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Lili-Naz Hazrati

TitleNeuropathologist
InstitutionThe Hospital for Sick Children
DepartmentPaediatric Laboratory Medicine (PLM)
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. D'Arcy CE, Bitnun A, Coulthart MB, D'Amour R, Friedman J, Knox JD, Rapoport A, Carter S, Widjaja E, Hazrati LN, Jansen GH. Sporadic Creutzfeldt-Jakob Disease in a Young Girl With Unusually Long Survival. J Neuropathol Exp Neurol. 2019 Apr 01; 78(4):373-378. PMID: 30856268.
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    2. Finnegan ME, Visanji NP, Romero-Canelon I, House E, Rajan S, Mosselmans JFW, Hazrati LN, Dobson J, Collingwood JF. Synchrotron XRF imaging of Alzheimer's disease basal ganglia reveals linear dependence of high-field magnetic resonance microscopy on tissue iron concentration. J Neurosci Methods. 2019 Mar 06. PMID: 30851339.
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    3. Schwab N, Tator C, Hazrati LN. DNA damage as a marker of brain damage in individuals with history of concussions. Lab Invest. 2019 Feb 13. PMID: 30760862.
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    4. Alkhunaizi E, Shuster S, Shannon P, Siu VM, Darilek S, Mohila CA, Boissel S, Ellezam B, Fallet-Bianco C, Laberge AM, Zandberg J, Injeyan M, Hazrati LN, Hamdan F, Chitayat D. Homozygous/compound heterozygote RYR1 gene variants: Expanding the clinical spectrum. Am J Med Genet A. 2019 Mar; 179(3):386-396. PMID: 30652412.
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    5. Nimmo GAM, Venkatesh S, Pandey AK, Marshall CR, Hazrati LN, Blaser S, Ahmed S, Cameron J, Singh K, Ray PN, Suzuki CK, Yoon G. Bi-allelic mutations of LONP1 encoding the mitochondrial LonP1 protease cause pyruvate dehydrogenase deficiency and profound neurodegeneration with progressive cerebellar atrophy. Hum Mol Genet. 2019 Jan 15; 28(2):290-306. PMID: 30304514.
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    6. Van Ommeren RH, Gao AF, Blaser SI, Chitayat DA, Hazrati LN. BRAT1 Mutation: The First Reported Case of Chinese Origin and Review of the Literature. J Neuropathol Exp Neurol. 2018 Dec 01; 77(12):1071-1078. PMID: 30346566.
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    7. Leveille E, Gonorazky HD, Rioux MF, Hazrati LN, Ruskey JA, Carnevale A, Spiegelman D, Dionne-Laporte A, Rouleau GA, Yoon G, Gan-Or Z. Triple A syndrome presenting as complicated hereditary spastic paraplegia. Mol Genet Genomic Med. 2018 11; 6(6):1134-1139. PMID: 30381913.
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    8. Mathieu F, Abel TJ, Hazrati LN, Rutka JT. Intraosseous schwannoma of the occipital bone: a case report. Childs Nerv Syst. 2018 Sep; 34(9):1803-1805. PMID: 29732471.
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    9. Schwab N, Hazrati LN. Assessing the Limitations and Biases in the Current Understanding of Chronic Traumatic Encephalopathy. J Alzheimers Dis. 2018; 64(4):1067-1076. PMID: 30010133.
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    10. Whitney R, AlMehmadi S, McCoy B, Yau I, Ochi A, Otsubo H, Weiss SK, Rutka J, Hazrati LN, Snead OC, Go C. The Fault in Their Stars-Accumulating Astrocytic Inclusions Associated With Clusters of Epileptic Spasms in Children With Global Developmental Delay. Pediatr Neurol. 2017 Aug; 73:92-97.e3. PMID: 28549652.
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    11. Gonorazky HD, Marshall CR, Al-Murshed M, Hazrati LN, Thor MG, Hanna MG, Männikkö R, Ray PN, Yoon G. Congenital myopathy with "corona" fibres, selective muscle atrophy, and craniosynostosis associated with novel recessive mutations in SCN4A. Neuromuscul Disord. 2017 Jun; 27(6):574-580. PMID: 28262468.
