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Jamie Hutchison

TitleStaff Physician, PICU
InstitutionThe Hospital for Sick Children
DepartmentCritical Care Medicine
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Biography 
    Collapse education and training
    Queen's University, Kingston, ONDoctorate, Doctor of Medicine05/1983Medicine
    University of SaskatchewanPost-doctorate, FRCPC, Pediatrics Residency06/1990Pediatrics
    University of Western OntarioPost-doctorate, Certification, Pediatric Critical Care06/1992Pediatric Critical Care
    University of Western OntarioResearch Fellowship, Pediatric Critical Care06/1993
    Collapse awards and honors
    19921st Prize Fellows Category, Canadian Pediatric Resident and Fellows, Research Symposium
    19931st Prize Fellows Category, Canadian Pediatric Resident and Fellows, Research Symposium
    1994Resident Teaching Excellence, Department of Pediatrics, University of Ottawa
    2012Award for International Group Collaboration to Advance Resuscitation Science Laurie Morrison, PR, Rescu, Keenan Research Centre Li Ka Shing Knowledge Institute

    Collapse Overview 
    Collapse overview
    Dr. Jamie Hutchison is a Staff Physician, with a special focus on Neurocritical Care, and Director of Research in the Department of Critical Care at the Hospital for Sick Children (SickKids) in Toronto, Ontario, Canada. He is also a Professor of Pediatrics and Associate Scientist in the Institute for Medical Science at the University of Toronto and Senior Scientist in the Neuroscience and Mental Health Research Program at SickKids. His research focus is neuroprotection, and the discovery of biomarkers, in severe brain injuries and his laboratory is focused on mechanisms of neuroinflammation and cell death. He was the lead investigator in the largest multi-center randomized controlled trial of a potential neuroprotective (hypothermia) therapy in children with severe traumatic brain injury (TBI) published in the New England Journal of Medicine in 2008. Most recently Dr. Hutchison and his collaborators have discovered novel electrophysiologic, molecular and imaging biomarkers of prognosis in children with TBI. He is currently the principal investigator of “A National Biobank and Database for Patients with Traumatic Brain Injury (CanTBI)” funded by a Platform Support Grant from Brain Canada with funding partners from Vancouver to Halifax. He is Co-Chair (with Dr. Alexis Turgeon) of the Canadian Traumatic Brain Injury Research Consortium and past chair of the Canadian Critical Care Translational Biology Group both of which have core funding from the Canadian Institutes of Health Research and partners. Dr. Hutchison has trained and mentored many clinical and research trainees over the years many of whom have developed their own successful research programs.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Pong S, Urner M, Fowler RA, Mitsakakis N, Seto W, Hutchison JS, Science M, Daneman N. Testing for non-inferior mortality: a systematic review of non-inferiority margin sizes and trial characteristics. BMJ Open. 2021 Apr 20; 11(4):e044480. PMID: 33879485.
      View in: PubMed
    2. McInnis C, Solana Garcia MJ, Widjaja E, Frndova H, Van Huyse J, Guerguerian AM, Oyefiade A, Laughlin S, Raybaud C, Miller E, Tay K, Bigler ED, Dennis M, Fraser D, Campbell C, Choong K, Danani S, Lacroix J, Farrell C, Beauchamp MH, Schachar R, Hutchison JS, Wheeler A. Magnetic Resonance Imaging Findings are Associated with Long-term Global Neurological Function or Death Following Traumatic Brain Injury in Critically Ill Children. J Neurotrauma. 2021 Mar 31. PMID: 33787327.
      View in: PubMed
    3. Barlow KM, Kirk V, Brooks B, Esser MJ, Yeates KO, Zemek R, Kirton A, Mikrogianakis A, MacMaster F, Nettel-Aguirre A, Hutchison J, Turley B, Cameron C, Hill M, Boyd R, Dewey D. Efficacy of Melatonin for Sleep Disturbance in Children with Persistent Post-Concussion Symptoms: Secondary Analysis of a Randomized Controlled Trial. J Neurotrauma. 2021 Apr 15; 38(8):950-959. PMID: 32988292.
