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Last name

Hoon-Ki Sung

InstitutionThe Hospital for Sick Children
DepartmentTranslational Medicine
Address555 University Avenue
Toronto ON M5G 1X8
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    Collapse Biography 
    Collapse education and training
    University of Yeungnam, South KoreaDoctorate, PhD02/2004Clinical Anatomy & Functional Histology
    University of Yeungnam, South KoreaBachelor, MD02/1999Clinical Anatomy & Functional Histology
    University of Yeungnam, South KoreaDoctorate, MD02/1997Medicine

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Liang Q, Monetti C, Shutova MV, Neely EJ, Hacibekiroglu S, Yang H, Kim C, Zhang P, Li C, Nagy K, Mileikovsky M, Gyongy I, Sung HK, Nagy A. Linking a cell-division gene and a suicide gene to define and improve cell therapy safety. Nature. 2018 Nov; 563(7733):701-704. PMID: 30429614.
      View in: PubMed
    2. Das E, Moon JH, Lee JH, Thakkar N, Pausova Z, Sung HK. Adipose Tissue and Modulation of Hypertension. Curr Hypertens Rep. 2018 Sep 18; 20(11):96. PMID: 30229358.
      View in: PubMed
    3. Bae YU, Son Y, Kim CH, Kim KS, Hyun SH, Woo HG, Jee BA, Choi JH, Sung HK, Choi HC, Park SY, Bae JH, Doh KO, Kim JR. Embryonic stem cell-derived mmu-miR-291a-3p inhibits cellular senescence in human dermal fibroblasts through the TGF-?-receptor 2 pathway. J Gerontol A Biol Sci Med Sci. 2018 Sep 15. PMID: 30239625.
      View in: PubMed
    4. Lee JH, Yeganeh A, Konoeda H, Moon JH, Sung HK. Flow Cytometry and Lineage Tracing Study for Identification of Adipocyte Precursor Cell (APC) Populations. Methods Mol Biol. 2018; 1752:111-121. PMID: 29564767.
      View in: PubMed
    5. Guo L, Karoubi G, Duchesneau P, Shutova MV, Sung HK, Tonge P, Bear C, Rogers I, Nagy A, Waddell TK. Generation of Induced Progenitor-like Cells from Mature Epithelial Cells Using Interrupted Reprogramming. Stem Cell Reports. 2017 12 12; 9(6):1780-1795. PMID: 29198829.
      View in: PubMed
    6. Kim KH, Kim YH, Son JE, Lee JH, Kim S, Choe MS, Moon JH, Zhong J, Fu K, Lenglin F, Yoo JA, Bilan PJ, Klip A, Nagy A, Kim JR, Park JG, Hussein SM, Doh KO, Hui CC, Sung HK. Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage. Cell Res. 2017 Nov; 27(11):1309-1326. PMID: 29039412.
      View in: PubMed
    7. Bae YU, Sung HK, Kim JR. Collection of Serum- and Feeder-free Mouse Embryonic Stem Cell-conditioned Medium for a Cell-free Approach. J Vis Exp. 2017 01 08; (119). PMID: 28117789.
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    8. Bae YU, Choi JH, Nagy A, Sung HK, Kim JR. Antisenescence effect of mouse embryonic stem cell conditioned medium through a PDGF/FGF pathway. FASEB J. 2016 Mar; 30(3):1276-86. PMID: 26675707.
      View in: PubMed
    9. Lepage SI, Nagy K, Sung HK, Kandel RA, Nagy A, Koch TG. Generation, Characterization, and Multilineage Potency of Mesenchymal-Like Progenitors Derived from Equine Induced Pluripotent Stem Cells. Stem Cells Dev. 2016 Jan 01; 25(1):80-9. PMID: 26414480.
      View in: PubMed
    10. Ben-Meir A, Burstein E, Borrego-Alvarez A, Chong J, Wong E, Yavorska T, Naranian T, Chi M, Wang Y, Bentov Y, Alexis J, Meriano J, Sung HK, Gasser DL, Moley KH, Hekimi S, Casper RF, Jurisicova A. Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging. Aging Cell. 2015 Oct; 14(5):887-95. PMID: 26111777; PMCID: PMC4568976.
    11. Thomson BR, Heinen S, Jeansson M, Ghosh AK, Fatima A, Sung HK, Onay T, Chen H, Yamaguchi S, Economides AN, Flenniken A, Gale NW, Hong YK, Fawzi A, Liu X, Kume T, Quaggin SE. A lymphatic defect causes ocular hypertension and glaucoma in mice. J Clin Invest. 2014 Oct; 124(10):4320-4. PMID: 25202984; PMCID: PMC4191022.
