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Giles Santyr

TitleSenior Scientist
InstitutionThe Hospital for Sick Children
DepartmentTranslational Medicine
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Riberdy V, Litvack M, Stirrat E, Couch M, Post M, Santyr GE. Hyperpolarized 129 Xe imaging of embryonic stem cell-derived alveolar-like macrophages in rat lungs: proof-of-concept study using superparamagnetic iron oxide nanoparticles. Magn Reson Med. 2019 Sep 25. PMID: 31556154.
      View in: PubMed
    2. Rayment JH, Couch MJ, McDonald N, Kanhere N, Manson D, Santyr G, Ratjen F. Hyperpolarised 129Xe magnetic resonance imaging to monitor treatment response in children with cystic fibrosis. Eur Respir J. 2019 May; 53(5). PMID: 30819815.
      View in: PubMed
    3. Zanette B, Santyr G. Accelerated interleaved spiral-IDEAL imaging of hyperpolarized 129 Xe for parametric gas exchange mapping in humans. Magn Reson Med. 2019 Sep; 82(3):1113-1119. PMID: 30989730.
      View in: PubMed
    4. Couch MJ, Thomen R, Kanhere N, Hu R, Ratjen F, Woods J, Santyr G. A two-center analysis of hyperpolarized 129Xe lung MRI in stable pediatric cystic fibrosis: Potential as a biomarker for multi-site trials. J Cyst Fibros. 2019 Sep; 18(5):728-733. PMID: 30922812.
      View in: PubMed
    5. Santyr G, Kanhere N, Morgado F, Rayment JH, Ratjen F, Couch MJ. Hyperpolarized Gas Magnetic Resonance Imaging of Pediatric Cystic Fibrosis Lung Disease. Acad Radiol. 2019 Mar; 26(3):344-354. PMID: 30087066.
      View in: PubMed
    6. Morgado F, Couch MJ, Stirrat E, Santyr G. Effect of T1 relaxation on ventilation mapping using hyperpolarized 129 Xe multiple breath wash-out imaging. Magn Reson Med. 2018 12; 80(6):2670-2680. PMID: 30009427.
      View in: PubMed
    7. Kanhere N, Couch MJ, Rayment JH, Ratjen F, Santyr G. Reply to Verbanck and Vanderhelst: The Respective Roles of Lung Clearance Index and Magnetic Resonance Imaging in the Clinical Management of Patients with Cystic Fibrosis. Am J Respir Crit Care Med. 2018 02 01; 197(3):411-412. PMID: 28800249.
      View in: PubMed
    8. Zanette B, Stirrat E, Jelveh S, Hope A, Santyr G. Physiological gas exchange mapping of hyperpolarized 129 Xe using spiral-IDEAL and MOXE in a model of regional radiation-induced lung injury. Med Phys. 2018 Feb; 45(2):803-816. PMID: 29238999.
      View in: PubMed
    9. Kanhere N, Couch MJ, Kowalik K, Zanette B, Rayment JH, Manson D, Subbarao P, Ratjen F, Santyr G. Correlation of Lung Clearance Index with Hyperpolarized 129Xe Magnetic Resonance Imaging in Pediatric Subjects with Cystic Fibrosis. Am J Respir Crit Care Med. 2017 10 15; 196(8):1073-1075. PMID: 28245140.
      View in: PubMed
    10. Zanette B, Stirrat E, Jelveh S, Hope A, Santyr G. Detection of regional radiation-induced lung injury using hyperpolarized 129Xe chemical shift imaging in a rat model involving partial lung irradiation: Proof-of-concept demonstration. Adv Radiat Oncol. 2017 Jul-Sep; 2(3):475-484. PMID: 29114616.
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    11. Ouriadov AV, Santyr GE. High spatial resolution hyperpolarized 3 He MRI of the rodent lung using a single breath X-centric gradient-recalled echo approach. Magn Reson Med. 2017 Dec; 78(6):2334-2341. PMID: 28112867.
