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Gail Annich

TitleStaff Physician, PICU Division
InstitutionThe Hospital for Sick Children
DepartmentCritical Care Medicine
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Barbaro RP, Boonstra PS, Kuo KW, Selewski DT, Bailly DK, Stone CL, Chow CY, Annich GM, Moler FW, Paden ML. Evaluating Mortality Risk Adjustment Among Children Receiving Extracorporeal Support for Respiratory Failure. ASAIO J. 2019 Mar/Apr; 65(3):277-284. PMID: 29746311.
      View in: PubMed
    2. Ontaneda A, Annich GM. Novel Surfaces in Extracorporeal Membrane Oxygenation Circuits. Front Med (Lausanne). 2018; 5:321. PMID: 30525038.
      View in: PubMed
    3. Grasso C, Annich GM. Venoarterial Extracorporeal Membrane Oxygenation in Severe Pediatric Septic Shock. Pediatr Crit Care Med. 2018 10; 19(10):1000-999. PMID: 30281570.
      View in: PubMed
    4. Eytan D, Bitterman Y, Annich GM. VV extracorporeal life support for the Third Millennium: will we need anticoagulation? J Thorac Dis. 2018 Mar; 10(Suppl 5):S698-S706. PMID: 29732189.
      View in: PubMed
    5. Domico M, Ridout D, MacLaren G, Barbaro R, Annich G, Schlapbach LJ, Brown KL. Extracorporeal Membrane Oxygenation for Pertussis: Predictors of Outcome Including Pulmonary Hypertension and Leukodepletion. Pediatr Crit Care Med. 2018 03; 19(3):254-261. PMID: 29319632.
      View in: PubMed
    6. Annich GM, Zaulan O, Neufeld M, Wagner D, Reynolds MM. Thromboprophylaxis in Extracorporeal Circuits: Current Pharmacological Strategies and Future Directions. Am J Cardiovasc Drugs. 2017 Dec; 17(6):425-439. PMID: 28536932.
      View in: PubMed
    7. Yu JS, Barbaro RP, Granoski DA, Bauman ME, Massicotte MP, Lequier LL, Annich GM, Ryerson LM. Prospective Side by Side Comparison of Outcomes and Complications With a Simple Versus Intensive Anticoagulation Monitoring Strategy in Pediatric Extracorporeal Life Support Patients. Pediatr Crit Care Med. 2017 Nov; 18(11):1055-1062. PMID: 28922263.
      View in: PubMed
    8. Scoville BA, Vulaj V, Mueller BA, Annich GM, Wagner DS. Acetaminophen clearance during ex vivo continuous renal replacement therapies. J Artif Organs. 2018 Jun; 21(2):215-219. PMID: 29063343.
      View in: PubMed
    9. Gaudreault-Tremblay MM, Faqeehi H, Langlois V, H├ębert D, Parra DA, Annich G, Harvey E, Lemaire M. Management of Severe Hyponatremia With a Custom Continuous Renal Replacement Therapy in an Infant With Newly Diagnosed Chronic Kidney Disease. Kidney Int Rep. 2017 Nov; 2(6):1254-1258. PMID: 29270536.
      View in: PubMed
    10. Barbaro RP, Boonstra PS, Paden ML, Roberts LA, Annich GM, Bartlett RH, Moler FW, Davis MM. Development and validation of the pediatric risk estimate score for children using extracorporeal respiratory support (Ped-RESCUERS). Intensive Care Med. 2016 May; 42(5):879-888. PMID: 27007109.
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    11. Barbaro RP, Bartlett RH, Chapman RL, Paden ML, Roberts LA, Gebremariam A, Annich GM, Davis MM. Development and Validation of the Neonatal Risk Estimate Score for Children Using Extracorporeal Respiratory Support. J Pediatr. 2016 Jun; 173:56-61.e3. PMID: 27004674.
