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Search Results to Michael Salter

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One or more keywords matched the following properties of Salter, Michael

overview Dr. Salter is Chief of Research at The Hospital for Sick Children (SickKids), a Senior Scientist in the Program in Neurosciences & Mental Health, and a Professor of Physiology at the University of Toronto. Dr. Salter received an MD degree from the University of Western Ontario in 1982 and went on to obtain a Ph.D. in Physiology from McGill in 1987. After post-doctoral training at Toronto Western and at Mt. Sinai hospitals, he joined the Research Institute of SickKids in 1990. From 1999 to 2009 Dr. Salter was the founding Director of the University of Toronto Centre for the Study of Pain. Dr. Salter’s main research focus is on synaptic physiology, in particular in relation to pain, and he has done groundbreaking work that has led to new paradigms about neuroplasticity and about how synaptic transmission in the central nervous system is regulated by biochemical processes within neurons and by glial-neuronal interactions. His discoveries have broad implications for the control of cell-cell communication throughout the nervous system and his work has regularly appeared in elite journals including Nature, Science, Cell, Nature Medicine and Neuron. Dr. Salter has a broad interest in neuroscience and his work relevant to learning and memory, stroke-induced neuron death, epilepsy and schizophrenia. As a distinct line of research, he and his collaborators reported in Cell in 2006 their discovery of a previously unsuspected role for sensory neurons in the pathogenesis of diabetes and in the control of glucose homeostasis. To facilitate the translation of his fundamental studies to the development of new therapies for humans, Dr. Salter is a founding scientist and actively involved in two startup biotech companies – NoNO Inc and Afference Therapeutics. Dr. Salter currently holds the Northbridge Chair in Paediatric Research. He has received numerous awards including the E.B. Eastburn Award, the John Charles Polyani Prize in Physiology or Medicine, the Early Career Investigator Award of the Canadian Pain Society, the Distinguished Career Investigator Award of the Canadian Pain Society, and was an International Research Scholar of the Howard Hughes Medical Institute. He is a Fellow of the Royal Society of Canada.

One or more keywords matched the following items that are connected to Salter, Michael

Item TypeName
Concept Synaptic Transmission
Concept Neural Inhibition
Concept Post-Synaptic Density
Concept Synaptic Potentials
Academic Article Recruitment of NMDA receptors into synaptic transmission after kindling-induced epilepsy and its possible mechanism.
Academic Article Purine-induced depression of dorsal horn neurons in the cat spinal cord: enhancement by tachykinins.
Academic Article Tachykinins enhance the depression of spinal nociceptive neurons caused by cutaneously applied vibration in the cat.
Academic Article Effects of adenosine 5'-monophosphate and adenosine 5'-triphosphate on functionally identified units in the cat spinal dorsal horn. Evidence for a differential effect of adenosine 5'-triphosphate on nociceptive vs non-nociceptive units.
Academic Article Substance P released endogenously by high-intensity sensory stimulation potentiates purinergic inhibition of nociceptive dorsal horn neurons induced by peripheral vibration.
Academic Article Determination of brain nitric oxide synthase inhibition in vivo: ex vivo assays of nitric oxide synthase can give incorrect results.
Academic Article Physiological roles for adenosine and ATP in synaptic transmission in the spinal dorsal horn.
Academic Article NMDA channel regulation by channel-associated protein tyrosine kinase Src.
Academic Article Src, N-methyl-D-aspartate (NMDA) receptors, and synaptic plasticity.
Academic Article Gain control of NMDA-receptor currents by intracellular sodium.
Academic Article An ambiguous fast synapse: a new twist in the tale of two transmitters.
Academic Article Src, a molecular switch governing gain control of synaptic transmission mediated by N-methyl-D-aspartate receptors.
Academic Article Src potentiation of NMDA receptors in hippocampal and spinal neurons is not mediated by reducing zinc inhibition.
Academic Article Neuronal plasticity: increasing the gain in pain.
Academic Article NMDA receptor regulation by Src kinase signalling in excitatory synaptic transmission and plasticity.
Academic Article Tyrosine phosphatase STEP is a tonic brake on induction of long-term potentiation.
Academic Article Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactions.
Academic Article Src kinases: a hub for NMDA receptor regulation.
Academic Article Unique domain anchoring of Src to synaptic NMDA receptors via the mitochondrial protein NADH dehydrogenase subunit 2.
Academic Article NMDA receptors are movin' in.
Academic Article Src in synaptic transmission and plasticity.
Academic Article Cellular neuroplasticity mechanisms mediating pain persistence.
Academic Article Cellular signalling pathways of spinal pain neuroplasticity as targets for analgesic development.
Academic Article PSD-95 is a negative regulator of the tyrosine kinase Src in the NMDA receptor complex.
Academic Article ErbB4 is a suppressor of long-term potentiation in the adult hippocampus.
Academic Article Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning.
Academic Article alpha5 Subunit-containing GABA(A) receptors mediate a slowly decaying inhibitory synaptic current in CA1 pyramidal neurons following Schaffer collateral activation.
Academic Article Microglia-neuronal signalling in neuropathic pain hypersensitivity 2.0.
Academic Article Plasticity of synaptic GluN receptors is required for the Src-dependent induction of long-term potentiation at CA3-CA1 synapses.
Academic Article Neto1 is an auxiliary subunit of native synaptic kainate receptors.
Academic Article DIP/WISH deficiency enhances synaptic function and performance in the Barnes maze.
Academic Article Rett syndrome induced pluripotent stem cell-derived neurons reveal novel neurophysiological alterations.
Academic Article Neto2 interacts with the scaffolding protein GRIP and regulates synaptic abundance of kainate receptors.
Academic Article Vertebrate intersectin1 is repurposed to facilitate cortical midline connectivity and higher order cognition.
Academic Article Calcium-permeable ion channels in pain signaling.
Academic Article GluN2B and GluN2D NMDARs dominate synaptic responses in the adult spinal cord.
Academic Article Fyn Kinase regulates GluN2B subunit-dominant NMDA receptors in human induced pluripotent stem cell-derived neurons.
Academic Article Infantile spasms in down syndrome: Rescue by knockdown of the GIRK2 channel.
Academic Article Potentiation of Synaptic GluN2B NMDAR Currents by Fyn Kinase Is Gated through BDNF-Mediated Disinhibition in Spinal Pain Processing.
Academic Article Neto Auxiliary Subunits Regulate Interneuron Somatodendritic and Presynaptic Kainate Receptors to Control Network Inhibition.
Academic Article Priming of Adult Incision Response by Early-Life Injury: Neonatal Microglial Inhibition Has Persistent But Sexually Dimorphic Effects in Adult Rats.
Academic Article Synaptic Dysfunction in Human Neurons With Autism-Associated Deletions in PTCHD1-AS.
Academic Article Control of Long-Term Synaptic Potentiation and Learning by Alternative Splicing of the NMDA Receptor Subunit GluN1.

Search criteria
  • Synaptic
  • Inhibition