      View in: PubMed
    12. Doganay O, Stirrat E, McKenzie C, Schulte RF, Santyr GE. Quantification of regional early stage gas exchange changes using hyperpolarized (129)Xe MRI in a rat model of radiation-induced lung injury. Med Phys. 2016 May; 43(5):2410. PMID: 27147352.
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    13. Doganay O, Wade T, Hegarty E, McKenzie C, Schulte RF, Santyr GE. Hyperpolarized (129) Xe imaging of the rat lung using spiral IDEAL. Magn Reson Med. 2016 08; 76(2):566-76. PMID: 26332385.
      View in: PubMed
    14. Ouriadov A, Fox M, Hegarty E, Parraga G, Wong E, Santyr GE. Early stage radiation-induced lung injury detected using hyperpolarized (129) Xe Morphometry: Proof-of-concept demonstration in a rat model. Magn Reson Med. 2016 06; 75(6):2421-31. PMID: 26154889.
      View in: PubMed
    15. Ouriadov A, Farag A, Kirby M, McCormack DG, Parraga G, Santyr GE. Pulmonary hyperpolarized (129) Xe morphometry for mapping xenon gas concentrations and alveolar oxygen partial pressure: Proof-of-concept demonstration in healthy and COPD subjects. Magn Reson Med. 2015 Dec; 74(6):1726-32. PMID: 25483611.
      View in: PubMed
    16. Santyr G, Fox M, Thind K, Hegarty E, Ouriadov A, Jensen M, Scholl TJ, Van Dyk J, Wong E. Anatomical, functional and metabolic imaging of radiation-induced lung injury using hyperpolarized MRI. NMR Biomed. 2014 Dec; 27(12):1515-24. PMID: 25156928.
      View in: PubMed
    17. Kirby M, Ouriadov A, Svenningsen S, Owrangi A, Wheatley A, Etemad-Rezai R, Santyr GE, McCormack DG, Parraga G. Hyperpolarized 3He and 129Xe magnetic resonance imaging apparent diffusion coefficients: physiological relevance in older never- and ex-smokers. Physiol Rep. 2014 Jul 16; 2(7). PMID: 25347853.
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    18. Fox MS, Ouriadov A, Thind K, Hegarty E, Wong E, Hope A, Santyr GE. Detection of radiation induced lung injury in rats using dynamic hyperpolarized (129)Xe magnetic resonance spectroscopy. Med Phys. 2014 Jul; 41(7):072302. PMID: 24989401.
      View in: PubMed
    19. Fox MS, Ouriadov A, Santyr GE. Comparison of hyperpolarized (3)He and (129)Xe MRI for the measurement of absolute ventilated lung volume in rats. Magn Reson Med. 2014 Mar; 71(3):1130-6. PMID: 23649901.
      View in: PubMed
    20. Thind K, Jensen MD, Hegarty E, Chen AP, Lim H, Martinez-Santiesteban F, Van Dyk J, Wong E, Scholl TJ, Santyr GE. Mapping metabolic changes associated with early Radiation Induced Lung Injury post conformal radiotherapy using hyperpolarized ¹³C-pyruvate Magnetic Resonance Spectroscopic Imaging. Radiother Oncol. 2014 Feb; 110(2):317-22. PMID: 24440041.
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    21. Ouriadov A, Farag A, Kirby M, McCormack DG, Parraga G, Santyr GE. Lung morphometry using hyperpolarized (129) Xe apparent diffusion coefficient anisotropy in chronic obstructive pulmonary disease. Magn Reson Med. 2013 Dec; 70(6):1699-706. PMID: 23359386.
      View in: PubMed
    22. Kirby M, Svenningsen S, Kanhere N, Owrangi A, Wheatley A, Coxson HO, Santyr GE, Paterson NA, McCormack DG, Parraga G. Pulmonary ventilation visualized using hyperpolarized helium-3 and xenon-129 magnetic resonance imaging: differences in COPD and relationship to emphysema. J Appl Physiol (1985). 2013 Mar 15; 114(6):707-15. PMID: 23239874.