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    12. Yu J, Brisbois E, Handa H, Annich G, Meyerhoff M, Bartlett R, Major T. The immobilization of a direct thrombin inhibitor to a polyurethane as a nonthrombogenic surface coating for extracorporeal circulation. J Mater Chem B. 2016 Apr 07; 4(13):2264-2272. PMID: 27458521.
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    13. Werho DK, Pasquali SK, Yu S, Donohue J, Annich GM, Thiagarajan RR, Hirsch-Romano JC, Gaies M. Epidemiology of Stroke in Pediatric Cardiac Surgical Patients Supported With Extracorporeal Membrane Oxygenation. Ann Thorac Surg. 2015 Nov; 100(5):1751-7. PMID: 26298170.
      View in: PubMed
    14. Annich GM. Extracorporeal life support: the precarious balance of hemostasis. J Thromb Haemost. 2015 Jun; 13 Suppl 1:S336-42. PMID: 26149045.
      View in: PubMed
    15. Kawai Y, Cornell TT, Cooley EG, Beckman CN, Baldridge PK, Mottes TA, Luckritz KE, Plomaritas KS, Meade JM, Odetola FO, Han YY, Blatt NB, Annich GM. Therapeutic plasma exchange may improve hemodynamics and organ failure among children with sepsis-induced multiple organ dysfunction syndrome receiving extracorporeal life support. Pediatr Crit Care Med. 2015 May; 16(4):366-74. PMID: 25599148.
      View in: PubMed
    16. Barbaro RP, Odetola FO, Kidwell KM, Paden ML, Bartlett RH, Davis MM, Annich GM. Association of hospital-level volume of extracorporeal membrane oxygenation cases and mortality. Analysis of the extracorporeal life support organization registry. Am J Respir Crit Care Med. 2015 Apr 15; 191(8):894-901. PMID: 25695688.
      View in: PubMed
    17. Werho DK, Pasquali SK, Yu S, Donohue J, Annich GM, Thiagarajan RR, Hirsch-Romano JC, Gaies MG. Hemorrhagic complications in pediatric cardiac patients on extracorporeal membrane oxygenation: an analysis of the Extracorporeal Life Support Organization Registry. Pediatr Crit Care Med. 2015 Mar; 16(3):276-88. PMID: 25651048.
      View in: PubMed
    18. Gray BW, Haft JW, Hirsch JC, Annich GM, Hirschl RB, Bartlett RH. Extracorporeal life support: experience with 2,000 patients. ASAIO J. 2015 Jan-Feb; 61(1):2-7. PMID: 25251585.
      View in: PubMed
    19. Gaffney AM, Santos-Martinez MJ, Satti A, Major TC, Wynne KJ, Gun'ko YK, Annich GM, Elia G, Radomski MW. Blood biocompatibility of surface-bound multi-walled carbon nanotubes. Nanomedicine. 2015 Jan; 11(1):39-46. PMID: 25072378.
      View in: PubMed
    20. Major TC, Handa H, Annich GM, Bartlett RH. Development and hemocompatibility testing of nitric oxide releasing polymers using a rabbit model of thrombogenicity. J Biomater Appl. 2014 Oct; 29(4):479-501. PMID: 24934500.
      View in: PubMed
    21. Major TC, Brisbois EJ, Jones AM, Zanetti ME, Annich GM, Bartlett RH, Handa H. The effect of a polyurethane coating incorporating both a thrombin inhibitor and nitric oxide on hemocompatibility in extracorporeal circulation. Biomaterials. 2014 Aug; 35(26):7271-85. PMID: 24927680.
      View in: PubMed
    22. Long MT, Wagner D, Maslach-Hubbard A, Pasko DA, Baldridge P, Annich GM. Safety and efficacy of recombinant activated factor VII for refractory hemorrhage in pediatric patients on extracorporeal membrane oxygenation: a single center review. Perfusion. 2014 Mar; 29(2):163-70. PMID: 23942787.
