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Diane Wherrett

TitleStaff Physician
InstitutionThe Hospital for Sick Children
DepartmentEndocrinology
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Sims EK, Geyer S, Johnson SB, Libman I, Jacobsen LM, Boulware D, Rafkin LE, Matheson D, Atkinson MA, Rodriguez H, Spall M, Larsson HE, Wherrett DK, Greenbaum CJ, Krischer J, DiMeglio LA. Who Is Enrolling? The Path to Monitoring in Type 1 Diabetes TrialNet's Pathway to Prevention. Diabetes Care. 2019 Sep 26. PMID: 31558546.
      View in: PubMed
    2. Herold KC, Bundy BN, Long SA, Bluestone JA, DiMeglio LA, Dufort MJ, Gitelman SE, Gottlieb PA, Krischer JP, Linsley PS, Marks JB, Moore W, Moran A, Rodriguez H, Russell WE, Schatz D, Skyler JS, Tsalikian E, Wherrett DK, Ziegler AG, Greenbaum CJ. An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes. N Engl J Med. 2019 08 15; 381(7):603-613. PMID: 31180194.
      View in: PubMed
    3. Couper JJ, Haller MJ, Greenbaum CJ, Ziegler AG, Wherrett DK, Knip M, Craig ME. ISPAD Clinical Practice Consensus Guidelines 2018: Stages of type 1 diabetes in children and adolescents. Pediatr Diabetes. 2018 10; 19 Suppl 27:20-27. PMID: 30051639.
      View in: PubMed
    4. Wherrett DK, Ho J, Huot C, Legault L, Nakhla M, Rosolowsky E. Type 1 Diabetes in Children and Adolescents. Can J Diabetes. 2018 Apr; 42 Suppl 1:S234-S246. PMID: 29650103.
      View in: PubMed
    5. Bingley PJ, Wherrett DK, Shultz A, Rafkin LE, Atkinson MA, Greenbaum CJ. Type 1 Diabetes TrialNet: A Multifaceted Approach to Bringing Disease-Modifying Therapy to Clinical Use in Type 1 Diabetes. Diabetes Care. 2018 04; 41(4):653-661. PMID: 29559451.
      View in: PubMed
    6. Nathan BM, Boulware D, Geyer S, Atkinson MA, Colman P, Goland R, Russell W, Wentworth JM, Wilson DM, Evans-Molina C, Wherrett D, Skyler JS, Moran A, Sosenko JM. Dysglycemia and Index60 as Prediagnostic End Points for Type 1 Diabetes Prevention Trials. Diabetes Care. 2017 11; 40(11):1494-1499. PMID: 28860125.
      View in: PubMed
    7. Beam CA, MacCallum C, Herold KC, Wherrett DK, Palmer J, Ludvigsson J. GAD vaccine reduces insulin loss in recently diagnosed type 1 diabetes: findings from a Bayesian meta-analysis. Diabetologia. 2017 01; 60(1):43-49. PMID: 27704166.
      View in: PubMed
    8. Saleh DS, Lawrence S, Geraghty MT, Gallego PH, McAssey K, Wherrett DK, Chakraborty P. Prediction of congenital hypothyroidism based on initial screening thyroid-stimulating-hormone. BMC Pediatr. 2016 Feb 02; 16:24. PMID: 26839208.
      View in: PubMed
    9. Wherrett DK, Chiang JL, Delamater AM, DiMeglio LA, Gitelman SE, Gottlieb PA, Herold KC, Lovell DJ, Orchard TJ, Ryan CM, Schatz DA, Wendler DS, Greenbaum CJ. Defining pathways for development of disease-modifying therapies in children with type 1 diabetes: a consensus report. Diabetes Care. 2015 Oct; 38(10):1975-85. PMID: 26404927.
      View in: PubMed
    10. Turner JR, Close KL, Fleming GA, Wherrett DK, DiMeglio LA. Alternate approaches for pediatric type 1 diabetes drug development and potential regulatory approval: a perspective. Diabetes Care. 2015 Oct; 38(10):1986-91. PMID: 26404928.
      View in: PubMed
    11. Cameron FJ, Wherrett DK. Care of diabetes in children and adolescents: controversies, changes, and consensus. Lancet. 2015 May 23; 385(9982):2096-106. PMID: 26009230.
      View in: PubMed
    12. Wherrett DK. Approach to the Infant with a Suspected Disorder of Sex Development. Pediatr Clin North Am. 2015 Aug; 62(4):983-99. PMID: 26210628.
      View in: PubMed
    13. Wherrett DK. Trials in the prevention of type 1 diabetes: current and future. Can J Diabetes. 2014 Aug; 38(4):279-84. PMID: 25092646.
      View in: PubMed
    14. Orban T, Bundy B, Becker DJ, Dimeglio LA, Gitelman SE, Goland R, Gottlieb PA, Greenbaum CJ, Marks JB, Monzavi R, Moran A, Peakman M, Raskin P, Russell WE, Schatz D, Wherrett DK, Wilson DM, Krischer JP, Skyler JS. Costimulation modulation with abatacept in patients with recent-onset type 1 diabetes: follow-up 1 year after cessation of treatment. Diabetes Care. 2014 Apr; 37(4):1069-75. PMID: 24296850.
