WK, Colan SD, Sleeper LA, Manlhiot C, Arrington CB, Cnota JF, Graham EM, Mitchell ME, Goldmuntz E, Li JS, Levine JC, Lee TM, Margossian R, Hsu DT. Renin-angiotensin-aldosterone genotype influences ventricular remodeling in infants with single ventricle. Circulation. 2011 May 31; 123(21):2353-62. PMID: 21576655; PMCID: PMC3137902.
    59. Davies RR, Russo MJ, Hong KN, Mital S, Mosca RS, Quaegebeur JM, Chen JM. Increased short- and long-term mortality at low-volume pediatric heart transplant centers: should minimum standards be set? Retrospective data analysis. Ann Surg. 2011 Feb; 253(2):393-401. PMID: 21183849.
      View in: PubMed
    60. Ofori-Amanfo G, Hsu D, Lamour JM, Mital S, O'Byrne ML, Smerling AJ, Chen JM, Mosca R, Addonizio LJ. Heart transplantation in children with markedly elevated pulmonary vascular resistance: impact of right ventricular failure on outcome. J Heart Lung Transplant. 2011 Jun; 30(6):659-66. PMID: 21256766.
      View in: PubMed
    61. Lai WW, Vetter VL, Richmond M, Li JS, Saul JP, Mital S, Colan SD, Newburger JW, Sleeper LA, McCrindle BW, Minich LL, Goldmuntz E, Marino BS, Williams IA, Pearson GD, Evans F, Scott JD, Cohen MS. Clinical research careers: reports from a NHLBI pediatric heart network clinical research skills development conference. Am Heart J. 2011 Jan; 161(1):13-67. PMID: 21167335; PMCID: PMC3654379.
    62. Hsu DT, Zak V, Mahony L, Sleeper LA, Atz AM, Levine JC, Barker PC, Ravishankar C, McCrindle BW, Williams RV, Altmann K, Ghanayem NS, Margossian R, Chung WK, Border WL, Pearson GD, Stylianou MP, Mital S. Enalapril in infants with single ventricle: results of a multicenter randomized trial. Circulation. 2010 Jul 27; 122(4):333-40. PMID: 20625111; PMCID: PMC3692364.
    63. Ohye RG, Sleeper LA, Mahony L, Newburger JW, Pearson GD, Lu M, Goldberg CS, Tabbutt S, Frommelt PC, Ghanayem NS, Laussen PC, Rhodes JF, Lewis AB, Mital S, Ravishankar C, Williams IA, Dunbar-Masterson C, Atz AM, Colan S, Minich LL, Pizarro C, Kanter KR, Jaggers J, Jacobs JP, Krawczeski CD, Pike N, McCrindle BW, Virzi L, Gaynor JW. Comparison of shunt types in the Norwood procedure for single-ventricle lesions. N Engl J Med. 2010 May 27; 362(21):1980-92. PMID: 20505177; PMCID: PMC2891109.
    64. Stevens KN, Hakonarson H, Kim CE, Doevendans PA, Koeleman BP, Mital S, Raue J, Glessner JT, Coles JG, Moreno V, Granger A, Gruber SB, Gruber PJ. Common variation in ISL1 confers genetic susceptibility for human congenital heart disease. PLoS One. 2010 May 26; 5(5):e10855. PMID: 20520780; PMCID: PMC2877111.
    65. Silversides CK, Marelli A, Beauchesne L, Dore A, Kiess M, Salehian O, Bradley T, Colman J, Connelly M, Harris L, Khairy P, Mital S, Niwa K, Oechslin E, Poirier N, Schwerzmann M, Taylor D, Vonder Muhll I, Baumgartner H, Benson L, Celermajer D, Greutmann M, Horlick E, Landzberg M, Meijboom F, Mulder B, Warnes C, Webb G, Therrien J. Canadian Cardiovascular Society 2009 Consensus Conference on the management of adults with congenital heart disease: executive summary. Can J Cardiol. 2010 Mar; 26(3):143-50. PMID: 20352134; PMCID: PMC2851468.
    66. Marelli A, Beauchesne L, Mital S, Therrien J, Silversides CK. Canadian Cardiovascular Society 2009 Consensus Conference on the management of adults with congenital heart disease: introduction. Can J Cardiol. 2010 Mar; 26(3):e65-9. PMID: 20352136; PMCID: PMC2851470.
    67. Williams RV, Ravishankar C, Zak V, Evans F, Atz AM, Border WL, Levine J, Li JS, Mahony L, Mital S, Pearson GD, Prakash A, Hsu DT. Birth weight and prematurity in infants with single ventricle physiology: pediatric heart network infant single ventricle trial screened population. Congenit Heart Dis. 2010 Mar-Apr; 5(2):96-103. PMID: 20412481; PMCID: PMC2895559.
