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Sarah Alexander

TitleStaff Physician
InstitutionThe Hospital for Sick Children
DepartmentHaematology/Oncology
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Egan G, Athale U, Johnston D, Pole JD, Silva M, Zorzi A, Alexander S. Outcomes of children with chronic myeloid leukemia: A population-based cohort study. Pediatr Blood Cancer. 2020 Jun 26; e28491. PMID: 32589368.
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    2. Lehrnbecher T, Fisher BT, Phillips B, Alexander S, Ammann RA, Beauchemin M, Carlesse F, Castagnola E, Davis BL, Dupuis LL, Egan G, Groll AH, Haeusler GM, Santolaya M, Steinbach WJ, van de Wetering M, Wolf J, Cabral S, Robinson PD, Sung L. Guideline for Antibacterial Prophylaxis Administration in Pediatric Cancer and Hematopoietic Stem Cell Transplantation. Clin Infect Dis. 2020 Jun 24; 71(1):226-236. PMID: 31676904.
      View in: PubMed
    3. Minard-Colin V, Aupérin A, Pillon M, Burke GAA, Barkauskas DA, Wheatley K, Delgado RF, Alexander S, Uyttebroeck A, Bollard CM, Zsiros J, Csoka M, Kazanowska B, Chiang AK, Miles RR, Wotherspoon A, Adamson PC, Vassal G, Patte C, Gross TG. Rituximab for High-Risk, Mature B-Cell Non-Hodgkin's Lymphoma in Children. N Engl J Med. 2020 06 04; 382(23):2207-2219. PMID: 32492302.
      View in: PubMed
    4. Sultan B, Benn P, Schembri G, Patel H, Brima N, Alexander S, Ison CA. Test of cure study: a feasibility study to estimate the time to test of cure (TOC) for Neisseria gonorrhoeae and Chlamydia trachomatis infections. Sex Transm Infect. 2020 May 23. PMID: 32447324.
      View in: PubMed
    5. Barrera M, Alexander S, Atenafu EG, Chung J, Hancock K, Solomon A, Desjardins L, Shama W, Mills D. Psychosocial screening and mental health in pediatric cancer: A randomized controlled trial. Health Psychol. 2020 May; 39(5):381-390. PMID: 31971403.
      View in: PubMed
    6. Barrera M, Hancock K, Atenafu E, Alexander S, Solomon A, Desjardins L, Shama W, Chung J, Mills D. Quality of life in pediatric oncology patients, caregivers and siblings after psychosocial screening: a randomized controlled trial. Support Care Cancer. 2020 Aug; 28(8):3659-3668. PMID: 31811485.
      View in: PubMed
    7. Alexander S, Science M, Breakey V, Clarke A, Gibson P. Recommendations for medical care in the pediatric oncology camp setting: Consensus statements based on Delphi methodology. Pediatr Blood Cancer. 2020 03; 67(3):e28107. PMID: 31797560.
      View in: PubMed
    8. Kovacevic A, Sivananthan A, Patel R, Patel P, Vennettilli A, Paw Cho Sing E, Zupanec S, Alexander S, Sung L, Dupuis LL. Chemotherapy-induced nausea and vomiting from oral chemotherapy for childhood acute lymphoblastic leukaemia: feasibility study. BMJ Support Palliat Care. 2019 Nov 29. PMID: 31784465.
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    9. Fisher BT, Zaoutis T, Dvorak CC, Nieder M, Zerr D, Wingard JR, Callahan C, Villaluna D, Chen L, Dang H, Esbenshade AJ, Alexander S, Wiley JM, Sung L. Effect of Caspofungin vs Fluconazole Prophylaxis on Invasive Fungal Disease Among Children and Young Adults With Acute Myeloid Leukemia: A Randomized Clinical Trial. JAMA. 2019 11 05; 322(17):1673-1681. PMID: 31688884.
      View in: PubMed
    10. Laskaratos FM, Mandair D, Hall A, Alexander S, von Stempel C, Bretherton J, Luong T, Watkins J, Ogunbiyi O, Rombouts K, Caplin M, Toumpanakis C. Clinicopathological correlations of mesenteric fibrosis and evaluation of a novel biomarker for fibrosis detection in small bowel neuroendocrine neoplasms. Endocrine. 2020 Mar; 67(3):718-726. PMID: 31598848.