      View in: PubMed
    23. Thind K, Chen A, Friesen-Waldner L, Ouriadov A, Scholl TJ, Fox M, Wong E, VanDyk J, Hope A, Santyr G. Detection of radiation-induced lung injury using hyperpolarized (13)C magnetic resonance spectroscopy and imaging. Magn Reson Med. 2013 Sep; 70(3):601-9. PMID: 23074042.
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    24. Fox MS, Welch I, Hobson D, Santyr GE. A novel intubation technique for minimally invasive longitudinal studies of rat lungs using hyperpolarized 3He magnetic resonance imaging. Lab Anim. 2012 Oct; 46(4):311-7. PMID: 23097565.
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    25. Kirby M, Svenningsen S, Owrangi A, Wheatley A, Farag A, Ouriadov A, Santyr GE, Etemad-Rezai R, Coxson HO, McCormack DG, Parraga G. Hyperpolarized 3He and 129Xe MR imaging in healthy volunteers and patients with chronic obstructive pulmonary disease. Radiology. 2012 Nov; 265(2):600-10. PMID: 22952383.
      View in: PubMed
    26. Shukla Y, Wheatley A, Kirby M, Svenningsen S, Farag A, Santyr GE, Paterson NA, McCormack DG, Parraga G. Hyperpolarized 129Xe magnetic resonance imaging: tolerability in healthy volunteers and subjects with pulmonary disease. Acad Radiol. 2012 Aug; 19(8):941-51. PMID: 22591724.
      View in: PubMed
    27. Boudreau M, Xu X, Santyr GE. Measurement of 129Xe gas apparent diffusion coefficient anisotropy in an elastase-instilled rat model of emphysema. Magn Reson Med. 2013 Jan; 69(1):211-20. PMID: 22378050.
      View in: PubMed
    28. Couch MJ, Ouriadov A, Santyr GE. Regional ventilation mapping of the rat lung using hyperpolarized ¹²?Xe magnetic resonance imaging. Magn Reson Med. 2012 Nov; 68(5):1623-31. PMID: 22231781.
      View in: PubMed
    29. Mathew L, Kirby M, Farquhar D, Licskai C, Santyr G, Etemad-Rezai R, Parraga G, McCormack DG. Hyperpolarized 3He functional magnetic resonance imaging of bronchoscopic airway bypass in chronic obstructive pulmonary disease. Can Respir J. 2012 Jan-Feb; 19(1):41-3. PMID: 22332133.
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    30. Xu X, Boudreau M, Ouriadov A, Santyr GE. Mapping of (3) He apparent diffusion coefficient anisotropy at sub-millisecond diffusion times in an elastase-instilled rat model of emphysema. Magn Reson Med. 2012 Apr; 67(4):1146-53. PMID: 22135238.
      View in: PubMed
    31. Dominguez-Viqueira W, Ouriadov A, O'Halloran R, Fain SB, Santyr GE. Signal-to-noise ratio for hyperpolarized ³He MR imaging of human lungs: a 1.5 T and 3 T comparison. Magn Reson Med. 2011 Nov; 66(5):1400-4. PMID: 21523821.
      View in: PubMed
    32. Santyr GE, Couch MJ, Lam WW, Ouriadov A, Drangova M, McCormack DG, Holdsworth DW. Comparison of hyperpolarized (3)He MRI with Xe-enhanced computed tomography imaging for ventilation mapping of rat lung. NMR Biomed. 2011 Nov; 24(9):1073-80. PMID: 21274963.
      View in: PubMed
    33. Olding T, Holmes O, Dejean P, McAuley KB, Nkongchu K, Santyr G, Schreiner LJ. Small field dose delivery evaluations using cone beam optical computed tomography-based polymer gel dosimetry. J Med Phys. 2011 Jan; 36(1):3-14. PMID: 21430853.
