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Johann Hitzler

TitleStaff Physician
InstitutionThe Hospital for Sick Children
DepartmentHaematology/Oncology
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Hitzler JK, Alonzo T, Gerbing RB, Beckman A, Hirsch B, Raimondi S, Chisholm K, Viola SA, Eidenschink Brodersen L, Loken MR, Tong RS, Druley TE, O'Brien MM, Hijiya N, Heerema-McKenney AE, Wang J, Schore R, Taub JW, Gamis AS, Kolb EA, Berman JN. High-dose AraC is Essential for the Treatment of ML-DS Independent of Post-Induction MRD: Results of COG AAML1531. Blood. 2021 07 28. PMID: 34320162.
      View in: PubMed
    2. Wagenblast E, Araújo J, Gan OI, Cutting SK, Murison A, Krivdova G, Azkanaz M, McLeod JL, Smith SA, Gratton BA, Marhon SA, Gabra M, Medeiros JJF, Manteghi S, Chen J, Chan-Seng-Yue M, Garcia-Prat L, Salmena L, De Carvalho DD, Abelson S, Abdelhaleem M, Chong K, Roifman M, Shannon P, Wang JCY, Hitzler JK, Chitayat D, Dick JE, Lechman ER. Mapping the cellular origin and early evolution of leukemia in Down syndrome. Science. 2021 07 09; 373(6551). PMID: 34244384.
      View in: PubMed
    3. Rajakumar SA, Papp E, Lee KK, Grandal I, Merico D, Liu CC, Allo B, Zhang L, Grynpas MD, Minden MD, Hitzler JK, Guidos CJ, Danska JS. B cell acute lymphoblastic leukemia cells mediate RANK-RANKL-dependent bone destruction. Sci Transl Med. 2020 09 16; 12(561). PMID: 32938796.
      View in: PubMed
    4. Mast KJ, Taub JW, Alonzo TA, Gamis AS, Mosse CA, Mathew P, Berman JN, Wang YC, Jones HM, Campana D, Coustan-Smith E, Raimondi SC, Hirsch B, Hitzler JK, Head DR. Pathologic Features of Down Syndrome Myelodysplastic Syndrome and Acute Myeloid Leukemia: A Report From the Children's Oncology Group Protocol AAML0431. Arch Pathol Lab Med. 2020 04; 144(4):466-472. PMID: 31429606.
      View in: PubMed
    5. Taub JW, Berman JN, Hitzler JK, Sorrell AD, Lacayo NJ, Mast K, Head D, Raimondi S, Hirsch B, Ge Y, Gerbing RB, Wang YC, Alonzo TA, Campana D, Coustan-Smith E, Mathew P, Gamis AS. Improved outcomes for myeloid leukemia of Down syndrome: a report from the Children's Oncology Group AAML0431 trial. Blood. 2017 06 22; 129(25):3304-3313. PMID: 28389462.
      View in: PubMed
    6. Ali S, Ashraf K, Chen J, Hitzler JK. Detection of a clone-specific GATA1 mutation to monitor treatment response and involvement of a monozygotic twin in myeloid leukemia of Down syndrome. Pediatr Blood Cancer. 2017 08; 64(8). PMID: 28074551.
      View in: PubMed
    7. van der Plas E, Nieman BJ, Butcher DT, Hitzler JK, Weksberg R, Ito S, Schachar R. Neurocognitive Late Effects of Chemotherapy in Survivors of Acute Lymphoblastic Leukemia: Focus on Methotrexate. J Can Acad Child Adolesc Psychiatry. 2015; 24(1):25-32. PMID: 26336377.
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    8. Gassas A, Krueger J, Alvi S, Sung L, Hitzler J, Lieberman L. Diagnosis of central nervous system relapse of pediatric acute lymphoblastic leukemia: Impact of routine cytological CSF analysis at the time of intrathecal chemotherapy. Pediatr Blood Cancer. 2014 Dec; 61(12):2215-7. PMID: 25212396.
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    9. Perova T, Grandal I, Nutter LM, Papp E, Matei IR, Beyene J, Kowalski PE, Hitzler JK, Minden MD, Guidos CJ, Danska JS. Therapeutic potential of spleen tyrosine kinase inhibition for treating high-risk precursor B cell acute lymphoblastic leukemia. Sci Transl Med. 2014 May 14; 6(236):236ra62. PMID: 24828076.