      View in: PubMed
    11. Desjardins L, Etkin-Spigelman L, Hancock K, Chung J, Shama W, Mills D, Alexander S, Barrera M. Healthcare provider utility ratings of a psychosocial screening summary: from diagnosis to 6 months. Support Care Cancer. 2020 Apr; 28(4):1717-1723. PMID: 31292754.
      View in: PubMed
    12. Egan G, Robinson PD, Martinez JPD, Alexander S, Ammann RA, Dupuis LL, Fisher BT, Lehrnbecher T, Phillips B, Cabral S, Tomlinson G, Sung L. Efficacy of antibiotic prophylaxis in patients with cancer and hematopoietic stem cell transplantation recipients: A systematic review of randomized trials. Cancer Med. 2019 08; 8(10):4536-4546. PMID: 31274245.
      View in: PubMed
    13. Bhojwani D, Sposto R, Shah NN, Rodriguez V, Yuan C, Stetler-Stevenson M, O'Brien MM, McNeer JL, Quereshi A, Cabannes A, Schlegel P, Rossig C, Dalla-Pozza L, August K, Alexander S, Bourquin JP, Zwaan M, Raetz EA, Loh ML, Rheingold SR. Correction: Inotuzumab ozogamicin in pediatric patients with relapsed/refractory acute lymphoblastic leukemia. Leukemia. 2019 Apr; 33(4):1061-1062. PMID: 30842605.
      View in: PubMed
    14. Wheaton L, Alexander S. Pregnancy Screening and Contraceptive Counseling in Young Women with Hodgkin Lymphoma: A Single Center Retrospective Review. J Adolesc Young Adult Oncol. 2019 06; 8(3):349-353. PMID: 30811262.
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    15. Egan G, Goldman S, Alexander S. Mature B-NHL in children, adolescents and young adults: current therapeutic approach and emerging treatment strategies. Br J Haematol. 2019 06; 185(6):1071-1085. PMID: 30613948.
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    16. Bhojwani D, Sposto R, Shah NN, Rodriguez V, Yuan C, Stetler-Stevenson M, O'Brien MM, McNeer JL, Quereshi A, Cabannes A, Schlegel P, Rossig C, Dalla-Pozza L, August K, Alexander S, Bourquin JP, Zwaan M, Raetz EA, Loh ML, Rheingold SR. Inotuzumab ozogamicin in pediatric patients with relapsed/refractory acute lymphoblastic leukemia. Leukemia. 2019 04; 33(4):884-892. PMID: 30267011.
      View in: PubMed
    17. Alexander S, Fisher BT, Gaur AH, Dvorak CC, Villa Luna D, Dang H, Chen L, Green M, Nieder ML, Fisher B, Bailey LC, Wiernikowski J, Sung L. Effect of Levofloxacin Prophylaxis on Bacteremia in Children With Acute Leukemia or Undergoing Hematopoietic Stem Cell Transplantation: A Randomized Clinical Trial. JAMA. 2018 09 11; 320(10):995-1004. PMID: 30208456.
      View in: PubMed
    18. Barrera M, Alexander S, Shama W, Mills D, Desjardins L, Hancock K. Perceived benefits of and barriers to psychosocial risk screening in pediatric oncology by health care providers. Pediatr Blood Cancer. 2018 12; 65(12):e27429. PMID: 30160072.
      View in: PubMed
    19. Gibson P, Pole JD, Lazor T, Johnston D, Portwine C, Silva M, Alexander S, Sung L. Treatment-related mortality in newly diagnosed pediatric cancer: a population-based analysis. Cancer Med. 2018 03; 7(3):707-715. PMID: 29473334.
      View in: PubMed
    20. Alexander S, Greenberg M, Malkin D, Portwine C, Johnston D, Silva M, Zelcer S, Sonshine S, Manzo J, Bennett C, Brodeur-Robb K, Deveault C, Ramachandran N, Gibson P. Pediatric oncology clinical trial participation where the geography is vast: Development of a clinical research system for tertiary and satellite centers in Ontario, Canada. Pediatr Blood Cancer. 2018 04; 65(4). PMID: 29271602.