      View in: PubMed
    4. Barlow KM, Brooks BL, Esser MJ, Kirton A, Mikrogianakis A, Zemek RL, MacMaster FP, Nettel-Aguirre A, Yeates KO, Kirk V, Hutchison JS, Crawford S, Turley B, Cameron C, Hill MD, Samuel T, Buchhalter J, Richer L, Platt R, Boyd R, Dewey D. Efficacy of Melatonin in Children With Postconcussive Symptoms: A Randomized Clinical Trial. Pediatrics. 2020 04; 145(4). PMID: 32217739.
      View in: PubMed
    5. Lalgudi Ganesan S, Stewart CP, Atenafu EG, Sharma R, Guerguerian AM, Hutchison JS, Hahn CD. Seizure Identification by Critical Care Providers Using Quantitative Electroencephalography. Crit Care Med. 2018 12; 46(12):e1105-e1111. PMID: 30188384.
      View in: PubMed
    6. Hutchison JS, Emery C, Gagnon I, Léger C, Riopelle R, Wellington C, Wilson E, Turgeon AF. The Canadian Traumatic Brain Injury Research Consortium: Epitomizing Collaborative Research in Canada. J Neurotrauma. 2018 08 15; 35(16):1858-1863. PMID: 30074867.
      View in: PubMed
    7. Crichton A, Anderson V, Oakley E, Greenham M, Hearps S, Delzoppo C, Beauchamp MH, Hutchison JS, Guerguerian AM, Boutis K, Babl FE. Fatigue Following Traumatic Brain Injury in Children and Adolescents: A Longitudinal Follow-Up 6 to 12 Months After Injury. J Head Trauma Rehabil. 2018 May/Jun; 33(3):200-209. PMID: 28926479.
      View in: PubMed
    8. Parshuram CS, Dryden-Palmer K, Farrell C, Gottesman R, Gray M, Hutchison JS, Helfaer M, Hunt EA, Joffe AR, Lacroix J, Moga MA, Nadkarni V, Ninis N, Parkin PC, Wensley D, Willan AR, Tomlinson GA. Effect of a Pediatric Early Warning System on All-Cause Mortality in Hospitalized Pediatric Patients: The EPOCH Randomized Clinical Trial. JAMA. 2018 03 13; 319(10):1002-1012. PMID: 29486493.
      View in: PubMed
    9. Crichton A, Oakley E, Babl FE, Greenham M, Hearps S, Delzoppo C, Beauchamp MH, Hutchison JS, Guerguerian AM, Boutis K, Anderson V. Predicting Fatigue 12 Months after Child Traumatic Brain Injury: Child Factors and Postinjury Symptoms. J Int Neuropsychol Soc. 2018 03; 24(3):224-236. PMID: 28974281.
      View in: PubMed
    10. Jain S, Menon K, Piquette D, Gottesman R, Hutchison J, Gilfoyle E. The Development of a Critical Care Resident Research Curriculum: A Needs Assessment. Can Respir J. 2016; 2016:9795739. PMID: 27610029.
      View in: PubMed
    11. Menon K, McNally JD, Choong K, Lawson ML, Ramsay T, Hutchison JS, Foster J, Wong HR. A Cohort Study of Pediatric Shock: Frequency of Corticosteriod Use and Association with Clinical Outcomes. Shock. 2015 Nov; 44(5):402-9. PMID: 25692259.
      View in: PubMed
    12. Tijssen JA, Prince DK, Morrison LJ, Atkins DL, Austin MA, Berg R, Brown SP, Christenson J, Egan D, Fedor PJ, Fink EL, Meckler GD, Osmond MH, Sims KA, Hutchison JS. Time on the scene and interventions are associated with improved survival in pediatric out-of-hospital cardiac arrest. Resuscitation. 2015 Sep; 94:1-7. PMID: 26095301.
      View in: PubMed
    13. Parshuram CS, Dryden-Palmer K, Farrell C, Gottesman R, Gray M, Hutchison JS, Helfaer M, Hunt E, Joffe A, Lacroix J, Nadkarni V, Parkin P, Wensley D, Willan AR. Evaluating processes of care and outcomes of children in hospital (EPOCH): study protocol for a randomized controlled trial. Trials. 2015 Jun 02; 16:245. PMID: 26033094.