      View in: PubMed
    10. Avila ML, Macartney CA, Hitzler JK, Williams S, Kiss A, Brandão LR. Assessment of the outcomes associated with periprocedural anticoagulation management in children with acute lymphoblastic leukemia. J Pediatr. 2014 May; 164(5):1201-7. PMID: 24582006.
      View in: PubMed
    11. Hitzler JK, He W, Doyle J, Cairo M, Camitta BM, Chan KW, Diaz Perez MA, Fraser C, Gross TG, Horan JT, Kennedy-Nasser AA, Kitko C, Kurtzberg J, Lehmann L, O'Brien T, Pulsipher MA, Smith FO, Zhang MJ, Eapen M, Carpenter PA. Outcome of transplantation for acute lymphoblastic leukemia in children with Down syndrome. Pediatr Blood Cancer. 2014 Jun; 61(6):1126-8. PMID: 24391118.
      View in: PubMed
    12. Hitzler JK, He W, Doyle J, Cairo M, Camitta BM, Chan KW, Diaz Perez MA, Fraser C, Gross TG, Horan JT, Kennedy-Nasser AA, Kitko C, Kurtzberg J, Lehmann L, O'Brien T, Pulsipher MA, Smith FO, Zhang MJ, Eapen M, Carpenter PA. Outcome of transplantation for acute myelogenous leukemia in children with Down syndrome. Biol Blood Marrow Transplant. 2013 Jun; 19(6):893-7. PMID: 23467128.
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    13. Williams BA, Meyn MS, Hitzler JK. Transient leukemia in newborns without down syndrome: diagnostic and management challenges. J Pediatr Hematol Oncol. 2011 Aug; 33(6):e261-3. PMID: 21768885.
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    14. Chen J, Li Y, Doedens M, Wang P, Shago M, Dick JE, Dick J, Hitzler JK. Functional differences between myeloid leukemia-initiating and transient leukemia cells in Down's syndrome. Leukemia. 2010 May; 24(5):1012-7. PMID: 20220775.
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    15. Hitzler JK. Acute megakaryoblastic leukemia in Down syndrome. Pediatr Blood Cancer. 2007 Dec; 49(7 Suppl):1066-9. PMID: 17943965.
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    16. Spiegler BJ, Kennedy K, Maze R, Greenberg ML, Weitzman S, Hitzler JK, Nathan PC. Comparison of long-term neurocognitive outcomes in young children with acute lymphoblastic leukemia treated with cranial radiation or high-dose or very high-dose intravenous methotrexate. J Clin Oncol. 2006 Aug 20; 24(24):3858-64. PMID: 16921038.
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    17. Sun Y, Boyd K, Xu W, Ma J, Jackson CW, Fu A, Shillingford JM, Robinson GW, Hennighausen L, Hitzler JK, Ma Z, Morris SW. Acute myeloid leukemia-associated Mkl1 (Mrtf-a) is a key regulator of mammary gland function. Mol Cell Biol. 2006 Aug; 26(15):5809-26. PMID: 16847333.
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    18. Kawaguchi H, Hitzler JK, Ma Z, Morris SW. RBM15 and MKL1 mutational screening in megakaryoblastic leukemia cell lines and clinical samples. Leukemia. 2005 Aug; 19(8):1492-4. PMID: 15920491.
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    19. Gassas A, Doyle JJ, Weitzman S, Freedman MH, Hitzler JK, Sharathkumar A, Dror Y. A basic classification and a comprehensive examination of pediatric myeloproliferative syndromes. J Pediatr Hematol Oncol. 2005 Apr; 27(4):192-6. PMID: 15838389.
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    20. Hitzler JK, Zipursky A. Origins of leukaemia in children with Down syndrome. Nat Rev Cancer. 2005 Jan; 5(1):11-20. PMID: 15630411.
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    21. Lightfoot J, Hitzler JK, Zipursky A, Albert M, Macgregor PF. Distinct gene signatures of transient and acute megakaryoblastic leukemia in Down syndrome. Leukemia. 2004 Oct; 18(10):1617-23. PMID: 15343346.
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    22. Hanissian SH, Akbar U, Teng B, Janjetovic Z, Hoffmann A, Hitzler JK, Iscove N, Hamre K, Du X, Tong Y, Mukatira S, Robertson JH, Morris SW. cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP. Oncogene. 2004 Apr 29; 23(20):3700-7. PMID: 15116101.