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    34. Kraayvanger RJ, Bidinosti CP, Dominguez-Viqueira W, Parra-Robles J, Fox M, Lam WW, Santyr GE. Measurement of alveolar oxygen partial pressure in the rat lung using Carr-Purcell-Meiboom-Gill spin-spin relaxation times of hyperpolarized 3He and 129Xe at 74 mT. Magn Reson Med. 2010 Nov; 64(5):1484-90. PMID: 20593371.
      View in: PubMed
    35. Kirby M, Mathew L, Wheatley A, Santyr GE, McCormack DG, Parraga G. Chronic obstructive pulmonary disease: longitudinal hyperpolarized (3)He MR imaging. Radiology. 2010 Jul; 256(1):280-9. PMID: 20574101.
      View in: PubMed
    36. Akhavan Sharif MR, Lam WW, Ouriadov AV, Holdsworth DW, Santyr GE. Comparison of hyperpolarized (3)He MRI rat lung volume measurement with micro-computed tomography. NMR Biomed. 2010 May; 23(4):359-67. PMID: 20099370.
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    37. Ouriadov AV, Lam WW, Santyr GE. Rapid 3-D mapping of hyperpolarized 3He spin-lattice relaxation times using variable flip angle gradient echo imaging with application to alveolar oxygen partial pressure measurement in rat lungs. MAGMA. 2009 Oct; 22(5):309-18. PMID: 19653021.
      View in: PubMed
    38. Coxson HO, Mayo J, Lam S, Santyr G, Parraga G, Sin DD. New and current clinical imaging techniques to study chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2009 Oct 01; 180(7):588-97. PMID: 19608719.
      View in: PubMed
    39. Mathew L, Evans A, Ouriadov A, Etemad-Rezai R, Fogel R, Santyr G, McCormack DG, Parraga G. Hyperpolarized 3He magnetic resonance imaging of chronic obstructive pulmonary disease: reproducibility at 3.0 tesla. Acad Radiol. 2008 Oct; 15(10):1298-311. PMID: 18790402.
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    40. Evans A, McCormack DG, Santyr G, Parraga G. Mapping and quantifying hyperpolarized 3He magnetic resonance imaging apparent diffusion coefficient gradients. J Appl Physiol (1985). 2008 Aug; 105(2):693-9. PMID: 18535126.
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    41. Parraga G, Mathew L, Etemad-Rezai R, McCormack DG, Santyr GE. Hyperpolarized 3He magnetic resonance imaging of ventilation defects in healthy elderly volunteers: initial findings at 3.0 Tesla. Acad Radiol. 2008 Jun; 15(6):776-85. PMID: 18486013.
      View in: PubMed
    42. Santyr GE, Lam WW, Ouriadov A. Rapid and efficient mapping of regional ventilation in the rat lung using hyperpolarized 3He with Flip Angle Variation for Offset of RF and Relaxation (FAVOR). Magn Reson Med. 2008 Jun; 59(6):1304-10. PMID: 18506796.
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    43. Parra-Robles J, Dominguez Viqueira W, Xu X, Ouriadov A, Santyr GE. Theoretical prediction and experimental measurement of the field dependence of the apparent transverse relaxation of hyperpolarized noble gases in lungs. J Magn Reson. 2008 May; 192(1):85-91. PMID: 18358755.
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    44. Evans A, McCormack D, Ouriadov A, Etemad-Rezai R, Santyr G, Parraga G. Anatomical distribution of 3He apparent diffusion coefficients in severe chronic obstructive pulmonary disease. J Magn Reson Imaging. 2007 Dec; 26(6):1537-47. PMID: 17968961.
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    45. Lam WW, Holdsworth DW, Du LY, Drangova M, McCormack DG, Santyr GE. Micro-CT imaging of rat lung ventilation using continuous image acquisition during xenon gas contrast enhancement. J Appl Physiol (1985). 2007 Nov; 103(5):1848-56. PMID: 17690202.
