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Donna Wall

TitleStaff Physician
InstitutionThe Hospital for Sick Children
DepartmentHaematology/Oncology
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
ORCID ORCID Icon0000-0002-5442-5536 Additional info
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    Collapse Biography 
    Collapse education and training
    University of Manitoba, Winnipeg, ManitobaB.Sc.1981Medicine
    University of Manitoba, , Winnipeg, ManitobaM.D.1981Medicine
    Columbia Presbyterian Medical Centre, New York, New York1982Intern, Pediatrics
    New England Medical Centre, Boston, Massachusetts1984Resident, Pediatrics, Tufts
    The Children's Hospital, Boston, Massachusetts1987Fellowship, Medicine, Haematology/Oncology
    Dana-Farber Cancer Institute, Boston, Massachusetts1987Fellowship, Pediatric Oncology
    Harvard Medical School, Boston, Massachusetts1987Research Fellowship, Pediatrics
    Collapse awards and honors
    2017 - 2018Garron Family/Hats Off 2 Kidz Chair in Pediatric Leukemia Research, The Hospital for Sick Children
    2014 - 2016Bihlers' Professorship in Stem Cell Research, University of Manitoba
    2013Schilly Award, Canadian Blood Services
    2001Spirit of Health Award, American Cancer Society
    1999Wendell G. Scott Award for Contributions in Cancer Control, American Cancer Society
    1989 - 1990Young Investigator Award, American Society of Clinical Oncology
    1985 - 1989Research Fellow, Medical Research Council of Canada
    1985 - 1987Farley Fund Clinical Fellowship, Harvard Medical School
    1994Teaching Award, Tufts Medical School

    Collapse Overview 
    Collapse overview
    I joined SickKids/University of Toronto in the fall of 2016 as Section Head of the Blood and Marrow Transplant/Cellular Therapy program. After completing training in New York and Boston I went on to establish BMT and public cord blood bank programs in St. Louis and San Antonio, followed by leading Manitoba Blood and Marrow Transplant program. My research focuses on improving the outcomes of children undergoing transplant/cellular therapy through a better understanding the interaction between donor/host hematopoietic stem cells and immune cells and their new environment as tolerance is established and as a tool to treat leukemia, immune, and blood disorders.


    Collapse Research 
    Collapse research activities and funding
         (S. Banerji)
    rovincial Clinical Genomics Testing using Next Generation Sequencing (NGS)
    CCMB Infrastructure
    Role Description: Submitted on behalf of 3 major departments within CCMB – RIOH, Medical Oncology/Hematology, and Manitoba BMT program; in strategic partnership with Diagnostic Services Manitoba
    Role: Co-Applicant

         (Joerg Krueger)Mar 1, 2017 - Mar 1, 2018
    Canadian National Transplant Research Program
    Preparing for Combined Stem Cell and Solid Organ Transplants: Learning from Hematopoietic Mixed Chimeras
    Role: Co-Applicant

         (Sowmya Viswanathan)Jun 1, 2017
    Institute of Biomaterials & Biomedical Engineering, University of Toronto
    Investigating anti-angiogenic properties of culture engineered MSCs for anti-tumor therapeutic applications
    Role: Collaborator

         (Donna Wall)Apr 1, 2018 - Mar 1, 2020
    Medicine by Design New Ideas Fund
    Impact of pre-transplant inflammation on the host hematopoietic stem cell susceptibility to the transplant preparative regimen. Canada First Research Excellence Fund (CFREF).

