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William Hanley

TitleAdjunct Scientist
InstitutionThe Hospital for Sick Children
DepartmentClinical and Metabolic Genetics
Address555 University Avenue
Toronto ON M5G 1X8
Phone416-813-1500
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. van Vliet D, van Wegberg AMJ, Ahring K, Bik-Multanowski M, Casas K, Didycz B, Djordjevic M, Hertecant JL, Leuzzi V, Mathisen P, Nardecchia F, Powell KK, Rutsch F, Stojiljkovic M, Trefz FK, Usurelu N, Wilson C, van Karnebeek CD, Hanley WB, van Spronsen FJ. Untreated PKU Patients without Intellectual Disability: What Do They Teach Us? Nutrients. 2019 Oct 25; 11(11). PMID: 31731404.
      View in: PubMed
    2. van Vliet D, van Wegberg AMJ, Ahring K, Bik-Multanowski M, Blau N, Bulut FD, Casas K, Didycz B, Djordjevic M, Federico A, Feillet F, Gizewska M, Gramer G, Hertecant JL, Hollak CEM, Jørgensen JV, Karall D, Landau Y, Leuzzi V, Mathisen P, Moseley K, Mungan NÖ, Nardecchia F, Õunap K, Powell KK, Ramachandran R, Rutsch F, Setoodeh A, Stojiljkovic M, Trefz FK, Usurelu N, Wilson C, van Karnebeek CD, Hanley WB, van Spronsen FJ. Can untreated PKU patients escape from intellectual disability? A systematic review. Orphanet J Rare Dis. 2018 08 29; 13(1):149. PMID: 30157945.
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    3. Hanley WB. Optimal serum phenylalanine for adult patients with phenylketonuria (PKU). Mol Genet Metab. 2013 Nov; 110(3):199-200. PMID: 24090705.
      View in: PubMed
    4. Hanley WB. Non-PKU mild hyperphenylalaninemia (MHP)--the dilemma. Mol Genet Metab. 2011 Sep-Oct; 104(1-2):23-6. PMID: 21632269.
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    5. Hanley WB. Finding the fertile woman with phenylketonuria. Eur J Obstet Gynecol Reprod Biol. 2008 Apr; 137(2):131-5. PMID: 18262326.
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    6. Hanley WB. Phenylketonuria: questioning the gospel. Expert Rev Endocrinol Metab. 2007 Nov; 2(6):809-816. PMID: 30290468.
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    7. Hanley WB. Newborn screening in Canada - Are we out of step? Paediatr Child Health. 2005 Apr; 10(4):203-7. PMID: 19668615.
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    8. Hanley WB. Adult phenylketonuria. Am J Med. 2004 Oct 15; 117(8):590-5. PMID: 15465508.
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    9. Hanley WB, Azen C, Koch R, Michals-Matalon K, Matalon R, Rouse B, Trefz F, Waisbren S, de la Cruz F. Maternal Phenylketonuria Collaborative Study (MPKUCS)--the 'outliers'. J Inherit Metab Dis. 2004; 27(6):711-23. PMID: 15505376.
      View in: PubMed
    10. Koch R, Azen C, Friedman E, Hanley W, Levy H, Matalon R, Rouse B, Trefz F, Ning J, de la Cruz F. Research design, organization, and sample characteristics of the Maternal PKU Collaborative Study. Pediatrics. 2003 Dec; 112(6 Pt 2):1519-22. PMID: 14654657.
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    11. Koch R, Hanley W, Levy H, Matalon K, Matalon R, Rouse B, Trefz F, Güttler F, Azen C, Platt L, Waisbren S, Widaman K, Ning J, Friedman EG, de la Cruz F. The Maternal Phenylketonuria International Study: 1984-2002. Pediatrics. 2003 Dec; 112(6 Pt 2):1523-9. PMID: 14654658.
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    12. Güttler F, Azen C, Guldberg P, Romstad A, Hanley WB, Levy HL, Matalon R, Rouse BM, Trefz F, de la Cruz F, Koch R. Impact of the phenylalanine hydroxylase gene on maternal phenylketonuria outcome. Pediatrics. 2003 Dec; 112(6 Pt 2):1530-3. PMID: 14654659.