      View in: PubMed
    46. Parraga G, Ouriadov A, Evans A, McKay S, Lam WW, Fenster A, Etemad-Rezai R, McCormack D, Santyr G. Hyperpolarized 3He ventilation defects and apparent diffusion coefficients in chronic obstructive pulmonary disease: preliminary results at 3.0 Tesla. Invest Radiol. 2007 Jun; 42(6):384-91. PMID: 17507809.
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    47. Nkongchu K, Santyr G. Phase-encoding strategies for optimal spatial resolution and T1 accuracy in 3D Look-Locker imaging. Magn Reson Imaging. 2007 Oct; 25(8):1203-14. PMID: 17524588.
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    48. Yankeelov TE, Cron GO, Addison CL, Wallace JC, Wilkins RC, Pappas BA, Santyr GE, Gore JC. Comparison of a reference region model with direct measurement of an AIF in the analysis of DCE-MRI data. Magn Reson Med. 2007 Feb; 57(2):353-61. PMID: 17260371.
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    49. Abdeen N, Cross A, Cron G, White S, Rand T, Miller D, Santyr G. Measurement of xenon diffusing capacity in the rat lung by hyperpolarized 129Xe MRI and dynamic spectroscopy in a single breath-hold. Magn Reson Med. 2006 Aug; 56(2):255-64. PMID: 16767751.
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    50. Gherase MR, Wallace JC, Cross AR, Santyr GE. Two-compartment radial diffusive exchange analysis of the NMR lineshape of (129)Xe dissolved in a perfluorooctyl bromide emulsion. J Chem Phys. 2006 Jul 28; 125(4):44906. PMID: 16942191.
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    51. Nkongchu K, Santyr G. An improved 3-D Look--Locker imaging method for T(1) parameter estimation. Magn Reson Imaging. 2005 Sep; 23(7):801-7. PMID: 16214611.
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    52. Cron GO, Wallace JC, Stevens WD, Fortin T, Pappas BA, Wilkins RC, Kelcz F, Santyr GE. A comparison of T2*-weighted magnitude and phase imaging for measuring the arterial input function in the rat aorta following intravenous injection of gadolinium contrast agent. Magn Reson Imaging. 2005 Jun; 23(5):619-27. PMID: 16051036.
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    53. Parra-Robles J, Cross AR, Santyr GE. Passive shimming of the fringe field of a superconducting magnet for ultra-low field hyperpolarized noble gas MRI. J Magn Reson. 2005 May; 174(1):116-24. PMID: 15809179.
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    54. Parra-Robles J, Cross AR, Santyr GE. Theoretical signal-to-noise ratio and spatial resolution dependence on the magnetic field strength for hyperpolarized noble gas magnetic resonance imaging of human lungs. Med Phys. 2005 Jan; 32(1):221-9. PMID: 15719973.
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    55. Cron GO, Kelcz F, Santyr GE. Improvement in breast lesion characterization with dynamic contrast-enhanced MRI using pharmacokinetic modeling and bookend T(1) measurements. Magn Reson Med. 2004 May; 51(5):1066-70. PMID: 15122692.
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    56. Cross AR, McDonald M, Parra Robles J, Santyr GE. Laser-polarized 129Xe NMR at 1.88 T and 8.5 mT: a signal-to-noise ratio comparison. J Magn Reson. 2003 Jun; 162(2):241-9. PMID: 12810008.
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    57. Moudrakovski IL, Lang S, Ratcliffe CI, Simard B, Santyr G, Ripmeester JA. Chemical shift imaging with continuously flowing hyperpolarized xenon for the characterization of materials. J Magn Reson. 2000 Jun; 144(2):372-7. PMID: 10828205.
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    58. Cron GO, Santyr G, Kelcz F. Accurate and rapid quantitative dynamic contrast-enhanced breast MR imaging using spoiled gradient-recalled echoes and bookend T(1) measurements. Magn Reson Med. 1999 Oct; 42(4):746-53. PMID: 10502764.
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    59. Wilson GJ, Santyr GE, Anderson ME, DeLuca PM. Longitudinal relaxation times of 129Xe in rat tissue homogenates at 9.4 T. Magn Reson Med. 1999 May; 41(5):933-8. PMID: 10332876.