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    12. Rubinger L, Hazrati LN, Ahmed R, Rutka J, Snead C, Widjaja E. Microscopic and macroscopic infarct complicating pediatric epilepsy surgery. Epilepsia. 2017 03; 58(3):393-401. PMID: 28111751.
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    13. Hiploylee C, Dufort PA, Davis HS, Wennberg RA, Tartaglia MC, Mikulis D, Hazrati LN, Tator CH. Longitudinal Study of Postconcussion Syndrome: Not Everyone Recovers. J Neurotrauma. 2017 04 15; 34(8):1511-1523. PMID: 27784191.
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    14. Schaafsma JD, Hui F, Wisco D, Staugaitis SM, Uchino K, Kouzmitcheva E, Jaigobin C, Hazrati LN, Mikulis DJ, Mandell DM. High-Resolution Vessel Wall MRI : Appearance of Intravascular Lymphoma Mimics Central Nervous System Vasculitis. Clin Neuroradiol. 2017 Mar; 27(1):105-108. PMID: 27530660.
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    15. Soliman SE, Wan MJ, Heon E, Hazrati LN, Gallie B. Retinoblastoma versus advanced Coats' disease: Is enucleation the answer? Ophthalmic Genet. 2017 May-Jun; 38(3):291-293. PMID: 27435805.
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    16. Doherty MK, Jao K, Shepherd FA, Hazrati LN, Leighl NB. Central Nervous System Pseudoprogression in a Patient Treated with PD-1 Checkpoint Inhibitor. J Thorac Oncol. 2015 Oct; 10(10):e100-1. PMID: 26398825.
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    17. Hadley KC, Rakhit R, Guo H, Sun Y, Jonkman JE, McLaurin J, Hazrati LN, Emili A, Chakrabartty A. Determining composition of micron-scale protein deposits in neurodegenerative disease by spatially targeted optical microproteomics. Elife. 2015 Sep 29; 4. PMID: 26418743; PMCID: PMC4630677.
    18. Kouzmitcheva E, Steriade C, Prica A, Hazrati LN, Mandell DM. Clinical Reasoning: A 66-year-old man with recurrent multi-territory infarcts. Neurology. 2015 Jun 09; 84(23):e195-201. PMID: 26054898.
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    19. Visanji NP, Kamali Sarvestani I, Creed MC, Shams Shoaei Z, Nobrega JN, Hamani C, Hazrati LN. Deep brain stimulation of the subthalamic nucleus preferentially alters the translational profile of striatopallidal neurons in an animal model of Parkinson's disease. Front Cell Neurosci. 2015; 9:221. PMID: 26106299; PMCID: PMC4460554.
    20. Matsuzaki S, Lee L, Knock E, Srikumar T, Sakurai M, Hazrati LN, Katayama T, Staniszewski A, Raught B, Arancio O, Fraser PE. SUMO1 Affects Synaptic Function, Spine Density and Memory. Sci Rep. 2015 May 29; 5:10730. PMID: 26022678; PMCID: PMC4650663.
    21. Meissner A, Visanji NP, Momen MA, Feng R, Francis BM, Bolz SS, Hazrati LN. Tumor Necrosis Factor-a Underlies Loss of Cortical Dendritic Spine Density in a Mouse Model of Congestive Heart Failure. J Am Heart Assoc. 2015 May 06; 4(5). PMID: 25948533; PMCID: PMC4599420.
    22. Ling H, Asi YT, Petrovic IN, Ahmed Z, Prashanth LK, Hazrati LN, Nishizawa M, Ozawa T, Lang A, Lees AJ, Revesz T, Holton JL. Minimal change multiple system atrophy: an aggressive variant? Mov Disord. 2015 Jun; 30(7):960-7. PMID: 25854893.