      View in: PubMed
    15. Pescovitz MD, Greenbaum CJ, Bundy B, Becker DJ, Gitelman SE, Goland R, Gottlieb PA, Marks JB, Moran A, Raskin P, Rodriguez H, Schatz DA, Wherrett DK, Wilson DM, Krischer JP, Skyler JS. B-lymphocyte depletion with rituximab and ß-cell function: two-year results. Diabetes Care. 2014 Feb; 37(2):453-9. PMID: 24026563.
      View in: PubMed
    16. Moran A, Bundy B, Becker DJ, DiMeglio LA, Gitelman SE, Goland R, Greenbaum CJ, Herold KC, Marks JB, Raskin P, Sanda S, Schatz D, Wherrett DK, Wilson DM, Krischer JP, Skyler JS, Pickersgill L, de Koning E, Ziegler AG, Böehm B, Badenhoop K, Schloot N, Bak JF, Pozzilli P, Mauricio D, Donath MY, Castaño L, Wägner A, Lervang HH, Perrild H, Mandrup-Poulsen T. Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials. Lancet. 2013 Jun 01; 381(9881):1905-15. PMID: 23562090.
      View in: PubMed
    17. Wherrett D, Huot C, Mitchell B, Pacaud D. Type 1 diabetes in children and adolescents. Can J Diabetes. 2013 Apr; 37 Suppl 1:S153-62. PMID: 24070940.
      View in: PubMed
    18. Gucev ZS, Tee MK, Chitayat D, Wherrett DK, Miller WL. Distinguishing deficiencies in the steroidogenic acute regulatory protein and the cholesterol side chain cleavage enzyme causing neonatal adrenal failure. J Pediatr. 2013 Apr; 162(4):819-22. PMID: 23158025.
      View in: PubMed
    19. Romao RL, Salle JL, Wherrett DK. Update on the management of disorders of sex development. Pediatr Clin North Am. 2012 Aug; 59(4):853-69. PMID: 22857833.
      View in: PubMed
    20. Moalem S, Babul-Hirji R, Stavropolous DJ, Wherrett D, Bägli DJ, Thomas P, Chitayat D. XX male sex reversal with genital abnormalities associated with a de novo SOX3 gene duplication. Am J Med Genet A. 2012 Jul; 158A(7):1759-64. PMID: 22678921.
      View in: PubMed
    21. Wherrett DK, Daneman D. Prevention of type 1 diabetes. Pediatr Clin North Am. 2011 Oct; 58(5):1257-70, xi. PMID: 21981959.
      View in: PubMed
    22. Orban T, Bundy B, Becker DJ, DiMeglio LA, Gitelman SE, Goland R, Gottlieb PA, Greenbaum CJ, Marks JB, Monzavi R, Moran A, Raskin P, Rodriguez H, Russell WE, Schatz D, Wherrett D, Wilson DM, Krischer JP, Skyler JS. Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial. Lancet. 2011 Jul 30; 378(9789):412-9. PMID: 21719096.
      View in: PubMed
    23. Wherrett DK, Bundy B, Becker DJ, DiMeglio LA, Gitelman SE, Goland R, Gottlieb PA, Greenbaum CJ, Herold KC, Marks JB, Monzavi R, Moran A, Orban T, Palmer JP, Raskin P, Rodriguez H, Schatz D, Wilson DM, Krischer JP, Skyler JS. Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: a randomised double-blind trial. Lancet. 2011 Jul 23; 378(9788):319-27. PMID: 21714999.
      View in: PubMed
    24. Vehik K, Haller MJ, Beam CA, Schatz DA, Wherrett DK, Sosenko JM, Krischer JP. Islet autoantibody seroconversion in the DPT-1 study: justification for repeat screening throughout childhood. Diabetes Care. 2011 Feb; 34(2):358-62. PMID: 21270193.
      View in: PubMed
    25. Szauter KM, Ordas A, Laxer RM, Pope E, Wherrett D, Alman B, Mink M, Boyd CD, Csiszar K, Hinek A. A novel fibrotic disorder associated with increased dermal fibroblast proliferation and downregulation of genes of the microfibrillar network. Br J Dermatol. 2010 Nov; 163(5):1102-15. PMID: 20560960.
      View in: PubMed
    26. Yinon Y, Kingdom JC, Proctor LK, Kelly EN, Salle JL, Wherrett D, Keating S, Nevo O, Chitayat D. Hypospadias in males with intrauterine growth restriction due to placental insufficiency: the placental role in the embryogenesis of male external genitalia. Am J Med Genet A. 2010 Jan; 152A(1):75-83. PMID: 20014131.
      View in: PubMed
    27. Wherrett DK, Daneman D. Prevention of type 1 diabetes. Endocrinol Metab Clin North Am. 2009 Dec; 38(4):777-90. PMID: 19944292.
