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Neil Sweezey

TitleRespirologist
InstitutionThe Hospital for Sick Children
DepartmentRespiratory Medicine
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Khan MA, Ali ZS, Sweezey N, Grasemann H, Palaniyar N. Progression of Cystic Fibrosis Lung Disease from Childhood to Adulthood: Neutrophils, Neutrophil Extracellular Trap (NET) Formation, and NET Degradation. Genes (Basel). 2019 02 26; 10(3). PMID: 30813645.
      View in: PubMed
    2. Xiu F, Sabz Ali Z, Palaniyar N, Sweezey N. A dual neutrophil-T cell purification procedure and methodological considerations in studying the effects of estrogen on human Th17 cell differentiation. J Immunol Methods. 2019 04; 467:1-11. PMID: 30771291.
      View in: PubMed
    3. Azzouz D, Khan MA, Sweezey N, Palaniyar N. Two-in-one: UV radiation simultaneously induces apoptosis and NETosis. Cell Death Discov. 2018; 4:51. PMID: 29736268.
      View in: PubMed
    4. Khan MA, Philip LM, Cheung G, Vadakepeedika S, Grasemann H, Sweezey N, Palaniyar N. Regulating NETosis: Increasing pH Promotes NADPH Oxidase-Dependent NETosis. Front Med (Lausanne). 2018; 5:19. PMID: 29487850.
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    5. Even-Or E, Ghandourah H, Ali M, Krueger J, Sweezey NB, Schechter T. Efficacy of high-dose steroids for bronchiolitis obliterans syndrome post pediatric hematopoietic stem cell transplantation. Pediatr Transplant. 2018 03; 22(2). PMID: 29417689.
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    6. Naffah de Souza C, Breda LCD, Khan MA, de Almeida SR, Câmara NOS, Sweezey N, Palaniyar N. Alkaline pH Promotes NADPH Oxidase-Independent Neutrophil Extracellular Trap Formation: A Matter of Mitochondrial Reactive Oxygen Species Generation and Citrullination and Cleavage of Histone. Front Immunol. 2017; 8:1849. PMID: 29375550.
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    7. Djiadeu P, Farmakovski N, Azzouz D, Kotra LP, Sweezey N, Palaniyar N. Surfactant protein D regulates caspase-8-mediated cascade of the intrinsic pathway of apoptosis while promoting bleb formation. Mol Immunol. 2017 12; 92:190-198. PMID: 29107869.
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    8. Khan MA, Farahvash A, Douda DN, Licht JC, Grasemann H, Sweezey N, Palaniyar N. JNK Activation Turns on LPS- and Gram-Negative Bacteria-Induced NADPH Oxidase-Dependent Suicidal NETosis. Sci Rep. 2017 06 13; 7(1):3409. PMID: 28611461.
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    9. Djiadeu P, Kotra LP, Sweezey N, Palaniyar N. Surfactant protein D delays Fas- and TRAIL-mediated extrinsic pathway of apoptosis in T cells. Apoptosis. 2017 05; 22(5):730-740. PMID: 28168327.
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    10. Djiadeu P, Azzouz D, Khan MA, Kotra LP, Sweezey N, Palaniyar N. Ultraviolet irradiation increases green fluorescence of dihydrorhodamine (DHR) 123: false-positive results for reactive oxygen species generation. Pharmacol Res Perspect. 2017 04; 5(2):e00303. PMID: 28357129.
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    11. Zhang H, Kho AT, Wu Q, Halayko AJ, Limbert Rempel K, Chase RP, Sweezey NB, Weiss ST, Kaplan F. CRISPLD2 (LGL1) inhibits proinflammatory mediators in human fetal, adult, and COPD lung fibroblasts and epithelial cells. Physiol Rep. 2016 09; 4(17). PMID: 27597766.
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    12. Zhang H, Sweezey NB, Kaplan F. LGL1 modulates proliferation, apoptosis, and migration of human fetal lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2015 Feb 15; 308(4):L391-402. PMID: 25480331.
