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Daniela Rotin

TitleSenior Scientist
InstitutionThe Hospital for Sick Children
DepartmentCell Biology
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Demian WL, Persaud A, Jiang C, Coyaud É, Liu S, Kapus A, Kafri R, Raught B, Rotin D. The Ion Transporter NKCC1 Links Cell Volume to Cell Mass Regulation by Suppressing mTORC1. Cell Rep. 2019 May 07; 27(6):1886-1896.e6. PMID: 31067471.
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    2. Wasserman SS, Shteiman-Kotler A, Harris K, Iliadi KG, Persaud A, Zhong Y, Zhang Y, Fang X, Boulianne GL, Stewart B, Rotin D. Regulation of SH3PX1 by dNedd4-long at the Drosophila neuromuscular junction. J Biol Chem. 2019 02 01; 294(5):1739-1752. PMID: 30518551.
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    3. Persaud A, Cormerais Y, Pouyssegur J, Rotin D. Dynamin inhibitors block activation of mTORC1 by amino acids independently of dynamin. J Cell Sci. 2018 01 04; 131(1). PMID: 29150487.
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    4. Crosby JR, Zhao C, Jiang C, Bai D, Katz M, Greenlee S, Kawabe H, McCaleb M, Rotin D, Guo S, Monia BP. Inhaled ENaC antisense oligonucleotide ameliorates cystic fibrosis-like lung disease in mice. J Cyst Fibros. 2017 Nov; 16(6):671-680. PMID: 28539224.
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    5. Jiang C, Kawabe H, Rotin D. The Ubiquitin Ligase Nedd4L Regulates the Na/K/2Cl Co-transporter NKCC1/SLC12A2 in the Colon. J Biol Chem. 2017 02 24; 292(8):3137-3145. PMID: 28087701.
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    6. Attali I, Tobelaim WS, Persaud A, Motamedchaboki K, Simpson-Lavy KJ, Mashahreh B, Levin-Kravets O, Keren-Kaplan T, Pilzer I, Kupiec M, Wiener R, Wolf DA, Rotin D, Prag G. Ubiquitylation-dependent oligomerization regulates activity of Nedd4 ligases. EMBO J. 2017 02 15; 36(4):425-440. PMID: 28069708.
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    7. Lu C, Thoeni C, Connor A, Kawabe H, Gallinger S, Rotin D. Intestinal knockout of Nedd4 enhances growth of Apcmin tumors. Oncogene. 2016 11 10; 35(45):5839-5849. PMID: 27086928.
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    8. Zhang W, Wu KP, Sartori MA, Kamadurai HB, Ordureau A, Jiang C, Mercredi PY, Murchie R, Hu J, Persaud A, Mukherjee M, Li N, Doye A, Walker JR, Sheng Y, Hao Z, Li Y, Brown KR, Lemichez E, Chen J, Tong Y, Harper JW, Moffat J, Rotin D, Schulman BA, Sidhu SS. System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes. Mol Cell. 2016 Apr 07; 62(1):121-36. PMID: 26949039.
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    9. Safi F, Shteiman-Kotler A, Zhong Y, Iliadi KG, Boulianne GL, Rotin D. Drosophila Nedd4-long reduces Amphiphysin levels in muscles and leads to impaired T-tubule formation. Mol Biol Cell. 2016 Mar 15; 27(6):907-18. PMID: 26823013.
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    10. Milkereit R, Persaud A, Vanoaica L, Guetg A, Verrey F, Rotin D. LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation. Nat Commun. 2015 May 22; 6:7250. PMID: 25998567.
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    11. Trzcinska-Daneluti AM, Chen A, Nguyen L, Murchie R, Jiang C, Moffat J, Pelletier L, Rotin D. RNA Interference Screen to Identify Kinases That Suppress Rescue of ?F508-CFTR. Mol Cell Proteomics. 2015 Jun; 14(6):1569-83. PMID: 25825526.