    68. Minich LL, Atz AM, Colan SD, Sleeper LA, Mital S, Jaggers J, Margossian R, Prakash A, Li JS, Cohen MS, Lacro RV, Klein GL, Hawkins JA. Partial and transitional atrioventricular septal defect outcomes. Ann Thorac Surg. 2010 Feb; 89(2):530-6. PMID: 20103337; PMCID: PMC2900854.
    69. Cadeiras M, Shahzad K, John MM, Gruber D, Bayern Mv, Auerbach S, Sinha A, Latif F, Unniachan S, Memon S, Mital S, Restaino S, Marboe CC, Addonizio LJ, Deng MC. Relationship between a validated molecular cardiac transplant rejection classifier and routine organ function parameters. Clin Transplant. 2010 May-Jun; 24(3):321-7. PMID: 19712087.
      View in: PubMed
    70. Auerbach SR, Manlhiot C, Reddy S, Kinnear C, Richmond ME, Gruber D, McCrindle BW, Deng L, Chen JM, Addonizio LJ, Chung WK, Mital S. Recipient genotype is a predictor of allograft cytokine expression and outcomes after pediatric cardiac transplantation. J Am Coll Cardiol. 2009 May 19; 53(20):1909-17. PMID: 19442892.
      View in: PubMed
    71. Hsu DT, Mital S, Ravishankar C, Margossian R, Li JS, Sleeper LA, Williams RV, Levine JC, McCrindle BW, Atz AM, Servedio D, Mahony L. Rationale and design of a trial of angiotensin-converting enzyme inhibition in infants with single ventricle. Am Heart J. 2009 Jan; 157(1):37-45. PMID: 19081394; PMCID: PMC2637409.
    72. Osorio JC, Cheema FH, Martens TP, Mahmut N, Kinnear C, Gonzalez AM, Bonney W, Homma S, Liao JK, Mital S. Simvastatin reverses cardiac hypertrophy caused by disruption of the bradykinin 2 receptor. Can J Physiol Pharmacol. 2008 Sep; 86(9):633-42. PMID: 18758513; PMCID: PMC3034156.
    73. Kaufman BD, Desai M, Reddy S, Osorio JC, Chen JM, Mosca RS, Ferrante AW, Mital S. Genomic profiling of left and right ventricular hypertrophy in congenital heart disease. J Card Fail. 2008 Nov; 14(9):760-7. PMID: 18995181.
      View in: PubMed
    74. Paridon SM, Mitchell PD, Colan SD, Williams RV, Blaufox A, Li JS, Margossian R, Mital S, Russell J, Rhodes J. A cross-sectional study of exercise performance during the first 2 decades of life after the Fontan operation. J Am Coll Cardiol. 2008 Jul 08; 52(2):99-107. PMID: 18598887.
      View in: PubMed
    75. Davies RR, Russo MJ, Hong KN, O'Byrne ML, Cork DP, Moskowitz AJ, Gelijns AC, Mital S, Mosca RS, Chen JM. The use of mechanical circulatory support as a bridge to transplantation in pediatric patients: an analysis of the United Network for Organ Sharing database. J Thorac Cardiovasc Surg. 2008 Feb; 135(2):421-7, 427.e1. PMID: 18242279.
      View in: PubMed
    76. Davies RR, Russo MJ, Mital S, Martens TM, Sorabella RS, Hong KN, Gelijns AC, Moskowitz AJ, Quaegebeur JM, Mosca RS, Chen JM. Predicting survival among high-risk pediatric cardiac transplant recipients: an analysis of the United Network for Organ Sharing database. J Thorac Cardiovasc Surg. 2008 Jan; 135(1):147-55, 155.e1-2. PMID: 18179931.
      View in: PubMed
    77. Bograd AJ, Mital S, Schwarzenberger JC, Mosca RS, Quaegebeur JM, Addonizio LJ, Hsu DT, Lamour JM, Chen JM. Twenty-year experience with heart transplantation for infants and children with restrictive cardiomyopathy: 1986-2006. Am J Transplant. 2008 Jan; 8(1):201-7. PMID: 17973960.
      View in: PubMed
    78. Vogt KN, Manlhiot C, Van Arsdell G, Russell JL, Mital S, McCrindle BW. Somatic growth in children with single ventricle physiology impact of physiologic state. J Am Coll Cardiol. 2007 Nov 06; 50(19):1876-83. PMID: 17980255.