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    13. Kushwah R, Gagnon S, Sweezey NB. T cell unresponsiveness in a pediatric cystic fibrosis patient: a case report. Allergy Asthma Clin Immunol. 2014 Jan 17; 10(1):2. PMID: 24438707.
      View in: PubMed
    14. Kushwah R, Gagnon S, Sweezey NB. Intrinsic predisposition of naïve cystic fibrosis T cells to differentiate towards a Th17 phenotype. Respir Res. 2013 Dec 17; 14:138. PMID: 24344776.
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    15. Sweezey NB, Ratjen F. The cystic fibrosis gender gap: potential roles of estrogen. Pediatr Pulmonol. 2014 Apr; 49(4):309-17. PMID: 24339235.
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    16. Wang Y, Cela E, Gagnon S, Sweezey NB. Estrogen aggravates inflammation in Pseudomonas aeruginosa pneumonia in cystic fibrosis mice. Respir Res. 2010 Nov 30; 11:166. PMID: 21118573.
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    17. Nadeau K, Montermini L, Mandeville I, Xu M, Weiss ST, Sweezey NB, Kaplan F. Modulation of Lgl1 by steroid, retinoic acid, and vitamin D models complex transcriptional regulation during alveolarization. Pediatr Res. 2010 Apr; 67(4):375-81. PMID: 20057335.
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    18. Manwani N, Gagnon S, Post M, Joza S, Muglia L, Cornejo S, Kaplan F, Sweezey NB. Reduced viability of mice with lung epithelial-specific knockout of glucocorticoid receptor. Am J Respir Cell Mol Biol. 2010 Nov; 43(5):599-606. PMID: 20042713.
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    19. Amin R, Kwon S, Moayedi Y, Sweezey N. Pulmonary vein stenosis: Case report and literature review. Can Respir J. 2009 Nov-Dec; 16(6):e77-80. PMID: 20011721.
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    20. Lan J, Ribeiro L, Mandeville I, Nadeau K, Bao T, Cornejo S, Sweezey NB, Kaplan F. Inflammatory cytokines, goblet cell hyperplasia and altered lung mechanics in Lgl1+/- mice. Respir Res. 2009 Sep 21; 10:83. PMID: 19772569.
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    21. Zhang H, Garber SJ, Cui Z, Foley JP, Mohan GS, Jobanputra M, Kaplan F, Sweezey NB, Gonzales LW, Savani RC. The angiogenic factor midkine is regulated by dexamethasone and retinoic acid during alveolarization and in alveolar epithelial cells. Respir Res. 2009 Aug 21; 10:77. PMID: 19698107.
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    22. Kim Chiaw P, Huan LJ, Gagnon S, Ly D, Sweezey N, Rotin D, Deber CM, Bear CE. Functional rescue of DeltaF508-CFTR by peptides designed to mimic sorting motifs. Chem Biol. 2009 May 29; 16(5):520-30. PMID: 19477416.
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    23. Nemati B, Atmodjo W, Gagnon S, Humes D, McKerlie C, Kaplan F, Sweezey NB. Glucocorticoid receptor disruption delays structural maturation in the lungs of newborn mice. Pediatr Pulmonol. 2008 Feb; 43(2):125-33. PMID: 18085690.
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    24. Quinlan J, Kaplan F, Sweezey N, Goodyer P. LGL1, a novel branching morphogen in developing kidney, is induced by retinoic acid. Am J Physiol Renal Physiol. 2007 Oct; 293(4):F987-93. PMID: 17670908.
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    25. Sweezey NB, Smith D, Corey M, Ellis L, Carpenter S, Tullis DE, Durie P, O'Brodovich HM. Amiloride-insensitive nasal potential difference varies with the menstrual cycle in cystic fibrosis. Pediatr Pulmonol. 2007 Jun; 42(6):519-24. PMID: 17469152.
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    26. Taylor L, Corey M, Matlow A, Sweezey NB, Ratjen F. Comparison of throat swabs and nasopharyngeal suction specimens in non-sputum-producing patients with cystic fibrosis. Pediatr Pulmonol. 2006 Sep; 41(9):839-43. PMID: 16850448.