      View in: PubMed
    21. Giulino-Roth L, O'Donohue T, Chen Z, Bartlett NL, LaCasce A, Martin-Doyle W, Barth MJ, Davies K, Blum KA, Christian B, Casulo C, Smith SM, Godfrey J, Termuhlen A, Oberley MJ, Alexander S, Weitzman S, Appel B, Mizukawa B, Svoboda J, Afify Z, Pauly M, Dave H, Gardner R, Stephens DM, Zeitler WA, Forlenza C, Levine J, Williams ME, Sima JL, Bollard CM, Leonard JP. Outcomes of adults and children with primary mediastinal B-cell lymphoma treated with dose-adjusted EPOCH-R. Br J Haematol. 2017 12; 179(5):739-747. PMID: 29082519.
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    22. Lehrnbecher T, Robinson P, Fisher B, Alexander S, Ammann RA, Beauchemin M, Carlesse F, Groll AH, Haeusler GM, Santolaya M, Steinbach WJ, Castagnola E, Davis BL, Dupuis LL, Gaur AH, Tissing WJE, Zaoutis T, Phillips R, Sung L. Guideline for the Management of Fever and Neutropenia in Children With Cancer and Hematopoietic Stem-Cell Transplantation Recipients: 2017 Update. J Clin Oncol. 2017 Jun 20; 35(18):2082-2094. PMID: 28459614.
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    23. Even-Or E, Di Mola M, Ali M, Courtney S, McDougall E, Alexander S, Schechter T, Whitlock JA, Licht C, Krueger J. Optimizing autologous nonmobilized mononuclear cell collections for cellular therapy in pediatric patients with high-risk leukemia. Transfusion. 2017 06; 57(6):1536-1542. PMID: 28439898.
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    24. Pole JD, Gibson P, Ethier MC, Lazor T, Johnston DL, Portwine C, Silva M, Alexander S, Sung L. Evaluation of treatment-related mortality among paediatric cancer deaths: a population based analysis. Br J Cancer. 2017 Feb 14; 116(4):540-545. PMID: 28095399.
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    25. Nihayah S, Shammas A, Vali R, Parra D, Alexander S, Amaral J, Connolly B. Correlation of PET/CT and Image-Guided Biopsies of Pediatric Malignancies. AJR Am J Roentgenol. 2017 Mar; 208(3):656-662. PMID: 28026209.
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    26. Field N, Clifton S, Alexander S, Ison CA, Khanom R, Saunders P, Hughes G, Heath L, Beddows S, Mercer CH, Tanton C, Johnson AM, Sonnenberg P. Trichomonas vaginalis infection is uncommon in the British general population: implications for clinical testing and public health screening. Sex Transm Infect. 2018 05; 94(3):226-229. PMID: 27686884.
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    27. Ceppi F, Weitzman S, Woessmann W, Davies K, Lassaletta A, Reismüller B, Mellgren K, Uyttebroeck A, Maia I, Abdullah S, Miakova N, Glaser D, Cohn R, Abla O, Attarbaschi A, Alexander S. Safety and efficacy of intrathecal rituximab in children with B cell lymphoid CD20+ malignancies: An international retrospective study. Am J Hematol. 2016 May; 91(5):486-91. PMID: 26872652.
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    28. Alexander S, Pole JD, Gibson P, Lee M, Hesser T, Chi SN, Dvorak CC, Fisher B, Hasle H, Kanerva J, Möricke A, Phillips B, Raetz E, Rodriguez-Galindo C, Samarasinghe S, Schmiegelow K, Tissing W, Lehrnbecher T, Sung L. Classification of treatment-related mortality in children with cancer: a systematic assessment. Lancet Oncol. 2015 Dec; 16(16):e604-10. PMID: 26678213.
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    29. Shaikh F, Dupuis LL, Alexander S, Gupta A, Mertens L, Nathan PC. Cardioprotection and Second Malignant Neoplasms Associated With Dexrazoxane in Children Receiving Anthracycline Chemotherapy: A Systematic Review and Meta-Analysis. J Natl Cancer Inst. 2016 Apr; 108(4). PMID: 26598513.