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    23. Alturkustani M, Keith J, Hazrati LN, Rademakers R, Ang LC. Pathologic staging of white matter lesions in adult-onset leukoencephalopathy/leukodystrophy with axonal spheroids. J Neuropathol Exp Neurol. 2015 Mar; 74(3):233-40. PMID: 25668567.
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    24. Visanji NP, Marras C, Kern DS, Al Dakheel A, Gao A, Liu LW, Lang AE, Hazrati LN. Colonic mucosal a-synuclein lacks specificity as a biomarker for Parkinson disease. Neurology. 2015 Feb 10; 84(6):609-16. PMID: 25589666; PMCID: PMC4335990.
    25. Barucker C, Sommer A, Beckmann G, Eravci M, Harmeier A, Schipke CG, Brockschnieder D, Dyrks T, Althoff V, Fraser PE, Hazrati LN, George-Hyslop PS, Breitner JC, Peters O, Multhaup G. Alzheimer amyloid peptide aß42 regulates gene expression of transcription and growth factors. J Alzheimers Dis. 2015; 44(2):613-24. PMID: 25318543.
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    26. Kalia LV, Lang AE, Hazrati LN, Fujioka S, Wszolek ZK, Dickson DW, Ross OA, Van Deerlin VM, Trojanowski JQ, Hurtig HI, Alcalay RN, Marder KS, Clark LN, Gaig C, Tolosa E, Ruiz-Martínez J, Marti-Masso JF, Ferrer I, López de Munain A, Goldman SM, Schüle B, Langston JW, Aasly JO, Giordana MT, Bonifati V, Puschmann A, Canesi M, Pezzoli G, Maues De Paula A, Hasegawa K, Duyckaerts C, Brice A, Stoessl AJ, Marras C. Clinical correlations with Lewy body pathology in LRRK2-related Parkinson disease. JAMA Neurol. 2015 Jan; 72(1):100-5. PMID: 25401511; PMCID: PMC4399368.
    27. Visanji NP, Marras C, Liu LW, Hazrati LN, Lang AE. Reply to: Gray et al. Mov Disord. 2014 Aug; 29(9):1225-6. PMID: 24925804.
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    28. Tartaglia MC, Hazrati LN, Davis KD, Green RE, Wennberg R, Mikulis D, Ezerins LJ, Keightley M, Tator C. Chronic traumatic encephalopathy and other neurodegenerative proteinopathies. Front Hum Neurosci. 2014; 8:30. PMID: 24550810; PMCID: PMC3907709.
    29. Connolly BS, Hazrati LN, Lang AE. Neuropathological findings in chorea-acanthocytosis: new insights into mechanisms underlying parkinsonism and seizures. Acta Neuropathol. 2014 Apr; 127(4):613-5. PMID: 24394886.
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    30. Visanji NP, Marras C, Hazrati LN, Liu LW, Lang AE. Alimentary, my dear Watson? The challenges of enteric a-synuclein as a Parkinson's disease biomarker. Mov Disord. 2014 Apr; 29(4):444-50. PMID: 24375496.
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    31. Butcher NJ, Kiehl TR, Hazrati LN, Chow EW, Rogaeva E, Lang AE, Bassett AS. Association between early-onset Parkinson disease and 22q11.2 deletion syndrome: identification of a novel genetic form of Parkinson disease and its clinical implications. JAMA Neurol. 2013 Nov; 70(11):1359-66. PMID: 24018986; PMCID: PMC4464823.
    32. Wong JC, O'Neill B, Hawkins CE, Kleinschmidt-DeMasters BK, Hazrati LN. Child Neurology: Pediatric seizures with hyaline astrocytic inclusions. Neurology. 2013 Jul 16; 81(3):e14-6. PMID: 23858415; PMCID: PMC3770161.
    33. Wong JC, Hazrati LN. Parkinson's disease, parkinsonism, and traumatic brain injury. Crit Rev Clin Lab Sci. 2013 Jul-Oct; 50(4-5):103-6. PMID: 24156652.