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Ivison S, Malek M, Garcia RV, Broady R, Halpin A, Richaud M, Brant RF, Wang SI, Goupil M, Guan Q, Ashton P, Warren J, Rajab A, Urschel S, Kumar D, Streitz M, Sawitzki B, Schlickeiser S, Bijl JJ, Wall DA, Delisle JS, West LJ, Brinkman RR, Levings MK. A standardized immune phenotyping and automated data analysis platform for multicenter biomarker studies. JCI Insight. 2018 Dec 06; 3(23). PMID: 30518691.
      View in: PubMed
    2. Papaz T, Allen U, Blydt-Hansen T, Birk PE, Min S, Hamiwka L, Phan V, Schechter T, Wall DA, Urschel S, Foster BJ, Mital S. Pediatric Outcomes in Transplant: PersOnaliSing Immunosuppression To ImproVe Efficacy (POSITIVE Study): The Collaboration and Design of a National Transplant Precision Medicine Program. Transplant Direct. 2018 Dec; 4(12):e410. PMID: 30584591.
      View in: PubMed
    3. Wang W, Fujii H, Kim HJ, Hermans K, Usenko T, Xie S, Luo ZJ, Ma J, Celso CL, Dick JE, Schroeder T, Krueger J, Wall D, Egeler RM, Zandstra PW. Enhanced human hematopoietic stem and progenitor cell engraftment by blocking donor T cell-mediated TNFa signaling. Sci Transl Med. 2017 Dec 20; 9(421). PMID: 29263228.
      View in: PubMed
    4. Portwine C, Rae C, Davis J, Teira P, Schechter T, Lewis V, Mitchell D, Wall DA, Pullenayegum E, Barr RD. Health-Related Quality of Life in Survivors of High-Risk Neuroblastoma After Stem Cell Transplant: A National Population-Based Perspective. Pediatr Blood Cancer. 2016 09; 63(9):1615-21. PMID: 27203368.
      View in: PubMed
    5. Michelis FV, Atenafu EG, Couban S, Frazer J, Shivakumar S, Hogge DE, Toze CL, Rajkhan W, Kim HJ, Daly A, Slaby J, Finke J, Kiss T, Bredeson C, Sabloff M, Sheppard D, Bakkar M, Brune M, Wall DA, Paulson K, Popradi G, Walker I, Messner HA. Duration of first remission and hematopoietic cell transplantation-specific comorbidity index but not age predict survival of patients with AML transplanted in CR2: a retrospective multicenter study. Bone Marrow Transplant. 2016 07; 51(7):1019-21. PMID: 26974273.
      View in: PubMed
    6. Guan Q, Blankstein AR, Anjos K, Synova O, Tulloch M, Giftakis A, Yang B, Lambert P, Peng Z, Cuvelier GD, Wall DA. Functional Myeloid-Derived Suppressor Cell Subsets Recover Rapidly after Allogeneic Hematopoietic Stem/Progenitor Cell Transplantation. Biol Blood Marrow Transplant. 2015 Jul; 21(7):1205-14. PMID: 25963921.
      View in: PubMed
    7. Yanik GA, Grupp SA, Pulsipher MA, Levine JE, Schultz KR, Wall DA, Langholz B, Dvorak CC, Alangaden K, Goyal RK, White ES, Collura JM, Skeens MA, Eid S, Pierce EM, Cooke KR. TNF-receptor inhibitor therapy for the treatment of children with idiopathic pneumonia syndrome. A joint Pediatric Blood and Marrow Transplant Consortium and Children's Oncology Group Study (ASCT0521). Biol Blood Marrow Transplant. 2015 Jan; 21(1):67-73. PMID: 25270958; PMCID: PMC4286345.
    8. Pulsipher MA, Langholz B, Wall DA, Schultz KR, Bunin N, Carroll WL, Raetz E, Gardner S, Gastier-Foster JM, Howrie D, Goyal RK, Douglas JG, Borowitz M, Barnes Y, Teachey DT, Taylor C, Grupp SA. The addition of sirolimus to tacrolimus/methotrexate GVHD prophylaxis in children with ALL: a phase 3 Children's Oncology Group/Pediatric Blood and Marrow Transplant Consortium trial. Blood. 2014 Mar 27; 123(13):2017-25. PMID: 24497539; PMCID: PMC3968388.