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    12. Fang NN, Chan GT, Zhu M, Comyn SA, Persaud A, Deshaies RJ, Rotin D, Gsponer J, Mayor T. Rsp5/Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress. Nat Cell Biol. 2014 Dec; 16(12):1227-37. PMID: 25344756.
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    13. Persaud A, Alberts P, Mari S, Tong J, Murchie R, Maspero E, Safi F, Moran MF, Polo S, Rotin D. Tyrosine phosphorylation of NEDD4 activates its ubiquitin ligase activity. Sci Signal. 2014 Oct 07; 7(346):ra95. PMID: 25292214.
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    14. Hsia HE, Kumar R, Luca R, Takeda M, Courchet J, Nakashima J, Wu S, Goebbels S, An W, Eickholt BJ, Polleux F, Rotin D, Wu H, Rossner MJ, Bagni C, Rhee JS, Brose N, Kawabe H. Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth. Proc Natl Acad Sci U S A. 2014 Sep 09; 111(36):13205-10. PMID: 25157163.
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    15. Carlile GW, Robert R, Goepp J, Matthes E, Liao J, Kus B, Macknight SD, Rotin D, Hanrahan JW, Thomas DY. Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking. J Cyst Fibros. 2015 Jan; 14(1):16-25. PMID: 24974227.
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    16. Murchie R, Guo CH, Persaud A, Muise A, Rotin D. Protein tyrosine phosphatase s targets apical junction complex proteins in the intestine and regulates epithelial permeability. Proc Natl Acad Sci U S A. 2014 Jan 14; 111(2):693-8. PMID: 24385580.
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    17. Beck J, Maerki S, Posch M, Metzger T, Persaud A, Scheel H, Hofmann K, Rotin D, Pedrioli P, Swedlow JR, Peter M, Sumara I. Ubiquitylation-dependent localization of PLK1 in mitosis. Nat Cell Biol. 2013 Apr; 15(4):430-9. PMID: 23455478.
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    18. Ernst A, Avvakumov G, Tong J, Fan Y, Zhao Y, Alberts P, Persaud A, Walker JR, Neculai AM, Neculai D, Vorobyov A, Garg P, Beatty L, Chan PK, Juang YC, Landry MC, Yeh C, Zeqiraj E, Karamboulas K, Allali-Hassani A, Vedadi M, Tyers M, Moffat J, Sicheri F, Pelletier L, Durocher D, Raught B, Rotin D, Yang J, Moran MF, Dhe-Paganon S, Sidhu SS. A strategy for modulation of enzymes in the ubiquitin system. Science. 2013 Feb 01; 339(6119):590-5. PMID: 23287719.
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    19. Nagpal P, Plant PJ, Correa J, Bain A, Takeda M, Kawabe H, Rotin D, Bain JR, Batt JA. The ubiquitin ligase Nedd4-1 participates in denervation-induced skeletal muscle atrophy in mice. PLoS One. 2012; 7(10):e46427. PMID: 23110050.
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    20. Glowacka WK, Alberts P, Ouchida R, Wang JY, Rotin D. LAPTM5 protein is a positive regulator of proinflammatory signaling pathways in macrophages. J Biol Chem. 2012 Aug 10; 287(33):27691-702. PMID: 22733818.
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    21. Rotin D, Staub O. Nedd4-2 and the regulation of epithelial sodium transport. Front Physiol. 2012; 3:212. PMID: 22737130.
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    22. Trzcinska-Daneluti AM, Nguyen L, Jiang C, Fladd C, Uehling D, Prakesch M, Al-awar R, Rotin D. Use of kinase inhibitors to correct ?F508-CFTR function. Mol Cell Proteomics. 2012 Sep; 11(9):745-57. PMID: 22700489.
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    23. Zhong Y, Shtineman-Kotler A, Nguyen L, Iliadi KG, Boulianne GL, Rotin D. A splice isoform of DNedd4, DNedd4-long, negatively regulates neuromuscular synaptogenesis and viability in Drosophila. PLoS One. 2011; 6(11):e27007. PMID: 22110599.
