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Thomas Eiwegger

TitleStaff Physician
InstitutionThe Hospital for Sick Children
DepartmentImmunology & Allergy
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Bluemchen K, Eiwegger T. Oral peanut immunotherapy How much is too much? How much is enough? Allergy. 2019 Feb; 74(2):220-222. PMID: 30347127.
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    2. Hung L, Obernolte H, Sewald K, Eiwegger T. Human ex vivo and in vitro disease models to study food allergy. Asia Pac Allergy. 2019 Jan; 9(1):e4. PMID: 30740352.
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    3. Lunjani N, Satitsuksanoa P, Lukasik Z, Sokolowska M, Eiwegger T, O'Mahony L. Recent developments and highlights in mechanisms of allergic diseases: Microbiome. Allergy. 2018 Dec; 73(12):2314-2327. PMID: 30325537.
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    4. Bublin M, Kostadinova M, Radauer C, Varga EM, Hafner C, Schmidthaler K, Saidova A, Maleki SJ, Szépfalusi Z, Eiwegger T, Breiteneder H. Engineering of structural variants of the major peanut allergens Ara h 2 and Ara h 6 for allergen-specific immunotherapy. J Allergy Clin Immunol. 2019 Mar; 143(3):1226-1229.e10. PMID: 30414861.
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    5. Ponce M, Schroeder F, Bannert C, Schmidthaler K, Hansen CS, Lindholm Bøgh K, Soldo R, Tsui SK, Weinhäusel A, Szépfalusi Z, Eiwegger T. Preventive sublingual immunotherapy with House Dust Mite extract modulates epitope diversity in pre-school children. Allergy. 2018 Nov 05. PMID: 30394551.
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    6. Jaeger-Lansky A, Schmidthaler K, Kuessel L, Gstöttner M, Waidhofer-Söllner P, Zlabinger GJ, Wenzl R, Eiwegger T. Local and systemic levels of cytokines and danger signals in endometriosis-affected women. J Reprod Immunol. 2018 Nov; 130:7-10. PMID: 30099220.
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    7. Waltl EE, Selb R, Eckl-Dorna J, Mueller CA, Cabauatan CR, Eiwegger T, Resch-Marat Y, Niespodziana K, Vrtala S, Valenta R, Niederberger V. Betamethasone prevents human rhinovirus- and cigarette smoke- induced loss of respiratory epithelial barrier function. Sci Rep. 2018 Jun 26; 8(1):9688. PMID: 29946071.
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    8. Saidova A, Hershkop AM, Ponce M, Eiwegger T. Allergen-Specific T Cells in IgE-Mediated Food Allergy. Arch Immunol Ther Exp (Warsz). 2018 Jun; 66(3):161-170. PMID: 29256092.
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    9. Goña-Höpler M, Pfaller B, Argeny J, Kanolzer S, Gruber S, Schmidthaler K, Renner S, Nachbaur E, Fucik P, Glaser AG, Debiasi M, Szépfalusi Z, Crameri R, Rhyner C, Eiwegger T. Aspergillus fumigatus-specific immunoglobulin levels in BALF of CF patients. ERJ Open Res. 2017 Oct; 3(4). PMID: 29164145.
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    10. Diesner SC, Lukas J, Stifter E, Raimann A, Nachbaur E, Eiwegger T, Renner S, Emminger W, Geleff S, Szepfalusi Z. Bilateral Infiltrative Dacryoadenitis and Granulomatous Pneumonia in an 11-Year-Old Boy: A Case Report. Klin Padiatr. 2017 03; 229(2):96-99. PMID: 28444655.
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    11. Diesner SC, Bergmayr C, Pfitzner B, Assmann V, Krishnamurthy D, Starkl P, Endesfelder D, Rothballer M, Welzl G, Rattei T, Eiwegger T, Szépfalusi Z, Fehrenbach H, Jensen-Jarolim E, Hartmann A, Pali-Schöll I, Untersmayr E. A distinct microbiota composition is associated with protection from food allergy in an oral mouse immunization model. Clin Immunol. 2016 Dec; 173:10-18. PMID: 27789346.