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    34. Thomason LA, Smithson LJ, Hazrati LN, McLaurin J, Kawaja MD. Reactive astrocytes associated with plaques in TgCRND8 mouse brain and in human Alzheimer brain express phosphoprotein enriched in astrocytes (PEA-15). FEBS Lett. 2013 Aug 02; 587(15):2448-54. PMID: 23792157.
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    35. Hazrati LN, Tartaglia MC, Diamandis P, Davis KD, Green RE, Wennberg R, Wong JC, Ezerins L, Tator CH. Absence of chronic traumatic encephalopathy in retired football players with multiple concussions and neurological symptomatology. Front Hum Neurosci. 2013; 7:222. PMID: 23745112; PMCID: PMC3662898.
    36. Visanji NP, Brooks PL, Hazrati LN, Lang AE. The prion hypothesis in Parkinson's disease: Braak to the future. Acta Neuropathol Commun. 2013 May 08; 1:2. PMID: 24252164; PMCID: PMC3776210.
    37. Perlas A, Wong P, Abdallah F, Hazrati LN, Tse C, Chan V. Ultrasound-guided popliteal block through a common paraneural sheath versus conventional injection: a prospective, randomized, double-blind study. Reg Anesth Pain Med. 2013 May-Jun; 38(3):218-25. PMID: 23558372.
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    38. Begcevic I, Kosanam H, Martínez-Morillo E, Dimitromanolakis A, Diamandis P, Kuzmanov U, Hazrati LN, Diamandis EP. Semiquantitative proteomic analysis of human hippocampal tissues from Alzheimer's disease and age-matched control brains. Clin Proteomics. 2013 May 01; 10(1):5. PMID: 23635041; PMCID: PMC3648498.
    39. Visanji NP, Collingwood JF, Finnegan ME, Tandon A, House E, Hazrati LN. Iron deficiency in parkinsonism: region-specific iron dysregulation in Parkinson's disease and multiple system atrophy. J Parkinsons Dis. 2013; 3(4):523-37. PMID: 24113558.
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    40. Xi Z, Zinman L, Grinberg Y, Moreno D, Sato C, Bilbao JM, Ghani M, Hernández I, Ruiz A, Boada M, Morón FJ, Lang AE, Marras C, Bruni A, Colao R, Maletta RG, Puccio G, Rainero I, Pinessi L, Galimberti D, Morrison KE, Moorby C, Stockton JD, Masellis M, Black SE, Hazrati LN, Liang Y, van Haersma de With J, Fornazzari L, Villagra R, Rojas-Garcia R, Clarimón J, Mayeux R, Robertson J, St George-Hyslop P, Rogaeva E. Investigation of c9orf72 in 4 neurodegenerative disorders. Arch Neurol. 2012 Dec; 69(12):1583-90. PMID: 22964832.
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    41. Guerreiro R, Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E, Cruchaga C, Sassi C, Kauwe JS, Younkin S, Hazrati L, Collinge J, Pocock J, Lashley T, Williams J, Lambert JC, Amouyel P, Goate A, Rademakers R, Morgan K, Powell J, St George-Hyslop P, Singleton A, Hardy J. TREM2 variants in Alzheimer's disease. N Engl J Med. 2013 Jan 10; 368(2):117-27. PMID: 23150934.
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    42. Wong JC, Armstrong MJ, Lang AE, Hazrati LN. Clinicopathological review of pallidonigroluysian atrophy. Mov Disord. 2013 Mar; 28(3):274-81. PMID: 23114877.
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    43. Hazrati LN, Wong JC, Hamani C, Lozano AM, Poon YY, Dostrovsky JO, Hutchison WD, Zadikoff C, Moro E. Clinicopathological study in progressive supranuclear palsy with pedunculopontine stimulation. Mov Disord. 2012 Sep 01; 27(10):1304-7. PMID: 22865554.
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    44. Hazrati LN, Van Cauwenberghe C, Brooks PL, Brouwers N, Ghani M, Sato C, Cruts M, Sleegers K, St George-Hyslop P, Van Broeckhoven C, Rogaeva E. Genetic association of CR1 with Alzheimer's disease: a tentative disease mechanism. Neurobiol Aging. 2012 Dec; 33(12):2949.e5-2949.e12. PMID: 22819390.