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    24. Milkereit R, Rotin D. A role for the ubiquitin ligase Nedd4 in membrane sorting of LAPTM4 proteins. PLoS One. 2011; 6(11):e27478. PMID: 22096579.
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    25. Persaud A, Alberts P, Hayes M, Guettler S, Clarke I, Sicheri F, Dirks P, Ciruna B, Rotin D. Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function. EMBO J. 2011 Jul 15; 30(16):3259-73. PMID: 21765395.
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    26. Kimura T, Kawabe H, Jiang C, Zhang W, Xiang YY, Lu C, Salter MW, Brose N, Lu WY, Rotin D. Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease. Proc Natl Acad Sci U S A. 2011 Feb 22; 108(8):3216-21. PMID: 21300902.
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    27. Persaud A, Rotin D. Use of proteome arrays to globally identify substrates for E3 ubiquitin ligases. Methods Mol Biol. 2011; 759:215-24. PMID: 21863490.
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    28. Rotin D, Staub O. Role of the ubiquitin system in regulating ion transport. Pflugers Arch. 2011 Jan; 461(1):1-21. PMID: 20972579.
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    29. Alberts P, Rotin D. Regulation of lipid droplet turnover by ubiquitin ligases. BMC Biol. 2010 Jul 19; 8:94. PMID: 20646264.
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    30. Robert R, Carlile GW, Liao J, Balghi H, Lesimple P, Liu N, Kus B, Rotin D, Wilke M, de Jonge HR, Scholte BJ, Thomas DY, Hanrahan JW. Correction of the Delta phe508 cystic fibrosis transmembrane conductance regulator trafficking defect by the bioavailable compound glafenine. Mol Pharmacol. 2010 Jun; 77(6):922-30. PMID: 20200141.
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    31. Fouladkou F, Lu C, Jiang C, Zhou L, She Y, Walls JR, Kawabe H, Brose N, Henkelman RM, Huang A, Bruneau BG, Rotin D. The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1. J Biol Chem. 2010 Feb 26; 285(9):6770-80. PMID: 20026598.
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    32. Persaud A, Alberts P, Amsen EM, Xiong X, Wasmuth J, Saadon Z, Fladd C, Parkinson J, Rotin D. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. Mol Syst Biol. 2009; 5:333. PMID: 19953087.
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    33. Kim Chiaw P, Huan LJ, Gagnon S, Ly D, Sweezey N, Rotin D, Deber CM, Bear CE. Functional rescue of DeltaF508-CFTR by peptides designed to mimic sorting motifs. Chem Biol. 2009 May 29; 16(5):520-30. PMID: 19477416.
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    34. Rotin D, Kumar S. Physiological functions of the HECT family of ubiquitin ligases. Nat Rev Mol Cell Biol. 2009 Jun; 10(6):398-409. PMID: 19436320.
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    35. Muise AM, Walters TD, Glowacka WK, Griffiths AM, Ngan BY, Lan H, Xu W, Silverberg MS, Rotin D. Polymorphisms in E-cadherin (CDH1) result in a mis-localised cytoplasmic protein that is associated with Crohn's disease. Gut. 2009 Aug; 58(8):1121-7. PMID: 19398441.
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    36. Trzcinska-Daneluti AM, Ly D, Huynh L, Jiang C, Fladd C, Rotin D. High-content functional screen to identify proteins that correct F508del-CFTR function. Mol Cell Proteomics. 2009 Apr; 8(4):780-90. PMID: 19088066.
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    37. Rotin D. Role of the UPS in Liddle syndrome. BMC Biochem. 2008 Oct 21; 9 Suppl 1:S5. PMID: 19007435.
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    38. Bruce MC, Kanelis V, Fouladkou F, Debonneville A, Staub O, Rotin D. Regulation of Nedd4-2 self-ubiquitination and stability by a PY motif located within its HECT-domain. Biochem J. 2008 Oct 01; 415(1):155-63. PMID: 18498246.
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    39. Bezsonova I, Bruce MC, Wiesner S, Lin H, Rotin D, Forman-Kay JD. Interactions between the three CIN85 SH3 domains and ubiquitin: implications for CIN85 ubiquitination. Biochemistry. 2008 Aug 26; 47(34):8937-49. PMID: 18680311.