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    12. Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA. Interleukins (from IL-1 to IL-38), interferons, transforming growth factor ß, and TNF-a: Receptors, functions, and roles in diseases. J Allergy Clin Immunol. 2016 10; 138(4):984-1010. PMID: 27577879.
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    13. Hansen CS, Dufva M, Bøgh KL, Sullivan E, Patel J, Eiwegger T, Szépfalusi Z, Nielsen M, Christiansen A. Linear epitope mapping of peanut allergens demonstrates individualized and persistent antibody-binding patterns. J Allergy Clin Immunol. 2016 12; 138(6):1728-1730. PMID: 27523433.
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    14. Ponce M, Diesner SC, Szépfalusi Z, Eiwegger T. Markers of tolerance development to food allergens. Allergy. 2016 10; 71(10):1393-404. PMID: 27286276.
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    15. Angelina A, Sirvent S, Palladino C, Vereda A, Cuesta-Herranz J, Eiwegger T, Rodríguez R, Breiteneder H, Villalba M, Palomares O. The lipid interaction capacity of Sin a 2 and Ara h 1, major mustard and peanut allergens of the cupin superfamily, endorses allergenicity. Allergy. 2016 09; 71(9):1284-94. PMID: 26991432.
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    16. O'Mahony L, Akdis CA, Eiwegger T. Innate mechanisms can predict successful allergy immunotherapy. J Allergy Clin Immunol. 2016 Feb; 137(2):559-61. PMID: 26853131.
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    17. Upton J, Eiwegger T. How Low Should We Go. Int Arch Allergy Immunol. 2015; 168(3):147-9. PMID: 26788722.
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    18. Christiansen A, Kringelum JV, Hansen CS, Bøgh KL, Sullivan E, Patel J, Rigby NM, Eiwegger T, Szépfalusi Z, de Masi F, Nielsen M, Lund O, Dufva M. High-throughput sequencing enhanced phage display enables the identification of patient-specific epitope motifs in serum. Sci Rep. 2015 Aug 06; 5:12913. PMID: 26246327; PMCID: PMC4650709.
    19. Soyka MB, Holzmann D, Basinski TM, Wawrzyniak M, Bannert C, Bürgler S, Akkoc T, Treis A, Rückert B, Akdis M, Akdis CA, Eiwegger T. The Induction of IL-33 in the Sinus Epithelium and Its Influence on T-Helper Cell Responses. PLoS One. 2015; 10(5):e0123163. PMID: 25932636; PMCID: PMC4416791.
    20. Boyman O, Kaegi C, Akdis M, Bavbek S, Bossios A, Chatzipetrou A, Eiwegger T, Firinu D, Harr T, Knol E, Matucci A, Palomares O, Schmidt-Weber C, Simon HU, Steiner UC, Vultaggio A, Akdis CA, Spertini F. EAACI IG Biologicals task force paper on the use of biologic agents in allergic disorders. Allergy. 2015 Jul; 70(7):727-54. PMID: 25819018.
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    21. Ackerbauer D, Bublin M, Radauer C, Varga EM, Hafner C, Ebner C, Szépfalusi Z, Fröschl R, Hoffmann-Sommergruber K, Eiwegger T, Breiteneder H. Component-resolved IgE profiles in Austrian patients with a convincing history of peanut allergy. Int Arch Allergy Immunol. 2015; 166(1):13-24. PMID: 25765158.
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    22. Szépfalusi Z, Bannert C, Ronceray L, Mayer E, Hassler M, Wissmann E, Dehlink E, Gruber S, Graf A, Lupinek C, Valenta R, Eiwegger T, Urbanek R. Preventive sublingual immunotherapy in preschool children: first evidence for safety and pro-tolerogenic effects. Pediatr Allergy Immunol. 2014 Dec; 25(8):788-95. PMID: 25406682.
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    23. Zaleska A, Eiwegger T, Soyer O, van de Veen W, Rhyner C, Soyka MB, Bekpen C, Demiröz D, Treis A, Söllner S, Palomares O, Kwok WW, Rose H, Senti G, Kündig TM, Ozoren N, Jutel M, Akdis CA, Crameri R, Akdis M. Immune regulation by intralymphatic immunotherapy with modular allergen translocation MAT vaccine. Allergy. 2014 Sep; 69(9):1162-70. PMID: 24934402.
