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Jason Maynes

TitleAnesthesiologist in Chief
InstitutionThe Hospital for Sick Children
DepartmentAnaesthesia
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Petre MA, Levin DN, Englesakis M, Maynes JT, Pechlivanoglou P, Aoyama K. Dexmedetomidine vs. total intravenous anaesthesia in paediatric emergence delirium: A network meta-analysis. Eur J Anaesthesiol. 2021 Nov 01; 38(11):1111-1123. PMID: 33720063.
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    2. Malhi M, Norris MJ, Duan W, Moraes TJ, Maynes JT. Statin-mediated disruption of Rho GTPase prenylation and activity inhibits respiratory syncytial virus infection. Commun Biol. 2021 10 29; 4(1):1239. PMID: 34716403.
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    3. Shao Z, Masuho I, Tumber A, Maynes JT, Tavares E, Ali A, Hewson S, Schulze A, Kannu P, Martemyanov KA, Vincent A. Extended Phenotyping and Functional Validation Facilitate Diagnosis of a Complex Patient Harboring Genetic Variants in MCCC1 and GNB5 Causing Overlapping Phenotypes. Genes (Basel). 2021 Aug 29; 12(9). PMID: 34573334.
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    4. Shioji N, Aoyama K, Englesakis M, Annich G, Maynes JT. Multisystem inflammatory syndrome in children during the coronavirus disease pandemic of 2019: a review of clinical features and acute phase management. J Anesth. 2021 08; 35(4):563-570. PMID: 34052944.
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    5. Toyama Y, Harkness RW, Lee TYT, Maynes JT, Kay LE. Oligomeric assembly regulating mitochondrial HtrA2 function as examined by methyl-TROSY NMR. Proc Natl Acad Sci U S A. 2021 03 16; 118(11). PMID: 33692127.
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    6. Hogarth K, Vanama RB, Stratmann G, Maynes JT. Singular and short-term anesthesia exposure in the developing brain induces persistent neuronal changes consistent with chronic neurodegenerative disease. Sci Rep. 2021 03 11; 11(1):5673. PMID: 33707598.
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    7. Gai N, Aoyama K, Faraoni D, Goldenberg NM, Levin DN, Maynes JT, McVey MJ, Munshey F, Siddiqui A, Switzer T, Steinberg BE. General medical publications during COVID-19 show increased dissemination despite lower validation. PLoS One. 2021; 16(2):e0246427. PMID: 33529266.
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    8. Traister A, Patel R, Huang A, Patel S, Plakhotnik J, Lee JE, Medina MG, Welsh C, Ruparel P, Zhang L, Friedberg M, Maynes J, Coles J. Correction: Cardiac regenerative capacity is age- and disease-dependent in childhood heart disease. PLoS One. 2021; 16(1):e0245808. PMID: 33471867.
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    9. Daeschler SC, Manson N, Joachim K, Chin AWH, Chan K, Chen PZ, Tajdaran K, Mirmoeini K, Zhang JJ, Maynes JT, Zhang L, Science M, Darbandi A, Stephens D, Gu F, Poon LLM, Borschel GH. CMAJ. 2020 Dec 07; 192(49):E1747-E1756. PMID: 33288514.
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    10. Tabbarah S, Tavares E, Charish J, Vincent A, Paterson A, Di Scipio M, Yin Y, Mendoza-Londono R, Maynes J, Heon E, Monnier PP. COG5 variants lead to complex early onset retinal degeneration, upregulation of PERK and DNA damage. Sci Rep. 2020 12 04; 10(1):21269. PMID: 33277529.
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    11. Dou W, Wang L, Malhi M, Liu H, Zhao Q, Plakhotnik J, Xu Z, Huang Z, Simmons CA, Maynes JT, Sun Y. A microdevice platform for characterizing the effect of mechanical strain magnitudes on the maturation of iPSC-Cardiomyocytes. Biosens Bioelectron. 2021 Mar 01; 175:112875. PMID: 33303322.
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    12. Ishii R, Okumura K, Akazawa Y, Malhi M, Ebata R, Sun M, Fujioka T, Kato H, Honjo O, Kabir G, Kuebler WM, Connelly K, Maynes JT, Friedberg MK. Heart Rate Reduction Improves Right Ventricular Function and Fibrosis in Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2020 12; 63(6):843-855. PMID: 32915674.