      View in: PubMed
    14. Choong K, Foster G, Fraser DD, Hutchison JS, Joffe AR, Jouvet PA, Menon K, Pullenayegum E, Ward RE. Acute rehabilitation practices in critically ill children: a multicenter study. Pediatr Crit Care Med. 2014 Jul; 15(6):e270-9. PMID: 24777303.
      View in: PubMed
    15. Nenadovic V, Perez Velazquez JL, Hutchison JS. Phase synchronization in electroencephalographic recordings prognosticates outcome in paediatric coma. PLoS One. 2014; 9(4):e94942. PMID: 24752289.
      View in: PubMed
    16. Payne ET, Zhao XY, Frndova H, McBain K, Sharma R, Hutchison JS, Hahn CD. Seizure burden is independently associated with short term outcome in critically ill children. Brain. 2014 May; 137(Pt 5):1429-38. PMID: 24595203.
      View in: PubMed
    17. Bell MJ, Adelson PD, Hutchison JS, Kochanek PM, Tasker RC, Vavilala MS, Beers SR, Fabio A, Kelsey SF, Wisniewski SR. Differences in medical therapy goals for children with severe traumatic brain injury-an international study. Pediatr Crit Care Med. 2013 Oct; 14(8):811-8. PMID: 23863819.
      View in: PubMed
    18. Hutchison JS, Guerguerian AM. Cooling of children with severe traumatic brain injury. Lancet Neurol. 2013 Jun; 12(6):527-9. PMID: 23664371.
      View in: PubMed
    19. McCoy B, Sharma R, Ochi A, Go C, Otsubo H, Hutchison JS, Atenafu EG, Hahn CD. Predictors of nonconvulsive seizures among critically ill children. Epilepsia. 2011 Nov; 52(11):1973-8. PMID: 22003955.
      View in: PubMed
    20. Parshuram CS, Duncan HP, Joffe AR, Farrell CA, Lacroix JR, Middaugh KL, Hutchison JS, Wensley D, Blanchard N, Beyene J, Parkin PC. Multicentre validation of the bedside paediatric early warning system score: a severity of illness score to detect evolving critical illness in hospitalised children. Crit Care. 2011 Aug 03; 15(4):R184. PMID: 21812993.
      View in: PubMed
    21. Fraser DD, Close TE, Rose KL, Ward R, Mehl M, Farrell C, Lacroix J, Creery D, Kesselman M, Stanimirovic D, Hutchison JS. Severe traumatic brain injury in children elevates glial fibrillary acidic protein in cerebrospinal fluid and serum. Pediatr Crit Care Med. 2011 May; 12(3):319-24. PMID: 20625342.
      View in: PubMed
    22. Hutchison JS, Frndova H, Lo TY, Guerguerian AM. Impact of hypotension and low cerebral perfusion pressure on outcomes in children treated with hypothermia therapy following severe traumatic brain injury: a post hoc analysis of the Hypothermia Pediatric Head Injury Trial. Dev Neurosci. 2010; 32(5-6):406-12. PMID: 21252486.
      View in: PubMed
    23. Stewart CP, Otsubo H, Ochi A, Sharma R, Hutchison JS, Hahn CD. Seizure identification in the ICU using quantitative EEG displays. Neurology. 2010 Oct 26; 75(17):1501-8. PMID: 20861452.
      View in: PubMed
    24. Gauvin F, Spinella PC, Lacroix J, Choker G, Ducruet T, Karam O, Hébert PC, Hutchison JS, Hume HA, Tucci M. Association between length of storage of transfused red blood cells and multiple organ dysfunction syndrome in pediatric intensive care patients. Transfusion. 2010 Sep; 50(9):1902-13. PMID: 20456697.
      View in: PubMed
    25. Bourdages M, Bigras JL, Farrell CA, Hutchison JS, Lacroix J. Cardiac arrhythmias associated with severe traumatic brain injury and hypothermia therapy. Pediatr Crit Care Med. 2010 May; 11(3):408-14. PMID: 20464781.