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    13. Levy HL, Waisbren SE, Güttler F, Hanley WB, Matalon R, Rouse B, Trefz FK, de la Cruz F, Azen CG, Koch R. Pregnancy experiences in the woman with mild hyperphenylalaninemia. Pediatrics. 2003 Dec; 112(6 Pt 2):1548-52. PMID: 14654663.
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    14. Levy HL, Guldberg P, Güttler F, Hanley WB, Matalon R, Rouse BM, Trefz F, Azen C, Allred EN, de la Cruz F, Koch R. Congenital heart disease in maternal phenylketonuria: report from the Maternal PKU Collaborative Study. Pediatr Res. 2001 May; 49(5):636-42. PMID: 11328945.
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    15. Hanley WB, Hanley AJ. The efficacy of stethoscope placement when not in use: traditional versus "cool". CMAJ. 2000 Dec 12; 163(12):1562-3. PMID: 11138413.
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    16. Koch R, Friedman E, Azen C, Hanley W, Levy H, Matalon R, Rouse B, Trefz F, Waisbren S, Michals-Matalon K, Acosta P, Güttler F, Ullrich K, Platt L, de la Cruz F. The International Collaborative Study of Maternal Phenylketonuria: status report 1998. Eur J Pediatr. 2000 Oct; 159 Suppl 2:S156-60. PMID: 11043164.
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    17. Koch R, Hanley W, Levy H, Matalon R, Rouse B, Trefz F, Guttler F, Azen C, Friedman E, Platt L, de la Cruz F. Maternal phenylketonuria: an international study. Mol Genet Metab. 2000 Sep-Oct; 71(1-2):233-9. PMID: 11001815.
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    18. Hanley WB, Lee AW, Hanley AJ, Lehotay DC, Austin VJ, Schoonheyt WE, Platt BA, Clarke JT. "Hypotyrosinemia" in phenylketonuria. Mol Genet Metab. 2000 Apr; 69(4):286-94. PMID: 10870846.
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    19. Smith ML, Saltzman J, Klim P, Hanley WB, Feigenbaum A, Clarke JT. Neuropsychological function in mild hyperphenylalaninemia. Am J Ment Retard. 2000 Mar; 105(2):69-80. PMID: 10755172.
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    20. Waisbren SE, Hanley W, Levy HL, Shifrin H, Allred E, Azen C, Chang PN, Cipcic-Schmidt S, de la Cruz F, Hall R, Matalon R, Nanson J, Rouse B, Trefz F, Koch R. Outcome at age 4 years in offspring of women with maternal phenylketonuria: the Maternal PKU Collaborative Study. JAMA. 2000 Feb 09; 283(6):756-62. PMID: 10683054.
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    21. Platt LD, Koch R, Hanley WB, Levy HL, Matalon R, Rouse B, Trefz F, de la Cruz F, Güttler F, Azen C, Friedman EG. The international study of pregnancy outcome in women with maternal phenylketonuria: report of a 12-year study. Am J Obstet Gynecol. 2000 Feb; 182(2):326-33. PMID: 10694332.
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    22. Rouse B, Matalon R, Koch R, Azen C, Levy H, Hanley W, Trefz F, de la Cruz F. Maternal phenylketonuria syndrome: congenital heart defects, microcephaly, and developmental outcomes. J Pediatr. 2000 Jan; 136(1):57-61. PMID: 10636975.
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    23. Güttler F, Azen C, Guldberg P, Romstad A, Hanley WB, Levy HL, Matalon R, Rouse BM, Trefz F, de la Cruz F, Koch R. Relationship among genotype, biochemical phenotype, and cognitive performance in females with phenylalanine hydroxylase deficiency: report from the Maternal Phenylketonuria Collaborative Study. Pediatrics. 1999 Aug; 104(2 Pt 1):258-62. PMID: 10429004.
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    24. Hanley WB, Platt LD, Bachman RP, Buist N, Geraghty MT, Isaacs J, O'Flynn ME, Rhead WJ, Seidlitz G, Tishler B. Undiagnosed maternal phenylketonuria: the need for prenatal selective screening or case finding. Am J Obstet Gynecol. 1999 Apr; 180(4):986-94. PMID: 10203668.
