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Search Results to Steve Prescott

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One or more keywords matched the following properties of Prescott, Steve

keywords Computer Simulations
overview My lab studies how information is represented and processed by the nervous system. We are particularly interested in how somatosensory information is processed and how pathological disruption of that processing leads to chronic pain. We study these questions at many levels, from the electrodiffusion of ion s to the coordinated spiking of neurons within large neural networks. We combine computer simulations and mathematical analysis with a broad range of experimental methods including electrophysiology, calcium imaging and optogenetics

One or more keywords matched the following items that are connected to Prescott, Steve

Item TypeName
Concept Computer Simulation
Academic Article Nonlinear interaction between shunting and adaptation controls a switch between integration and coincidence detection in pyramidal neurons.
Academic Article Reduction of anion reversal potential subverts the inhibitory control of firing rate in spinal lamina I neurons: towards a biophysical basis for neuropathic pain.
Academic Article Hippocampal bursts caused by changes in NMDA receptor-dependent excitation in a mouse model of variant CJD.
Academic Article Pyramidal neurons switch from integrators in vitro to resonators under in vivo-like conditions.
Academic Article Efficacy of synaptic inhibition depends on multiple, dynamically interacting mechanisms implicated in chloride homeostasis.
Academic Article ClC-2 channels regulate neuronal excitability, not intracellular chloride levels.
Academic Article Identification of molecular pathologies sufficient to cause neuropathic excitability in primary somatosensory afferents using dynamical systems theory.
Academic Article Criticality and degeneracy in injury-induced changes in primary afferent excitability and the implications for neuropathic pain.
Academic Article Cooperativity between remote sites of ectopic spiking allows afterdischarge to be initiated and maintained at different locations.
Academic Article Regulation of Cortical Dynamic Range by Background Synaptic Noise and Feedforward Inhibition.
Academic Article Combined Changes in Chloride Regulation and Neuronal Excitability Enable Primary Afferent Depolarization to Elicit Spiking without Compromising its Inhibitory Effects.
Academic Article Nonlinear Relationship Between Spike-Dependent Calcium Influx and TRPC Channel Activation Enables Robust Persistent Spiking in Neurons of the Anterior Cingulate Cortex.
Academic Article Origin of heterogeneous spiking patterns from continuously distributed ion channel densities: a computational study in spinal dorsal horn neurons.
Academic Article Changes in White Matter Microstructure Impact Cognition by Disrupting the Ability of Neural Assemblies to Synchronize.
Grant Probing spike initiation properties of primary somatosensory neurons using optogenetics
Grant hloride dysregulation and neuropathic pain: Linking molecular mechanisms with altered pain processing via identification of cellular and circuit level changes

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  • Computers