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    30. Brulé D, Gillmeister B, Lee M, Alexander S, Gassas A, Hendershot E, Zupanec S, Dupuis L, Sung L. A Feasibility Pilot Trial of Individualized Homeopathic Treatment of Fatigue in Children Receiving Chemotherapy. Integr Cancer Ther. 2016 12; 15(4):495-501. PMID: 26574487.
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    31. Woodhall SC, Nichols T, Alexander S, da Silva FC, Mercer CH, Ison C, Gill ON, Soldan K. Can we use postal surveys with anonymous testing to monitor chlamydia prevalence in young women in England? Pilot study incorporating randomised controlled trial of recruitment methods. Sex Transm Infect. 2015 Sep; 91(6):412-4. PMID: 26294693.
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    32. Woodhall SC, Soldan K, Sonnenberg P, Mercer CH, Clifton S, Saunders P, da Silva F, Alexander S, Wellings K, Tanton C, Field N, Copas AJ, Ison CA, Johnson AM. Is chlamydia screening and testing in Britain reaching young adults at risk of infection? Findings from the third National Survey of Sexual Attitudes and Lifestyles (Natsal-3). Sex Transm Infect. 2016 May; 92(3):218-27. PMID: 26290483.
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    33. Grant RC, Shaikh F, Abdelhaleem M, Alexander SW, Cada M. Risk factors for inadequate bone marrow biopsies in children. Am J Hematol. 2015 Sep; 90(9):E187-9. PMID: 26043864.
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    34. Kassam A, Skiadaresis J, Alexander S, Wolfe J. Differences in end-of-life communication for children with advanced cancer who were referred to a palliative care team. Pediatr Blood Cancer. 2015 Aug; 62(8):1409-13. PMID: 25882665.
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    35. Fisher M, Wayal S, Smith H, Llewellyn C, Alexander S, Ison C, Parry JV, Singleton G, Perry N, Richardson D. Home sampling for sexually transmitted infections and HIV in men who have sex with men: a prospective observational study. PLoS One. 2015; 10(4):e0120810. PMID: 25848769.
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    36. DiLabio J, Doyle J, Alexander S, Gupta S, Punnett A. Impact of Ethnicity on Donor Search Results for Children Requiring Stem Cell Transplantation. J Pediatr Hematol Oncol. 2015 Apr; 37(3):e154-7. PMID: 25333838.
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    37. Shlien A, Campbell BB, de Borja R, Alexandrov LB, Merico D, Wedge D, Van Loo P, Tarpey PS, Coupland P, Behjati S, Pollett A, Lipman T, Heidari A, Deshmukh S, Avitzur N, Meier B, Gerstung M, Hong Y, Merino DM, Ramakrishna M, Remke M, Arnold R, Panigrahi GB, Thakkar NP, Hodel KP, Henninger EE, Göksenin AY, Bakry D, Charames GS, Druker H, Lerner-Ellis J, Mistry M, Dvir R, Grant R, Elhasid R, Farah R, Taylor GP, Nathan PC, Alexander S, Ben-Shachar S, Ling SC, Gallinger S, Constantini S, Dirks P, Huang A, Scherer SW, Grundy RG, Durno C, Aronson M, Gartner A, Meyn MS, Taylor MD, Pursell ZF, Pearson CE, Malkin D, Futreal PA, Stratton MR, Bouffet E, Hawkins C, Campbell PJ, Tabori U. Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers. Nat Genet. 2015 Mar; 47(3):257-62. PMID: 25642631.
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    38. Alexander S. Clinically defining and managing high-risk pediatric patients with acute lymphoblastic leukemia. Hematology Am Soc Hematol Educ Program. 2014 Dec 05; 2014(1):181-9. PMID: 25696853.
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    39. Flank J, Thackray J, Nielson D, August A, Schechter T, Alexander S, Sung L, Dupuis LL. Olanzapine for treatment and prevention of acute chemotherapy-induced vomiting in children: a retrospective, multi-center review. Pediatr Blood Cancer. 2015 Mar; 62(3):496-501. PMID: 25328089.