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    27. Gagnon S, Atmodjo W, Humes D, McKerlie C, Kaplan F, Sweezey NB. Transgenic glucocorticoid receptor expression driven by the SP-C promoter reduces neonatal lung cellularity and midkine expression in GRhypo mice. Biol Neonate. 2006; 90(1):46-57. PMID: 16534186.
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    28. Nadeau K, Jankov RP, Tanswell AK, Sweezey NB, Kaplan F. Lgl1 is suppressed in oxygen toxicity animal models of bronchopulmonary dysplasia and normalizes during recovery in air. Pediatr Res. 2006 Mar; 59(3):389-95. PMID: 16492977.
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    29. Jefferies C, Solomon M, Perlman K, Sweezey N, Daneman D. Continuous glucose monitoring in adolescents with cystic fibrosis. J Pediatr. 2005 Sep; 147(3):396-8. PMID: 16182684.
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    30. Katz SL, Das P, Ngan BY, Manson D, Pappo AS, Sweezey NB, Solomon MP. Remote intrapulmonary spread of recurrent respiratory papillomatosis with malignant transformation. Pediatr Pulmonol. 2005 Feb; 39(2):185-8. PMID: 15532092.
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    31. Koehler DR, Downey GP, Sweezey NB, Tanswell AK, Hu J. Lung inflammation as a therapeutic target in cystic fibrosis. Am J Respir Cell Mol Biol. 2004 Oct; 31(4):377-81. PMID: 15381503.
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    32. Yi M, Jankov RP, Belcastro R, Humes D, Copland I, Shek S, Sweezey NB, Post M, Albertine KH, Auten RL, Tanswell AK. Opposing effects of 60% oxygen and neutrophil influx on alveologenesis in the neonatal rat. Am J Respir Crit Care Med. 2004 Dec 01; 170(11):1188-96. PMID: 15347560.
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    33. Oyewumi L, Kaplan F, Sweezey NB. Lgl1, a mesenchymal modulator of early lung branching morphogenesis, is a secreted glycoprotein imported by late gestation lung epithelial cells. Biochem J. 2003 Nov 15; 376(Pt 1):61-9. PMID: 12880386.
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    34. Tao T, Lan J, Presley JF, Sweezey NB, Kaplan F. Nucleocytoplasmic shuttling of lgl2 is developmentally regulated in fetal lung. Am J Respir Cell Mol Biol. 2004 Mar; 30(3):350-9. PMID: 12871852.
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    35. Frangolias DD, Ruan J, Wilcox PJ, Davidson AG, Wong LT, Berthiaume Y, Hennessey R, Freitag A, Pedder L, Corey M, Sweezey N, Zielenski J, Tullis E, Sandford AJ. Alpha 1-antitrypsin deficiency alleles in cystic fibrosis lung disease. Am J Respir Cell Mol Biol. 2003 Sep; 29(3 Pt 1):390-6. PMID: 12689922.
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    36. Moraes TJ, Langer JC, Forte V, Shayan K, Sweezey N. Pediatric pulmonary carcinoid: a case report and review of the literature. Pediatr Pulmonol. 2003 Apr; 35(4):318-22. PMID: 12629632.
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    37. Oyewumi L, Kaplan F, Gagnon S, Sweezey NB. Antisense oligodeoxynucleotides decrease LGL1 mRNA and protein levels and inhibit branching morphogenesis in fetal rat lung. Am J Respir Cell Mol Biol. 2003 Feb; 28(2):232-40. PMID: 12540491.
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    38. Solomon MP, Wilson DC, Corey M, Kalnins D, Zielenski J, Tsui LC, Pencharz P, Durie P, Sweezey NB. Glucose intolerance in children with cystic fibrosis. J Pediatr. 2003 Feb; 142(2):128-32. PMID: 12584532.
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    39. Kaplan F, Comber J, Sladek R, Hudson TJ, Muglia LJ, Macrae T, Gagnon S, Asada M, Brewer JA, Sweezey NB. The growth factor midkine is modulated by both glucocorticoid and retinoid in fetal lung development. Am J Respir Cell Mol Biol. 2003 Jan; 28(1):33-41. PMID: 12495930.