      View in: PubMed
    26. Menon K, Ward RE, Lawson ML, Gaboury I, Hutchison JS, Hébert PC. A prospective multicenter study of adrenal function in critically ill children. Am J Respir Crit Care Med. 2010 Jul 15; 182(2):246-51. PMID: 20299532.
      View in: PubMed
    27. Doherty DR, Hutchison JS. Study of hypothermia therapy after pediatric cardiac arrest. Pediatr Crit Care Med. 2010 Mar; 11(2):315-6; author reply 316-7. PMID: 20216186.
      View in: PubMed
    28. Guerguerian AM, Lo TY, Hutchison JS. Clinical management and functional neuromonitoring in traumatic brain injury in children. Curr Opin Pediatr. 2009 Dec; 21(6):737-44. PMID: 19851107.
      View in: PubMed
    29. Parshuram CS, Hutchison J, Middaugh K. Development and initial validation of the Bedside Paediatric Early Warning System score. Crit Care. 2009; 13(4):R135. PMID: 19678924.
      View in: PubMed
    30. Choong K, Bohn D, Fraser DD, Gaboury I, Hutchison JS, Joffe AR, Litalien C, Menon K, McNamara P, Ward RE. Vasopressin in pediatric vasodilatory shock: a multicenter randomized controlled trial. Am J Respir Crit Care Med. 2009 Oct 01; 180(7):632-9. PMID: 19608718.
      View in: PubMed
    31. Doherty DR, Parshuram CS, Gaboury I, Hoskote A, Lacroix J, Tucci M, Joffe A, Choong K, Farrell R, Bohn DJ, Hutchison JS. Hypothermia therapy after pediatric cardiac arrest. Circulation. 2009 Mar 24; 119(11):1492-500. PMID: 19273725.
      View in: PubMed
    32. Hutchison JS, Ward RE, Lacroix J, Hébert PC, Barnes MA, Bohn DJ, Dirks PB, Doucette S, Fergusson D, Gottesman R, Joffe AR, Kirpalani HM, Meyer PG, Morris KP, Moher D, Singh RN, Skippen PW. Hypothermia therapy after traumatic brain injury in children. N Engl J Med. 2008 Jun 05; 358(23):2447-56. PMID: 18525042.
      View in: PubMed
    33. Nenadovic V, Hutchison JS, Dominguez LG, Otsubo H, Gray MP, Sharma R, Belkas J, Perez Velazquez JL. Fluctuations in cortical synchronization in pediatric traumatic brain injury. J Neurotrauma. 2008 Jun; 25(6):615-27. PMID: 18578633.
      View in: PubMed
    34. Hutchison JS, Doherty DR, Orlowski JP, Kissoon N. Hypothermia therapy for cardiac arrest in pediatric patients. Pediatr Clin North Am. 2008 Jun; 55(3):529-44, ix. PMID: 18501753.
      View in: PubMed
    35. Hare GM, Mazer CD, Hutchison JS, McLaren AT, Liu E, Rassouli A, Ai J, Shaye RE, Lockwood JA, Hawkins CE, Sikich N, To K, Baker AJ. Severe hemodilutional anemia increases cerebral tissue injury following acute neurotrauma. J Appl Physiol (1985). 2007 Sep; 103(3):1021-9. PMID: 17556499.
      View in: PubMed
    36. Lacroix J, Hébert PC, Hutchison JS, Hume HA, Tucci M, Ducruet T, Gauvin F, Collet JP, Toledano BJ, Robillard P, Joffe A, Biarent D, Meert K, Peters MJ. Transfusion strategies for patients in pediatric intensive care units. N Engl J Med. 2007 Apr 19; 356(16):1609-19. PMID: 17442904.
      View in: PubMed
    37. Mikrogianakis A, Shaye RE, Griffin P, Kawesa S, Lockwood J, Gendron NH, Gaboury I, Merali Z, Mackenzie AE, Hutchison JS. Hypoxia alters the expression of inhibitor of apoptosis proteins after brain trauma in the mouse. J Neurotrauma. 2007 Feb; 24(2):338-53. PMID: 17375998.