      View in: PubMed
    23. Handa H, Brisbois EJ, Major TC, Refahiyat L, Amoako KA, Annich GM, Bartlett RH, Meyerhoff ME. In vitro and in vivo study of sustained nitric oxide release coating using diazeniumdiolate-oped poly(vinyl chloride) matrix with poly(lactide-co-glycolide) additive. J Mater Chem B. 2013 Aug 07; 1(29):3578-3587. PMID: 23914297.
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    24. Major TC, Handa H, Brisbois EJ, Reynolds MM, Annich GM, Meyerhoff ME, Bartlett RH. The mediation of platelet quiescence by NO-releasing polymers via cGMP-induced serine 239 phosphorylation of vasodilator-stimulated phosphoprotein. Biomaterials. 2013 Nov; 34(33):8086-96. PMID: 23906514.
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    25. Bryner B, Miskulin J, Smith C, Cooley E, Grams R, Bartlett R, Annich G, Mychaliska GB. Extracorporeal life support for acute respiratory distress syndrome due to severe Legionella pneumonia. Perfusion. 2014 Jan; 29(1):39-43. PMID: 23863490.
      View in: PubMed
    26. MacLaren G, Dodge-Khatami A, Dalton HJ, MacLaren G, Dodge-Khatami A, Dalton HJ, Adachi I, Almodovar M, Annich G, Bartlett R, Bronicki R, Brown K, Butt W, Cooper D, Demuth M, D'Udekem Y, Fraser C, Guerguerian AM, Heard M, Horton S, Ichord R, Jaquiss R, Laussen P, Lequier L, Lou S, Marino B, McMullan M, Ogino M, Peek G, Pretre R, Rodefeld M, Schmidt A, Schwartz S, Shekerdemian L, Shime N, Sivarajan B, Stiller B, Thiagarajan R. Joint statement on mechanical circulatory support in children: a consensus review from the Pediatric Cardiac Intensive Care Society and Extracorporeal Life Support Organization. Pediatr Crit Care Med. 2013 Jun; 14(5 Suppl 1):S1-2. PMID: 23735979.
      View in: PubMed
    27. Annich G, Adachi I. Anticoagulation for pediatric mechanical circulatory support. Pediatr Crit Care Med. 2013 Jun; 14(5 Suppl 1):S37-42. PMID: 23735984.
      View in: PubMed
    28. Kuo KW, Cornell TT, Shanley TP, Odetola FO, Annich GM. The use of extracorporeal membrane oxygenation in pediatric patients with sickle cell disease. Perfusion. 2013 Sep; 28(5):424-32. PMID: 23630196.
      View in: PubMed
    29. Bembea MM, Annich G, Rycus P, Oldenburg G, Berkowitz I, Pronovost P. Variability in anticoagulation management of patients on extracorporeal membrane oxygenation: an international survey. Pediatr Crit Care Med. 2013 Feb; 14(2):e77-84. PMID: 23287906.
      View in: PubMed
    30. Gillogly A, Kilbourn C, Waldvogel J, Martin J, Annich G, Wagner D. In vitro clearance of intravenous acetaminophen in extracorporeal membrane oxygenation. Perfusion. 2013 Mar; 28(2):141-5. PMID: 23201817.
      View in: PubMed
    31. Selewski DT, Cornell TT, Blatt NB, Han YY, Mottes T, Kommareddi M, Gaies MG, Annich GM, Kershaw DB, Shanley TP, Heung M. Fluid overload and fluid removal in pediatric patients on extracorporeal membrane oxygenation requiring continuous renal replacement therapy. Crit Care Med. 2012 Sep; 40(9):2694-9. PMID: 22743776.
      View in: PubMed
    32. Wagner D, Pasko D, Phillips K, Waldvogel J, Annich G. In vitro clearance of dexmedetomidine in extracorporeal membrane oxygenation. Perfusion. 2013 Jan; 28(1):40-6. PMID: 22891035.
