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overview Much of biomedical research focuses on the identification of etiological factors for common disease. Human genetics provides an unparalleled opportunity to identify causal factors since the DNA sequence stays mostly the same in every cell of humans as they age, and reverse causality is unlikely. Based on the sequence of the human genome, recent advances in technologies have allowed high-throughput genotyping and sequencing to capture the majority of variation in the human genome. This provides an unparalleled opportunity to identify causal genes, pathways and mechanisms for common human diseases and traits. Such knowledge is important since it provides novel opportunities for improvements in screening, prevention and possibly treatments of such diseases, ultimately aimed at reducing the incidence and severity of numerous common diseases. Although the direct benefit may take many years to realise, foundational discoveries from human genetics offer great opportunity for the rationale development of strategies with impact. The main focus of my research is understanding the genetic bases of common complex disease, specifically type 1 diabetes and its long term complications. Approximately 1:300 Canadians develop type 1 diabetes during their lifetime, and decades-long hyperglycemia is associated with reduced life expectancy due to complications including hypoglycemia, nephropathy and cardiovascular disease. In addition, although the mechanisms that result in type 2 diabetes appear to be mostly distinct from type 1 diabetes, the complications of nephropathy and cardiovascular disease are also present in people with type 2 diabetes, which has a much higher population prevalence, with 8.3% of the population of Ontario having diabetes in 2010. It is likely that some of the same genetic risk factors for these long-term complications of type 2 diabetes are shared with those for the same complication of type 1 diabetes. Part of my time is spent as a co-director of the Statistical Analysis Facility of The Center for Applied Genomics at SickKids (www.tcag.ca/facilities/statisticalAnalysis.html). Work from this has resulted in a numerous publications, describing the mapping and cloning of a number of single gene diseases.

One or more keywords matched the following items that are connected to Paterson, Andrew