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    13. Tong J, Krieger JR, Taylor P, Bagshaw R, Kang J, Jeedigunta S, Wybenga-Groot LE, Zhang W, Badr H, Mirhadi S, Pham NA, Coyaud É, Yu M, Li M, Cabanero M, Raught B, Maynes JT, Hawkins C, Tsao MS, Moran MF. Cancer proteome and metabolite changes linked to SHMT2. PLoS One. 2020; 15(9):e0237981. PMID: 32903271.
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    14. Grudzinska Pechhacker MK, Yoon G, Hazrati LN, Maynes J, MacDonald H, Tavares E, Vincent A, Heon E. FLVCR1-related disease as a rare cause of retinitis pigmentosa and hereditary sensory autonomic neuropathy. Eur J Med Genet. 2020 Nov; 63(11):104037. PMID: 32822874.
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    15. Gai N, Maynes JT, Aoyama K. Unique challenges in pediatric anesthesia created by COVID-19. J Anesth. 2021 06; 35(3):345-350. PMID: 32770277.
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    16. Vig A, Poulter JA, Ottaviani D, Tavares E, Toropova K, Tracewska AM, Mollica A, Kang J, Kehelwathugoda O, Paton T, Maynes JT, Wheway G, Arno G, Khan KN, McKibbin M, Toomes C, Ali M, Di Scipio M, Li S, Ellingford J, Black G, Webster A, Rydzanicz M, Stawinski P, Ploski R, Vincent A, Cheetham ME, Inglehearn CF, Roberts A, Heon E. DYNC2H1 hypomorphic or retina-predominant variants cause nonsyndromic retinal degeneration. Genet Med. 2020 12; 22(12):2041-2051. PMID: 32753734.
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    17. Dou W, Zhao Q, Malhi M, Liu X, Zhang Z, Wang L, Masse S, Nanthakumar K, Hamilton R, Maynes JT, Sun Y. Label-free conduction velocity mapping and gap junction assessment of functional iPSC-Cardiomyocyte monolayers. Biosens Bioelectron. 2020 Nov 01; 167:112468. PMID: 32829174.
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    18. Daeschler SC, Manson N, Joachim K, Chin AWH, Chan K, Chen PZ, Tajdaran K, Mirmoeini K, Zhang JJ, Maynes JT, Zhang L, Science M, Darbandi A, Stephens D, Gu F, Poon LLM, Borschel GH. Effect of moist heat reprocessing of N95 respirators on SARS-CoV-2 inactivation and respirator function. CMAJ. 2020 10 13; 192(41):E1189-E1197. PMID: 32732229.
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    19. Steinberg BE, Aoyama K, McVey M, Levin D, Siddiqui A, Munshey F, Goldenberg NM, Faraoni D, Maynes JT. Efficacy and safety of decontamination for N95 respirator reuse: a systematic literature search and narrative synthesis. Can J Anaesth. 2020 Dec; 67(12):1814-1823. PMID: 32720256.
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    20. Aoyama K, Heath A, Yang A, Maynes JT, Petroz G, Robertson J, Mc Donnell C, Velummailum R, Bond E, Pechlivanoglou P. Estimating the risk of SARS-CoV-2 transmission to pediatric anesthesiologists: a microsimulation model. Can J Anaesth. 2020 11; 67(11):1694-1696. PMID: 32720258.
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    21. Wang X, Wang L, Dou W, Huang Z, Zhao Q, Malhi M, Maynes JT, Sun Y. Electrical impedance-based contractile stress measurement of human iPSC-Cardiomyocytes. Biosens Bioelectron. 2020 Oct 15; 166:112399. PMID: 32692665.
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    22. Kletke SN, Vincent A, Maynes JT, Elbaz U, Mireskandari K, Lam WC, Ali A. A de novo mutation in PITX2 underlies a unique form of Axenfeld-Rieger syndrome with corneal neovascularization and extensive proliferative vitreoretinopathy. Ophthalmic Genet. 2020 08; 41(4):358-362. PMID: 32429730.
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    23. Abrahamson JR, Read A, Chin K, Mistry N, Joo H, Desjardins JF, Liu E, Thai K, Wilson DF, Vinogradov SA, Maynes JT, Gilbert RE, Connelly KA, Baker AJ, Mazer CD, Hare GMT. Renal tissue Po2 sensing during acute hemodilution is dependent on the diluent. . 2020 04 01; 318(4):R799-R812. PMID: 32130021.