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    33. Amoako KA, Archangeli C, Handa H, Major T, Meyerhoff ME, Annich GM, Bartlett RH. Thromboresistance characterization of extruded nitric oxide-releasing silicone catheters. ASAIO J. 2012 May-Jun; 58(3):238-46. PMID: 22395119.
      View in: PubMed
    34. Custer JR, Annich GM. A little patience for our patients with lung disease: ECMO... eventually. Pediatr Crit Care Med. 2012 Jan; 13(1):94-6. PMID: 22222644.
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    35. Lingadevaru H, Romano MA, Fauman K, Cooley E, Annich GM, Cornell TT. Challenges during repeat extracorporeal life support in a patient with pulmonary alveolar proteinosis. ASAIO J. 2011 Sep-Oct; 57(5):473-4. PMID: 21873931.
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    36. Major TC, Brant DO, Burney CP, Amoako KA, Annich GM, Meyerhoff ME, Handa H, Bartlett RH. The hemocompatibility of a nitric oxide generating polymer that catalyzes S-nitrosothiol decomposition in an extracorporeal circulation model. Biomaterials. 2011 Sep; 32(26):5957-69. PMID: 21696821.
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    37. Hervey-Jumper SL, Annich GM, Yancon AR, Garton HJ, Muraszko KM, Maher CO. Neurological complications of extracorporeal membrane oxygenation in children. J Neurosurg Pediatr. 2011 Apr; 7(4):338-44. PMID: 21456903.
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    38. Raimer PL, Han YY, Weber MS, Annich GM, Custer JR. A normal capillary refill time of = 2 seconds is associated with superior vena cava oxygen saturations of = 70%. J Pediatr. 2011 Jun; 158(6):968-72. PMID: 21238980.
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    39. Reynolds MM, Annich GM. The artificial endothelium. Organogenesis. 2011 Jan-Mar; 7(1):42-9. PMID: 21289481.
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    40. Andreatta P, Saxton E, Thompson M, Annich G. Simulation-based mock codes significantly correlate with improved pediatric patient cardiopulmonary arrest survival rates. Pediatr Crit Care Med. 2011 Jan; 12(1):33-8. PMID: 20581734.
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    41. Gaffney AM, Wildhirt SM, Griffin MJ, Annich GM, Radomski MW. Extracorporeal life support. BMJ. 2010 Nov 02; 341:c5317. PMID: 21045023.
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    42. Major TC, Brant DO, Reynolds MM, Bartlett RH, Meyerhoff ME, Handa H, Annich GM. The attenuation of platelet and monocyte activation in a rabbit model of extracorporeal circulation by a nitric oxide releasing polymer. Biomaterials. 2010 Apr; 31(10):2736-45. PMID: 20042236.
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    43. Nardell K, Annich GM, Hirsch JC, Fahrner C, Brownlee P, King K, Fleming GM, Gajarski RJ. Risk factors for bleeding in pediatric post-cardiotomy patients requiring ECLS. Perfusion. 2009 May; 24(3):191-7. PMID: 19767331.
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    44. Pohlmann JR, Toomasian JM, Hampton CE, Cook KE, Annich GM, Bartlett RH. The relationships between air exposure, negative pressure, and hemolysis. ASAIO J. 2009 Sep-Oct; 55(5):469-73. PMID: 19730004.
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    45. Fleming GM, Gurney JG, Donohue JE, Remenapp RT, Annich GM. Mechanical component failures in 28,171 neonatal and pediatric extracorporeal membrane oxygenation courses from 1987 to 2006. Pediatr Crit Care Med. 2009 Jul; 10(4):439-44. PMID: 19307816.
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    46. Fleming GM, Cornell TT, Welling TH, Magee JC, Annich GM. Hepatopulmonary syndrome: use of extracorporeal life support for life-threatening hypoxia following liver transplantation. Liver Transpl. 2008 Jul; 14(7):966-70. PMID: 18581508.