      View in: PubMed
    40. Tran TH, Lee M, Alexander S, Gibson P, Bartels U, Johnston DL, Portwine C, Silva M, Pole JD, Sung L. Lack of treatment-related mortality definitions in clinical trials of children, adolescents and young adults with lymphomas, solid tumors and brain tumors: a systematic review. BMC Cancer. 2014 Aug 26; 14:612. PMID: 25155014.
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    41. Alexander S, Kraveka JM, Weitzman S, Lowe E, Smith L, Lynch JC, Chang M, Kinney MC, Perkins SL, Laver J, Gross TG, Weinstein H. Advanced stage anaplastic large cell lymphoma in children and adolescents: results of ANHL0131, a randomized phase III trial of APO versus a modified regimen with vinblastine: a report from the children's oncology group. Pediatr Blood Cancer. 2014 Dec; 61(12):2236-42. PMID: 25156886.
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    42. Shaikh F, Voicu L, Tole S, To T, Doria AS, Sung L, Alexander S. The risk of traumatic lumbar punctures in children with acute lymphoblastic leukaemia. Eur J Cancer. 2014 May; 50(8):1482-9. PMID: 24656342.
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    43. Kassam A, Skiadaresis J, Alexander S, Wolfe J. Parent and clinician preferences for location of end-of-life care: home, hospital or freestanding hospice? Pediatr Blood Cancer. 2014 May; 61(5):859-64. PMID: 24265171.
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    44. Kirwan C, Ngan BY, Halliday W, Alexander S, Ali A. Primary conjunctival anaplastic large cell lymphoma in a child. J AAPOS. 2013 Aug; 17(4):437-9. PMID: 23896363.
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    45. Rodrigues A, Wong C, Mattiussi A, Alexander S, Lau E, Dupuis LL. Methylnaltrexone for opioid-induced constipation in pediatric oncology patients. Pediatr Blood Cancer. 2013 Oct; 60(10):1667-70. PMID: 23766091.
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    46. Shaikh F, Brzezinski J, Alexander S, Arzola C, Carvalho JC, Beyene J, Sung L. Ultrasound imaging for lumbar punctures and epidural catheterisations: systematic review and meta-analysis. BMJ. 2013 Mar 26; 346:f1720. PMID: 23532866.
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    47. Kassam A, Skiadaresis J, Habib S, Alexander S, Wolfe J. Moving toward quality palliative cancer care: parent and clinician perspectives on gaps between what matters and what is accessible. J Clin Oncol. 2013 Mar 01; 31(7):910-5. PMID: 23182989.
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    48. Al Mahmoud R, Weitzman S, Schechter T, Ngan B, Abdelhaleem M, Alexander S. Peripheral T-cell lymphoma in children and adolescents: a single-institution experience. J Pediatr Hematol Oncol. 2012 Nov; 34(8):611-6. PMID: 23042011.
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    49. Diorio C, Tomlinson D, Boydell KM, Regier DA, Ethier MC, Alli A, Alexander S, Gassas A, Taylor J, Kellow C, Mills D, Sung L. Attitudes toward infection prophylaxis in pediatric oncology: a qualitative approach. PLoS One. 2012; 7(10):e47815. PMID: 23112849.
      View in: PubMed
    50. Regier DA, Diorio C, Ethier MC, Alli A, Alexander S, Boydell KM, Gassas A, Taylor J, Kellow C, Mills D, Sung L. Discrete choice experiment to evaluate factors that influence preferences for antibiotic prophylaxis in pediatric oncology. PLoS One. 2012; 7(10):e47470. PMID: 23082169.
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    51. Lehrnbecher T, Phillips R, Alexander S, Alvaro F, Carlesse F, Fisher B, Hakim H, Santolaya M, Castagnola E, Davis BL, Dupuis LL, Gibson F, Groll AH, Gaur A, Gupta A, Kebudi R, Petrilli S, Steinbach WJ, Villarroel M, Zaoutis T, Sung L. Guideline for the management of fever and neutropenia in children with cancer and/or undergoing hematopoietic stem-cell transplantation. J Clin Oncol. 2012 Dec 10; 30(35):4427-38. PMID: 22987086.
      View in: PubMed
    52. Shaikh F, Ngan BY, Alexander S, Grant R. Progressive transformation of germinal centers in children and adolescents: an intriguing cause of lymphadenopathy. Pediatr Blood Cancer. 2013 Jan; 60(1):26-30. PMID: 22707034.