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    60. Niendorf ER, Grist TM, Lee FT, Brazy PC, Santyr GE. Rapid in vivo measurement of single-kidney extraction fraction and glomerular filtration rate with MR imaging. Radiology. 1998 Mar; 206(3):791-8. PMID: 9494503.
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    61. Niendorf ER, Grist TM, Frayne R, Brazy PC, Santyr GE. Rapid measurement of Gd-DTPA extraction fraction in a dialysis system using echo-planar imaging. Med Phys. 1997 Dec; 24(12):1907-13. PMID: 9434973.
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    62. Bishop JE, Santyr GE, Kelcz F, Plewes DB. Limitations of the keyhole technique for quantitative dynamic contrast-enhanced breast MRI. J Magn Reson Imaging. 1997 Jul-Aug; 7(4):716-23. PMID: 9243393.
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    63. Niendorf ER, Santyr GE, Brazy PC, Grist TM. Measurement of Gd-DTPA dialysis clearance rates by using a look-locker imaging technique. Magn Reson Med. 1996 Oct; 36(4):571-8. PMID: 8892210.
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    64. Kelcz F, Santyr GE, Cron GO, Mongin SJ. Application of a quantitative model to differentiate benign from malignant breast lesions detected by dynamic, gadolinium-enhanced MRI. J Magn Reson Imaging. 1996 Sep-Oct; 6(5):743-52. PMID: 8890012.
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    65. Santyr GE, Kelcz F, Schneider E. Pulsed magnetization transfer contrast for MR imaging with application to breast. J Magn Reson Imaging. 1996 Jan-Feb; 6(1):203-12. PMID: 8851429.
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    66. Fairbanks EJ, Santyr GE, Sorenson JA. One-shot measurement of spin-lattice relaxation times in the off-resonance rotating frame using MR imaging, with application to breast. J Magn Reson B. 1995 Mar; 106(3):279-83. PMID: 7719626.
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    67. Santyr GE, Mulkern RV. Magnetization transfer in MR imaging. Relaxometry and Biophysics Committee. J Magn Reson Imaging. 1995 Jan-Feb; 5(1):121-4. PMID: 7696802.
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    68. Kelcz F, Santyr G. Gadolinium-enhanced breast MRI. Crit Rev Diagn Imaging. 1995; 36(4):287-338. PMID: 8845065.
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    69. Santyr GE. MR imaging of the breast. Imaging and tissue characterization without intravenous contrast. Magn Reson Imaging Clin N Am. 1994 Nov; 2(4):673-90. PMID: 7489316.
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    70. Santyr GE, Fairbanks EJ, Kelcz F, Sorenson JA. Off-resonance spin locking for MR imaging. Magn Reson Med. 1994 Jul; 32(1):43-51. PMID: 8084236.
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    71. Bronskill MJ, Santyr GE, Walters B, Henkelman RM. Analysis of discrete T2 components of NMR relaxation for aqueous solutions in hollow fiber capillaries. Magn Reson Med. 1994 Jun; 31(6):611-8. PMID: 8057813.
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    72. Wood ML, Bronskill MJ, Mulkern RV, Santyr GE. Physical MR desktop data. J Magn Reson Imaging. 1993 Nov-Dec; 3 Suppl:19-24. PMID: 8280987.
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    73. Santyr GE. Magnetization transfer effects in multislice MR imaging. Magn Reson Imaging. 1993; 11(4):521-32. PMID: 8316065.
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    74. Mo LY, Yip G, Cobbold RS, Gutt C, Joy M, Santyr G, Shung KK. Non-newtonian behavior of whole blood in a large diameter tube. Biorheology. 1991; 28(5):421-7. PMID: 1782394.
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    75. Santyr GE, Henkelman RM, Bronskill MJ. Spin locking for magnetic resonance imaging with application to human breast. Magn Reson Med. 1989 Oct; 12(1):25-37. PMID: 2607958.
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