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Yun Li

TitleScientist
InstitutionThe Hospital for Sick Children
DepartmentDevelopmental & Stem Cell Biology
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
ORCID ORCID Icon0000-0002-5849-5910 Additional info
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    Collapse Biography 
    Collapse education and training
    Whitehead Institute, MIT, Cambridge, USAPostdoctoral Fellowship11/2017Stem Cells
    University of Texas Southwestern, Dallas, USAPhD12/2008Neurobiology

    Collapse Overview 

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Li Y, Muffat J, Omer Javed A, Keys HR, Lungjangwa T, Bosch I, Khan M, Virgilio MC, Gehrke L, Sabatini DM, Jaenisch R. Genome-wide CRISPR screen for Zika virus resistance in human neural cells. Proc Natl Acad Sci U S A. 2019 05 07; 116(19):9527-9532. PMID: 31019072.
      View in: PubMed
    2. Omer Javed A, Li Y, Muffat J, Su KC, Cohen MA, Lungjangwa T, Aubourg P, Cheeseman IM, Jaenisch R. Microcephaly Modeling of Kinetochore Mutation Reveals a Brain-Specific Phenotype. Cell Rep. 2018 10 09; 25(2):368-382.e5. PMID: 30304678.
      View in: PubMed
    3. Muffat J, Li Y, Omer A, Durbin A, Bosch I, Bakiasi G, Richards E, Meyer A, Gehrke L, Jaenisch R. Human induced pluripotent stem cell-derived glial cells and neural progenitors display divergent responses to Zika and dengue infections. Proc Natl Acad Sci U S A. 2018 07 03; 115(27):7117-7122. PMID: 29915057.
      View in: PubMed
    4. Liu XS, Wu H, Krzisch M, Wu X, Graef J, Muffat J, Hnisz D, Li CH, Yuan B, Xu C, Li Y, Vershkov D, Cacace A, Young RA, Jaenisch R. Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene. Cell. 2018 02 22; 172(5):979-992.e6. PMID: 29456084.
      View in: PubMed
    5. Mellios N, Feldman DA, Sheridan SD, Ip JPK, Kwok S, Amoah SK, Rosen B, Rodriguez BA, Crawford B, Swaminathan R, Chou S, Li Y, Ziats M, Ernst C, Jaenisch R, Haggarty SJ, Sur M. MeCP2-regulated miRNAs control early human neurogenesis through differential effects on ERK and AKT signaling. Mol Psychiatry. 2018 04; 23(4):1051-1065. PMID: 28439102.
      View in: PubMed
    6. Li Y, Muffat J, Omer A, Bosch I, Lancaster MA, Sur M, Gehrke L, Knoblich JA, Jaenisch R. Induction of Expansion and Folding in Human Cerebral Organoids. Cell Stem Cell. 2017 03 02; 20(3):385-396.e3. PMID: 28041895.
      View in: PubMed
    7. Muffat J, Li Y, Jaenisch R. CNS disease models with human pluripotent stem cells in the CRISPR age. Curr Opin Cell Biol. 2016 12; 43:96-103. PMID: 27768957.
      View in: PubMed
    8. Muffat J, Li Y, Yuan B, Mitalipova M, Omer A, Corcoran S, Bakiasi G, Tsai LH, Aubourg P, Ransohoff RM, Jaenisch R. Efficient derivation of microglia-like cells from human pluripotent stem cells. Nat Med. 2016 11; 22(11):1358-1367. PMID: 27668937.
      View in: PubMed
    9. Li Y, Wang H, Muffat J, Cheng AW, Orlando DA, Lovén J, Kwok SM, Feldman DA, Bateup HS, Gao Q, Hockemeyer D, Mitalipova M, Lewis CA, Vander Heiden MG, Sur M, Young RA, Jaenisch R. Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons. Cell Stem Cell. 2013 Oct 03; 13(4):446-58. PMID: 24094325.
      View in: PubMed
    10. Li Y, Yui D, Luikart BW, McKay RM, Li Y, Rubenstein JL, Parada LF. Conditional ablation of brain-derived neurotrophic factor-TrkB signaling impairs striatal neuron development. Proc Natl Acad Sci U S A. 2012 Sep 18; 109(38):15491-6. PMID: 22949667.
      View in: PubMed
    11. Sanchez-Ortiz E, Yui D, Song D, Li Y, Rubenstein JL, Reichardt LF, Parada LF. TrkA gene ablation in basal forebrain results in dysfunction of the cholinergic circuitry. J Neurosci. 2012 Mar 21; 32(12):4065-79. PMID: 22442072.
      View in: PubMed
    12. Li Y, Li Y, McKay RM, Riethmacher D, Parada LF. Neurofibromin modulates adult hippocampal neurogenesis and behavioral effects of antidepressants. J Neurosci. 2012 Mar 07; 32(10):3529-39. PMID: 22399775.
      View in: PubMed
    13. Luikart BW, Bensen AL, Washburn EK, Perederiy JV, Su KG, Li Y, Kernie SG, Parada LF, Westbrook GL. miR-132 mediates the integration of newborn neurons into the adult dentate gyrus. PLoS One. 2011; 6(5):e19077. PMID: 21611182.
      View in: PubMed
    14. Choi SH, Li Y. Elevated levels of BMP6 impair neurogenesis in Alzheimer's disease. J Neurosci. 2011 Jan 12; 31(2):371-2. PMID: 21228148.
      View in: PubMed
    15. Choi SH, Li Y, Parada LF, Sisodia SS. Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF. Mol Neurodegener. 2009 Dec 21; 4:52. PMID: 20025751.
      View in: PubMed
    16. Li Y, Luikart BW, Birnbaum S, Chen J, Kwon CH, Kernie SG, Bassel-Duby R, Parada LF. TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment. Neuron. 2008 Aug 14; 59(3):399-412. PMID: 18701066.
      View in: PubMed
    17. Lush ME, Li Y, Kwon CH, Chen J, Parada LF. Neurofibromin is required for barrel formation in the mouse somatosensory cortex. J Neurosci. 2008 Feb 13; 28(7):1580-7. PMID: 18272679.
      View in: PubMed
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