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    40. Rotin D, Schild L. ENaC and its regulatory proteins as drug targets for blood pressure control. Curr Drug Targets. 2008 Aug; 9(8):709-16. PMID: 18691017.
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    41. Muise A, Rotin D. Apical junction complex proteins and ulcerative colitis: a focus on the PTPRS gene. Expert Rev Mol Diagn. 2008 Jul; 8(4):465-77. PMID: 18598228.
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    42. Fouladkou F, Landry T, Kawabe H, Neeb A, Lu C, Brose N, Stambolic V, Rotin D. The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization. Proc Natl Acad Sci U S A. 2008 Jun 24; 105(25):8585-90. PMID: 18562292.
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    43. Wiesner S, Ogunjimi AA, Wang HR, Rotin D, Sicheri F, Wrana JL, Forman-Kay JD. Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain. Cell. 2007 Aug 24; 130(4):651-62. PMID: 17719543.
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    44. Muise AM, Walters T, Wine E, Griffiths AM, Turner D, Duerr RH, Regueiro MD, Ngan BY, Xu W, Sherman PM, Silverberg MS, Rotin D. Protein-tyrosine phosphatase sigma is associated with ulcerative colitis. Curr Biol. 2007 Jul 17; 17(14):1212-8. PMID: 17614280.
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    45. Lu C, Pribanic S, Debonneville A, Jiang C, Rotin D. The PY motif of ENaC, mutated in Liddle syndrome, regulates channel internalization, sorting and mobilization from subapical pool. Traffic. 2007 Sep; 8(9):1246-64. PMID: 17605762.
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    46. Gupta R, Kus B, Fladd C, Wasmuth J, Tonikian R, Sidhu S, Krogan NJ, Parkinson J, Rotin D. Ubiquitination screen using protein microarrays for comprehensive identification of Rsp5 substrates in yeast. Mol Syst Biol. 2007; 3:116. PMID: 17551511.
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    47. Lu C, Jiang C, Pribanic S, Rotin D. CFTR stabilizes ENaC at the plasma membrane. J Cyst Fibros. 2007 Nov 30; 6(6):419-22. PMID: 17434346.
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    48. Pak Y, Glowacka WK, Bruce MC, Pham N, Rotin D. Transport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitination. J Cell Biol. 2006 Nov 20; 175(4):631-45. PMID: 17116753.
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    49. Ing B, Shteiman-Kotler A, Castelli M, Henry P, Pak Y, Stewart B, Boulianne GL, Rotin D. Regulation of Commissureless by the ubiquitin ligase DNedd4 is required for neuromuscular synaptogenesis in Drosophila melanogaster. Mol Cell Biol. 2007 Jan; 27(2):481-96. PMID: 17074801.
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    50. Siu R, Fladd C, Rotin D. N-cadherin is an in vivo substrate for protein tyrosine phosphatase sigma (PTPsigma) and participates in PTPsigma-mediated inhibition of axon growth. Mol Cell Biol. 2007 Jan; 27(1):208-19. PMID: 17060446.
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    51. Kirkham DL, Pacey LK, Axford MM, Siu R, Rotin D, Doering LC. Neural stem cells from protein tyrosine phosphatase sigma knockout mice generate an altered neuronal phenotype in culture. BMC Neurosci. 2006 Jun 19; 7:50. PMID: 16784531.
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    52. Staub O, Rotin D. Role of ubiquitylation in cellular membrane transport. Physiol Rev. 2006 Apr; 86(2):669-707. PMID: 16601271.
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    53. Kanelis V, Bruce MC, Skrynnikov NR, Rotin D, Forman-Kay JD. Structural determinants for high-affinity binding in a Nedd4 WW3* domain-Comm PY motif complex. Structure. 2006 Mar; 14(3):543-53. PMID: 16531238.