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    24. Drost CC, Rovas A, Kusche-Vihrog K, Van Slyke P, Kim H, Hoang VC, Maynes JT, Wennmann DO, Pavenstädt H, Linke W, Lukasz A, Hesse B, Kümpers P. Erratum: Tie2 Activation Promotes Protection and Reconstitution of the Endothelial Glycocalyx in Human Sepsis. Thromb Haemost. 2019 Nov; 119(11):e1. PMID: 31995834.
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    25. Shao Z, Tumber A, Maynes J, Tavares E, Kannu P, Heon E, Vincent A. Unique retinal signaling defect in GNB5-related disease. Doc Ophthalmol. 2020 06; 140(3):273-277. PMID: 31720979.
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    26. Echaniz G, Chan V, Maynes JT, Jozaghi Y, Agur A. Ultrasound-guided maxillary nerve block: an anatomical study using the suprazygomatic approach. Can J Anaesth. 2020 02; 67(2):186-193. PMID: 31549339.
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    27. Drost CC, Rovas A, Kusche-Vihrog K, Van Slyke P, Kim H, Hoang VC, Maynes JT, Wennmann DO, Pavenstädt H, Linke W, Lukasz A, Hesse B, Kümpers P. Tie2 Activation Promotes Protection and Reconstitution of the Endothelial Glycocalyx in Human Sepsis. Thromb Haemost. 2019 Nov; 119(11):1827-1838. PMID: 31493777.
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    28. Lokoff A, Maynes JT. The incidence, significance, and management of accidental intra-arterial injection: a narrative review. Can J Anaesth. 2019 05; 66(5):576-592. PMID: 30877587.
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    29. O'Leary JD, Janus M, Duku E, Wijeysundera DN, To T, Li P, Maynes JT, Faraoni D, Crawford MW. Influence of Surgical Procedures and General Anesthesia on Child Development Before Primary School Entry Among Matched Sibling Pairs. JAMA Pediatr. 2019 01 01; 173(1):29-36. PMID: 30398535.
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    30. Norris MJ, Malhi M, Duan W, Ouyang H, Granados A, Cen Y, Tseng YC, Gubbay J, Maynes J, Moraes TJ. Targeting Intracellular Ion Homeostasis for the Control of Respiratory Syncytial Virus. Am J Respir Cell Mol Biol. 2018 12; 59(6):733-744. PMID: 30095982.
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    31. Chatterjee D, Fatah M, Akdis D, Spears DA, Koopmann TT, Mittal K, Rafiq MA, Cattanach BM, Zhao Q, Healey JS, Ackerman MJ, Bos JM, Sun Y, Maynes JT, Brunckhorst C, Medeiros-Domingo A, Duru F, Saguner AM, Hamilton RM. An autoantibody identifies arrhythmogenic right ventricular cardiomyopathy and participates in its pathogenesis. Eur Heart J. 2018 11 21; 39(44):3932-3944. PMID: 30239670.
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    32. Selvadurai S, Maynes JT, McDonnell C, Cushing SL, Propst EJ, Lorenzo A, Lim A, Meltzer LJ, Lu Z, Horner RL, Narang I. Evaluating the effects of general anesthesia on sleep in children undergoing elective surgery: an observational case-control study. Sleep. 2018 08 01; 41(8). PMID: 29741674.
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    33. Traister A, Patel R, Huang A, Patel S, Plakhotnik J, Lee JE, Medina MG, Welsh C, Ruparel P, Zhang L, Friedberg M, Maynes J, Coles J. Cardiac regenerative capacity is age- and disease-dependent in childhood heart disease. PLoS One. 2018; 13(7):e0200342. PMID: 30044800.
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    34. Moran J, G Sanderson K, Maynes J, Vig A, Batmanabane V, Kannu P, Tavares E, Vincent A, Héon E. IFT80 mutations cause a novel complex ciliopathy phenotype with retinal degeneration. Clin Genet. 2018 10; 94(3-4):368-372. PMID: 29923190.
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    35. Wang L, Dou W, Malhi M, Zhu M, Liu H, Plakhotnik J, Xu Z, Zhao Q, Chen J, Chen S, Hamilton R, Simmons CA, Maynes JT, Sun Y. Microdevice Platform for Continuous Measurement of Contractility, Beating Rate, and Beating Rhythm of Human-Induced Pluripotent Stem Cell-Cardiomyocytes inside a Controlled Incubator Environment. ACS Appl Mater Interfaces. 2018 Jun 27; 10(25):21173-21183. PMID: 29874032.
