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Monica Justice

TitleProgram Head & Senior Scientist
InstitutionThe Hospital for Sick Children
DepartmentGenetics and Genome Biology
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Tracey LJ, Brooke-Bisschop T, Jansen PWTC, Campos EI, Vermeulen M, Justice MJ. The pluripotency regulator PRDM14 requires hematopoietic regulator CBFA2T3 to initiate leukemia in mice. Mol Cancer Res. 2019 Apr 23. PMID: 31015254.
      View in: PubMed
    2. Justice MJ. DMM Prize 2018 winner: Wenqing Zhou. Dis Model Mech. 2019 03 26; 12(3). PMID: 30923050.
      View in: PubMed
    3. Vashi N, Justice MJ. Treating Rett syndrome: from mouse models to human therapies. Mamm Genome. 2019 Feb 28. PMID: 30820643.
      View in: PubMed
    4. Hmeljak J, Justice MJ. From gene to treatment: supporting rare disease translational research through model systems. Dis Model Mech. 2019 02 22; 12(2). PMID: 30819728.
      View in: PubMed
    5. Kyle SM, Vashi N, Justice MJ. Rett syndrome: a neurological disorder with metabolic components. Open Biol. 2018 02; 8(2). PMID: 29445033.
      View in: PubMed
    6. Allemang-Grand R, Ellegood J, Spencer Noakes L, Ruston J, Justice M, Nieman BJ, Lerch JP. Neuroanatomy in mouse models of Rett syndrome is related to the severity of Mecp2 mutation and behavioral phenotypes. Mol Autism. 2017; 8:32. PMID: 28670438.
      View in: PubMed
    7. Kyle SM, Saha PK, Brown HM, Chan LC, Justice MJ. MeCP2 co-ordinates liver lipid metabolism with the NCoR1/HDAC3 corepressor complex. Hum Mol Genet. 2016 07 15; 25(14):3029-3041. PMID: 27288453.
      View in: PubMed
    8. Carofino BL, Ayanga B, Tracey LJ, Brooke-Bisschop T, Justice MJ. PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL. Biol Open. 2016 May 15; 5(5):645-53. PMID: 27106930.
      View in: PubMed
    9. Justice MJ, Dhillon P. Using the mouse to model human disease: increasing validity and reproducibility. Dis Model Mech. 2016 Feb; 9(2):101-3. PMID: 26839397.
      View in: PubMed
    10. Sen P, Dharmadhikari AV, Majewski T, Mohammad MA, Kalin TV, Zabielska J, Ren X, Bray M, Brown HM, Welty S, Thevananther S, Langston C, Szafranski P, Justice MJ, Kalinichenko VV, Gambin A, Belmont J, Stankiewicz P. Comparative analyses of lung transcriptomes in patients with alveolar capillary dysplasia with misalignment of pulmonary veins and in foxf1 heterozygous knockout mice. PLoS One. 2014; 9(4):e94390. PMID: 24722050.
      View in: PubMed
    11. Buchovecky CM, Hill MG, Borkey JM, Kyle SM, Justice MJ. Evaluation of Rett Syndrome Symptom Improvement by Metabolic Modulators in Mecp2-Mutant Mice. Curr Protoc Mouse Biol. 2013 Dec 19; 3(4):187-204. PMID: 26069093.
      View in: PubMed
    12. Justice MJ, Buchovecky CM, Kyle SM, Djukic A. A role for metabolism in Rett syndrome pathogenesis: New clinical findings and potential treatment targets. Rare Dis. 2013; 1:e27265. PMID: 25003017.
      View in: PubMed
    13. Allache R, Lachance S, Guyot MC, De Marco P, Merello E, Justice MJ, Capra V, Kibar Z. Novel mutations in Lrp6 orthologs in mouse and human neural tube defects affect a highly dosage-sensitive Wnt non-canonical planar cell polarity pathway. Hum Mol Genet. 2014 Apr 01; 23(7):1687-99. PMID: 24203697.
      View in: PubMed
    14. Carofino BL, Ayanga B, Justice MJ. A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL). Dis Model Mech. 2013 Nov; 6(6):1494-506. PMID: 24046360.
      View in: PubMed
    15. Buchovecky CM, Turley SD, Brown HM, Kyle SM, McDonald JG, Liu B, Pieper AA, Huang W, Katz DM, Russell DW, Shendure J, Justice MJ. A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome. Nat Genet. 2013 Sep; 45(9):1013-20. PMID: 23892605.
      View in: PubMed
    16. Justice M. Of mice and men, and medicine: an interview with Monica Justice. Dis Model Mech. 2013 Jul; 6(4):871-3. PMID: 23828642.
      View in: PubMed
    17. Cagan RL, Justice MJ, Tidmarsh GF. Bridging the gap between basic and applied biology: towards preclinical translation. Dis Model Mech. 2013 May; 6(3):559-61. PMID: 23616075.
      View in: PubMed
    18. Adams D, Baldock R, Bhattacharya S, Copp AJ, Dickinson M, Greene ND, Henkelman M, Justice M, Mohun T, Murray SA, Pauws E, Raess M, Rossant J, Weaver T, West D. Bloomsbury report on mouse embryo phenotyping: recommendations from the IMPC workshop on embryonic lethal screening. Dis Model Mech. 2013 May; 6(3):571-9. PMID: 23519032.