Item TypeName
Concept Human Genome Project
Concept Mothers
Concept Genome, Plant
Concept Genome, Human
Concept Genome-Wide Association Study
Concept Genome
Academic Article Transmission ratio distortion in families from the Framingham Heart Study.
Academic Article Genetic analysis of common factors underlying cardiovascular disease-related traits.
Academic Article Progressive loss of renal function is an age-dependent heritable trait in type 1 autosomal dominant polycystic kidney disease.
Academic Article Genetic Analysis Workshop 14: microsatellite and single-nucleotide polymorphism marker loci for genome-wide scans.
Academic Article A genome scan for parent-of-origin linkage effects in alcoholism.
Academic Article Stratified false discovery control for large-scale hypothesis testing with application to genome-wide association studies.
Academic Article CRYBA4, a novel human cataract gene, is also involved in microphthalmia.
Academic Article Genome-wide linkage scan of a large family with IgA nephropathy localizes a novel susceptibility locus to chromosome 2q36.
Academic Article Sex, age and generation effects on genome-wide linkage analysis of gene expression in transformed lymphoblasts.
Academic Article Genome-wide linkage analyses of quantitative and categorical autism subphenotypes.
Academic Article Identification of LTBP2 on chromosome 14q as a novel candidate gene for bone mineral density variation and fracture risk association.
Academic Article Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes.
Academic Article Type 1 diabetes in the BB rat: a polygenic disease.
Academic Article Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE Statement.
Academic Article Strengthening the reporting of genetic association studies (STREGA): an extension of the strengthening the reporting of observational studies in epidemiology (STROBE) statement.
Academic Article Genome-wide association scan for diabetic nephropathy susceptibility genes in type 1 diabetes.
Academic Article STrengthening the REporting of Genetic Association Studies (STREGA)--an extension of the STROBE statement.
Academic Article STrengthening the REporting of Genetic Association studies (STREGA)--an extension of the STROBE statement.
Academic Article Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies.
Academic Article Were genome-wide linkage studies a waste of time? Exploiting candidate regions within genome-wide association studies.
Academic Article Genome-wide association identifies the ABO blood group as a major locus associated with serum levels of soluble E-selectin.
Academic Article A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose.
Academic Article Phenotype definition and development--contributions from Group 7.
Academic Article Genome-wide association analysis of cardiovascular-related quantitative traits in the Framingham Heart Study.
Academic Article Pathway-based analysis of a genome-wide case-control association study of rheumatoid arthritis.
Academic Article Family-based association study of IGF1 microsatellites and height, weight, and body mass index.
Academic Article New susceptibility loci associated with kidney disease in type 1 diabetes.
Academic Article Functional impact of global rare copy number variation in autism spectrum disorders.
Academic Article A genome-wide scan for common alleles affecting risk for autism.
Academic Article Rare familial 16q21 microdeletions under a linkage peak implicate cadherin 8 (CDH8) in susceptibility to autism and learning disability.
Academic Article BR-squared: a practical solution to the winner's curse in genome-wide scans.
Academic Article Common variants in ZNF365 are associated with both mammographic density and breast cancer risk.
Academic Article Novel method for combined linkage and genome-wide association analysis finds evidence of distinct genetic architecture for two subtypes of autism.
Academic Article Identification of genetic loci underlying the phenotypic constructs of autism spectrum disorders.
Academic Article Genome-wide scan for loci of adolescent obesity and their relationship with blood pressure.
Academic Article Sex differences in repetitive stereotyped behaviors in autism: implications for genetic liability.
Academic Article Effect of linkage disequilibrium on the identification of functional variants.
Academic Article A genome-wide linkage study of mammographic density, a risk factor for breast cancer.
Academic Article Mammographic breast density and breast cancer: evidence of a shared genetic basis.
Academic Article Identification of a novel percent mammographic density locus at 12q24.
Academic Article Common genetic determinants of intraocular pressure and primary open-angle glaucoma.
Academic Article Pilot genome-wide association search identifies potential loci for risk of erectile dysfunction in type 1 diabetes using the DCCT/EDIC study cohort.
Academic Article Individual common variants exert weak effects on the risk for autism spectrum disorders.
Academic Article Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.
Academic Article Meta-analysis of genome-wide association studies in five cohorts reveals common variants in RBFOX1, a regulator of tissue-specific splicing, associated with refractive error.
Academic Article The C-type lectin receptor CLEC4M binds, internalizes, and clears von Willebrand factor and contributes to the variation in plasma von Willebrand factor levels.
Academic Article Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.
Academic Article Letter to the editor: expression of concern, reaffirmed.
Academic Article Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
Academic Article Genome-wide association study of urinary albumin excretion rate in patients with type 1 diabetes.
Academic Article GWAS identifies an NAT2 acetylator status tag single nucleotide polymorphism to be a major locus for skin fluorescence.
Academic Article Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
Academic Article Drinking from the Holy Grail: analysis of whole-genome sequencing from the Genetic Analysis Workshop 18.
Academic Article Genome-wide meta-analysis of myopia and hyperopia provides evidence for replication of 11 loci.
Academic Article Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk.
Academic Article Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium.
Academic Article Using extended pedigrees to identify novel autism spectrum disorder (ASD) candidate genes.
Academic Article Dynamic pathway analysis of genes associated with blood pressure using whole genome sequence data.
Academic Article Assessing models for genetic prediction of complex traits: a comparison of visualization and quantitative methods.
Academic Article Corrigendum: genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk.
Academic Article Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes.
Academic Article Variation in SLC19A3 and Protection From Microvascular Damage in Type 1 Diabetes.
Academic Article Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error.
Academic Article Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia: The CREAM Consortium.
Academic Article New Locus for Skin Intrinsic Fluorescence in Type 1 Diabetes Also Associated With Blood and Skin Glycated Proteins.
Academic Article Genome-Wide DNA Methylation Analysis Reveals Epigenetic Dysregulation of MicroRNA-34A in TP53-Associated Cancer Susceptibility.
Academic Article Association of host genome with intestinal microbial composition in a large healthy cohort.
Academic Article Genetic Variants Associated with Circulating Parathyroid Hormone.
Academic Article Combined genome-wide linkage and targeted association analysis of head circumference in autism spectrum disorder families.
Academic Article Meta-genome-wide association studies identify a locus on chromosome 1 and multiple variants in the MHC region for serum C-peptide in type 1 diabetes.
Academic Article Novel risk genes identified in a genome-wide association study for coronary artery disease in patients with type 1 diabetes.
Academic Article A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes.
Academic Article Metaphyseal dysplasia with maxillary hypoplasia and brachydactyly is caused by a duplication in RUNX2.
Academic Article Expression of concern re: Kulminski, A. 2011. Complex phenotypes and phenomenon of genome-wide inter-chromosomal linkage disequilibrium in the human genome. Experimental Gerontology. DOI: 10.1016/j.exger.2011.08.010.
Academic Article The Genetic Landscape of Renal Complications in Type 1 Diabetes.
Academic Article Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error.
Academic Article Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative.
Academic Article A genome-wide linkage study of autism spectrum disorder and the broad autism phenotype in extended pedigrees.
Academic Article Prevalence Estimates of Polycystic Kidney and Liver Disease by Population Sequencing.
Academic Article Allele-defined genome of the autopolyploid sugarcane Saccharum spontaneum L.
Academic Article Genetic Analysis of Gossypium Fiber Quality Traits in Reciprocal Advanced Backcross Populations.
Academic Article Publisher Correction: Allele-defined genome of the autopolyploid sugarcane Saccharum spontaneum L.
Academic Article Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control.
Academic Article Genetic Determinants of Glycated Hemoglobin in Type 1 Diabetes.
Academic Article gpart: human genome partitioning and visualization of high-density SNP data by identifying haplotype blocks.
Academic Article Fast and Accurate Shared Segment Detection and Relatedness Estimation in Un-phased Genetic Data via TRUFFLE.
Academic Article Analysis of Genetic Association of Intestinal Permeability in Healthy First-degree Relatives of Patients with Crohn's Disease.
Academic Article Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen.
Academic Article Rare Genetic Variants of Large Effect Influence Risk of Type 1 Diabetes.
Academic Article MCScanX: a toolkit for detection and evolutionary analysis of gene synteny and collinearity.
Academic Article Challenges of detecting directional selection after a bottleneck: lessons from Sorghum bicolor.
Academic Article A 3347-locus genetic recombination map of sequence-tagged sites reveals features of genome organization, transmission and evolution of cotton (Gossypium).
Academic Article Plant Genome Duplication Database.
Academic Article Screening synteny blocks in pairwise genome comparisons through integer programming.
Academic Article Toward sequencing cotton (Gossypium) genomes.
Academic Article Erratum. Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control. Diabetes 2019;68:441-456.
Academic Article Genome-wide association study of emotional empathy in children.
Academic Article A comparative phylogenetic approach for dating whole genome duplication events.
Academic Article Genome-Wide Association for HbA1c in Malay Identified Deletion on SLC4A1 that Influences HbA1c Independent of Glycemia.

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