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    25. Waisbren SE, Chang P, Levy HL, Shifrin H, Allred E, Azen C, de la Cruz F, Hanley W, Koch R, Matalon R, Rouse B. Neonatal neurological assessment of offspring in maternal phenylketonuria. J Inherit Metab Dis. 1998 Feb; 21(1):39-48. PMID: 9501268.
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    26. Smith ML, Hanley WB, Clarke JT, Klim P, Schoonheyt W, Austin V, Lehotay DC. Randomised controlled trial of tyrosine supplementation on neuropsychological performance in phenylketonuria. Arch Dis Child. 1998 Feb; 78(2):116-21. PMID: 9579151.
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    27. Rouse B, Azen C, Koch R, Matalon R, Hanley W, de la Cruz F, Trefz F, Friedman E, Shifrin H. Maternal Phenylketonuria Collaborative Study (MPKUCS) offspring: facial anomalies, malformations, and early neurological sequelae. Am J Med Genet. 1997 Mar 03; 69(1):89-95. PMID: 9066890.
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    28. Hanley WB, Demshar H, Preston MA, Borczyk A, Schoonheyt WE, Clarke JT, Feigenbaum A. Newborn phenylketonuria (PKU) Guthrie (BIA) screening and early hospital discharge. Early Hum Dev. 1997 Jan 03; 47(1):87-96. PMID: 9118832.
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    29. Guldberg P, Levy HL, Hanley WB, Koch R, Matalon R, Rouse BM, Trefz F, de la Cruz F, Henriksen KF, Güttler F. Phenylalanine hydroxylase gene mutations in the United States: report from the Maternal PKU Collaborative Study. Am J Hum Genet. 1996 Jul; 59(1):84-94. PMID: 8659548.
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    30. Levy HL, Waisbren SE, Lobbregt D, Allred E, Leviton A, Koch R, Hanley WB, Rouse B, Matalon R, de la Cruz F. Maternal non-phenylketonuric mild hyperphenylalaninemia. Eur J Pediatr. 1996 Jul; 155 Suppl 1:S20-5. PMID: 8828603.
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    31. Hanley WB, Feigenbaum AS, Clarke JT, Schoonheyt WE, Austin VJ. Vitamin B12 deficiency in adolescents and young adults with phenylketonuria. Eur J Pediatr. 1996 Jul; 155 Suppl 1:S145-7. PMID: 8828632.
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    32. Friedman EG, Koch R, Azen C, Levy H, Hanley W, Matalon R, Rouse B, Trefz F, de la Cruz F. The International Collaborative Study on maternal phenylketonuria: organization, study design and description of the sample. Eur J Pediatr. 1996 Jul; 155 Suppl 1:S158-61. PMID: 8828635.
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    33. Koch R, Levy H, Hanley W, Matalon R, Rouse B, Trefz F, de la Cruz F. Outcome implications of the International Maternal Phenylketonuria Collaborative Study (MPKUCS): 1994. Eur J Pediatr. 1996 Jul; 155 Suppl 1:S162-4. PMID: 8828636.
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    34. Hanley WB, Koch R, Levy HL, Matalon R, Rouse B, Azen C, de la Cruz F. The North American Maternal Phenylketonuria Collaborative Study, developmental assessment of the offspring: preliminary report. Eur J Pediatr. 1996 Jul; 155 Suppl 1:S169-72. PMID: 8828638.
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    35. Koch R, Levy HL, Matalon R, Rouse B, Hanley WB, Trefz F, Azen C, Friedman EG, de la Cruz F, Güttler F, et al. The international collaborative study of maternal phenylketonuria: status report 1994. Acta Paediatr Suppl. 1994 Dec; 407:111-9. PMID: 7766945.
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    36. Schoonheyt WE, Clarke JT, Hanley WB, Johnson JM, Lehotay DC. Feto-maternal plasma phenylalanine concentration gradient from 19 weeks gestation to term. Clin Chim Acta. 1994 Mar; 225(2):165-9. PMID: 8088005.