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    40. Kaplan F, MacRae T, Comber J, Gagnon S, Sladek R, Hudson TJ, Sweezey NB. Application of expression microarrays to the investigation of fetal lung development in a glucocorticoid receptor knockout mouse model. Chest. 2002 Mar; 121(3 Suppl):90S. PMID: 11893717.
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    41. Zhang C, Sweezey NB, Gagnon S, Muskat B, Koehler D, Post M, Kaplan F. A novel karyopherin-beta homolog is developmentally and hormonally regulated in fetal lung. Am J Respir Cell Mol Biol. 2000 Apr; 22(4):451-9. PMID: 10745026.
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    42. Kaplan F, Ledoux P, Kassamali FQ, Gagnon S, Post M, Koehler D, Deimling J, Sweezey NB. A novel developmentally regulated gene in lung mesenchyme: homology to a tumor-derived trypsin inhibitor. Am J Physiol. 1999 06; 276(6):L1027-36. PMID: 10362728.
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    43. Sweezey NB, Ghibu F, Gagnon S, Schotman E, Hamid Q. Glucocorticoid receptor mRNA and protein in fetal rat lung in vivo: modulation by glucocorticoid and androgen. Am J Physiol. 1998 07; 275(1):L103-9. PMID: 9688941.
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    44. Sweezey N, Tchepichev S, Gagnon S, Fertuck K, O'Brodovich H. Female gender hormones regulate mRNA levels and function of the rat lung epithelial Na channel. Am J Physiol. 1998 02; 274(2):C379-86. PMID: 9486127.
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    45. Sweezey NB, Ghibu F, Gagnon S. Sex hormones regulate CFTR in developing fetal rat lung epithelial cells. Am J Physiol. 1997 May; 272(5 Pt 1):L844-51. PMID: 9176247.
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    46. Sweezey NB, Gauthier C, Gagnon S, Ferretti E, Kopelman H. Progesterone and estradiol inhibit CFTR-mediated ion transport by pancreatic epithelial cells. Am J Physiol. 1996 Nov; 271(5 Pt 1):G747-54. PMID: 8944687.
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    47. Sweezey N, Mawdsley C, Ghibu F, Song L, Buch S, Moore A, Antakly T, Post M. Differential regulation of glucocorticoid receptor expression by ligand in fetal rat lung cells. Pediatr Res. 1995 Oct; 38(4):506-12. PMID: 8559601.
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    48. MacLeod RJ, Hamilton JR, Kopelman H, Sweezey NB. Developmental differences of cystic fibrosis transmembrane conductance regulator functional expression in isolated rat fetal distal airway epithelial cells. Pediatr Res. 1994 Jan; 35(1):45-9. PMID: 7510872.
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    49. Buch S, Jones C, Sweezey N, Tanswell K, Post M. Platelet-derived growth factor and growth-related genes in rat lung. I. Developmental expression. Am J Respir Cell Mol Biol. 1991 Oct; 5(4):371-6. PMID: 1910822.
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    50. Sweezey NB, Fellows KE. Bronchial artery embolization for severe hemoptysis in cystic fibrosis. Chest. 1990 Jun; 97(6):1322-6. PMID: 2347216.
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    51. Nielsen HC, Kirk WO, Sweezey N, Torday JS. Coordination of growth and differentiation in the fetal lung. Exp Cell Res. 1990 May; 188(1):89-96. PMID: 2328780.
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    52. Griscom NT, Wheeler WB, Sweezey NB, Kim YC, Lindsey JC, Wohl ME. Bronchopulmonary dysplasia: radiographic appearance in middle childhood. Radiology. 1989 Jun; 171(3):811-4. PMID: 2717757.
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    53. Marx SJ, Lasker RD, Brown EM, Fitzpatrick LA, Sweezey NB, Goldbloom RB, Gillis DA, Cole DE. Secretory dysfunction in parathyroid cells from a neonate with severe primary hyperparathyroidism. J Clin Endocrinol Metab. 1986 Feb; 62(2):445-9. PMID: 3941166.
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