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    24. Diesner SC, Bannert C, Gruber S, Dehlink E, Eiwegger T, Szepfalusi Z. The mydriaticum cyclopentolate induces severe allergy in a 5-year-old child. Klin Padiatr. 2014 Jul; 226(4):252-3. PMID: 25010132.
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    25. Tiringer K, Treis A, Kanolzer S, Witt C, Ghanim B, Gruber S, Schmidthaler K, Renner S, Dehlink E, Nachbaur E, Frischer T, Klepetko W, Akdis CA, Szépfalusi Z, Eiwegger T. Differential expression of IL-33 and HMGB1 in the lungs of stable cystic fibrosis patients. Eur Respir J. 2014 Sep; 44(3):802-5. PMID: 24969657.
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    26. Bublin M, Eiwegger T, Breiteneder H. Do lipids influence the allergic sensitization process? J Allergy Clin Immunol. 2014 Sep; 134(3):521-9. PMID: 24880633; PMCID: PMC4151997.
    27. Martín-Fontecha M, Eiwegger T, Jartti T, Rueda-Zubiaurre A, Tiringer K, Stepanow J, Puhakka T, Rückert B, Ortega-Gutiérrez S, López-Rodríguez ML, Akdis M, Akdis CA, Palomares O. The expression of cannabinoid receptor 1 is significantly increased in atopic patients. J Allergy Clin Immunol. 2014 Mar; 133(3):926-9.e2. PMID: 24486070.
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    28. Bøgh KL, Nielsen H, Eiwegger T, Madsen CB, Mills EN, Rigby NM, Szépfalusi Z, Roggen EL. IgE versus IgG4 epitopes of the peanut allergen Ara h 1 in patients with severe allergy. Mol Immunol. 2014 Apr; 58(2):169-76. PMID: 24365751.
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    29. Prelog M, Schönlaub J, Jeller V, Almanzar G, Höfner K, Gruber S, Eiwegger T, Würzner R. Reduced varicella-zoster-virus (VZV)-specific lymphocytes and IgG antibody avidity in solid organ transplant recipients. Vaccine. 2013 May 07; 31(20):2420-6. PMID: 23583889.
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    30. Diesner SC, Gruber S, Dehlink E, Mühlebner A, Eiwegger T, Szepfalusi Z. Somnolence upon allergen provocation in a child with Hen's egg allergy. Klin Padiatr. 2013 Jul; 225(4):232-3. PMID: 23519753.
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    31. Tiringer K, Treis A, Fucik P, Gona M, Gruber S, Renner S, Dehlink E, Nachbaur E, Horak F, Jaksch P, Döring G, Crameri R, Jung A, Rochat MK, Hörmann M, Spittler A, Klepetko W, Akdis CA, Szépfalusi Z, Frischer T, Eiwegger T. A Th17- and Th2-skewed cytokine profile in cystic fibrosis lungs represents a potential risk factor for Pseudomonas aeruginosa infection. Am J Respir Crit Care Med. 2013 Mar 15; 187(6):621-9. PMID: 23306544.
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    32. Eiwegger T, Gruber S, Szépfalusi Z, Akdis CA. Novel developments in the mechanisms of immune tolerance to allergens. Hum Vaccin Immunother. 2012 Oct; 8(10):1485-91. PMID: 23095863; PMCID: PMC3660770.
    33. Soyka MB, Wawrzyniak P, Eiwegger T, Holzmann D, Treis A, Wanke K, Kast JI, Akdis CA. Defective epithelial barrier in chronic rhinosinusitis: the regulation of tight junctions by IFN-? and IL-4. J Allergy Clin Immunol. 2012 Nov; 130(5):1087-1096.e10. PMID: 22840853.
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    34. Bøgh KL, Nielsen H, Madsen CB, Mills EN, Rigby N, Eiwegger T, Szépfalusi Z, Roggen EL. IgE epitopes of intact and digested Ara h 1: a comparative study in humans and rats. Mol Immunol. 2012 Jul; 51(3-4):337-46. PMID: 22555070.
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    35. Soyka MB, Treis A, Eiwegger T, Menz G, Zhang S, Holzmann D, Akdis CA, Meyer N. Regulation and expression of IL-32 in chronic rhinosinusitis. Allergy. 2012 Jun; 67(6):790-8. PMID: 22486709.