      View in: PubMed
    28. Pescovitz MD, Greenbaum CJ, Krause-Steinrauf H, Becker DJ, Gitelman SE, Goland R, Gottlieb PA, Marks JB, McGee PF, Moran AM, Raskin P, Rodriguez H, Schatz DA, Wherrett D, Wilson DM, Lachin JM, Skyler JS. Rituximab, B-lymphocyte depletion, and preservation of beta-cell function. N Engl J Med. 2009 Nov 26; 361(22):2143-52. PMID: 19940299.
      View in: PubMed
    29. Afzal S, Wherrett D, Bartels U, Tabori U, Huang A, Stephens D, Bouffet E. Challenges in management of patients with intracranial germ cell tumor and diabetes insipidus treated with cisplatin and/or ifosfamide based chemotherapy. J Neurooncol. 2010 May; 97(3):393-9. PMID: 19820898.
      View in: PubMed
    30. Blanchard R, Lykins AD, Wherrett D, Kuban ME, Cantor JM, Blak T, Dickey R, Klassen PE. Pedophilia, hebephilia, and the DSM-V. Arch Sex Behav. 2009 Jun; 38(3):335-50. PMID: 18686026.
      View in: PubMed
    31. Spitzer RF, Wherrett D, Chitayat D, Colgan T, Dodge JE, Salle JL, Allen L. Maternal luteoma of pregnancy presenting with virilization of the female infant. J Obstet Gynaecol Can. 2007 Oct; 29(10):835-40. PMID: 17915067.
      View in: PubMed
    32. Das PK, Wherrett D, Dror Y. Remission of aplastic anemia induced by treatment for Graves disease in a pediatric patient. Pediatr Blood Cancer. 2007 Aug; 49(2):210-2. PMID: 16456859.
      View in: PubMed
    33. Rachmiel M, Charron M, Gupta A, Hamilton J, Wherrett D, Forte V, Daneman D. Evidence-based review of treatment and follow up of pediatric patients with differentiated thyroid carcinoma. J Pediatr Endocrinol Metab. 2006 Dec; 19(12):1377-93. PMID: 17252690.
      View in: PubMed
    34. Stein R, Wherrett D, Daneman D. Management of 21-hydroxylase deficiency congenital adrenal hyperplasia: A survey of Canadian paediatric endocrinologists. Paediatr Child Health. 2005 Jul; 10(6):323-6. PMID: 19675839.
      View in: PubMed
    35. Razack NN, Wherrett DK. Type 1 diabetes: New horizons in prediction and prevention. Paediatr Child Health. 2005 Jan; 10(1):35-7. PMID: 19657444.
      View in: PubMed
    36. Capra M, Wherrett D, Weitzman S, Dirks P, Hawkins C, Bouffet E. Pituitary stalk thickening and primary central nervous system lymphoma. J Neurooncol. 2004 Mar-Apr; 67(1-2):227-31. PMID: 15072472.
      View in: PubMed
    37. Teebi AS, Dupuis L, Wherrett D, Khoury A, Zucker KJ. Alopecia congenita universalis, microcephaly, cutis marmorata, short stature and XY gonadal dysgenesis: variable expression of El-Shanti syndrome. Eur J Pediatr. 2004 Mar; 163(3):170-2. PMID: 14691719.
      View in: PubMed
    38. Konrad D, Daneman D, Kirby M, Wherrett D. Cardiac failure after initiation of insulin treatment in diabetic patients with beta-thalassemia major. J Pediatr. 2003 Oct; 143(4):541-2. PMID: 14571237.
      View in: PubMed
    39. Huang C, Banerjee K, Sochett E, Perlman K, Wherrett D, Daneman D. Hypoglycemia associated with clonidine testing for growth hormone deficiency. J Pediatr. 2001 Aug; 139(2):323-4. PMID: 11487765.
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    40. Wherrett DK. Measurement of soluble adhesion molecules: can it improve diabetes prediction? Pediatr Res. 2001 Jan; 49(1):5-7. PMID: 11134483.
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    41. Zimmerman B, Gold M, Wherrett D, Hanna AK. Adrenal suppression in two patients with asthma treated with low doses of the inhaled steroid fluticasone propionate. J Allergy Clin Immunol. 1998 Mar; 101(3):425-6. PMID: 9525464.
      View in: PubMed
    42. Wherrett DK, Singer SM, McDevitt HO. Reduction in diabetes incidence in an I-Ag7 transgenic nonobese diabetic mouse line. Diabetes. 1997 Dec; 46(12):1970-4. PMID: 9392482.
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    43. Patel SD, Cope AP, Congia M, Chen TT, Kim E, Fugger L, Wherrett D, Sonderstrup-McDevitt G. Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR(alpha1*0101,beta1*0401) transgenic mice. Proc Natl Acad Sci U S A. 1997 Jul 22; 94(15):8082-7. PMID: 9223318.
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    44. Hudson RW, Wherrett D. Comparison of the nuclear 5 alpha-reduction of testosterone and androstenedione in human prostatic carcinoma and benign prostatic hyperplasia. J Steroid Biochem. 1990 Feb; 35(2):231-6. PMID: 1689784.
      View in: PubMed
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