      View in: PubMed
    19. Buchovecky CM, Hill MG, Borkey JM, Kyle SM, Justice MJ. A protocol for evaluation of Rett Syndrome symptom improvement by metabolic modulators in Mecp2-mutant mice. Curr Protoc Mouse Biol. 2013; 2013. PMID: 25506514.
      View in: PubMed
    20. Beck TF, Veenma D, Shchelochkov OA, Yu Z, Kim BJ, Zaveri HP, van Bever Y, Choi S, Douben H, Bertin TK, Patel PI, Lee B, Tibboel D, de Klein A, Stockton DW, Justice MJ, Scott DA. Deficiency of FRAS1-related extracellular matrix 1 (FREM1) causes congenital diaphragmatic hernia in humans and mice. Hum Mol Genet. 2013 Mar 01; 22(5):1026-38. PMID: 23221805.
      View in: PubMed
    21. Jiang Z, Zhu L, Hu L, Slesnick TC, Pautler RG, Justice MJ, Belmont JW. Zic3 is required in the extra-cardiac perinodal region of the lateral plate mesoderm for left-right patterning and heart development. Hum Mol Genet. 2013 Mar 01; 22(5):879-89. PMID: 23184148.
      View in: PubMed
    22. Katz DM, Berger-Sweeney JE, Eubanks JH, Justice MJ, Neul JL, Pozzo-Miller L, Blue ME, Christian D, Crawley JN, Giustetto M, Guy J, Howell CJ, Kron M, Nelson SB, Samaco RC, Schaevitz LR, St Hillaire-Clarke C, Young JL, Zoghbi HY, Mamounas LA. Preclinical research in Rett syndrome: setting the foundation for translational success. Dis Model Mech. 2012 Nov; 5(6):733-45. PMID: 23115203.
      View in: PubMed
    23. Justice MJ, Siracusa LD, Stewart AF. Technical approaches for mouse models of human disease. Dis Model Mech. 2011 May; 4(3):305-10. PMID: 21558063.
      View in: PubMed
    24. Dettman EJ, Simko SJ, Ayanga B, Carofino BL, Margolin JF, Morse HC, Justice MJ. Prdm14 initiates lymphoblastic leukemia after expanding a population of cells resembling common lymphoid progenitors. Oncogene. 2011 Jun 23; 30(25):2859-73. PMID: 21339739.
      View in: PubMed
    25. Kamp A, Peterson MA, Svenson KL, Bjork BC, Hentges KE, Rajapaksha TW, Moran J, Justice MJ, Seidman JG, Seidman CE, Moskowitz IP, Beier DR. Genome-wide identification of mouse congenital heart disease loci. Hum Mol Genet. 2010 Aug 15; 19(16):3105-13. PMID: 20511334.
      View in: PubMed
    26. Justice MJ. Removing the cloak of invisibility: phenotyping the mouse. Dis Model Mech. 2008 Sep-Oct; 1(2-3):109-12. PMID: 19048073.
      View in: PubMed
    27. Weiser KC, Liu B, Hansen GM, Skapura D, Hentges KE, Yarlagadda S, Morse Iii HC, Justice MJ. Retroviral insertions in the VISION database identify molecular pathways in mouse lymphoid leukemia and lymphoma. Mamm Genome. 2007 Oct; 18(10):709-22. PMID: 17926094.
      View in: PubMed
    28. Meehan TP, Tabeta K, Du X, Woodward LS, Firozi K, Beutler B, Justice MJ. Point mutations in the melanocortin-4 receptor cause variable obesity in mice. Mamm Genome. 2006 Dec; 17(12):1162-71. PMID: 17143585.
      View in: PubMed
    29. Noveroske JK, Hardy R, Dapper JD, Vogel H, Justice MJ. A new ENU-induced allele of mouse quaking causes severe CNS dysmyelination. Mamm Genome. 2005 Sep; 16(9):672-82. PMID: 16245024.
      View in: PubMed
    30. Lossie AC, Meehan TP, Castillo A, Zheng L, Weiser KC, Strivens MA, Justice MJ. 18th international mouse genome conference. Mamm Genome. 2005 Jul; 16(7):471-5. PMID: 16151691.
      View in: PubMed
    31. Bi W, Ohyama T, Nakamura H, Yan J, Visvanathan J, Justice MJ, Lupski JR. Inactivation of Rai1 in mice recapitulates phenotypes observed in chromosome engineered mouse models for Smith-Magenis syndrome. Hum Mol Genet. 2005 Apr 15; 14(8):983-95. PMID: 15746153.
      View in: PubMed
    32. Lossie AC, Nakamura H, Thomas SE, Justice MJ. Mutation of l7Rn3 shows that Odz4 is required for mouse gastrulation. Genetics. 2005 Jan; 169(1):285-99. PMID: 15489520.