    9. Zorzi AP, Bernstein M, Samson Y, Wall DA, Desai S, Nicksy D, Wainman N, Eisenhauer E, Baruchel S. A phase I study of histone deacetylase inhibitor, pracinostat (SB939), in pediatric patients with refractory solid tumors: IND203 a trial of the NCIC IND program/C17 pediatric phase I consortium. Pediatr Blood Cancer. 2013 Nov; 60(11):1868-74. PMID: 23893953.
      View in: PubMed
    10. Schultz RK, Baker KS, Boelens JJ, Bollard CM, Egeler RM, Cowan M, Ladenstein R, Lankester A, Locatelli F, Lawitschka A, Levine JE, Loh M, Nemecek E, Niemeyer C, Prasad VK, Rocha V, Shenoy S, Strahm B, Veys P, Wall D, Bader P, Grupp SA, Pulsipher MA, Peters C. Challenges and opportunities for international cooperative studies in pediatric hematopoeitic cell transplantation: priorities of the Westhafen Intercontinental Group. Biol Blood Marrow Transplant. 2013 Sep; 19(9):1279-87. PMID: 23883618; PMCID: PMC4198148.
    11. Regan DM, Wofford JD, Wall DA. Comparison of cord blood thawing methods on cell recovery, potency, and infusion. Transfusion. 2010 Dec; 50(12):2670-5. PMID: 21126251.
      View in: PubMed
    12. Szwajcer D, Jennings-Coutts A, Giftakis A, Wall DA. Identification of the CD34 enumeration on the day before stem cell harvest that best predicts poor mobilization. Transfusion. 2011 Mar; 51(3):587-90. PMID: 21388392.
      View in: PubMed
    13. Fujii H, Cuvelier G, She K, Aslanian S, Shimizu H, Kariminia A, Krailo M, Chen Z, McMaster R, Bergman A, Goldman F, Grupp SA, Wall DA, Gilman AL, Schultz KR. Biomarkers in newly diagnosed pediatric-extensive chronic graft-versus-host disease: a report from the Children's Oncology Group. Blood. 2008 Mar 15; 111(6):3276-85. PMID: 17925486; PMCID: PMC2265463.
    14. Sandler ES, Homans A, Mandell L, Amylon M, Wall DA, Devidas M, Buchanan GR, Lipton JM, Billett AL. Hematopoietic stem cell transplantation after first marrow relapse of non-T, non-B acute lymphoblastic leukemia: a pediatric oncology group pilot feasibility study. J Pediatr Hematol Oncol. 2006 Apr; 28(4):210-5. PMID: 16679917.
      View in: PubMed
    15. Bicknese AR, Goodwin HS, Quinn CO, Henderson VC, Chien SN, Wall DA. Human umbilical cord blood cells can be induced to express markers for neurons and glia. Cell Transplant. 2002; 11(3):261-4. PMID: 12075991.
      View in: PubMed
    16. Goodwin HS, Bicknese AR, Chien SN, Bogucki BD, Quinn CO, Wall DA. Multilineage differentiation activity by cells isolated from umbilical cord blood: expression of bone, fat, and neural markers. Biol Blood Marrow Transplant. 2001; 7(11):581-8. PMID: 11760145.
      View in: PubMed
    17. Knutsen AP, Wall DA. Umbilical cord blood transplantation in severe T-cell immunodeficiency disorders: two-year experience. J Clin Immunol. 2000 Nov; 20(6):466-76. PMID: 11202237.
      View in: PubMed
    18. Knutsen AP, Wall DA. Kinetics of T-cell development of umbilical cord blood transplantation in severe T-cell immunodeficiency disorders. J Allergy Clin Immunol. 1999 May; 103(5 Pt 1):823-32. PMID: 10329816.
      View in: PubMed
    19. Gardner JP, Rosenzweig M, Marks DF, Harper D, Gaynor K, Fallon RJ, Wall DA, Johnson RP, Scadden DT. T-lymphopoietic capacity of cord blood-derived CD34+ progenitor cells. Exp Hematol. 1998 Sep; 26(10):991-9. PMID: 9728935.
      View in: PubMed
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