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    54. Amsen EM, Pham N, Pak Y, Rotin D. The guanine nucleotide exchange factor CNrasGEF regulates melanogenesis and cell survival in melanoma cells. J Biol Chem. 2006 Jan 06; 281(1):121-8. PMID: 16272156.
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    55. Tyers M, Brown E, Andrews DW, Bergeron JJ, Boone C, Bremner R, Bussey HA, Cross JC, Davies JE, Desjardins M, Dick JE, Dumont DJ, Durocher D, Ellison MJ, Golding GB, Gray MW, Harrington LA, Hieter PA, Johnston G, Kelvin DJ, McCarry BE, Michnick SW, Ouellette F, Pearlman RE, Penn LJ, Pelletier J, Rachubinski RA, Rennie PS, Rotin D, Rottapel R, Sadowski I, Sicheri F, Siminovitch L, Sonenberg N, Siu KW, Tremblay ML, Winegarden N, Wozniak RW, Wright GD, Woodgett JR. Problems with co-funding in Canada. Science. 2005 Jun 24; 308(5730):1867. PMID: 15976286.
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    56. Kus B, Gajadhar A, Stanger K, Cho R, Sun W, Rouleau N, Lee T, Chan D, Wolting C, Edwards A, Bosse R, Rotin D. A high throughput screen to identify substrates for the ubiquitin ligase Rsp5. J Biol Chem. 2005 Aug 19; 280(33):29470-8. PMID: 15955809.
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    57. Rougier JS, van Bemmelen MX, Bruce MC, Jespersen T, Gavillet B, Apothéloz F, Cordonier S, Staub O, Rotin D, Abriel H. Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins. Am J Physiol Cell Physiol. 2005 Mar; 288(3):C692-701. PMID: 15548568.
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    58. Ishikawa T, Jiang C, Stutts MJ, Marunaka Y, Rotin D. Regulation of the epithelial Na+ channel by cytosolic ATP. J Biol Chem. 2003 Oct 03; 278(40):38276-86. PMID: 12876281.
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    59. Vecchione A, Marchese A, Henry P, Rotin D, Morrione A. The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor. Mol Cell Biol. 2003 May; 23(9):3363-72. PMID: 12697834.
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    60. Henry PC, Kanelis V, O'Brien MC, Kim B, Gautschi I, Forman-Kay J, Schild L, Rotin D. Affinity and specificity of interactions between Nedd4 isoforms and the epithelial Na+ channel. J Biol Chem. 2003 May 30; 278(22):20019-28. PMID: 12654927.
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    61. Batt J, Cutz E, Fladd C, Rotin D. Apparent normal lung architecture in protein tyrosine phosphatase-sigma-deficient mice. Am J Physiol Lung Cell Mol Physiol. 2003 Jan; 284(1):L214-23. PMID: 12471016.
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    62. Pak Y, Pham N, Rotin D. Direct binding of the beta1 adrenergic receptor to the cyclic AMP-dependent guanine nucleotide exchange factor CNrasGEF leads to Ras activation. Mol Cell Biol. 2002 Nov; 22(22):7942-52. PMID: 12391161.
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    63. Meathrel K, Adamek T, Batt J, Rotin D, Doering LC. Protein tyrosine phosphatase sigma-deficient mice show aberrant cytoarchitecture and structural abnormalities in the central nervous system. J Neurosci Res. 2002 Oct 01; 70(1):24-35. PMID: 12237861.
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    64. Myat A, Henry P, McCabe V, Flintoft L, Rotin D, Tear G. Drosophila Nedd4, a ubiquitin ligase, is recruited by Commissureless to control cell surface levels of the roundabout receptor. Neuron. 2002 Aug 01; 35(3):447-59. PMID: 12165468.
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    65. McLean J, Batt J, Doering LC, Rotin D, Bain JR. Enhanced rate of nerve regeneration and directional errors after sciatic nerve injury in receptor protein tyrosine phosphatase sigma knock-out mice. J Neurosci. 2002 Jul 01; 22(13):5481-91. PMID: 12097500.