      View in: PubMed
    79. Kaufman BD, Auerbach S, Reddy S, Manlhiot C, Deng L, Prakash A, Printz BF, Gruber D, Papavassiliou DP, Hsu DT, Sehnert AJ, Chung WK, Mital S. RAAS gene polymorphisms influence progression of pediatric hypertrophic cardiomyopathy. Hum Genet. 2007 Dec; 122(5):515-23. PMID: 17851694.
      View in: PubMed
    80. Richmond ME, Addonizio LJ, Hsu DT, Mital SR, Mosca RS, Quaegebeur JM, Chen J, Lamour JM. Cardiac retransplantation in high risk pediatric patients. Pediatr Transplant. 2007 Sep; 11(6):615-23. PMID: 17663683.
      View in: PubMed
    81. Gonzalez AM, Osorio JC, Manlhiot C, Gruber D, Homma S, Mital S. Hypertrophy signaling during peripartum cardiac remodeling. Am J Physiol Heart Circ Physiol. 2007 Nov; 293(5):H3008-13. PMID: 17766481.
      View in: PubMed
    82. Mital S. Value of surveillance biopsy in pediatric heart transplantation. Pediatr Transplant. 2007 May; 11(3):233-5. PMID: 17430475.
      View in: PubMed
    83. McCrindle BW, Williams RV, Mital S, Clark BJ, Russell JL, Klein G, Eisenmann JC. Physical activity levels in children and adolescents are reduced after the Fontan procedure, independent of exercise capacity, and are associated with lower perceived general health. Arch Dis Child. 2007 Jun; 92(6):509-14. PMID: 17307794; PMCID: PMC2066169.
    84. Russo MJ, Chen JM, Sorabella RA, Martens TP, Garrido M, Davies RR, George I, Cheema FH, Mosca RS, Mital S, Ascheim DD, Argenziano M, Stewart AS, Oz MC, Naka Y. The effect of ischemic time on survival after heart transplantation varies by donor age: an analysis of the United Network for Organ Sharing database. J Thorac Cardiovasc Surg. 2007 Feb; 133(2):554-9. PMID: 17258599.
      View in: PubMed
    85. Mital S. Right ventricle in congenital heart disease: is it just a "weaker" left ventricle? Arch Mal Coeur Vaiss. 2006 Dec; 99(12):1244-51. PMID: 18942528.
      View in: PubMed
    86. Russo MJ, Davies RR, Sorabella RA, Martens TP, George I, Cheema FH, Mital S, Mosca RS, Chen JM. Adult-age donors offer acceptable long-term survival to pediatric heart transplant recipients: an analysis of the United Network of Organ Sharing database. J Thorac Cardiovasc Surg. 2006 Nov; 132(5):1208-12. PMID: 17059945.
      View in: PubMed
    87. Reddy S, Osorio JC, Duque AM, Kaufman BD, Phillips AB, Chen JM, Quaegebeur J, Mosca RS, Mital S. Failure of right ventricular adaptation in children with tetralogy of Fallot. Circulation. 2006 Jul 04; 114(1 Suppl):I37-42. PMID: 16820602.
      View in: PubMed
    88. Mital S, Andron A, Lamour JM, Hsu DT, Addonizio LJ, Softness B. Effects of growth hormone therapy in children after cardiac transplantation. J Heart Lung Transplant. 2006 Jul; 25(7):772-7. PMID: 16818119.
      View in: PubMed
    89. Xydas S, Yang JK, Burke EM, Chen JM, Addonizio LJ, Mital SR, Itescu S, Hsu DT, Lamour JM. Utility of post-transplant anti-HLA antibody measurements in pediatric cardiac transplant recipients. J Heart Lung Transplant. 2005 Sep; 24(9):1289-96. PMID: 16143247.
      View in: PubMed
    90. Rodriguez RJ, Addonizio LJ, Lamour JM, Mital S, Mosca R, West LJ, Nova JC, Hsu DT. Pediatric heart transplantation across ABO blood type barriers: a case study. Prog Transplant. 2005 Jun; 15(2):161-5. PMID: 16013465.
      View in: PubMed
    91. Rosenthal D, Chrisant MR, Edens E, Mahony L, Canter C, Colan S, Dubin A, Lamour J, Ross R, Shaddy R, Addonizio L, Beerman L, Berger S, Bernstein D, Blume E, Boucek M, Checchia P, Dipchand A, Drummond-Webb J, Fricker J, Friedman R, Hallowell S, Jaquiss R, Mital S, Pahl E, Pearce FB, Pearce B, Rhodes L, Rotondo K, Rusconi P, Scheel J, Pal Singh T, Towbin J. International Society for Heart and Lung Transplantation: Practice guidelines for management of heart failure in children. J Heart Lung Transplant. 2004 Dec; 23(12):1313-33. PMID: 15607659.