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    47. Fleming GM, Gupta M, Cooley E, Remenapp R, Bartlett RH, Annich GM. Maintaining the standard: a quality assurance study for new equipment in the Michigan ECMO Program. ASAIO J. 2007 Sep-Oct; 53(5):556-60. PMID: 17885327.
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    48. Cornell T, Wyrick P, Fleming G, Pasko D, Han Y, Custer J, Haft J, Annich G. A case series describing the use of argatroban in patients on extracorporeal circulation. ASAIO J. 2007 Jul-Aug; 53(4):460-3. PMID: 17667231.
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    49. Skrzypchak AM, Lafayette NG, Bartlett RH, Zhou Z, Frost MC, Meyerhoff ME, Reynolds MM, Annich GM. Effect of varying nitric oxide release to prevent platelet consumption and preserve platelet function in an in vivo model of extracorporeal circulation. Perfusion. 2007 May; 22(3):193-200. PMID: 18018399.
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    50. LaFayette NG, Skrzypchak AM, Merz S, Bartlett RH, Annich GM. An in vitro method for assessing biomaterial-associated platelet activation. ASAIO J. 2007 Mar-Apr; 53(2):159-62. PMID: 17413554.
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    51. Zhou Z, Annich GM, Wu Y, Meyerhoff ME. Water-soluble poly(ethylenimine)-based nitric oxide donors: preparation, characterization, and potential application in hemodialysis. Biomacromolecules. 2006 Sep; 7(9):2565-74. PMID: 16961319.
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    52. Skrzypchak AM, Miskulin J, Bartlett RH, Annich GM. Developing a small animal model of extracorporeal circulation. ASAIO J. 2006 May-Jun; 52(3):296-302. PMID: 16760719.
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    53. Fleming GM, Remenapp RT, Bartlett RH, Annich GM. Hyperkalemia of the blood-primed ECLS circuit does not result in post-initiation hyperkalemia in infants < 10 kg. Perfusion. 2006 May; 21(3):173-7. PMID: 16817290.
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    54. Bhatt-Meht V, Annich G. Sedative clearance during extracorporeal membrane oxygenation. Perfusion. 2005 Oct; 20(6):309-15. PMID: 16363315.
      View in: PubMed
    55. Chepeha DB, Annich G, Pynnonen MA, Beck J, Wolf GT, Teknos TN, Bradford CR, Carroll WR, Esclamado RM. Pectoralis major myocutaneous flap vs revascularized free tissue transfer: complications, gastrostomy tube dependence, and hospitalization. Arch Otolaryngol Head Neck Surg. 2004 Feb; 130(2):181-6. PMID: 14967747.
      View in: PubMed
    56. Meinhardt JP, Annich GM, Miskulin J, Kawai T, Ashton BA, Bartlett RH. Thrombogenicity is not reduced when heparin and phospholipid bonded circuits are used in a rabbit model of extracorporeal circulation. ASAIO J. 2003 Jul-Aug; 49(4):395-400. PMID: 12918580.
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    57. Meinhardt JP, Ashton BA, Annich GM, Quintel M, Hirschl RB. The dependency of expiratory airway collapse on pump system and flow rate in liquid ventilated rabbits. Eur J Med Res. 2003 May 30; 8(5):212-20. PMID: 12844476.
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    58. Haefner SM, Bratton SL, Annich GM, Bartlett RH, Custer JR. Complications of intermittent prone positioning in pediatric patients receiving extracorporeal membrane oxygenation for respiratory failure. Chest. 2003 May; 123(5):1589-94. PMID: 12740278.
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    59. Zhang H, Annich GM, Miskulin J, Stankiewicz K, Osterholzer K, Merz SI, Bartlett RH, Meyerhoff ME. Nitric oxide-releasing fumed silica particles: synthesis, characterization, and biomedical application. J Am Chem Soc. 2003 Apr 30; 125(17):5015-24. PMID: 12708851.