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    66. Ostenson CG, Sandberg-Nordqvist AC, Chen J, Hällbrink M, Rotin D, Langel U, Efendic S. Overexpression of protein-tyrosine phosphatase PTP sigma is linked to impaired glucose-induced insulin secretion in hereditary diabetic Goto-Kakizaki rats. Biochem Biophys Res Commun. 2002 Mar 08; 291(4):945-50. PMID: 11866457.
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    67. Batt J, Asa S, Fladd C, Rotin D. Pituitary, pancreatic and gut neuroendocrine defects in protein tyrosine phosphatase-sigma-deficient mice. Mol Endocrinol. 2002 Jan; 16(1):155-69. PMID: 11773446.
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    68. Hanwell D, Ishikawa T, Saleki R, Rotin D. Trafficking and cell surface stability of the epithelial Na+ channel expressed in epithelial Madin-Darby canine kidney cells. J Biol Chem. 2002 Mar 22; 277(12):9772-9. PMID: 11773057.
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    69. Pham N, Rotin D. Nedd4 regulates ubiquitination and stability of the guanine-nucleotide exchange factor CNrasGEF. J Biol Chem. 2001 Dec 14; 276(50):46995-7003. PMID: 11598133.
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    70. Rotin D, Kanelis V, Schild L. Trafficking and cell surface stability of ENaC. Am J Physiol Renal Physiol. 2001 Sep; 281(3):F391-9. PMID: 11502587.
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    71. Kanelis V, Rotin D, Forman-Kay JD. Solution structure of a Nedd4 WW domain-ENaC peptide complex. Nat Struct Biol. 2001 May; 8(5):407-12. PMID: 11323714.
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    72. Rotin D. Regulation of the epithelial sodium channel (ENaC) by accessory proteins. Curr Opin Nephrol Hypertens. 2000 Sep; 9(5):529-34. PMID: 10990373.
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    73. Rotin D, Staub O, Haguenauer-Tsapis R. Ubiquitination and endocytosis of plasma membrane proteins: role of Nedd4/Rsp5p family of ubiquitin-protein ligases. J Membr Biol. 2000 Jul 01; 176(1):1-17. PMID: 10882424.
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    74. Plant PJ, Lafont F, Lecat S, Verkade P, Simons K, Rotin D. Apical membrane targeting of Nedd4 is mediated by an association of its C2 domain with annexin XIIIb. J Cell Biol. 2000 Jun 26; 149(7):1473-84. PMID: 10871286.
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    75. Pham N, Cheglakov I, Koch CA, de Hoog CL, Moran MF, Rotin D. The guanine nucleotide exchange factor CNrasGEF activates ras in response to cAMP and cGMP. Curr Biol. 2000 May 04; 10(9):555-8. PMID: 10801446.
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    76. Kanelis V, Donaldson L, Muhandiram DR, Rotin D, Forman-Kay JD, Kay LE. Sequential assignment of proline-rich regions in proteins: application to modular binding domain complexes. J Biomol NMR. 2000 Mar; 16(3):253-9. PMID: 10805132.
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    77. Staub O, Abriel H, Plant P, Ishikawa T, Kanelis V, Saleki R, Horisberger JD, Schild L, Rotin D. Regulation of the epithelial Na+ channel by Nedd4 and ubiquitination. Kidney Int. 2000 Mar; 57(3):809-15. PMID: 10720933.
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    78. Chow CW, Woodside M, Demaurex N, Yu FH, Plant P, Rotin D, Grinstein S, Orlowski J. Proline-rich motifs of the Na+/H+ exchanger 2 isoform. Binding of Src homology domain 3 and role in apical targeting in epithelia. J Biol Chem. 1999 Apr 09; 274(15):10481-8. PMID: 10187839.
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    79. Wallace MJ, Batt J, Fladd CA, Henderson JT, Skarnes W, Rotin D. Neuronal defects and posterior pituitary hypoplasia in mice lacking the receptor tyrosine phosphatase PTPsigma. Nat Genet. 1999 Mar; 21(3):334-8. PMID: 10080192.