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    36. Gruber S, Eiwegger T, Nachbaur E, Tiringer K, Aigner C, Jaksch P, Keplinger M, Klepetko W, Lang G, Taghavi S, Graf A, Eichler I, Frischer T, Szépfalusi Z. Lung transplantation in children and young adults: a 20-year single-centre experience. Eur Respir J. 2012 Aug; 40(2):462-9. PMID: 22362858.
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    37. Meyer N, Christoph J, Makrinioti H, Indermitte P, Rhyner C, Soyka M, Eiwegger T, Chalubinski M, Wanke K, Fujita H, Wawrzyniak P, Bürgler S, Zhang S, Akdis M, Menz G, Akdis C. Inhibition of angiogenesis by IL-32: possible role in asthma. J Allergy Clin Immunol. 2012 Apr; 129(4):964-73.e7. PMID: 22336080.
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    38. Mayer E, Bannert C, Gruber S, Klunker S, Spittler A, Akdis CA, Szépfalusi Z, Eiwegger T. Cord blood derived CD4+ CD25(high) T cells become functional regulatory T cells upon antigen encounter. PLoS One. 2012; 7(1):e29355. PMID: 22272233; PMCID: PMC3260151.
    39. Eiwegger T, Akdis CA. IL-33 links tissue cells, dendritic cells and Th2 cell development in a mouse model of asthma. Eur J Immunol. 2011 Jun; 41(6):1535-8. PMID: 21618506.
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    40. Gruber S, Tiringer K, Dehlink E, Eiwegger T, Mayer E, Konstantin H, Kikic Z, Graf A, Szépfalusi Z. Allergic sensitization in kidney-transplanted patients prevails under tacrolimus treatment. Clin Exp Allergy. 2011 Aug; 41(8):1125-32. PMID: 21545550.
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    41. Akdis M, Burgler S, Crameri R, Eiwegger T, Fujita H, Gomez E, Klunker S, Meyer N, O'Mahony L, Palomares O, Rhyner C, Ouaked N, Quaked N, Schaffartzik A, Van De Veen W, Zeller S, Zimmermann M, Akdis CA. Interleukins, from 1 to 37, and interferon-?: receptors, functions, and roles in diseases. J Allergy Clin Immunol. 2011 Mar; 127(3):701-21.e1-70. PMID: 21377040.
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    42. Zimmermann M, Koreck A, Meyer N, Basinski T, Meiler F, Simone B, Woehrl S, Moritz K, Eiwegger T, Schmid-Grendelmeier P, Kemeny L, Akdis CA. TNF-like weak inducer of apoptosis (TWEAK) and TNF-a cooperate in the induction of keratinocyte apoptosis. J Allergy Clin Immunol. 2011 Jan; 127(1):200-7, 207.e1-10. PMID: 21211655.
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    43. Szépfalusi Z, Gruber S, Eiwegger T, Dehlink E. Clinical practice: Allergen-specific immunotherapy in children: facts and FAQs. Eur J Pediatr. 2011 Feb; 170(2):137-48. PMID: 21153032.
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    44. Eiwegger T, Stahl B, Haidl P, Schmitt J, Boehm G, Dehlink E, Urbanek R, Szépfalusi Z. Prebiotic oligosaccharides: in vitro evidence for gastrointestinal epithelial transfer and immunomodulatory properties. Pediatr Allergy Immunol. 2010 Dec; 21(8):1179-88. PMID: 20444147.
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    45. Eiwegger T, Gruber S, Geiger C, Mayer E, Dehlink E, Bannert C, Frischer T, Kasper D, Jaksch P, Klepetko W, Akdis C, Szépfalusi Z. Impact of systemic immuno-suppression after solid organ transplantation on allergen-specific responses. Allergy. 2011 Feb; 66(2):271-8. PMID: 21208218.
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    46. Basinski TM, Holzmann D, Eiwegger T, Zimmermann M, Klunker S, Meyer N, Schmid-Grendelmeier P, Jutel M, Akdis CA. Dual nature of T cell-epithelium interaction in chronic rhinosinusitis. J Allergy Clin Immunol. 2009 Jul; 124(1):74-80.e1-8. PMID: 19523671.