      View in: PubMed
    38. Haqqani AS, Hutchison JS, Ward R, Stanimirovic DB. Biomarkers and diagnosis; protein biomarkers in serum of pediatric patients with severe traumatic brain injury identified by ICAT-LC-MS/MS. J Neurotrauma. 2007 Jan; 24(1):54-74. PMID: 17263670.
      View in: PubMed
    39. Duncan H, Hutchison J, Parshuram CS. The Pediatric Early Warning System score: a severity of illness score to predict urgent medical need in hospitalized children. J Crit Care. 2006 Sep; 21(3):271-8. PMID: 16990097.
      View in: PubMed
    40. Vandenberg S, Hutchison J, Parshuram CS, Fan E. Cross-sectional survey of levels of care and response mechanisms for evolving critical illness in north american pediatric hospitals. Can J Anaesth. 2006 Apr; 53(4):A416-7. PMID: 27518521.
      View in: PubMed
    41. McIntyre LA, Fergusson DA, Hutchison JS, Pagliarello G, Marshall JC, Yetisir E, Hare GM, Hébert PC. Effect of a liberal versus restrictive transfusion strategy on mortality in patients with moderate to severe head injury. Neurocrit Care. 2006; 5(1):4-9. PMID: 16960287.
      View in: PubMed
    42. Hutchison J, Ward R, Lacroix J, Hébert P, Skippen P, Barnes M, Meyer P, Morris K, Kirpalani H, Singh R, Dirks P, Bohn D, Moher D. Hypothermia pediatric head injury trial: the value of a pretrial clinical evaluation phase. Dev Neurosci. 2006; 28(4-5):291-301. PMID: 16943652.
      View in: PubMed
    43. Liet JM, Millotte B, Tucci M, Laflammme S, Hutchison J, Creery D, Ducruet T, Lacroix J. Noninvasive therapy with helium-oxygen for severe bronchiolitis. J Pediatr. 2005 Dec; 147(6):812-7. PMID: 16356437.
      View in: PubMed
    44. Hutchison JS, Ichord R, Guerguerian AM, Deveber G. Cerebrovascular disorders. Semin Pediatr Neurol. 2004 Jun; 11(2):139-46. PMID: 15259867.
      View in: PubMed
    45. Campbell CG, Kuehn SM, Richards PM, Ventureyra E, Hutchison JS. Medical and cognitive outcome in children with traumatic brain injury. Can J Neurol Sci. 2004 May; 31(2):213-9. PMID: 15198446.
      View in: PubMed
    46. McIntyre LA, Fergusson DA, Hébert PC, Moher D, Hutchison JS. Prolonged therapeutic hypothermia after traumatic brain injury in adults: a systematic review. JAMA. 2003 Jun 11; 289(22):2992-9. PMID: 12799408.
      View in: PubMed
    47. Hutchison JS, Derrane RE, Johnston DL, Gendron N, Barnes D, Fliss H, King WJ, Rasquinha I, MacManus J, Robertson GS, MacKenzie AE. Neuronal apoptosis inhibitory protein expression after traumatic brain injury in the mouse. J Neurotrauma. 2001 Dec; 18(12):1333-47. PMID: 11780864.
      View in: PubMed
    48. Sutcliffe IT, Smith HA, Stanimirovic D, Hutchison JS. Effects of moderate hypothermia on IL-1 beta-induced leukocyte rolling and adhesion in pial microcirculation of mice and on proinflammatory gene expression in human cerebral endothelial cells. J Cereb Blood Flow Metab. 2001 Nov; 21(11):1310-9. PMID: 11702046.
      View in: PubMed
    49. Creery WD, Hashmi A, Hutchison JS, Singh RN. Surfactant therapy improves pulmonary function in infants with Pneumocystis carinii pneumonia and acquired immunodeficiency syndrome. Pediatr Pulmonol. 1997 Nov; 24(5):370-3. PMID: 9407571.
      View in: PubMed
    50. Hutchison JS, Joubert GI, Whitehouse SR, Kissoon N. Pericardial effusion and cardiac tamponade after respiratory syncytial viral infection. Pediatr Emerg Care. 1994 Aug; 10(4):219-21. PMID: 7937300.
      View in: PubMed
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