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    80. Ishikawa T, Marunaka Y, Rotin D. Electrophysiological characterization of the rat epithelial Na+ channel (rENaC) expressed in MDCK cells. Effects of Na+ and Ca2+. J Gen Physiol. 1998 Jun; 111(6):825-46. PMID: 9607939.
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    81. Liu J, Fitzli D, Liu M, Tseu I, Caniggia I, Rotin D, Post M. PDGF-induced glycosaminoglycan synthesis is mediated via phosphatidylinositol 3-kinase. Am J Physiol. 1998 05; 274(5):L702-13. PMID: 9612285.
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    82. Wallace MJ, Fladd C, Batt J, Rotin D. The second catalytic domain of protein tyrosine phosphatase delta (PTP delta) binds to and inhibits the first catalytic domain of PTP sigma. Mol Cell Biol. 1998 May; 18(5):2608-16. PMID: 9566880.
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    83. Rotin D. WW (WWP) domains: from structure to function. Curr Top Microbiol Immunol. 1998; 228:115-33. PMID: 9401204.
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    84. Kanelis V, Farrow NA, Kay LE, Rotin D, Forman-Kay JD. NMR studies of tandem WW domains of Nedd4 in complex with a PY motif-containing region of the epithelial sodium channel. Biochem Cell Biol. 1998; 76(2-3):341-50. PMID: 9923703.
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    85. Staub O, Gautschi I, Ishikawa T, Breitschopf K, Ciechanover A, Schild L, Rotin D. Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination. EMBO J. 1997 Nov 03; 16(21):6325-36. PMID: 9351815.
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    86. Staub O, Rotin D. Regulation of ion transport by protein-protein interaction domains. Curr Opin Nephrol Hypertens. 1997 Sep; 6(5):447-54. PMID: 9327203.
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    87. Staub O, Yeger H, Plant PJ, Kim H, Ernst SA, Rotin D. Immunolocalization of the ubiquitin-protein ligase Nedd4 in tissues expressing the epithelial Na+ channel (ENaC). Am J Physiol. 1997 Jun; 272(6 Pt 1):C1871-80. PMID: 9227416.
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    88. Staub O, Dho S, Henry P, Correa J, Ishikawa T, McGlade J, Rotin D. WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome. EMBO J. 1996 May 15; 15(10):2371-80. PMID: 8665844.
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    89. Staub O, Rotin D. WW domains. Structure. 1996 May 15; 4(5):495-9. PMID: 8736547.
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    90. Kim H, Yeger H, Han R, Wallace M, Goldstein B, Rotin D. Expression of LAR-PTP2 in rat lung is confined to proliferating epithelia lining the airways and air sacs. Am J Physiol. 1996 Apr; 270(4 Pt 1):L566-76. PMID: 8928816.
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    91. Fialkow L, Chan CK, Rotin D, Grinstein S, Downey GP. Activation of the mitogen-activated protein kinase signaling pathway in neutrophils. Role of oxidants. J Biol Chem. 1994 Dec 09; 269(49):31234-42. PMID: 7983067.
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    92. Rotin D, Bar-Sagi D, O'Brodovich H, Merilainen J, Lehto VP, Canessa CM, Rossier BC, Downey GP. An SH3 binding region in the epithelial Na+ channel (alpha rENaC) mediates its localization at the apical membrane. EMBO J. 1994 Oct 03; 13(19):4440-50. PMID: 7925286.
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    93. Rotin D, Goldstein BJ, Fladd CA. Expression of the tyrosine phosphatase LAR-PTP2 is developmentally regulated in lung epithelia. Am J Physiol. 1994 Sep; 267(3 Pt 1):L263-70. PMID: 7943253.
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    95. Rotin D, Grinstein S. Impaired cell volume regulation in Na(+)-H+ exchange-deficient mutants. Am J Physiol. 1989 Dec; 257(6 Pt 1):C1158-65. PMID: 2558570.
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    96. Grinstein S, Rotin D, Mason MJ. Na+/H+ exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation. Biochim Biophys Acta. 1989 Jan 18; 988(1):73-97. PMID: 2535787.
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