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    60. Bratton SL, Annich GM. Packed red blood cell transfusions for critically ill pediatric patients: when and for what conditions? J Pediatr. 2003 Feb; 142(2):95-7. PMID: 12584524.
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    61. Meyer RJ, Moler FW, Maxvold NJ, Annich GM, Odetola FO, Sadowski R, Custer JR. Pediatric extracorporeal life support after high frequency ventilation: predictors of survival. ASAIO J. 2002 Sep-Oct; 48(5):472-5. PMID: 12296564.
      View in: PubMed
    62. Kolovos NS, Schuerer DJ, Moler FW, Bratton SL, Swaniker F, Bartlett RH, Custer JR, Annich G. Extracorporal life support for pulmonary hemorrhage in children: a case series. Crit Care Med. 2002 Mar; 30(3):577-80. PMID: 11990918.
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    63. Zhang H, Annich GM, Miskulin J, Osterholzer K, Merz SI, Bartlett RH, Meyerhoff ME. Nitric oxide releasing silicone rubbers with improved blood compatibility: preparation, characterization, and in vivo evaluation. Biomaterials. 2002 Mar; 23(6):1485-94. PMID: 11829445.
      View in: PubMed
    64. Meyer RJ, Brophy PD, Bunchman TE, Annich GM, Maxvold NJ, Mottes TA, Custer JR. Survival and renal function in pediatric patients following extracorporeal life support with hemofiltration. Pediatr Crit Care Med. 2001 Jul; 2(3):238-242. PMID: 12793948.
      View in: PubMed
    65. Annich GM, Meinhardt JP, Mowery KA, Ashton BA, Merz SI, Hirschl RB, Meyerhoff ME, Bartlett RH. Reduced platelet activation and thrombosis in extracorporeal circuits coated with nitric oxide release polymers. Crit Care Med. 2000 Apr; 28(4):915-20. PMID: 10809259.
      View in: PubMed
    66. Zahraa JN, Moler FW, Annich GM, Maxvold NJ, Bartlett RH, Custer JR. Venovenous versus venoarterial extracorporeal life support for pediatric respiratory failure: are there differences in survival and acute complications? Crit Care Med. 2000 Feb; 28(2):521-5. PMID: 10708194.
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    67. Annich G, White T, Damm D, Zhao Y, Mahdi F, Meinhardt J, Rebello S, Lucchesi B, Bartlett RH, Schmaier AH. Recombinant Kunitz protease inhibitory domain of the amyloid beta-protein precursor as an anticoagulant in venovenous extracorporeal circulation in rabbits. Thromb Haemost. 1999 Nov; 82(5):1474-81. PMID: 10595641.
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    68. Kawai T, Annich GM, Meinhardt JP, Ichiba S, Brant DO, Bartlett RH. Effect of blood flow rate on thrombogenesis in a rabbit extracorporeal circulation model. ASAIO J. 1999 Sep-Oct; 45(5):478-81. PMID: 10503629.
      View in: PubMed
    69. Rich PB, Awad SS, Kolla S, Annich G, Schreiner RJ, Hirschl RB, Bartlett RH. An approach to the treatment of severe adult respiratory failure. J Crit Care. 1998 Mar; 13(1):26-36. PMID: 9556124.
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    70. Skippen P, Seear M, Poskitt K, Kestle J, Cochrane D, Annich G, Handel J. Effect of hyperventilation on regional cerebral blood flow in head-injured children. Crit Care Med. 1997 Aug; 25(8):1402-9. PMID: 9267957.
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    71. Fenton AC, Annich G, Mason E, Solimano A, Field DJ. Chronic lung disease following neonatal ventilation. I. incidence in two geographically defined populations. Pediatr Pulmonol. 1996 Jan; 21(1):20-3. PMID: 8776261.
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    72. Fenton AC, Field DJ, Solimano A, Annich G. The CRIB score. Lancet. 1993 Sep 04; 342(8871):612; author reply 613. PMID: 8102735.
      View in: PubMed
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