      View in: PubMed
    92. Chen JM, Davies RR, Mital SR, Mercando ML, Addonizio LJ, Pinney SP, Hsu DT, Lamour JM, Quaegebeur JM, Mosca RS. Trends and outcomes in transplantation for complex congenital heart disease: 1984 to 2004. Ann Thorac Surg. 2004 Oct; 78(4):1352-61; discussion 1352-61. PMID: 15464499.
      View in: PubMed
    93. Lamour JM, Hsu DT, Quaegebeur JM, Pinney SP, Mital SR, Mosca RS, Chen JM, Addonizio LJ. Heart transplantation to a physiologic single lung in patients with congenital heart disease. J Heart Lung Transplant. 2004 Aug; 23(8):948-53. PMID: 15312824.
      View in: PubMed
    94. Mital S, Loke KE, Chen JM, Mosca RS, Quaegebeur JM, Addonizio LJ, Hintze TH. Mitochondrial respiratory abnormalities in patients with end-stage congenital heart disease. J Heart Lung Transplant. 2004 Jan; 23(1):72-9. PMID: 14734130.
      View in: PubMed
    95. Mital S, Addonizio LJ, Lamour JM, Hsu DT. Outcome of children with end-stage congenital heart disease waiting for cardiac transplantation. J Heart Lung Transplant. 2003 Feb; 22(2):147-53. PMID: 12581762.
      View in: PubMed
    96. Sun D, Huang A, Mital S, Kichuk MR, Marboe CC, Addonizio LJ, Michler RE, Koller A, Hintze TH, Kaley G. Norepinephrine elicits beta2-receptor-mediated dilation of isolated human coronary arterioles. Circulation. 2002 Jul 30; 106(5):550-5. PMID: 12147535.
      View in: PubMed
    97. Mital S, Barbone A, Addonizio LJ, Quaegebeur JM, Mosca RJ, Oz MC, Hintze TH. Endogenous endothelium-derived nitric oxide inhibits myocardial caspase activity: implications for treatment of end-stage heart failure. J Heart Lung Transplant. 2002 May; 21(5):576-85. PMID: 11983548.
      View in: PubMed
    98. Mital S, Addonizio LJ, Mosca RJ, Quaegebeur JM, Oz MC, Hintze TH. Nitric oxide regulates the apoptotic pathway in explanted failing human hearts. J Heart Lung Transplant. 2001 Feb; 20(2):220. PMID: 11250409.
      View in: PubMed
    99. Mital S, Loke KE, Addonizio LJ, Oz MC, Hintze TH. Left ventricular assist device implantation augments nitric oxide dependent control of mitochondrial respiration in failing human hearts. J Am Coll Cardiol. 2000 Nov 15; 36(6):1897-902. PMID: 11092662.
      View in: PubMed
    100. Konduri GG, Mital S. Adenosine and ATP cause nitric oxide-dependent pulmonary vasodilation in fetal lambs. Biol Neonate. 2000 Oct; 78(3):220-9. PMID: 11044772.
      View in: PubMed
    101. Konduri GG, Forman K, Mital S. Characterization of purine receptors in fetal lamb pulmonary circulation. Pediatr Res. 2000 Jan; 47(1):114-20. PMID: 10625091.
      View in: PubMed
    102. Shetty AK, Mital SR, Bahrainwala AH, Khubchandani RP, Kumta NB. Typhoid hepatitis in children. J Trop Pediatr. 1999 10; 45(5):287-90. PMID: 10584470.
      View in: PubMed
    103. Loke KE, Laycock SK, Mital S, Wolin MS, Bernstein R, Oz M, Addonizio L, Kaley G, Hintze TH. Nitric oxide modulates mitochondrial respiration in failing human heart. Circulation. 1999 Sep 21; 100(12):1291-7. PMID: 10491373.
      View in: PubMed
    104. Mital S, Loke KE, Slater JP, Addonizio L, Gersony WM, Hintze TH. Synergy of amlodipine and angiotensin-converting enzyme inhibitors in regulating myocardial oxygen consumption in normal canine and failing human hearts. Am J Cardiol. 1999 Jun 17; 83(12A):92H-98H. PMID: 10750596.
      View in: PubMed
    105. Karpawich PP, Mital S. Comparative left ventricular function following atrial, septal, and apical single chamber heart pacing in the young. Pacing Clin Electrophysiol. 1997 Aug; 20(8 Pt 1):1983-8. PMID: 9272537.
      View in: PubMed
    Mital's networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description