      View in: PubMed
    33. Yan J, Keener VW, Bi W, Walz K, Bradley A, Justice MJ, Lupski JR. Reduced penetrance of craniofacial anomalies as a function of deletion size and genetic background in a chromosome engineered partial mouse model for Smith-Magenis syndrome. Hum Mol Genet. 2004 Nov 01; 13(21):2613-24. PMID: 15459175.
      View in: PubMed
    34. Lorenzetti D, Bishop CE, Justice MJ. Deletion of the Parkin coregulated gene causes male sterility in the quaking(viable) mouse mutant. Proc Natl Acad Sci U S A. 2004 Jun 01; 101(22):8402-7. PMID: 15148410.
      View in: PubMed
    35. Hentges KE, Kyttälä M, Justice MJ, Peltonen L. Comparative physical maps of the human and mouse Meckel syndrome critical regions. Mamm Genome. 2004 Apr; 15(4):252-64. PMID: 15112103.
      View in: PubMed
    36. Lorenzetti D, Antalffy B, Vogel H, Noveroske J, Armstrong D, Justice M. The neurological mutant quaking(viable) is Parkin deficient. Mamm Genome. 2004 Mar; 15(3):210-7. PMID: 15014970.
      View in: PubMed
    37. Kile BT, Mason-Garrison CL, Justice MJ. Sex and strain-related differences in the peripheral blood cell values of inbred mouse strains. Mamm Genome. 2003 Jan; 14(1):81-5. PMID: 12532271.
      View in: PubMed
    38. Tsai TF, Chen KS, Weber JS, Justice MJ, Beaudet AL. Evidence for translational regulation of the imprinted Snurf-Snrpn locus in mice. Hum Mol Genet. 2002 Jul 01; 11(14):1659-68. PMID: 12075010.
      View in: PubMed
    39. Justice MJ, Carpenter DA, Favor J, Neuhauser-Klaus A, Hrabé de Angelis M, Soewarto D, Moser A, Cordes S, Miller D, Chapman V, Weber JS, Rinchik EM, Hunsicker PR, Russell WL, Bode VC. Effects of ENU dosage on mouse strains. Mamm Genome. 2000 Jul; 11(7):484-8. PMID: 10886010.
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    40. Noveroske JK, Weber JS, Justice MJ. The mutagenic action of N-ethyl-N-nitrosourea in the mouse. Mamm Genome. 2000 Jul; 11(7):478-83. PMID: 10886009.
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    41. Simpson EH, Suffolk R, Bell JA, Jordan SA, Johnson DK, Hunsicker PR, Weber JS, Justice MJ, Jackson IJ. A comparative transcript map and candidates for mutant phenotypes in the Tyrp1 (brown) deletion complex homologous to human 9p21-23. Mamm Genome. 2000 Jan; 11(1):58-63. PMID: 10602994.
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    42. Davis AP, Woychik RP, Justice MJ. Effective chemical mutagenesis in FVB/N mice requires low doses of ethylnitrosourea. Mamm Genome. 1999 Mar; 10(3):308-10. PMID: 10051330.
      View in: PubMed
    43. Justice MJ, Noveroske JK, Weber JS, Zheng B, Bradley A. Mouse ENU mutagenesis. Hum Mol Genet. 1999; 8(10):1955-63. PMID: 10469849.
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    44. Davis AP, Justice MJ. Meeting report: 11th International Mouse Genome Conference. Mamm Genome. 1998 May; 9(5):345-8. PMID: 9545489.
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    45. Hansen GM, Justice MJ. Pten, a candidate tumor suppressor gene, maps to mouse chromosome 19. Mamm Genome. 1998 Jan; 9(1):88-90. PMID: 9434957.
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    46. Justice MJ, Stephenson DA. Mouse chromosome 13. Mamm Genome. 1997; 7 Spec No:S223-37. PMID: 9233396.
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    47. Griffith AJ, Radice GL, Burgess DL, Kohrman DC, Hansen GM, Justice MJ, Johnson KR, Davisson MT, Meisler MH. Location of the 9257 and ataxia mutations on mouse chromosome 18. Mamm Genome. 1996 Jun; 7(6):417-9. PMID: 8662222.
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    48. Justice MJ, Stephenson DA. Encyclopedia of the mouse genome V. Mouse chromosome 13. Mamm Genome. 1996; 6 Spec No:S232-44. PMID: 8800768.
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    49. Justice MJ, Stephenson DA. Mouse chromosome 13. Mamm Genome. 1994; 5 Spec No:S196-206. PMID: 7719006.
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    50. Justice MJ, Stephenson DA. Encyclopedia of the mouse genome III. October 1993. Mouse chromosome 13. Mamm Genome. 1993; 4 Spec No:S192-202. PMID: 8268673.
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    51. Justice MJ, Stephenson DA. Mouse chromosome 13. Mamm Genome. 1992; 3 Spec No:S195-205. PMID: 1498432.
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    52. Taylor BA, Justice MJ, Reeves R. Mouse chromosome 10. Mamm Genome. 1991; 1 Spec No:S146-57. PMID: 1799797.
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    53. Justice MJ, Stephenson DA. Mouse chromosome 13. Mamm Genome. 1991; 1 Spec No:S205-20. PMID: 1799801.
      View in: PubMed
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