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    36. Coghlan M, Richards E, Shaik S, Rossi P, Vanama RB, Ahmadi S, Petroz C, Crawford M, Maynes JT. Inhalational Anesthetics Induce Neuronal Protein Aggregation and Affect ER Trafficking. Sci Rep. 2018 03 27; 8(1):5275. PMID: 29588456.
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    37. Gutbier B, Jiang X, Dietert K, Ehrler C, Lienau J, Van Slyke P, Kim H, Hoang VC, Maynes JT, Dumont DJ, Gruber AD, Weissmann N, Mitchell TJ, Suttorp N, Witzenrath M. Vasculotide reduces pulmonary hyperpermeability in experimental pneumococcal pneumonia. Crit Care. 2017 Nov 13; 21(1):274. PMID: 29132435.
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    38. Hogarth KA, Costford SR, Yoon G, Sondheimer N, Maynes JT. DNM1L Variant Alters Baseline Mitochondrial Function and Response to Stress in a Patient with Severe Neurological Dysfunction. Biochem Genet. 2018 Apr; 56(1-2):56-77. PMID: 29110115.
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    39. Wong BM, Keilman J, Zuccaro J, Kelly C, Maynes JT, Fish JS. Anesthetic Practices for Laser Rehabilitation of Pediatric Hypertrophic Burn Scars. J Burn Care Res. 2017 Jan/Feb; 38(1):e36-e41. PMID: 27532615.
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    40. O'Leary JD, Janus M, Duku E, Wijeysundera DN, To T, Li P, Maynes JT, Crawford MW. A Population-based Study Evaluating the Association between Surgery in Early Life and Child Development at Primary School Entry. Anesthesiology. 2016 08; 125(2):272-9. PMID: 27433745.
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    41. Vincent A, Ng J, Gerth-Kahlert C, Tavares E, Maynes JT, Wright T, Tiwari A, Tumber A, Li S, Hanson JV, Bahr A, MacDonald H, Bähr L, Westall C, Berger W, Cremers FP, den Hollander AI, Héon E. Biallelic Mutations in CRB1 Underlie Autosomal Recessive Familial Foveal Retinoschisis. Invest Ophthalmol Vis Sci. 2016 05 01; 57(6):2637-46. PMID: 27258436.
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    42. Vincent A, Audo I, Tavares E, Maynes JT, Tumber A, Wright T, Li S, Michiels C, Condroyer C, MacDonald H, Verdet R, Sahel JA, Hamel CP, Zeitz C, Héon E. Biallelic Mutations in GNB3 Cause a Unique Form of Autosomal-Recessive Congenital Stationary Night Blindness. Am J Hum Genet. 2016 05 05; 98(5):1011-1019. PMID: 27063057.
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    43. Traister A, Lu M, Coles JG, Maynes JT. Dataset of integrin-linked kinase protein: Protein interactions in cardiomyocytes identified by mass spectrometry. Data Brief. 2016 Jun; 7:1148-50. PMID: 27408918.
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    44. Sittampalam S, Eglen R, Ferguson S, Maynes JT, Olden K, Schrader L, Shelper T, Ferrer M. Three-Dimensional Cell Culture Assays: Are They More Predictive of In Vivo Efficacy than 2D Monolayer Cell-Based Assays? Assay Drug Dev Technol. 2015 Jun; 13(5):254-61. PMID: 26120951.
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    45. Vincent A, Forster N, Maynes JT, Paton TA, Billingsley G, Roslin NM, Ali A, Sutherland J, Wright T, Westall CA, Paterson AD, Marshall CR, Héon E. OTX2 mutations cause autosomal dominant pattern dystrophy of the retinal pigment epithelium. J Med Genet. 2014 Dec; 51(12):797-805. PMID: 25293953.
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    46. Traister A, Li M, Aafaqi S, Lu M, Arab S, Radisic M, Gross G, Guido F, Sherret J, Verma S, Slorach C, Mertens L, Hui W, Roy A, Delgado-Olguín P, Hannigan G, Maynes JT, Coles JG. Integrin-linked kinase mediates force transduction in cardiomyocytes by modulating SERCA2a/PLN function. Nat Commun. 2014 Sep 11; 5:4533. PMID: 25208486.