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    37. Matalon R, Michals K, Azen C, Friedman E, Koch R, Rouse B, Hanley WB, de la Cruz F. Maternal PKU Collaborative Study: pregnancy outcome and postnatal head growth. J Inherit Metab Dis. 1994; 17(3):353-5. PMID: 7807951.
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    38. Koch R, Levy HL, Matalon R, Rouse B, Hanley W, Azen C. The North American Collaborative Study of Maternal Phenylketonuria. Status report 1993. Am J Dis Child. 1993 Nov; 147(11):1224-30. PMID: 8237918.
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    39. Hanley WB, Feigenbaum A, Clarke JT, Schoonheyt W, Austin V. Vitamin B12 deficiency in adolescents and young adults with phenylketonuria. Lancet. 1993 Oct 16; 342(8877):997. PMID: 8105251.
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    40. Bodley JL, Austin VJ, Hanley WB, Clarke JT, Zlotkin S. Low iron stores in infants and children with treated phenylketonuria: a population at risk for iron-deficiency anaemia and associated cognitive deficits. Eur J Pediatr. 1993 Feb; 152(2):140-3. PMID: 8444222.
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    41. Platt LD, Koch R, Azen C, Hanley WB, Levy HL, Matalon R, Rouse B, de la Cruz F, Walla CA. Maternal phenylketonuria collaborative study, obstetric aspects and outcome: the first 6 years. Am J Obstet Gynecol. 1992 Apr; 166(4):1150-60; discussion 1160-2. PMID: 1566767.
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    42. Hanley WB, Clarke JT, Schoonheyt WE. Undiagnosed phenylketonuria in adult women: a hidden public health problem. CMAJ. 1990 Sep 15; 143(6):513-6. PMID: 2207906.
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    43. Rouse B, Lockhart L, Matalon R, Azen C, Koch R, Hanley W, Levy H, dela Cruz F, Friedman E. Maternal phenylketonuria pregnancy outcome: a preliminary report of facial dysmorphology and major malformations. J Inherit Metab Dis. 1990; 13(3):289-91. PMID: 2122088.
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    44. Koch R, Hanley W, Levy H, Matalon R, Rouse B, Dela Cruz F, Azen C, Gross Friedman E. A preliminary report of the collaborative study of maternal phenylketonuria in the United States and Canada. J Inherit Metab Dis. 1990; 13(4):641-50. PMID: 2122127.
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    45. Hanley WB, Clarke JT, Schoonheyt W. Maternal phenylketonuria (PKU)--a review. Clin Biochem. 1987 Jun; 20(3):149-56. PMID: 3308176.
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    46. Schoonheyt WE, Hanley WB, Clarke JT, Austin V, Howe DA. Maternal Phenylketonuria (MPKU). Can Fam Physician. 1986 Oct; 32:2253-8. PMID: 21267327.
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    47. Netley C, Hanley WB, Rudner HL. Phenylketonuria and its variants: observations on intellectual functioning. Can Med Assoc J. 1984 Oct 01; 131(7):751-5. PMID: 6478363.
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    48. Hanley WB, Bell L. Maternal phenylketonuria: finding and treating women before conception. Can Med Assoc J. 1982 Jun 01; 126(11):1259-60. PMID: 7074445.
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    49. Hanley WB, Linsao LS, Netley C. The efficacy of dietary therapy for phenylketonuria. Can Med Assoc J. 1971 Jun 19; 104(12):1089-91. PMID: 5104016.
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    50. Jackson SH, Hanley WB, Gero T, Gosse GD. Detection of phenylketonuric heterozygotes. Clin Chem. 1971 Jun; 17(6):538-43. PMID: 5103385.
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    51. Hanley WB, Linsao L, Davidson W, Moes CA. Malnutrition with early treatment of phenylketonuria. Pediatr Res. 1970 Jul; 4(4):318-27. PMID: 5447890.
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    52. Hackney IM, Hanley WB, Davidson W, Lindsao L. Phenylketonuria: mental development, behavior, and termination of low phenylalanine diet. J Pediatr. 1968 May; 72(5):646-55. PMID: 4171484.
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