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    45. Petrovic IN, Ling H, Asi Y, Ahmed Z, Kukkle PL, Hazrati LN, Lang AE, Revesz T, Holton JL, Lees AJ. Multiple system atrophy-parkinsonism with slow progression and prolonged survival: a diagnostic catch. Mov Disord. 2012 Aug; 27(9):1186-90. PMID: 22806758.
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    46. Ehsani S, Salehzadeh A, Huo H, Reginold W, Pocanschi CL, Ren H, Wang H, So K, Sato C, Mehrabian M, Strome R, Trimble WS, Hazrati LN, Rogaeva E, Westaway D, Carlson GA, Schmitt-Ulms G. LIV-1 ZIP ectodomain shedding in prion-infected mice resembles cellular response to transition metal starvation. J Mol Biol. 2012 Sep 28; 422(4):556-574. PMID: 22687393.
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    47. Huot P, Johnston TH, Visanji NP, Darr T, Pires D, Hazrati LN, Brotchie JM, Fox SH. Increased levels of 5-HT1A receptor binding in ventral visual pathways in Parkinson's disease. Mov Disord. 2012 May; 27(6):735-42. PMID: 22419526.
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    48. Visanji NP, Wong JC, Wang SX, Cappel B, Kleinschmidt-Demasters BK, Handler MH, Ochi A, Otsubo H, Rutka JT, Go C, Weiss S, Vinters HV, Hawkins CE, Desouza LV, Siu KW, Hazrati LN. A proteomic analysis of pediatric seizure cases associated with astrocytic inclusions. Epilepsia. 2012 Mar; 53(3):e50-4. PMID: 22220588.
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    49. Wong JC, Chow TW, Hazrati LN. Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia can present as frontotemporal dementia syndrome. Dement Geriatr Cogn Disord. 2011; 32(2):150-8. PMID: 21986056.
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    50. Reitz C, Tokuhiro S, Clark LN, Conrad C, Vonsattel JP, Hazrati LN, Palotás A, Lantigua R, Medrano M, Z Jiménez-Velázquez I, Vardarajan B, Simkin I, Haines JL, Pericak-Vance MA, Farrer LA, Lee JH, Rogaeva E, George-Hyslop PS, Mayeux R. SORCS1 alters amyloid precursor protein processing and variants may increase Alzheimer's disease risk. Ann Neurol. 2011 Jan; 69(1):47-64. PMID: 21280075.
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    51. Huot P, Johnston TH, Darr T, Hazrati LN, Visanji NP, Pires D, Brotchie JM, Fox SH. Increased 5-HT2A receptors in the temporal cortex of parkinsonian patients with visual hallucinations. Mov Disord. 2010 Jul 30; 25(10):1399-408. PMID: 20629135.
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    52. Hazrati LN, Bergeron C, Butany J. Neuropathology of cerebrovascular diseases. Semin Diagn Pathol. 2009 May; 26(2):103-15. PMID: 19891304.
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    53. Hazrati LN, Kleinschmidt-DeMasters BK, Handler MH, Smith ML, Ochi A, Otsubo H, Rutka JT, Go C, Weiss S, Hawkins CE. Astrocytic inclusions in epilepsy: expanding the spectrum of filaminopathies. J Neuropathol Exp Neurol. 2008 Jul; 67(7):669-76. PMID: 18596546.
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    54. Hazrati LN, Bergeron C. Neuropathology and genetics of corticobasal degeneration. Handb Clin Neurol. 2008; 89:523-32. PMID: 18631774.
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    55. Hazrati LN, Bril V, Nag S. Muscle and nerve involvement in granulomatous mycosis fungoides. Muscle Nerve. 2007 Dec; 36(6):860-5. PMID: 17487868.
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    56. Friedman Y, Paul JT, Turley J, Hazrati LN, Munoz D. Axial myopathy due to primary amyloidosis. Muscle Nerve. 2007 Oct; 36(4):542-6. PMID: 17405139.
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