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    47. Zhu J, Ide H, Fu YY, Teichert AM, Kato H, Weisel RD, Maynes JT, Coles JG, Caldarone CA. Losartan ameliorates "upstream" pulmonary vein vasculopathy in a piglet model of pulmonary vein stenosis. J Thorac Cardiovasc Surg. 2014 Dec; 148(6):2550-7. PMID: 25172325.
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    48. Kato H, Fu YY, Zhu J, Wang L, Aafaqi S, Rahkonen O, Slorach C, Traister A, Leung CH, Chiasson D, Mertens L, Benson L, Weisel RD, Hinz B, Maynes JT, Coles JG, Caldarone CA. Pulmonary vein stenosis and the pathophysiology of "upstream" pulmonary veins. J Thorac Cardiovasc Surg. 2014 Jul; 148(1):245-53. PMID: 24084286.
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    49. Skene-Arnold TD, Luu HA, Uhrig RG, De Wever V, Nimick M, Maynes J, Fong A, James MN, Trinkle-Mulcahy L, Moorhead GB, Holmes CF. Molecular mechanisms underlying the interaction of protein phosphatase-1c with ASPP proteins. Biochem J. 2013 Feb 01; 449(3):649-59. PMID: 23088536.
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    50. Maynes JT, Luu HA, Cherney MM, Andersen RJ, Williams D, Holmes CF, James MN. Crystal structures of protein phosphatase-1 bound to motuporin and dihydromicrocystin-LA: elucidation of the mechanism of enzyme inhibition by cyanobacterial toxins. J Mol Biol. 2006 Feb 10; 356(1):111-20. PMID: 16343532.
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    51. Maynes JT, Cherney MM, Qasim MA, Laskowski M, James MN. Structure of the subtilisin Carlsberg-OMTKY3 complex reveals two different ovomucoid conformations. Acta Crystallogr D Biol Crystallogr. 2005 May; 61(Pt 5):580-8. PMID: 15858268.
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    52. Maynes JT, Perreault KR, Cherney MM, Luu HA, James MN, Holmes CF. Crystal structure and mutagenesis of a protein phosphatase-1:calcineurin hybrid elucidate the role of the beta12-beta13 loop in inhibitor binding. J Biol Chem. 2004 Oct 08; 279(41):43198-206. PMID: 15280359.
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    53. Lamoureux JS, Maynes JT, Glover JN. Recognition of 5'-YpG-3' sequences by coupled stacking/hydrogen bonding interactions with amino acid residues. J Mol Biol. 2004 Jan 09; 335(2):399-408. PMID: 14672650.
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    54. Maynes JT, Garen C, Cherney MM, Newton G, Arad D, Av-Gay Y, Fahey RC, James MN. The crystal structure of 1-D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) from Mycobacterium tuberculosis reveals a zinc hydrolase with a lactate dehydrogenase fold. J Biol Chem. 2003 Nov 21; 278(47):47166-70. PMID: 12958317.
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    55. Holmes CF, Maynes JT, Perreault KR, Dawson JF, James MN. Molecular enzymology underlying regulation of protein phosphatase-1 by natural toxins. Curr Med Chem. 2002 Nov; 9(22):1981-9. PMID: 12369866.
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    56. Maynes JT, Bateman KS, Cherney MM, Das AK, Luu HA, Holmes CF, James MN. Crystal structure of the tumor-promoter okadaic acid bound to protein phosphatase-1. J Biol Chem. 2001 Nov 23; 276(47):44078-82. PMID: 11535607.
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    57. Maynes JT, Yuan RG, Snyder FF. Identification, expression, and characterization of Escherichia coli guanine deaminase. J Bacteriol. 2000 Aug; 182(16):4658-60. PMID: 10913105.
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    58. Maynes JT, Yuan RG, Phipps BM, Litster SA, Leung K, Snyder FF. Further refinement on the engineering of adenosine phosphorylase from purine nucleoside phosphorylase. Adv Exp Med Biol. 2000; 486:107-10. PMID: 11783463.
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    59. Maynes JT, Yam W, Jenuth JP, Gang Yuan R, Litster SA, Phipps BM, Snyder FF. Design of an adenosine phosphorylase by active-site modification of murine purine nucleoside phosphorylase. Enzyme kinetics and molecular dynamics simulation of Asn-243 and Lys-244 substitutions of purine nucleoside phosphorylase. Biochem J. 1999 Dec 01; 344 Pt 2:585-92. PMID: 10567244.
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