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    23. Nathan PC, Maze R, Spiegler B, Greenberg ML, Weitzman S, Hitzler JK. CNS-directed therapy in young children with T-lineage acute lymphoblastic leukemia: High-dose methotrexate versus cranial irradiation. Pediatr Blood Cancer. 2004 Jan; 42(1):24-9. PMID: 14752790.
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    24. Cen B, Selvaraj A, Burgess RC, Hitzler JK, Ma Z, Morris SW, Prywes R. Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes. Mol Cell Biol. 2003 Sep; 23(18):6597-608. PMID: 12944485.
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    25. Hitzler JK, Cheung J, Li Y, Scherer SW, Zipursky A. GATA1 mutations in transient leukemia and acute megakaryoblastic leukemia of Down syndrome. Blood. 2003 Jun 01; 101(11):4301-4. PMID: 12586620.
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    26. Hitzler JK. GATA1--a player in normal and leukemic megakaryopoiesis. Pediatr Res. 2002 Dec; 52(6):831. PMID: 12438656.
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    27. Inoue A, Seidel MG, Wu W, Kamizono S, Ferrando AA, Bronson RT, Iwasaki H, Akashi K, Morimoto A, Hitzler JK, Pestina TI, Jackson CW, Tanaka R, Chong MJ, McKinnon PJ, Inukai T, Grosveld GC, Look AT. Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo. Cancer Cell. 2002 Oct; 2(4):279-88. PMID: 12398892.
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    28. Anton N, Hitzler JK, Kavanagh BP. Treatment of life-threatening post-haemorrhagic anaemia with cell-free haemoglobin solution in an adolescent Jehovah's Witness. Br J Haematol. 2002 Sep; 118(4):1183-6. PMID: 12199805.
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    29. Carreau M, Liu L, Gan OI, Hitzler JK, Dick JE, Buchwald M. Short-term granulocyte colony-stimulating factor and erythropoietin treatment enhances hematopoiesis and survival in the mitomycin C-conditioned Fancc(-/-) mouse model, while long-term treatment is ineffective. Blood. 2002 Aug 15; 100(4):1499-501. PMID: 12149239.
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    30. Ma Z, Morris SW, Valentine V, Li M, Herbrick JA, Cui X, Bouman D, Li Y, Mehta PK, Nizetic D, Kaneko Y, Chan GC, Chan LC, Squire J, Scherer SW, Hitzler JK. Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. Nat Genet. 2001 Jul; 28(3):220-1. PMID: 11431691.
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    31. Hitzler JK, Witte DP, Jenkins NA, Copeland NG, Gilbert DJ, Naeve CW, Look AT, Morris SW. cDNA cloning, expression pattern, and chromosomal localization of Mlf1, murine homologue of a gene involved in myelodysplasia and acute myeloid leukemia. Am J Pathol. 1999 Jul; 155(1):53-9. PMID: 10393836.
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    32. Hitzler JK, Soares HD, Drolet DW, Inaba T, O'Connel S, Morgan JI, Look AT. Expression patterns of the hepatic leukemia factor gene in the nervous system of developing and adult mice. Brain Res. 1999 Feb 27; 820(1-2):1-11. PMID: 10023025.
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    33. Freedman MH, Hitzler JK, Bunin N, Grunberger T, Squire J. Juvenile chronic myelogenous leukemia multilineage CD34+ cells: aberrant growth and differentiation properties. Stem Cells. 1996 Nov; 14(6):690-701. PMID: 8948026.
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    34. Calderwood S, Doyle JJ, Hitzler JK, Saunders EF, Freedman MH. Administration of recombinant human granulocyte-macrophage colony-stimulating factor after autologous bone marrow transplantation in children with acute myelogenous leukemia: a note of caution. Bone Marrow Transplant. 1996 Jul; 18(1):87-91. PMID: 8832000.
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    35. Hitzler JK, Martinez-Valdez H, Bergsagel DB, Minden MD, Messner HA. Role of interleukin-6 in the proliferation of human multiple myeloma cell lines OCI-My 1 to 7 established from patients with advanced stage of the disease. Blood. 1991 Oct 15; 78(8):1996-2004. PMID: 1912582.
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