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    53. Phillips RS, Lehrnbecher T, Alexander S, Sung L. Updated systematic review and meta-analysis of the performance of risk prediction rules in children and young people with febrile neutropenia. PLoS One. 2012; 7(5):e38300. PMID: 22693615.
      View in: PubMed
    54. Gupta S, Crump HL, Alexander S. The utility of end-of-treatment bone marrow aspirates in pediatric acute lymphoblastic leukemia: a quality improvement project. Pediatr Blood Cancer. 2012 Dec 15; 59(7):1305-6. PMID: 22619044.
      View in: PubMed
    55. Sung L, Manji A, Beyene J, Dupuis LL, Alexander S, Phillips R, Lehrnbecher T. Fluoroquinolones in children with fever and neutropenia: a systematic review of prospective trials. Pediatr Infect Dis J. 2012 May; 31(5):431-5. PMID: 22189521.
      View in: PubMed
    56. Ethier MC, Alexander S, Abla O, Green G, Lam R, Sung L. Association between obesity at diagnosis and weight change during induction and survival in pediatric acute lymphoblastic leukemia. Leuk Lymphoma. 2012 Sep; 53(9):1677-81. PMID: 22390648.
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    57. Blanco E, Beyene J, Maloney AM, Almeida R, Ethier MC, Winick N, Alexander S, Sung L. Non-relapse mortality in pediatric acute lymphoblastic leukemia: a systematic review and meta-analysis. Leuk Lymphoma. 2012 May; 53(5):878-85. PMID: 22066711.
      View in: PubMed
    58. Dvorak CC, Fisher BT, Sung L, Steinbach WJ, Nieder M, Alexander S, Zaoutis TE. Antifungal prophylaxis in pediatric hematology/oncology: new choices & new data. Pediatr Blood Cancer. 2012 Jul 15; 59(1):21-6. PMID: 22102607.
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    59. Alexander S, Nieder M, Zerr DM, Fisher BT, Dvorak CC, Sung L. Prevention of bacterial infection in pediatric oncology: what do we know, what can we learn? Pediatr Blood Cancer. 2012 Jul 15; 59(1):16-20. PMID: 22102612.
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    60. Fisher BT, Alexander S, Dvorak CC, Zaoutis TE, Zerr DM, Sung L. Epidemiology and potential preventative measures for viral infections in children with malignancy and those undergoing hematopoietic cell transplantation. Pediatr Blood Cancer. 2012 Jul 15; 59(1):11-5. PMID: 22102619.
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    61. McCrone L, Alexander S, Karsli C, Taylor G, Amaral JG, Parra D, Temple M, John P, Connolly BL. US-guided percutaneous needle biopsy of anterior mediastinal masses in children. Pediatr Radiol. 2012 Jan; 42(1):40-9. PMID: 21863292.
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    62. Sung L, Yanofsky R, Klaassen RJ, Dix D, Pritchard S, Winick N, Alexander S, Klassen A. Quality of life during active treatment for pediatric acute lymphoblastic leukemia. Int J Cancer. 2011 Mar 01; 128(5):1213-20. PMID: 20473921.
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    63. Li S, Traubici J, Ethier MC, Gillmeister B, Alexander S, Gassas A, Sung L. Pneumatosis intestinalis in children with acute lymphoblastic leukemia and acute myeloid leukemia. Support Care Cancer. 2012 Feb; 20(2):343-7. PMID: 21234607.
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    64. Li X, Alexander S. Hereditary persistence of alpha-fetoprotein. Pediatr Blood Cancer. 2009 Mar; 52(3):403-5. PMID: 18985745.
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    65. Alexander S, Hopewell S, Hunter S, Chouksey A. Rituximab and desensitization for a patient with severe factor IX deficiency, inhibitors, and history of anaphylaxis. J Pediatr Hematol Oncol. 2008 Jan; 30(1):93-5. PMID: 18176193.
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    66. Jalal H, Stephen H, Alexander S, Carne C, Sonnex C. Development of real-time PCR assays for genotyping of Chlamydia trachomatis. J Clin Microbiol. 2007 Aug; 45(8):2649-53. PMID: 17567790.
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