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    47. Schulten V, Radakovics A, Hartz C, Mari A, Vazquez-Cortes S, Fernandez-Rivas M, Lauer I, Jahn-Schmid B, Eiwegger T, Scheurer S, Bohle B. Characterization of the allergic T-cell response to Pru p 3, the nonspecific lipid transfer protein in peach. J Allergy Clin Immunol. 2009 Jul; 124(1):100-7. PMID: 19356790.
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    48. Eiwegger T, Mayer E, Brix S, Schabussova I, Dehlink E, Bohle B, Barkholt V, Szépfalusi Z. Allergen specific responses in cord and adult blood are differentially modulated in the presence of endotoxins. Clin Exp Allergy. 2008 Oct; 38(10):1627-34. PMID: 18771487; PMCID: PMC2610394.
    49. Dehlink E, Domig KJ, Loibichler C, Kampl E, Eiwegger T, Georgopoulos A, Kneifel W, Urbanek R, Szépfalusi Z. Heat- and formalin-inactivated probiotic bacteria induce comparable cytokine patterns in intestinal epithelial cell-leucocyte cocultures. J Food Prot. 2007 Oct; 70(10):2417-21. PMID: 17969629.
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    50. Gruber S, Dehlink E, Eiwegger T, Gut S, Jaksch P, Klepetko W, Rumpold H, Szépfalusi Z. Immunoglobulin e-mediated allergies in lung-transplanted adults. Transplantation. 2007 Jul 27; 84(2):275-9. PMID: 17667823.
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    51. Eiwegger T, Dehlink E, Schwindt J, Pomberger G, Reider N, Frigo E, Rokitansky AM, Urbanek R, Szépfalusi Z. Early exposure to latex products mediates latex sensitization in spina bifida but not in other diseases with comparable latex exposure rates. Clin Exp Allergy. 2006 Oct; 36(10):1242-6. PMID: 17014431.
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    52. Eiwegger T, Rigby N, Mondoulet L, Bernard H, Krauth MT, Boehm A, Dehlink E, Valent P, Wal JM, Mills EN, Szépfalusi Z. Gastro-duodenal digestion products of the major peanut allergen Ara h 1 retain an allergenic potential. Clin Exp Allergy. 2006 Oct; 36(10):1281-8. PMID: 17014437.
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    53. Dehlink E, Gruber S, Eiwegger T, Gruber D, Mueller T, Huber WD, Klepetko W, Rumpold H, Urbanek R, Szépfalusi Z. Immunosuppressive therapy does not prevent the occurrence of immunoglobulin E-mediated allergies in children and adolescents with organ transplants. Pediatrics. 2006 Sep; 118(3):e764-70. PMID: 16950967.
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    54. Szépfalusi Z, Loibichler C, Hänel-Dekan S, Dehlink E, Gerstmayr M, Pichler J, Eiwegger T, Horvat R, Urbanek R. Most of diaplacentally transferred allergen is retained in the placenta. Clin Exp Allergy. 2006 Sep; 36(9):1130-7. PMID: 16961712.
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    55. Dehlink E, Eiwegger T, Gerstmayr M, Kampl E, Bohle B, Chen KW, Vrtala S, Urbanek R, Szépfalusi Z. Absence of systemic immunologic changes during dose build-up phase and early maintenance period in effective specific sublingual immunotherapy in children. Clin Exp Allergy. 2006 Jan; 36(1):32-9. PMID: 16393263.
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    56. Eiwegger T, Stahl B, Schmitt J, Boehm G, Gerstmayr M, Pichler J, Dehlink E, Loibichler C, Urbanek R, Szépfalusi Z. Human milk--derived oligosaccharides and plant-derived oligosaccharides stimulate cytokine production of cord blood T-cells in vitro. Pediatr Res. 2004 Oct; 56(4):536-40. PMID: 15295093.
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    57. Dehlink E, Prandstetter C, Eiwegger T, Putschögl B, Urbanek R, Szépfalusi Z. Increased prevalence of latex-sensitization among children with chronic renal failure. Allergy. 2004 Jul; 59(7):734-8. PMID: 15180760.
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