    12. Li H, Qu D, McDonald A, Isaac SM, Whiteley KJ, Sung HK, Nagy A, Adamson SL. Trophoblast-specific reduction of VEGFA alters placental gene expression and maternal cardiovascular function in mice. Biol Reprod. 2014 Oct; 91(4):87. PMID: 25122061.
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    13. Martinez-Fernandez A, Nelson TJ, Reyes S, Alekseev AE, Secreto F, Perez-Terzic C, Beraldi R, Sung HK, Nagy A, Terzic A. iPS cell-derived cardiogenicity is hindered by sustained integration of reprogramming transgenes. Circ Cardiovasc Genet. 2014 Oct; 7(5):667-76. PMID: 25077947; PMCID: PMC4273857.
    14. Michael IP, Westenskow PD, Hacibekiroglu S, Greenwald AC, Ballios BG, Kurihara T, Li Z, Warren CM, Zhang P, Aguilar E, Donaldson L, Marchetti V, Baba T, Hussein SM, Sung HK, Iruela-Arispe ML, Rini JM, van der Kooy D, Friedlander M, Nagy A. Local acting Sticky-trap inhibits vascular endothelial growth factor dependent pathological angiogenesis in the eye. EMBO Mol Med. 2014 May; 6(5):604-23. PMID: 24705878; PMCID: PMC4023884.
    15. Smemo S, Tena JJ, Kim KH, Gamazon ER, Sakabe NJ, Gómez-Marín C, Aneas I, Credidio FL, Sobreira DR, Wasserman NF, Lee JH, Puviindran V, Tam D, Shen M, Son JE, Vakili NA, Sung HK, Naranjo S, Acemel RD, Manzanares M, Nagy A, Cox NJ, Hui CC, Gomez-Skarmeta JL, Nóbrega MA. Obesity-associated variants within FTO form long-range functional connections with IRX3. Nature. 2014 Mar 20; 507(7492):371-5. PMID: 24646999; PMCID: PMC4113484.
    16. Kim M, Park HJ, Seol JW, Jang JY, Cho YS, Kim KR, Choi Y, Lydon JP, Demayo FJ, Shibuya M, Ferrara N, Sung HK, Nagy A, Alitalo K, Koh GY. VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy. EMBO Mol Med. 2013 Sep; 5(9):1415-30. PMID: 23853117; PMCID: PMC3799495.
    17. Han H, Irimia M, Ross PJ, Sung HK, Alipanahi B, David L, Golipour A, Gabut M, Michael IP, Nachman EN, Wang E, Trcka D, Thompson T, O'Hanlon D, Slobodeniuc V, Barbosa-Morais NL, Burge CB, Moffat J, Frey BJ, Nagy A, Ellis J, Wrana JL, Blencowe BJ. MBNL proteins repress ES-cell-specific alternative splicing and reprogramming. Nature. 2013 Jun 13; 498(7453):241-5. PMID: 23739326; PMCID: PMC3933998.
    18. Sung HK, Doh KO, Son JE, Park JG, Bae Y, Choi S, Nelson SM, Cowling R, Nagy K, Michael IP, Koh GY, Adamson SL, Pawson T, Nagy A. Adipose vascular endothelial growth factor regulates metabolic homeostasis through angiogenesis. Cell Metab. 2013 Jan 08; 17(1):61-72. PMID: 23312284.
      View in: PubMed
    19. Michael IP, Monetti C, Chiu AC, Zhang P, Baba T, Nishino K, Agha-Mohammadi S, Woltjen K, Sung HK, Nagy A. Highly efficient site-specific transgenesis in cancer cell lines. Mol Cancer. 2012 Dec 11; 11:89. PMID: 23231822; PMCID: PMC3537676.
    20. Jin J, Sison K, Li C, Tian R, Wnuk M, Sung HK, Jeansson M, Zhang C, Tucholska M, Jones N, Kerjaschki D, Shibuya M, Fantus IG, Nagy A, Gerber HP, Ferrara N, Pawson T, Quaggin SE. Soluble FLT1 binds lipid microdomains in podocytes to control cell morphology and glomerular barrier function. Cell. 2012 Oct 12; 151(2):384-99. PMID: 23063127.
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    21. Gabut M, Samavarchi-Tehrani P, Wang X, Slobodeniuc V, O'Hanlon D, Sung HK, Alvarez M, Talukder S, Pan Q, Mazzoni EO, Nedelec S, Wichterle H, Woltjen K, Hughes TR, Zandstra PW, Nagy A, Wrana JL, Blencowe BJ. An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell. 2011 Sep 30; 147(1):132-46. PMID: 21924763.
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    22. Nagy K, Sung HK, Zhang P, Laflamme S, Vincent P, Agha-Mohammadi S, Woltjen K, Monetti C, Michael IP, Smith LC, Nagy A. Induced pluripotent stem cell lines derived from equine fibroblasts. Stem Cell Rev. 2011 Sep; 7(3):693-702. PMID: 21347602; PMCID: PMC3137777.
    23. Mohseni P, Sung HK, Murphy AJ, Laliberte CL, Pallari HM, Henkelman M, Georgiou J, Xie G, Quaggin SE, Thorner PS, Eriksson JE, Nagy A. Nestin is not essential for development of the CNS but required for dispersion of acetylcholine receptor clusters at the area of neuromuscular junctions. J Neurosci. 2011 Aug 10; 31(32):11547-52. PMID: 21832185.
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    24. Koh YJ, Kim HZ, Hwang SI, Lee JE, Oh N, Jung K, Kim M, Kim KE, Kim H, Lim NK, Jeon CJ, Lee GM, Jeon BH, Nam DH, Sung HK, Nagy A, Yoo OJ, Koh GY. Double antiangiogenic protein, DAAP, targeting VEGF-A and angiopoietins in tumor angiogenesis, metastasis, and vascular leakage. Cancer Cell. 2010 Aug 09; 18(2):171-84. PMID: 20708158.
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    25. Samavarchi-Tehrani P, Golipour A, David L, Sung HK, Beyer TA, Datti A, Woltjen K, Nagy A, Wrana JL. Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming. Cell Stem Cell. 2010 Jul 02; 7(1):64-77. PMID: 20621051.
      View in: PubMed
    26. Sung HK, Michael IP, Nagy A. Multifaceted role of vascular endothelial growth factor signaling in adult tissue physiology: an emerging concept with clinical implications. Curr Opin Hematol. 2010 May; 17(3):206-12. PMID: 20216210.
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    27. Sung HK, Sung HK, Kim YW, Choi SJ, Kim JY, Jeune KH, Won KC, Kim JK, Koh GY, Koh GY, Park SY. COMP-angiopoietin-1 enhances skeletal muscle blood flow and insulin sensitivity in mice. Am J Physiol Endocrinol Metab. 2009 Aug; 297(2):E402-9. PMID: 19491299; PMCID: PMC4056742.
    28. Woltjen K, Michael IP, Mohseni P, Desai R, Mileikovsky M, Hämäläinen R, Cowling R, Wang W, Liu P, Gertsenstein M, Kaji K, Sung HK, Nagy A. piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature. 2009 Apr 09; 458(7239):766-70. PMID: 19252478.
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    29. Kim KE, Sung HK, Koh GY. Lymphatic development in mouse small intestine. Dev Dyn. 2007 Jul; 236(7):2020-5. PMID: 17576138.
      View in: PubMed
    30. Cho CH, Koh YJ, Han J, Sung HK, Jong Lee H, Morisada T, Schwendener RA, Brekken RA, Kang G, Oike Y, Choi TS, Suda T, Yoo OJ, Koh GY. Angiogenic role of LYVE-1-positive macrophages in adipose tissue. Circ Res. 2007 Mar 02; 100(4):e47-57. PMID: 17272806.
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    31. Sung HK, Morisada T, Cho CH, Oike Y, Lee J, Sung EK, Chung JH, Suda T, Koh GY. Intestinal and peri-tumoral lymphatic endothelial cells are resistant to radiation-induced apoptosis. Biochem Biophys Res Commun. 2006 Jun 30; 345(2):545-51. PMID: 16690025.
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    32. Cho CH, Sung HK, Kim KT, Cheon HG, Oh GT, Hong HJ, Yoo OJ, Koh GY. COMP-angiopoietin-1 promotes wound healing through enhanced angiogenesis, lymphangiogenesis, and blood flow in a diabetic mouse model. Proc Natl Acad Sci U S A. 2006 Mar 28; 103(13):4946-51. PMID: 16543381; PMCID: PMC1458775.
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